LeishMANIAdb
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Selenide, water dikinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Selenide, water dikinase
Gene product:
Selenophosphate synthetase 2
Species:
Leishmania major
UniProt:
SPS2_LEIMA
TriTrypDb:
LmjF.36.5410 , LMJLV39_360066300 * , LMJSD75_360066200
Length:
398

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4Q0M0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q0M0

PDB structure(s): 5l16_A

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 2
GO:0006520 amino acid metabolic process 3 2
GO:0006793 phosphorus metabolic process 3 11
GO:0006796 phosphate-containing compound metabolic process 4 11
GO:0006807 nitrogen compound metabolic process 2 2
GO:0008152 metabolic process 1 11
GO:0008652 amino acid biosynthetic process 4 2
GO:0009058 biosynthetic process 2 2
GO:0009069 serine family amino acid metabolic process 5 2
GO:0009070 serine family amino acid biosynthetic process 6 2
GO:0009987 cellular process 1 11
GO:0016053 organic acid biosynthetic process 4 2
GO:0016259 selenocysteine metabolic process 6 2
GO:0016260 selenocysteine biosynthetic process 7 2
GO:0016310 phosphorylation 5 11
GO:0019752 carboxylic acid metabolic process 5 2
GO:0043436 oxoacid metabolic process 4 2
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 2
GO:0044249 cellular biosynthetic process 3 2
GO:0044281 small molecule metabolic process 2 2
GO:0044283 small molecule biosynthetic process 3 2
GO:0046394 carboxylic acid biosynthetic process 5 2
GO:0071704 organic substance metabolic process 2 2
GO:1901564 organonitrogen compound metabolic process 3 2
GO:1901566 organonitrogen compound biosynthetic process 4 2
GO:1901576 organic substance biosynthetic process 3 2
GO:1901605 alpha-amino acid metabolic process 4 2
GO:1901607 alpha-amino acid biosynthetic process 5 2
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004756 selenide, water dikinase activity 5 6
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016781 phosphotransferase activity, paired acceptors 4 6
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0043169 cation binding 3 2
GO:0046872 metal ion binding 4 2
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 360 364 PF00656 0.466
CLV_NRD_NRD_1 258 260 PF00675 0.280
CLV_NRD_NRD_1 268 270 PF00675 0.224
CLV_PCSK_KEX2_1 258 260 PF00082 0.222
CLV_PCSK_KEX2_1 4 6 PF00082 0.666
CLV_PCSK_PC1ET2_1 4 6 PF00082 0.666
CLV_PCSK_SKI1_1 147 151 PF00082 0.259
CLV_PCSK_SKI1_1 163 167 PF00082 0.269
CLV_Separin_Metazoa 194 198 PF03568 0.340
DOC_CKS1_1 19 24 PF01111 0.294
DOC_CYCLIN_RxL_1 299 309 PF00134 0.466
DOC_CYCLIN_RxL_1 49 61 PF00134 0.538
DOC_CYCLIN_yCln2_LP_2 29 35 PF00134 0.406
DOC_MAPK_FxFP_2 98 101 PF00069 0.412
DOC_MAPK_gen_1 20 29 PF00069 0.447
DOC_MAPK_MEF2A_6 23 31 PF00069 0.430
DOC_PP2B_LxvP_1 29 32 PF13499 0.419
