Structure-specific endonuclease subunit SLX1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GIY-YIG catalytic domain containing protein, putative

Species:

Leishmania major

UniProt:

SLX1_LEIMA

TriTrypDb:

LmjF.25.1330 , LMJLV39_250020300 , LMJSD75_250020100

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	7
GO:0033557	Slx1-Slx4 complex	3	7
GO:0140513	nuclear protein-containing complex	2	7

Expansion

Sequence features

Q4Q9W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q9W0

Function

Biological processes
Term	Name	Level	Count
GO:0000724	double-strand break repair via homologous recombination	7	2
GO:0000725	recombinational repair	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006302	double-strand break repair	6	2
GO:0006310	DNA recombination	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0004520	DNA endonuclease activity	5	7
GO:0004536	DNA nuclease activity	4	7
GO:0005488	binding	1	3
GO:0008821	crossover junction DNA endonuclease activity	7	2
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	6	7
GO:0016889	DNA endonuclease activity, producing 3'-phosphomonoesters	6	2
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	7
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	6	2
GO:0017108	5'-flap endonuclease activity	7	7
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3
GO:0048256	flap endonuclease activity	6	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.422
CLV_NRD_NRD_1	302	304	PF00675	0.609
CLV_NRD_NRD_1	32	34	PF00675	0.269
CLV_NRD_NRD_1	46	48	PF00675	0.269
CLV_NRD_NRD_1	50	52	PF00675	0.269
CLV_NRD_NRD_1	513	515	PF00675	0.486
CLV_NRD_NRD_1	547	549	PF00675	0.538
CLV_NRD_NRD_1	554	556	PF00675	0.463
CLV_NRD_NRD_1	582	584	PF00675	0.556
CLV_NRD_NRD_1	619	621	PF00675	0.672
CLV_NRD_NRD_1	97	99	PF00675	0.375
CLV_PCSK_KEX2_1	143	145	PF00082	0.423
CLV_PCSK_KEX2_1	302	304	PF00082	0.609
CLV_PCSK_KEX2_1	32	34	PF00082	0.269
CLV_PCSK_KEX2_1	46	48	PF00082	0.269
CLV_PCSK_KEX2_1	50	52	PF00082	0.269
CLV_PCSK_KEX2_1	513	515	PF00082	0.486
CLV_PCSK_KEX2_1	541	543	PF00082	0.438
CLV_PCSK_KEX2_1	547	549	PF00082	0.502
CLV_PCSK_KEX2_1	554	556	PF00082	0.494
CLV_PCSK_KEX2_1	573	575	PF00082	0.630
CLV_PCSK_KEX2_1	581	583	PF00082	0.542
CLV_PCSK_KEX2_1	619	621	PF00082	0.674
CLV_PCSK_KEX2_1	97	99	PF00082	0.423
CLV_PCSK_PC1ET2_1	541	543	PF00082	0.438
CLV_PCSK_PC1ET2_1	573	575	PF00082	0.601
CLV_PCSK_PC7_1	46	52	PF00082	0.269
CLV_PCSK_SKI1_1	145	149	PF00082	0.458
CLV_PCSK_SKI1_1	229	233	PF00082	0.438
CLV_PCSK_SKI1_1	241	245	PF00082	0.594
CLV_PCSK_SKI1_1	537	541	PF00082	0.432
CLV_PCSK_SKI1_1	68	72	PF00082	0.269
DEG_APCC_DBOX_1	469	477	PF00400	0.342
DEG_Nend_UBRbox_2	1	3	PF02207	0.456
