LeishMANIAdb
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Frequently Asked Questions

Q1 Q2 Q3 Q4
Q: What is Leishmania?
A: Leishmaniasis is a parasitic protozoan disease, responsible for non-resolving and chronic infection, affecting over 10 million people worldwide, with ongoing environmental changes are considered to be helping the disease to spread to new regions. Leishmania pathogenesis is poorly understood and to combat the infection and to control the disease further insights into host-pathogen interaction are desperately needed. An integral part of the constant arms race between the host immune system and pathogens is the rapid appearance of pathogenic Short Linear Motifs (SLiMs), capable of modulating the host cell regulation. The limited sequence length of these protein-binding segments provides advantages for the pathogen, as SLiMs can arise de novo and many can be packed into a single protein. Their properties make them hard to identify at a large scale using biochemical methods alone, however, using bioinformatics approaches this process can be accelerated.

Q: What is LeishMANIAdb?
A: LeishMANIAdb is a database with primary focus on virulence factors from Leishmania species that may hijack host cell regulation. LeishMANIAdb contains information of putative linear motifs that can rewire host processes, enriched with localization, structural and functional annotations that may help to objectively select candidates for further studies. Information was collected in a way, so users not particularly interested in motif biology can still inspect and download them.

Q: How can I search or browse in the database?
A: The search bar on the top of the page can be used to quickly access any protein. UniProt identifiers, UniProt ACs, TritrypDB identifiers and protein names can be searched using this menu. Users can also browse predefined sets of proteins from the browse menu.

Q: How can I cite the database?
A: Gábor E. Tusnády, András Zeke, Zsófia E. Kálmán, Marie Fatoux, Sylvie Ricard-Blum, Toby Gibson, Laszlo Dobson. LeishMANIAdb: a comparative resource for Leishmania proteins, under revision

Preprint in bioRxiv (doi: 10.1101/2023.03.08.531706)


LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS