Probable U3 small nucleolar RNA-associated protein 11

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U3 snoRNA-associated protein UTP11, putative

Species:

Leishmania major

UniProt:

UTP11_LEIMA

TriTrypDb:

LmjF.19.0670 , LMJLV39_190012300 , LMJSD75_190011900

Length:

361

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0030684	preribosome	3	11
GO:0032040	small-subunit processome	4	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

Q9U178

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9U178

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.606
CLV_NRD_NRD_1	100	102	PF00675	0.293
CLV_NRD_NRD_1	113	115	PF00675	0.347
CLV_NRD_NRD_1	19	21	PF00675	0.386
CLV_NRD_NRD_1	213	215	PF00675	0.294
CLV_NRD_NRD_1	217	219	PF00675	0.278
CLV_NRD_NRD_1	225	227	PF00675	0.512
CLV_NRD_NRD_1	298	300	PF00675	0.448
CLV_NRD_NRD_1	333	335	PF00675	0.456
CLV_NRD_NRD_1	347	349	PF00675	0.418
CLV_NRD_NRD_1	358	360	PF00675	0.509
CLV_NRD_NRD_1	50	52	PF00675	0.419
CLV_NRD_NRD_1	56	58	PF00675	0.320
CLV_NRD_NRD_1	92	94	PF00675	0.293
CLV_PCSK_FUR_1	90	94	PF00082	0.379
CLV_PCSK_KEX2_1	113	115	PF00082	0.379
CLV_PCSK_KEX2_1	19	21	PF00082	0.280
CLV_PCSK_KEX2_1	213	215	PF00082	0.274
CLV_PCSK_KEX2_1	217	219	PF00082	0.274
CLV_PCSK_KEX2_1	225	227	PF00082	0.489
CLV_PCSK_KEX2_1	262	264	PF00082	0.671
CLV_PCSK_KEX2_1	298	300	PF00082	0.448
CLV_PCSK_KEX2_1	341	343	PF00082	0.451
CLV_PCSK_KEX2_1	347	349	PF00082	0.474
CLV_PCSK_KEX2_1	358	360	PF00082	0.458
CLV_PCSK_KEX2_1	50	52	PF00082	0.299
CLV_PCSK_KEX2_1	56	58	PF00082	0.328
CLV_PCSK_KEX2_1	62	64	PF00082	0.387
CLV_PCSK_KEX2_1	92	94	PF00082	0.298
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.274
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.353
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.671
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.460
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.304
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.236
CLV_PCSK_PC7_1	88	94	PF00082	0.321
CLV_PCSK_SKI1_1	16	20	PF00082	0.525
CLV_PCSK_SKI1_1	236	240	PF00082	0.451
CLV_PCSK_SKI1_1	247	251	PF00082	0.412
CLV_PCSK_SKI1_1	51	55	PF00082	0.278
CLV_Separin_Metazoa	175	179	PF03568	0.321
DEG_APCC_DBOX_1	31	39	PF00400	0.274
DEG_SPOP_SBC_1	141	145	PF00917	0.404
DOC_MAPK_gen_1	113	121	PF00069	0.352
DOC_MAPK_gen_1	47	55	PF00069	0.324
DOC_MAPK_gen_1	88	96	PF00069	0.454
DOC_PP1_RVXF_1	148	155	PF00149	0.274
DOC_PP1_RVXF_1	291	298	PF00149	0.568
DOC_USP7_MATH_1	141	145	PF00917	0.296
DOC_USP7_MATH_1	267	271	PF00917	0.548
DOC_USP7_MATH_1	9	13	PF00917	0.690
DOC_USP7_UBL2_3	246	250	PF12436	0.585
DOC_USP7_UBL2_3	331	335	PF12436	0.535
DOC_USP7_UBL2_3	50	54	PF12436	0.330
DOC_WW_Pin1_4	170	175	PF00397	0.274
DOC_WW_Pin1_4	229	234	PF00397	0.458
LIG_14-3-3_CanoR_1	322	327	PF00244	0.389
LIG_BIR_III_2	230	234	PF00653	0.464