DEG_SPOP_SBC_1	311	315	PF00917	0.522
DOC_CKS1_1	180	185	PF01111	0.572
DOC_CKS1_1	215	220	PF01111	0.509
DOC_CYCLIN_yCln2_LP_2	212	215	PF00134	0.411
DOC_MAPK_gen_1	537	545	PF00069	0.442
DOC_MAPK_gen_1	85	92	PF00069	0.437
DOC_PP2B_LxvP_1	212	215	PF13499	0.411
DOC_PP2B_LxvP_1	243	246	PF13499	0.572
DOC_PP4_FxxP_1	360	363	PF00568	0.661
DOC_PP4_FxxP_1	631	634	PF00568	0.510
DOC_USP7_MATH_1	187	191	PF00917	0.591
DOC_USP7_MATH_1	268	272	PF00917	0.618
DOC_USP7_MATH_1	293	297	PF00917	0.730
DOC_USP7_MATH_1	311	315	PF00917	0.650
DOC_USP7_MATH_1	347	351	PF00917	0.635
DOC_USP7_MATH_1	356	360	PF00917	0.576
DOC_USP7_MATH_1	366	370	PF00917	0.546
DOC_USP7_MATH_1	385	389	PF00917	0.464
DOC_USP7_MATH_1	401	405	PF00917	0.529
DOC_USP7_MATH_1	623	627	PF00917	0.622
DOC_USP7_MATH_1	641	645	PF00917	0.523
DOC_USP7_MATH_1	646	650	PF00917	0.761
DOC_USP7_MATH_1	683	687	PF00917	0.608
DOC_USP7_MATH_1	80	84	PF00917	0.469
DOC_USP7_UBL2_3	537	541	PF12436	0.432
DOC_USP7_UBL2_3	596	600	PF12436	0.487
DOC_WW_Pin1_4	155	160	PF00397	0.654
DOC_WW_Pin1_4	179	184	PF00397	0.599
DOC_WW_Pin1_4	214	219	PF00397	0.495
DOC_WW_Pin1_4	312	317	PF00397	0.615
DOC_WW_Pin1_4	323	328	PF00397	0.711
DOC_WW_Pin1_4	343	348	PF00397	0.604
DOC_WW_Pin1_4	359	364	PF00397	0.751
DOC_WW_Pin1_4	367	372	PF00397	0.665
DOC_WW_Pin1_4	402	407	PF00397	0.602
DOC_WW_Pin1_4	494	499	PF00397	0.633
DOC_WW_Pin1_4	507	512	PF00397	0.635
DOC_WW_Pin1_4	624	629	PF00397	0.653
DOC_WW_Pin1_4	644	649	PF00397	0.457
DOC_WW_Pin1_4	653	658	PF00397	0.768
LIG_14-3-3_CanoR_1	111	115	PF00244	0.429
LIG_14-3-3_CanoR_1	169	174	PF00244	0.612
LIG_14-3-3_CanoR_1	320	329	PF00244	0.723
LIG_14-3-3_CanoR_1	358	363	PF00244	0.610
LIG_14-3-3_CanoR_1	470	480	PF00244	0.359
LIG_14-3-3_CanoR_1	624	628	PF00244	0.606
LIG_APCC_ABBA_1	220	225	PF00400	0.366
LIG_CaM_IQ_9	549	565	PF13499	0.418
LIG_Clathr_ClatBox_1	221	225	PF01394	0.420
LIG_deltaCOP1_diTrp_1	286	292	PF00928	0.620
LIG_deltaCOP1_diTrp_1	74	77	PF00928	0.469
LIG_FHA_1	103	109	PF00498	0.383
LIG_FHA_1	119	125	PF00498	0.278
LIG_FHA_1	180	186	PF00498	0.584
LIG_FHA_1	215	221	PF00498	0.480
LIG_FHA_1	299	305	PF00498	0.637
LIG_FHA_1	87	93	PF00498	0.373
LIG_FHA_2	10	16	PF00498	0.469
LIG_FHA_2	225	231	PF00498	0.365
LIG_LIR_Apic_2	359	363	PF02991	0.655
LIG_LIR_Apic_2	630	634	PF02991	0.513
LIG_LIR_Apic_2	698	704	PF02991	0.566
LIG_LIR_Apic_2	74	80	PF02991	0.469
LIG_LIR_Gen_1	113	122	PF02991	0.473
LIG_LIR_Gen_1	2	11	PF02991	0.304
LIG_LIR_Nem_3	113	118	PF02991	0.487
LIG_LIR_Nem_3	2	8	PF02991	0.378
LIG_LIR_Nem_3	21	26	PF02991	0.497
LIG_LIR_Nem_3	422	426	PF02991	0.494
LIG_LYPXL_SIV_4	100	108	PF13949	0.387
LIG_MYND_1	214	218	PF01753	0.447
LIG_Pex14_2	125	129	PF04695	0.301
LIG_Pex14_2	73	77	PF04695	0.469
