Protein SEY1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

root hair defective 3 GTP-binding protein (RHD3), putative

Species:

Leishmania major

UniProt:

SEY1_LEIMA

TriTrypDb:

LmjF.32.0370 , LMJLV39_320008900 , LMJSD75_320008900

Length:

891

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0005789	endoplasmic reticulum membrane	4	11
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	11
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	12
GO:0005783	endoplasmic reticulum	5	1

Expansion

Sequence features

Q4Q5P8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q5P8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	11
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.359
CLV_C14_Caspase3-7	163	167	PF00656	0.407
CLV_C14_Caspase3-7	40	44	PF00656	0.637
CLV_C14_Caspase3-7	581	585	PF00656	0.365
CLV_NRD_NRD_1	254	256	PF00675	0.449
CLV_NRD_NRD_1	665	667	PF00675	0.549
CLV_NRD_NRD_1	88	90	PF00675	0.245
CLV_NRD_NRD_1	887	889	PF00675	0.447
CLV_PCSK_KEX2_1	16	18	PF00082	0.306
CLV_PCSK_KEX2_1	665	667	PF00082	0.548
CLV_PCSK_KEX2_1	88	90	PF00082	0.247
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.306
CLV_PCSK_SKI1_1	16	20	PF00082	0.361
CLV_PCSK_SKI1_1	212	216	PF00082	0.419
CLV_PCSK_SKI1_1	240	244	PF00082	0.426
CLV_PCSK_SKI1_1	321	325	PF00082	0.437
CLV_PCSK_SKI1_1	355	359	PF00082	0.516
CLV_PCSK_SKI1_1	364	368	PF00082	0.481
CLV_PCSK_SKI1_1	468	472	PF00082	0.504
CLV_PCSK_SKI1_1	596	600	PF00082	0.583
CLV_PCSK_SKI1_1	673	677	PF00082	0.561
CLV_PCSK_SKI1_1	795	799	PF00082	0.249
CLV_PCSK_SKI1_1	829	833	PF00082	0.415
CLV_PCSK_SKI1_1	94	98	PF00082	0.203
DEG_MDM2_SWIB_1	258	265	PF02201	0.231
DEG_MDM2_SWIB_1	766	774	PF02201	0.253
DOC_CYCLIN_RxL_1	175	186	PF00134	0.417
DOC_CYCLIN_RxL_1	668	680	PF00134	0.360
DOC_CYCLIN_RxL_1	826	833	PF00134	0.579
DOC_CYCLIN_yCln2_LP_2	777	783	PF00134	0.275
DOC_MAPK_gen_1	668	676	PF00069	0.369
DOC_MAPK_JIP1_4	232	238	PF00069	0.209
DOC_MAPK_MEF2A_6	152	160	PF00069	0.437
DOC_MAPK_MEF2A_6	212	221	PF00069	0.207
DOC_MAPK_MEF2A_6	232	239	PF00069	0.120
DOC_PP1_RVXF_1	671	677	PF00149	0.315
DOC_PP2B_LxvP_1	349	352	PF13499	0.207
DOC_USP7_MATH_1	125	129	PF00917	0.500
DOC_USP7_MATH_1	247	251	PF00917	0.274
DOC_USP7_MATH_1	272	276	PF00917	0.211
DOC_USP7_MATH_1	28	32	PF00917	0.660
DOC_USP7_MATH_1	703	707	PF00917	0.400
DOC_USP7_UBL2_3	613	617	PF12436	0.307
DOC_WW_Pin1_4	508	513	PF00397	0.307
DOC_WW_Pin1_4	776	781	PF00397	0.241
LIG_14-3-3_CanoR_1	152	157	PF00244	0.353
LIG_14-3-3_CanoR_1	178	183	PF00244	0.407
LIG_14-3-3_CanoR_1	255	259	PF00244	0.217
LIG_14-3-3_CanoR_1	306	314	PF00244	0.293
LIG_14-3-3_CanoR_1	405	410	PF00244	0.322
LIG_14-3-3_CanoR_1	458	464	PF00244	0.323
LIG_14-3-3_CanoR_1	578	583	PF00244	0.284
LIG_14-3-3_CanoR_1	607	615	PF00244	0.293
LIG_14-3-3_CanoR_1	88	98	PF00244	0.414
LIG_14-3-3_CanoR_1	883	890	PF00244	0.656
LIG_Actin_WH2_2	456	474	PF00022	0.321
LIG_Actin_WH2_2	623	641	PF00022	0.308
LIG_BIR_II_1	1	5	PF00653	0.482
LIG_BIR_III_4	652	656	PF00653	0.382
LIG_BIR_III_4	7	11	PF00653	0.445
LIG_DLG_GKlike_1	178	185	PF00625	0.407
LIG_eIF4E_1	635	641	PF01652	0.343
LIG_FHA_1	138	144	PF00498	0.486
LIG_FHA_1	151	157	PF00498	0.410
LIG_FHA_1	163	169	PF00498	0.434
LIG_FHA_1	188	194	PF00498	0.338
LIG_FHA_1	21	27	PF00498	0.522
LIG_FHA_1	232	238	PF00498	0.207
LIG_FHA_1	428	434	PF00498	0.323
LIG_FHA_1	556	562	PF00498	0.350
LIG_FHA_1	566	572	PF00498	0.347
LIG_FHA_1	610	616	PF00498	0.295
LIG_FHA_1	740	746	PF00498	0.236
LIG_FHA_1	815	821	PF00498	0.548
LIG_FHA_2	211	217	PF00498	0.207
LIG_FHA_2	241	247	PF00498	0.214
LIG_FHA_2	258	264	PF00498	0.207
LIG_FHA_2	297	303	PF00498	0.275
LIG_FHA_2	343	349	PF00498	0.225
LIG_FHA_2	351	357	PF00498	0.296
LIG_FHA_2	36	42	PF00498	0.630
LIG_FHA_2	80	86	PF00498	0.417
LIG_FHA_2	862	868	PF00498	0.703
LIG_GBD_Chelix_1	187	195	PF00786	0.241
LIG_LIR_Gen_1	257	265	PF02991	0.223
LIG_LIR_Gen_1	569	580	PF02991	0.289
LIG_LIR_Gen_1	688	696	PF02991	0.422
LIG_LIR_Gen_1	78	87	PF02991	0.403
LIG_LIR_Gen_1	800	810	PF02991	0.520
LIG_LIR_Nem_3	257	261	PF02991	0.232
LIG_LIR_Nem_3	337	343	PF02991	0.226
LIG_LIR_Nem_3	520	525	PF02991	0.271
LIG_LIR_Nem_3	569	575	PF02991	0.295
LIG_LIR_Nem_3	632	638	PF02991	0.326
LIG_LIR_Nem_3	688	692	PF02991	0.386
LIG_LIR_Nem_3	78	83	PF02991	0.507
LIG_LIR_Nem_3	800	805	PF02991	0.523
LIG_NRBOX	466	472	PF00104	0.372
LIG_PCNA_PIPBox_1	515	524	PF02747	0.365
LIG_PCNA_yPIPBox_3	508	522	PF02747	0.335
LIG_Pex14_2	258	262	PF04695	0.231
LIG_Pex14_2	76	80	PF04695	0.405
LIG_Pex14_2	766	770	PF04695	0.253
LIG_Pex14_2	793	797	PF04695	0.256
LIG_Pex14_2	798	802	PF04695	0.417
LIG_PTB_Apo_2	70	77	PF02174	0.427
LIG_REV1ctd_RIR_1	791	799	PF16727	0.335
LIG_SH2_CRK	55	59	PF00017	0.444
LIG_SH2_CRK	700	704	PF00017	0.368
LIG_SH2_GRB2like	424	427	PF00017	0.321
LIG_SH2_PTP2	285	288	PF00017	0.310
LIG_SH2_PTP2	549	552	PF00017	0.290
LIG_SH2_STAP1	381	385	PF00017	0.292
LIG_SH2_STAP1	424	428	PF00017	0.378
LIG_SH2_STAT3	290	293	PF00017	0.256
LIG_SH2_STAT5	21	24	PF00017	0.513
LIG_SH2_STAT5	285	288	PF00017	0.324
LIG_SH2_STAT5	316	319	PF00017	0.221
LIG_SH2_STAT5	335	338	PF00017	0.204
LIG_SH2_STAT5	549	552	PF00017	0.344
LIG_SH2_STAT5	635	638	PF00017	0.327
LIG_SH2_STAT5	686	689	PF00017	0.275
LIG_SH2_STAT5	775	778	PF00017	0.241
LIG_SH3_3	693	699	PF00018	0.268