DOC_PP4_FxxP_1 98 101 PF00568 0.412
DOC_USP7_MATH_1 101 105 PF00917 0.498
DOC_USP7_MATH_1 188 192 PF00917 0.554
DOC_USP7_MATH_1 253 257 PF00917 0.454
DOC_USP7_MATH_1 336 340 PF00917 0.412
DOC_USP7_MATH_1 345 349 PF00917 0.412
DOC_USP7_MATH_1 6 10 PF00917 0.718
DOC_WW_Pin1_4 18 23 PF00397 0.508
DOC_WW_Pin1_4 227 232 PF00397 0.436
DOC_WW_Pin1_4 239 244 PF00397 0.436
DOC_WW_Pin1_4 62 67 PF00397 0.486
LIG_14-3-3_CanoR_1 147 155 PF00244 0.479
LIG_Actin_WH2_2 215 230 PF00022 0.466
LIG_AP2alpha_2 105 107 PF02296 0.479
LIG_BIR_II_1 1 5 PF00653 0.680
LIG_BRCT_BRCA1_1 103 107 PF00533 0.466
LIG_CtBP_PxDLS_1 26 30 PF00389 0.482
LIG_FHA_1 149 155 PF00498 0.485
LIG_FHA_1 164 170 PF00498 0.522
LIG_FHA_1 197 203 PF00498 0.338
LIG_FHA_1 209 215 PF00498 0.402
LIG_FHA_1 377 383 PF00498 0.362
LIG_FHA_2 138 144 PF00498 0.429
LIG_FHA_2 148 154 PF00498 0.403
LIG_FHA_2 358 364 PF00498 0.493
LIG_GBD_Chelix_1 218 226 PF00786 0.254
LIG_LIR_Apic_2 95 101 PF02991 0.412
LIG_LIR_Gen_1 383 393 PF02991 0.397
LIG_LIR_Nem_3 21 27 PF02991 0.381
LIG_LIR_Nem_3 280 285 PF02991 0.412
LIG_LIR_Nem_3 326 331 PF02991 0.414
LIG_LIR_Nem_3 38 43 PF02991 0.330
LIG_LIR_Nem_3 383 389 PF02991 0.361
LIG_LIR_Nem_3 391 396 PF02991 0.292
LIG_LIR_Nem_3 97 103 PF02991 0.412
LIG_NRBOX 54 60 PF00104 0.399
LIG_PCNA_yPIPBox_3 49 59 PF02747 0.387
LIG_PDZ_Class_2 393 398 PF00595 0.342
LIG_SH2_CRK 386 390 PF00017 0.399
LIG_SH2_CRK 40 44 PF00017 0.362
LIG_SH2_NCK_1 250 254 PF00017 0.436
LIG_SH2_NCK_1 393 397 PF00017 0.351
LIG_SH2_SRC 233 236 PF00017 0.508
LIG_SH2_SRC 393 396 PF00017 0.432
LIG_SH2_STAP1 233 237 PF00017 0.514
LIG_SH2_STAT5 40 43 PF00017 0.357
LIG_SH3_3 100 106 PF00018 0.412
LIG_SH3_3 172 178 PF00018 0.412
LIG_SH3_3 341 347 PF00018 0.479
LIG_Sin3_3 186 193 PF02671 0.544
LIG_SUMO_SIM_anti_2 130 137 PF11976 0.436
LIG_SUMO_SIM_anti_2 206 211 PF11976 0.412
LIG_SUMO_SIM_par_1 206 211 PF11976 0.422
LIG_TRAF2_1 242 245 PF00917 0.437
LIG_UBA3_1 207 212 PF00899 0.501
MOD_CDK_SPK_2 18 23 PF00069 0.307
MOD_CDK_SPxxK_3 62 69 PF00069 0.484
MOD_CK1_1 335 341 PF00069 0.422
MOD_CK2_1 147 153 PF00069 0.421
MOD_CK2_1 188 194 PF00069 0.499
MOD_CK2_1 239 245 PF00069 0.445
MOD_CK2_1 6 12 PF00069 0.610
MOD_CK2_1 82 88 PF00069 0.519
MOD_GlcNHglycan 334 337 PF01048 0.213
MOD_GlcNHglycan 338 341 PF01048 0.210
MOD_GlcNHglycan 61 65 PF01048 0.393
MOD_GlcNHglycan 8 11 PF01048 0.721
MOD_GSK3_1 116 123 PF00069 0.426
MOD_GSK3_1 163 170 PF00069 0.425
MOD_GSK3_1 332 339 PF00069 0.422
MOD_GSK3_1 6 13 PF00069 0.716
MOD_LATS_1 145 151 PF00433 0.514
MOD_LATS_1 3 9 PF00433 0.646
MOD_NEK2_1 164 169 PF00069 0.499
MOD_NEK2_1 208 213 PF00069 0.412
MOD_NEK2_1 313 318 PF00069 0.474
MOD_NEK2_1 73 78 PF00069 0.398
MOD_NEK2_1 80 85 PF00069 0.367
MOD_NEK2_1 91 96 PF00069 0.192
MOD_NEK2_2 253 258 PF00069 0.454
MOD_PKA_2 196 202 PF00069 0.346
MOD_PKA_2 376 382 PF00069 0.482
MOD_PKB_1 161 169 PF00069 0.431