LIG_RPA_C_Fungi	543	555	PF08784	0.548
LIG_SH2_NCK_1	101	105	PF00017	0.385
LIG_SH2_NCK_1	482	486	PF00017	0.448
LIG_SH2_SRC	482	485	PF00017	0.394
LIG_SH2_STAP1	274	278	PF00017	0.515
LIG_SH2_STAT5	23	26	PF00017	0.304
LIG_SH2_STAT5	236	239	PF00017	0.443
LIG_SH2_STAT5	307	310	PF00017	0.632
LIG_SH2_STAT5	460	463	PF00017	0.453
LIG_SH2_STAT5	9	12	PF00017	0.304
LIG_SH3_1	303	309	PF00018	0.600
LIG_SH3_1	514	520	PF00018	0.415
LIG_SH3_2	414	419	PF14604	0.520
LIG_SH3_2	508	513	PF14604	0.601
LIG_SH3_3	177	183	PF00018	0.618
LIG_SH3_3	212	218	PF00018	0.418
LIG_SH3_3	303	309	PF00018	0.637
LIG_SH3_3	360	366	PF00018	0.801
LIG_SH3_3	388	394	PF00018	0.571
LIG_SH3_3	400	406	PF00018	0.565
LIG_SH3_3	411	417	PF00018	0.728
LIG_SH3_3	449	455	PF00018	0.391
LIG_SH3_3	502	508	PF00018	0.768
LIG_SH3_3	514	520	PF00018	0.339
LIG_SH3_3	605	611	PF00018	0.567
LIG_SH3_3	622	628	PF00018	0.595
LIG_SH3_CIN85_PxpxPR_1	410	415	PF14604	0.610
LIG_SUMO_SIM_anti_2	275	280	PF11976	0.504
LIG_SUMO_SIM_anti_2	89	94	PF11976	0.361
LIG_SUMO_SIM_par_1	689	695	PF11976	0.611
LIG_SUMO_SIM_par_1	88	94	PF11976	0.370
LIG_WRC_WIRS_1	357	362	PF05994	0.621
LIG_WRC_WIRS_1	636	641	PF05994	0.603
LIG_WW_2	183	186	PF00397	0.630
LIG_WW_3	364	368	PF00397	0.628
MOD_CDC14_SPxK_1	317	320	PF00782	0.642
MOD_CDC14_SPxK_1	510	513	PF00782	0.601
MOD_CDK_SPK_2	155	160	PF00069	0.654
MOD_CDK_SPK_2	367	372	PF00069	0.635
MOD_CDK_SPxK_1	314	320	PF00069	0.637
MOD_CDK_SPxK_1	507	513	PF00069	0.614
MOD_CDK_SPxxK_3	507	514	PF00069	0.595
MOD_CDK_SPxxK_3	658	665	PF00069	0.616
MOD_CK1_1	167	173	PF00069	0.762
MOD_CK1_1	262	268	PF00069	0.696
MOD_CK1_1	277	283	PF00069	0.553
MOD_CK1_1	288	294	PF00069	0.593
MOD_CK1_1	310	316	PF00069	0.719
MOD_CK1_1	346	352	PF00069	0.692
MOD_CK1_1	359	365	PF00069	0.568
MOD_CK1_1	370	376	PF00069	0.607
MOD_CK1_1	627	633	PF00069	0.618
MOD_CK1_1	644	650	PF00069	0.497
MOD_CK1_1	656	662	PF00069	0.530
MOD_CK1_1	686	692	PF00069	0.572
MOD_CK2_1	187	193	PF00069	0.772
MOD_CK2_1	224	230	PF00069	0.361
MOD_CK2_1	293	299	PF00069	0.653
MOD_CK2_1	627	633	PF00069	0.583
MOD_Cter_Amidation	48	51	PF01082	0.259
MOD_DYRK1A_RPxSP_1	624	628	PF00069	0.659
MOD_GlcNHglycan	126	129	PF01048	0.402
MOD_GlcNHglycan	246	249	PF01048	0.542
MOD_GlcNHglycan	264	267	PF01048	0.654
MOD_GlcNHglycan	309	312	PF01048	0.715
MOD_GlcNHglycan	372	375	PF01048	0.619
MOD_GlcNHglycan	385	388	PF01048	0.567
MOD_GlcNHglycan	61	64	PF01048	0.304
MOD_GlcNHglycan	648	651	PF01048	0.575
MOD_GlcNHglycan	658	661	PF01048	0.605
MOD_GlcNHglycan	82	85	PF01048	0.434
MOD_GSK3_1	160	167	PF00069	0.655
MOD_GSK3_1	203	210	PF00069	0.608
MOD_GSK3_1	264	271	PF00069	0.685
MOD_GSK3_1	307	314	PF00069	0.638
MOD_GSK3_1	343	350	PF00069	0.599
MOD_GSK3_1	366	373	PF00069	0.648
MOD_GSK3_1	487	494	PF00069	0.541
MOD_GSK3_1	569	576	PF00069	0.583
MOD_GSK3_1	623	630	PF00069	0.573
MOD_GSK3_1	644	651	PF00069	0.604
MOD_GSK3_1	667	674	PF00069	0.742
MOD_N-GLC_1	225	230	PF02516	0.364
MOD_N-GLC_1	288	293	PF02516	0.547
MOD_N-GLC_1	383	388	PF02516	0.633
MOD_NEK2_1	118	123	PF00069	0.346
MOD_NEK2_1	203	208	PF00069	0.620
MOD_NEK2_1	264	269	PF00069	0.696
MOD_NEK2_2	102	107	PF00069	0.381
MOD_NEK2_2	465	470	PF00069	0.409
MOD_PIKK_1	160	166	PF00454	0.653
MOD_PIKK_1	187	193	PF00454	0.615
MOD_PIKK_1	277	283	PF00454	0.500
MOD_PIKK_1	515	521	PF00454	0.460
MOD_PKA_1	573	579	PF00069	0.599
MOD_PKA_2	110	116	PF00069	0.426
MOD_PKA_2	168	174	PF00069	0.567
MOD_PKA_2	366	372	PF00069	0.712
MOD_PKA_2	45	51	PF00069	0.310
MOD_PKA_2	573	579	PF00069	0.606
MOD_PKA_2	623	629	PF00069	0.583
MOD_PKA_2	86	92	PF00069	0.375
MOD_PKB_1	51	59	PF00069	0.304
MOD_Plk_1	118	124	PF00069	0.339
MOD_Plk_1	259	265	PF00069	0.569
MOD_Plk_1	274	280	PF00069	0.574
MOD_Plk_1	288	294	PF00069	0.572
MOD_Plk_1	66	72	PF00069	0.237
MOD_Plk_1	686	692	PF00069	0.608
MOD_Plk_4	110	116	PF00069	0.444
MOD_Plk_4	216	222	PF00069	0.443
MOD_Plk_4	274	280	PF00069	0.506
MOD_Plk_4	531	537	PF00069	0.411
MOD_Plk_4	686	692	PF00069	0.670
MOD_ProDKin_1	155	161	PF00069	0.654
MOD_ProDKin_1	179	185	PF00069	0.601
MOD_ProDKin_1	214	220	PF00069	0.505
MOD_ProDKin_1	312	318	PF00069	0.614
MOD_ProDKin_1	323	329	PF00069	0.711
MOD_ProDKin_1	343	349	PF00069	0.601
MOD_ProDKin_1	359	365	PF00069	0.749
MOD_ProDKin_1	367	373	PF00069	0.663
MOD_ProDKin_1	402	408	PF00069	0.600
MOD_ProDKin_1	494	500	PF00069	0.635
MOD_ProDKin_1	507	513	PF00069	0.634
MOD_ProDKin_1	624	630	PF00069	0.652
MOD_ProDKin_1	644	650	PF00069	0.456
MOD_ProDKin_1	653	659	PF00069	0.768
MOD_SUMO_for_1	71	74	PF00179	0.304
TRG_DiLeu_BaEn_1	698	703	PF01217	0.508
TRG_DiLeu_BaEn_4	434	440	PF01217	0.492
TRG_DiLeu_BaEn_4	698	704	PF01217	0.545
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.483
TRG_ENDOCYTIC_2	423	426	PF00928	0.513
TRG_ER_diArg_1	143	145	PF00400	0.399
TRG_ER_diArg_1	302	304	PF00400	0.609
TRG_ER_diArg_1	31	33	PF00400	0.304
TRG_ER_diArg_1	50	53	PF00400	0.304
TRG_ER_diArg_1	512	514	PF00400	0.508
TRG_ER_diArg_1	547	549	PF00400	0.566
TRG_ER_diArg_1	554	557	PF00400	0.491
TRG_ER_diArg_1	580	583	PF00400	0.575
TRG_ER_diArg_1	585	588	PF00400	0.503
TRG_ER_diArg_1	96	98	PF00400	0.380
TRG_NLS_MonoExtN_4	537	544	PF00514	0.436
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7G5	Leptomonas seymouri	49%	100%
A0A3S7WZ95	Leishmania donovani	90%	100%
A4I1H7	Leishmania infantum	90%	100%
E9AIR5	Leishmania braziliensis	74%	100%
E9AXL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q9W0	Leishmania major	100%	100%