LIG_SH3_3	810	816	PF00018	0.606
LIG_SH3_3	873	879	PF00018	0.669
LIG_SH3_5	830	834	PF00018	0.533
LIG_SUMO_SIM_anti_2	155	161	PF11976	0.395
LIG_SUMO_SIM_anti_2	234	241	PF11976	0.217
LIG_SUMO_SIM_par_1	155	161	PF11976	0.474
LIG_SUMO_SIM_par_1	234	241	PF11976	0.207
LIG_SUMO_SIM_par_1	626	632	PF11976	0.318
LIG_TRAF2_1	462	465	PF00917	0.322
LIG_TRAF2_1	804	807	PF00917	0.580
LIG_TRAF2_1	852	855	PF00917	0.567
LIG_TYR_ITIM	53	58	PF00017	0.472
LIG_TYR_ITIM	633	638	PF00017	0.246
LIG_UBA3_1	279	283	PF00899	0.310
LIG_WRC_WIRS_1	406	411	PF05994	0.297
LIG_WRC_WIRS_1	518	523	PF05994	0.329
LIG_WRC_WIRS_1	689	694	PF05994	0.304
LIG_WW_3	539	543	PF00397	0.334
MOD_CK1_1	250	256	PF00069	0.274
MOD_CK1_1	257	263	PF00069	0.274
MOD_CK1_1	300	306	PF00069	0.280
MOD_CK1_1	35	41	PF00069	0.752
MOD_CK1_1	473	479	PF00069	0.398
MOD_CK1_1	602	608	PF00069	0.421
MOD_CK1_1	66	72	PF00069	0.403
MOD_CK1_1	688	694	PF00069	0.401
MOD_CK2_1	210	216	PF00069	0.207
MOD_CK2_1	257	263	PF00069	0.297
MOD_CK2_1	296	302	PF00069	0.324
MOD_CK2_1	335	341	PF00069	0.215
MOD_CK2_1	350	356	PF00069	0.353
MOD_CK2_1	43	49	PF00069	0.547
MOD_CK2_1	450	456	PF00069	0.327
MOD_CK2_1	459	465	PF00069	0.297
MOD_CK2_1	477	483	PF00069	0.331
MOD_CK2_1	79	85	PF00069	0.451
MOD_CK2_1	854	860	PF00069	0.699
MOD_GlcNHglycan	111	114	PF01048	0.280
MOD_GlcNHglycan	121	124	PF01048	0.280
MOD_GlcNHglycan	32	35	PF01048	0.475
MOD_GlcNHglycan	472	475	PF01048	0.576
MOD_GlcNHglycan	479	482	PF01048	0.674
MOD_GlcNHglycan	584	587	PF01048	0.532
MOD_GlcNHglycan	65	68	PF01048	0.177
MOD_GlcNHglycan	662	665	PF01048	0.605
MOD_GlcNHglycan	705	708	PF01048	0.578
MOD_GlcNHglycan	871	874	PF01048	0.405
MOD_GSK3_1	148	155	PF00069	0.428
MOD_GSK3_1	183	190	PF00069	0.323
MOD_GSK3_1	250	257	PF00069	0.246
MOD_GSK3_1	26	33	PF00069	0.644
MOD_GSK3_1	292	299	PF00069	0.338
MOD_GSK3_1	401	408	PF00069	0.402
MOD_GSK3_1	459	466	PF00069	0.340
MOD_GSK3_1	473	480	PF00069	0.296
MOD_GSK3_1	517	524	PF00069	0.377
MOD_GSK3_1	574	581	PF00069	0.334
MOD_GSK3_1	582	589	PF00069	0.336
MOD_GSK3_1	62	69	PF00069	0.403
MOD_GSK3_1	687	694	PF00069	0.361
MOD_GSK3_1	721	728	PF00069	0.286
MOD_GSK3_1	75	82	PF00069	0.403
MOD_GSK3_1	805	812	PF00069	0.580
MOD_GSK3_1	816	823	PF00069	0.553
MOD_N-GLC_1	433	438	PF02516	0.584
MOD_NEK2_1	183	188	PF00069	0.243
MOD_NEK2_1	210	215	PF00069	0.207
MOD_NEK2_1	308	313	PF00069	0.232
MOD_NEK2_1	470	475	PF00069	0.352
MOD_NEK2_1	517	522	PF00069	0.324
MOD_NEK2_1	582	587	PF00069	0.367
MOD_NEK2_1	594	599	PF00069	0.294
MOD_NEK2_1	608	613	PF00069	0.259
MOD_NEK2_1	685	690	PF00069	0.278
MOD_NEK2_1	797	802	PF00069	0.425
MOD_NEK2_1	805	810	PF00069	0.484
MOD_NEK2_2	586	591	PF00069	0.269