MOD_Plk_1 357 363 PF00069 0.414
MOD_Plk_1 38 44 PF00069 0.386
MOD_Plk_1 73 79 PF00069 0.374
MOD_Plk_4 128 134 PF00069 0.431
MOD_Plk_4 171 177 PF00069 0.412
MOD_Plk_4 365 371 PF00069 0.495
MOD_Plk_4 73 79 PF00069 0.409
MOD_ProDKin_1 18 24 PF00069 0.500
MOD_ProDKin_1 227 233 PF00069 0.436
MOD_ProDKin_1 239 245 PF00069 0.436
MOD_ProDKin_1 62 68 PF00069 0.488
MOD_SUMO_rev_2 12 22 PF00179 0.540
TRG_DiLeu_BaEn_1 144 149 PF01217 0.501
TRG_DiLeu_BaEn_1 263 268 PF01217 0.514
TRG_DiLeu_BaEn_1 88 93 PF01217 0.409
TRG_DiLeu_BaEn_4 244 250 PF01217 0.420
TRG_DiLeu_BaLyEn_6 177 182 PF01217 0.412
TRG_DiLeu_BaLyEn_6 326 331 PF01217 0.466
TRG_DiLeu_LyEn_5 144 149 PF01217 0.431
TRG_ENDOCYTIC_2 328 331 PF00928 0.412
TRG_ENDOCYTIC_2 386 389 PF00928 0.337
TRG_ENDOCYTIC_2 393 396 PF00928 0.289
TRG_ENDOCYTIC_2 40 43 PF00928 0.357
TRG_ER_diArg_1 161 164 PF00400 0.431
TRG_ER_diArg_1 257 259 PF00400 0.496
TRG_Pf-PMV_PEXEL_1 258 263 PF00026 0.314

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3Y2 Leptomonas seymouri 83% 100%
A0A0S4JLG7 Bodo saltans 63% 71%
A0A1X0P1E6 Trypanosomatidae 67% 100%
A0A3R7NFW8 Trypanosoma rangeli 68% 100%
A0A3S7XBT7 Leishmania donovani 97% 100%
A1APP9 Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1) 28% 100%
A1VE87 Desulfovibrio vulgaris subsp. vulgaris (strain DP4) 30% 100%
A1YIZ1 Sus scrofa 42% 88%
A3DA84 Shewanella baltica (strain OS155 / ATCC BAA-1091) 29% 100%
A4HQ56 Leishmania braziliensis 91% 100%
A4IDV5 Leishmania infantum 97% 100%
A4W9I2 Enterobacter sp. (strain 638) 27% 100%
A6QBB7 Sulfurovum sp. (strain NBC37-1) 27% 100%
A6WHQ5 Shewanella baltica (strain OS185) 29% 100%
A7MNU8 Cronobacter sakazakii (strain ATCC BAA-894) 29% 100%
A7ZMN3 Escherichia coli O139:H28 (strain E24377A / ETEC) 28% 100%
A8A0V7 Escherichia coli O9:H4 (strain HS) 28% 100%
A8EUZ4 Aliarcobacter butzleri (strain RM4018) 27% 100%
A8MHJ6 Alkaliphilus oremlandii (strain OhILAs) 28% 100%
A9KW79 Shewanella baltica (strain OS195) 29% 100%
B2RLG7 Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561) 32% 100%
B2TKP6 Clostridium botulinum (strain Eklund 17B / Type B) 26% 100%
B2V0F0 Clostridium botulinum (strain Alaska E43 / Type E3) 26% 100%
B3E7F7 Trichlorobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ) 27% 100%
B5EBG1 Citrifermentans bemidjiense (strain ATCC BAA-1014 / DSM 16622 / JCM 12645 / Bem) 31% 100%
B8EBM9 Shewanella baltica (strain OS223) 29% 100%
B8ES21 Methylocella silvestris (strain DSM 15510 / CIP 108128 / LMG 27833 / NCIMB 13906 / BL2) 32% 100%
B8FWU2 Desulfitobacterium hafniense (strain DSM 10664 / DCB-2) 28% 100%
C4ZDB0 Agathobacter rectalis (strain ATCC 33656 / DSM 3377 / JCM 17463 / KCTC 5835 / VPI 0990) 29% 100%
C6E5Z5 Geobacter sp. (strain M21) 30% 100%
D0A461 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 100%
E9ATX6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
O18373 Drosophila melanogaster 44% 100%