LIG_DLG_GKlike_1	322	329	PF00625	0.394
LIG_eIF4E_1	252	258	PF01652	0.504
LIG_FHA_1	129	135	PF00498	0.422
LIG_FHA_1	253	259	PF00498	0.589
LIG_FHA_1	290	296	PF00498	0.570
LIG_FHA_1	76	82	PF00498	0.274
LIG_FHA_2	105	111	PF00498	0.360
LIG_FHA_2	20	26	PF00498	0.318
LIG_Integrin_isoDGR_2	86	88	PF01839	0.266
LIG_LIR_Nem_3	158	164	PF02991	0.277
LIG_MAD2	188	196	PF02301	0.238
LIG_NRP_CendR_1	358	361	PF00754	0.536
LIG_PCNA_yPIPBox_3	288	299	PF02747	0.574
LIG_SH2_STAT5	118	121	PF00017	0.307
LIG_TRAF2_1	157	160	PF00917	0.361
LIG_WRC_WIRS_1	161	166	PF05994	0.321
MOD_CDK_SPxxK_3	229	236	PF00069	0.453
MOD_CK1_1	265	271	PF00069	0.548
MOD_CK2_1	104	110	PF00069	0.326
MOD_CK2_1	154	160	PF00069	0.389
MOD_CK2_1	19	25	PF00069	0.318
MOD_GlcNHglycan	11	14	PF01048	0.682
MOD_GlcNHglycan	201	204	PF01048	0.353
MOD_GlcNHglycan	208	211	PF01048	0.139
MOD_GlcNHglycan	226	229	PF01048	0.368
MOD_GlcNHglycan	326	329	PF01048	0.523
MOD_GSK3_1	24	31	PF00069	0.335
MOD_GSK3_1	265	272	PF00069	0.638
MOD_GSK3_1	320	327	PF00069	0.525
MOD_LATS_1	17	23	PF00433	0.324
MOD_NEK2_1	142	147	PF00069	0.404
MOD_NEK2_1	190	195	PF00069	0.304
MOD_NEK2_1	224	229	PF00069	0.561
MOD_NEK2_1	24	29	PF00069	0.368
MOD_NEK2_1	329	334	PF00069	0.369
MOD_PIKK_1	24	30	PF00454	0.274
MOD_PIKK_1	334	340	PF00454	0.520
MOD_PKA_1	19	25	PF00069	0.324
MOD_PKA_1	262	268	PF00069	0.443
MOD_PKA_1	334	340	PF00069	0.487
MOD_PKA_1	347	353	PF00069	0.450
MOD_PKA_2	128	134	PF00069	0.409
MOD_PKA_2	19	25	PF00069	0.324
MOD_PKA_2	224	230	PF00069	0.444
MOD_PKA_2	262	268	PF00069	0.493
MOD_PKA_2	347	353	PF00069	0.511
MOD_Plk_1	190	196	PF00069	0.379
MOD_Plk_1	289	295	PF00069	0.573
MOD_Plk_4	190	196	PF00069	0.290
MOD_ProDKin_1	170	176	PF00069	0.274
MOD_ProDKin_1	229	235	PF00069	0.454
MOD_SUMO_for_1	245	248	PF00179	0.460
MOD_SUMO_for_1	261	264	PF00179	0.492
TRG_DiLeu_BaEn_1	290	295	PF01217	0.572
TRG_DiLeu_LyEn_5	290	295	PF01217	0.572
TRG_ENDOCYTIC_2	118	121	PF00928	0.404
TRG_ER_diArg_1	183	186	PF00400	0.404
TRG_ER_diArg_1	224	226	PF00400	0.499
TRG_ER_diArg_1	297	299	PF00400	0.481
TRG_ER_diArg_1	358	361	PF00400	0.541
TRG_ER_diArg_1	55	57	PF00400	0.381
TRG_ER_diArg_1	89	92	PF00400	0.353
TRG_ER_diArg_1	93	96	PF00400	0.352
TRG_NLS_MonoCore_2	48	53	PF00514	0.353
TRG_NLS_MonoExtC_3	49	54	PF00514	0.324
TRG_NLS_MonoExtN_4	16	23	PF00514	0.642
TRG_NLS_MonoExtN_4	47	54	PF00514	0.297
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Z1	Leptomonas seymouri	82%	99%
A0A0S4INY9	Bodo saltans	38%	100%
A0A1X0P6A7	Trypanosomatidae	59%	100%
A0A3Q8IK07	Leishmania donovani	97%	100%
A0A3R7NS36	Trypanosoma rangeli	54%	100%
A4HA25	Leishmania braziliensis	89%	100%
D0A0L7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AS19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q9U178	Leishmania major	100%	100%
V5BX19	Trypanosoma cruzi	55%	100%