MOD_PIKK_1	28	34	PF00454	0.684
MOD_PIKK_1	308	314	PF00454	0.283
MOD_PIKK_1	350	356	PF00454	0.316
MOD_PIKK_1	620	626	PF00454	0.200
MOD_PIKK_1	721	727	PF00454	0.225
MOD_PIKK_1	740	746	PF00454	0.159
MOD_PIKK_1	797	803	PF00454	0.420
MOD_PKA_2	126	132	PF00069	0.480
MOD_PKA_2	254	260	PF00069	0.228
MOD_PKA_2	343	349	PF00069	0.259
MOD_PKA_2	392	398	PF00069	0.411
MOD_PKA_2	404	410	PF00069	0.341
MOD_PKA_2	441	447	PF00069	0.411
MOD_PKA_2	884	890	PF00069	0.719
MOD_Plk_1	433	439	PF00069	0.381
MOD_Plk_1	44	50	PF00069	0.489
MOD_Plk_1	463	469	PF00069	0.336
MOD_Plk_1	594	600	PF00069	0.385
MOD_Plk_1	854	860	PF00069	0.562
MOD_Plk_2-3	79	85	PF00069	0.522
MOD_Plk_4	152	158	PF00069	0.353
MOD_Plk_4	178	184	PF00069	0.407
MOD_Plk_4	187	193	PF00069	0.241
MOD_Plk_4	21	27	PF00069	0.558
MOD_Plk_4	231	237	PF00069	0.215
MOD_Plk_4	257	263	PF00069	0.286
MOD_Plk_4	405	411	PF00069	0.326
MOD_Plk_4	629	635	PF00069	0.319
MOD_Plk_4	67	73	PF00069	0.403
MOD_Plk_4	809	815	PF00069	0.543
MOD_Plk_4	816	822	PF00069	0.516
MOD_Plk_4	823	829	PF00069	0.493
MOD_ProDKin_1	508	514	PF00069	0.301
MOD_ProDKin_1	776	782	PF00069	0.241
MOD_SUMO_rev_2	225	234	PF00179	0.200
MOD_SUMO_rev_2	365	374	PF00179	0.404
TRG_DiLeu_BaEn_1	231	236	PF01217	0.207
TRG_DiLeu_BaLyEn_6	381	386	PF01217	0.319
TRG_DiLeu_BaLyEn_6	827	832	PF01217	0.504
TRG_ENDOCYTIC_2	284	287	PF00928	0.259
TRG_ENDOCYTIC_2	549	552	PF00928	0.283
TRG_ENDOCYTIC_2	55	58	PF00928	0.446
TRG_ENDOCYTIC_2	635	638	PF00928	0.234
TRG_ENDOCYTIC_2	689	692	PF00928	0.270
TRG_ER_diArg_1	665	668	PF00400	0.372
TRG_ER_diArg_1	671	674	PF00400	0.329
TRG_ER_diArg_1	87	89	PF00400	0.471
TRG_ER_diArg_1	882	885	PF00400	0.641
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	384	389	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	673	678	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	829	833	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P867	Leptomonas seymouri	65%	100%
A0A0S4IQA8	Bodo saltans	37%	100%
A0A1X0P6I5	Trypanosomatidae	46%	97%
A0A3R7KQ50	Trypanosoma rangeli	43%	100%
A0A3S7X571	Leishmania donovani	92%	93%
A2EK80	Trichomonas vaginalis	26%	100%
A4HK17	Leishmania braziliensis	79%	100%
A4I7K1	Leishmania infantum	92%	100%
C4R432	Komagataella phaffii (strain GS115 / ATCC 20864)	28%	100%
D0A0A4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B2F8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q0JLS6	Oryza sativa subsp. japonica	25%	100%
Q388F1	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	44%	100%
Q4DHA1	Trypanosoma cruzi (strain CL Brener)	45%	100%
Q4Q5P8	Leishmania major	100%	100%
V5DTG5	Trypanosoma cruzi	47%	100%