O62461 Caenorhabditis elegans 42% 100%
O67139 Aquifex aeolicus (strain VF5) 27% 100%
P16456 Escherichia coli (strain K12) 28% 100%
P49903 Homo sapiens 42% 100%
P59392 Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) 29% 100%
P59393 Shigella flexneri 28% 100%
P60819 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 34% 100%
P60820 Methanococcus maripaludis (strain S2 / LL) 33% 100%
P66793 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 28% 100%
P66794 Escherichia coli O157:H7 28% 100%
P97364 Mus musculus 42% 88%
Q0AFI6 Nitrosomonas eutropha (strain DSM 101675 / C91 / Nm57) 27% 100%
Q0HNW1 Shewanella sp. (strain MR-4) 27% 100%
Q0T4X1 Shigella flexneri serotype 5b (strain 8401) 28% 100%
Q0TH64 Escherichia coli O6:K15:H31 (strain 536 / UPEC) 28% 100%
Q0VC82 Bos taurus 42% 100%
Q182I1 Clostridioides difficile (strain 630) 26% 100%
Q1DAT6 Myxococcus xanthus (strain DK1622) 30% 100%
Q24NA9 Desulfitobacterium hafniense (strain Y51) 28% 100%
Q30RE1 Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) 27% 100%
Q321Q8 Shigella boydii serotype 4 (strain Sb227) 28% 100%
Q32GA8 Shigella dysenteriae serotype 1 (strain Sd197) 28% 100%
Q38A34 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 66% 100%
Q39RJ9 Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15) 30% 100%
Q3Z2B0 Shigella sonnei (strain Ss046) 28% 100%
Q4Q0M0 Leishmania major 100% 100%
Q5RF87 Pongo abelii 42% 100%
Q66AP0 Yersinia pseudotuberculosis serotype I (strain IP32953) 29% 100%
Q66I14 Danio rerio 42% 89%
Q6GL12 Xenopus tropicalis 41% 100%
Q6MK42 Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100) 26% 100%
Q6PF47 Xenopus laevis 41% 100%
Q72CF1 Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough) 30% 100%
Q73JP8 Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104) 26% 100%
Q7MU19 Porphyromonas gingivalis (strain ATCC BAA-308 / W83) 32% 100%
Q7N406 Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) 29% 100%
Q7VNG0 Haemophilus ducreyi (strain 35000HP / ATCC 700724) 27% 100%
Q7WE97 Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 30% 100%
Q7ZW38 Danio rerio 41% 100%
Q889F7 Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) 30% 100%
Q8BH69 Mus musculus 42% 100%
Q8EK99 Shewanella oneidensis (strain MR-1) 28% 100%
Q8R8W3 Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) 26% 100%
Q8TVM0 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 34% 100%
Q8Z6F4 Salmonella typhi 28% 100%
Q8ZEK1 Yersinia pestis 29% 100%
Q931D0 Rhizobium meliloti (strain 1021) 30% 100%
Q94497 Dictyostelium discoideum 46% 100%
Q99611 Homo sapiens 42% 89%
Q9AQI4 Pseudomonas straminea 31% 100%
Q9L473 Peptoclostridium acidaminophilum 28% 100%
Q9L4E1 Peptoclostridium acidaminophilum 29% 100%
Q9VKY8 Drosophila melanogaster 37% 100%
V5BKN8 Trypanosoma cruzi 67% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS