LeishMANIAdb
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Protein SEY1 homolog

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein SEY1 homolog
Gene product:
Dynamin family/Root hair defective 3 GTP-binding protein (RHD3) - putative
Species:
Leishmania infantum
UniProt:
SEY1_LEIIN
TriTrypDb:
LINF_320008800 *
Length:
895

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, SEY1 homolog LinJ32.0740

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005789 endoplasmic reticulum membrane 4 11
GO:0016020 membrane 2 12
GO:0031090 organelle membrane 3 11
GO:0110165 cellular anatomical entity 1 12
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0005783 endoplasmic reticulum 5 1

Expansion

Sequence features

A4I7K1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4I7K1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 11
GO:0003924 GTPase activity 7 11
GO:0005488 binding 1 12
GO:0005525 GTP binding 5 12
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0017076 purine nucleotide binding 4 12
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 11
GO:0019001 guanyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032561 guanyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 165 169 PF00656 0.406
CLV_C14_Caspase3-7 40 44 PF00656 0.629
CLV_C14_Caspase3-7 433 437 PF00656 0.344
CLV_C14_Caspase3-7 583 587 PF00656 0.361
CLV_C14_Caspase3-7 680 684 PF00656 0.287
CLV_NRD_NRD_1 256 258 PF00675 0.447
CLV_NRD_NRD_1 307 309 PF00675 0.449
CLV_NRD_NRD_1 668 670 PF00675 0.556
CLV_NRD_NRD_1 88 90 PF00675 0.243
CLV_NRD_NRD_1 891 893 PF00675 0.464
CLV_PCSK_KEX2_1 16 18 PF00082 0.305
CLV_PCSK_KEX2_1 307 309 PF00082 0.449
CLV_PCSK_KEX2_1 668 670 PF00082 0.555
CLV_PCSK_KEX2_1 88 90 PF00082 0.246
CLV_PCSK_PC1ET2_1 16 18 PF00082 0.305
CLV_PCSK_SKI1_1 16 20 PF00082 0.360
CLV_PCSK_SKI1_1 214 218 PF00082 0.406
CLV_PCSK_SKI1_1 242 246 PF00082 0.413
CLV_PCSK_SKI1_1 323 327 PF00082 0.424
CLV_PCSK_SKI1_1 357 361 PF00082 0.507
CLV_PCSK_SKI1_1 366 370 PF00082 0.482
CLV_PCSK_SKI1_1 470 474 PF00082 0.503
CLV_PCSK_SKI1_1 598 602 PF00082 0.581
CLV_PCSK_SKI1_1 676 680 PF00082 0.556
CLV_PCSK_SKI1_1 798 802 PF00082 0.247
CLV_PCSK_SKI1_1 832 836 PF00082 0.406
CLV_PCSK_SKI1_1 94 98 PF00082 0.236
DEG_MDM2_SWIB_1 260 267 PF02201 0.230
DEG_MDM2_SWIB_1 769 777 PF02201 0.250
DOC_CYCLIN_RxL_1 177 188 PF00134 0.416
DOC_CYCLIN_RxL_1 829 836 PF00134 0.569
DOC_CYCLIN_yCln2_LP_2 780 786 PF00134 0.273
DOC_MAPK_JIP1_4 234 240 PF00069 0.208
DOC_MAPK_MEF2A_6 214 223 PF00069 0.206
DOC_MAPK_MEF2A_6 234 241 PF00069 0.121
DOC_PP1_RVXF_1 674 680 PF00149 0.309
DOC_PP2B_LxvP_1 351 354 PF13499 0.206
DOC_USP7_MATH_1 125 129 PF00917 0.485
DOC_USP7_MATH_1 249 253 PF00917 0.272
DOC_USP7_MATH_1 274 278 PF00917 0.232
DOC_USP7_MATH_1 28 32 PF00917 0.654
DOC_USP7_MATH_1 706 710 PF00917 0.280
DOC_USP7_UBL2_3 615 619 PF12436 0.300
DOC_WW_Pin1_4 510 515 PF00397 0.303
DOC_WW_Pin1_4 779 784 PF00397 0.240
LIG_14-3-3_CanoR_1 180 185 PF00244 0.406
LIG_14-3-3_CanoR_1 257 261 PF00244 0.237
LIG_14-3-3_CanoR_1 407 412 PF00244 0.310
LIG_14-3-3_CanoR_1 460 466 PF00244 0.321
LIG_14-3-3_CanoR_1 525 531 PF00244 0.318
LIG_14-3-3_CanoR_1 580 585 PF00244 0.280
LIG_14-3-3_CanoR_1 609 617 PF00244 0.290
LIG_14-3-3_CanoR_1 88 98 PF00244 0.417
LIG_14-3-3_CanoR_1 887 894 PF00244 0.669
LIG_Actin_WH2_2 458 476 PF00022 0.319
LIG_Actin_WH2_2 625 643 PF00022 0.306
LIG_BIR_II_1 1 5 PF00653 0.479
LIG_Clathr_ClatBox_1 159 163 PF01394 0.386
LIG_DLG_GKlike_1 180 187 PF00625 0.406
LIG_eIF4E_1 637 643 PF01652 0.343
LIG_FHA_1 165 171 PF00498 0.474
LIG_FHA_1 190 196 PF00498 0.286
LIG_FHA_1 21 27 PF00498 0.562
LIG_FHA_1 234 240 PF00498 0.206
LIG_FHA_1 430 436 PF00498 0.317
LIG_FHA_1 558 564 PF00498 0.351
LIG_FHA_1 568 574 PF00498 0.346
LIG_FHA_1 612 618 PF00498 0.291
LIG_FHA_1 743 749 PF00498 0.234
LIG_FHA_1 818 824 PF00498 0.548
LIG_FHA_2 213 219 PF00498 0.206
LIG_FHA_2 243 249 PF00498 0.213
LIG_FHA_2 260 266 PF00498 0.306
LIG_FHA_2 345 351 PF00498 0.250
LIG_FHA_2 353 359 PF00498 0.311
LIG_FHA_2 36 42 PF00498 0.624
LIG_FHA_2 706 712 PF00498 0.261
LIG_FHA_2 80 86 PF00498 0.424
LIG_FHA_2 866 872 PF00498 0.710
LIG_GBD_Chelix_1 189 197 PF00786 0.240
LIG_LIR_Gen_1 259 267 PF02991 0.221
LIG_LIR_Gen_1 571 582 PF02991 0.287
LIG_LIR_Gen_1 691 699 PF02991 0.367
LIG_LIR_Gen_1 78 87 PF02991 0.402
LIG_LIR_Gen_1 803 813 PF02991 0.521
LIG_LIR_Nem_3 259 263 PF02991 0.242
LIG_LIR_Nem_3 339 345 PF02991 0.225
LIG_LIR_Nem_3 375 379 PF02991 0.313
LIG_LIR_Nem_3 522 527 PF02991 0.266
LIG_LIR_Nem_3 571 577 PF02991 0.293
LIG_LIR_Nem_3 634 640 PF02991 0.326
LIG_LIR_Nem_3 691 695 PF02991 0.333
LIG_LIR_Nem_3 78 83 PF02991 0.506
LIG_LIR_Nem_3 803 808 PF02991 0.524
LIG_NRBOX 468 474 PF00104 0.372
LIG_PCNA_PIPBox_1 517 526 PF02747 0.361
LIG_PCNA_yPIPBox_3 510 524 PF02747 0.331
LIG_Pex14_2 260 264 PF04695 0.230
LIG_Pex14_2 76 80 PF04695 0.402
LIG_Pex14_2 769 773 PF04695 0.250
LIG_Pex14_2 796 800 PF04695 0.254
LIG_Pex14_2 801 805 PF04695 0.416
LIG_PTAP_UEV_1 879 884 PF05743 0.688
LIG_PTB_Apo_2 70 77 PF02174 0.402
LIG_REV1ctd_RIR_1 794 802 PF16727 0.333
LIG_SH2_CRK 55 59 PF00017 0.440
LIG_SH2_CRK 703 707 PF00017 0.263
LIG_SH2_GRB2like 426 429 PF00017 0.316
LIG_SH2_GRB2like 530 533 PF00017 0.222
LIG_SH2_PTP2 287 290 PF00017 0.309
LIG_SH2_PTP2 551 554 PF00017 0.290
LIG_SH2_STAP1 383 387 PF00017 0.292
LIG_SH2_STAP1 426 430 PF00017 0.376
LIG_SH2_STAT3 292 295 PF00017 0.247
LIG_SH2_STAT5 21 24 PF00017 0.554
LIG_SH2_STAT5 287 290 PF00017 0.309
LIG_SH2_STAT5 318 321 PF00017 0.246
LIG_SH2_STAT5 337 340 PF00017 0.220
LIG_SH2_STAT5 530 533 PF00017 0.344
LIG_SH2_STAT5 551 554 PF00017 0.346
LIG_SH2_STAT5 637 640 PF00017 0.327
LIG_SH2_STAT5 689 692 PF00017 0.275
LIG_SH2_STAT5 778 781 PF00017 0.240
LIG_SH3_3 696 702 PF00018 0.207
LIG_SH3_3 813 819 PF00018 0.608
LIG_SH3_3 877 883 PF00018 0.683
LIG_SUMO_SIM_anti_2 236 243 PF11976 0.216
LIG_SUMO_SIM_par_1 157 163 PF11976 0.473
LIG_SUMO_SIM_par_1 236 243 PF11976 0.206
LIG_SUMO_SIM_par_1 628 634 PF11976 0.317
LIG_TRAF2_1 464 467 PF00917 0.319
LIG_TRAF2_1 807 810 PF00917 0.582
LIG_TYR_ITIM 53 58 PF00017 0.469
LIG_TYR_ITIM 635 640 PF00017 0.246
LIG_TYR_ITIM 690 695 PF00017 0.224
LIG_UBA3_1 281 285 PF00899 0.309
LIG_WRC_WIRS_1 373 378 PF05994 0.247
LIG_WRC_WIRS_1 408 413 PF05994 0.291
LIG_WRC_WIRS_1 520 525 PF05994 0.322
LIG_WW_3 541 545 PF00397 0.333
MOD_CK1_1 111 117 PF00069 0.455
MOD_CK1_1 252 258 PF00069 0.272
MOD_CK1_1 259 265 PF00069 0.304
MOD_CK1_1 302 308 PF00069 0.274
MOD_CK1_1 35 41 PF00069 0.748
MOD_CK1_1 475 481 PF00069 0.398
MOD_CK1_1 526 532 PF00069 0.326
MOD_CK1_1 604 610 PF00069 0.419
MOD_CK1_1 66 72 PF00069 0.402
MOD_CK1_1 691 697 PF00069 0.342
MOD_CK2_1 212 218 PF00069 0.206
MOD_CK2_1 259 265 PF00069 0.328
MOD_CK2_1 352 358 PF00069 0.366
MOD_CK2_1 43 49 PF00069 0.539
MOD_CK2_1 452 458 PF00069 0.333
MOD_CK2_1 461 467 PF00069 0.297
MOD_CK2_1 479 485 PF00069 0.329
MOD_CK2_1 79 85 PF00069 0.424
MOD_GlcNHglycan 109 113 PF01048 0.311
MOD_GlcNHglycan 121 124 PF01048 0.294
MOD_GlcNHglycan 32 35 PF01048 0.482
MOD_GlcNHglycan 45 48 PF01048 0.421
MOD_GlcNHglycan 474 477 PF01048 0.569
MOD_GlcNHglycan 481 484 PF01048 0.656
MOD_GlcNHglycan 487 490 PF01048 0.641
MOD_GlcNHglycan 586 589 PF01048 0.529
MOD_GlcNHglycan 65 68 PF01048 0.202
MOD_GlcNHglycan 665 668 PF01048 0.610
MOD_GlcNHglycan 708 711 PF01048 0.445
MOD_GSK3_1 185 192 PF00069 0.286
MOD_GSK3_1 208 215 PF00069 0.195
MOD_GSK3_1 252 259 PF00069 0.242
MOD_GSK3_1 26 33 PF00069 0.664
MOD_GSK3_1 403 410 PF00069 0.387
MOD_GSK3_1 461 468 PF00069 0.340
MOD_GSK3_1 475 482 PF00069 0.289
MOD_GSK3_1 519 526 PF00069 0.372
MOD_GSK3_1 576 583 PF00069 0.331
MOD_GSK3_1 584 591 PF00069 0.332
MOD_GSK3_1 62 69 PF00069 0.438
MOD_GSK3_1 690 697 PF00069 0.305
MOD_GSK3_1 75 82 PF00069 0.446
MOD_GSK3_1 808 815 PF00069 0.582
MOD_GSK3_1 819 826 PF00069 0.552
MOD_GSK3_1 878 885 PF00069 0.620
MOD_N-GLC_1 208 213 PF02516 0.395
MOD_NEK2_1 108 113 PF00069 0.533
MOD_NEK2_1 185 190 PF00069 0.240
MOD_NEK2_1 212 217 PF00069 0.206
MOD_NEK2_1 310 315 PF00069 0.248
MOD_NEK2_1 472 477 PF00069 0.353
MOD_NEK2_1 519 524 PF00069 0.317
MOD_NEK2_1 584 589 PF00069 0.364
MOD_NEK2_1 596 601 PF00069 0.291
MOD_NEK2_1 610 615 PF00069 0.258
MOD_NEK2_1 688 693 PF00069 0.278
MOD_NEK2_1 800 805 PF00069 0.424
MOD_NEK2_1 808 813 PF00069 0.486
MOD_NEK2_1 830 835 PF00069 0.592
MOD_NEK2_2 588 593 PF00069 0.266
MOD_PIKK_1 28 34 PF00454 0.697
MOD_PIKK_1 310 316 PF00454 0.320
MOD_PIKK_1 352 358 PF00454 0.310
MOD_PIKK_1 724 730 PF00454 0.224
MOD_PIKK_1 743 749 PF00454 0.159
MOD_PIKK_1 800 806 PF00454 0.419
MOD_PKA_2 256 262 PF00069 0.216
MOD_PKA_2 345 351 PF00069 0.243
MOD_PKA_2 394 400 PF00069 0.413
MOD_PKA_2 412 418 PF00069 0.277
MOD_PKA_2 443 449 PF00069 0.312
MOD_PKA_2 888 894 PF00069 0.734
MOD_Plk_1 208 214 PF00069 0.195
MOD_Plk_1 435 441 PF00069 0.363
MOD_Plk_1 465 471 PF00069 0.335
MOD_Plk_1 596 602 PF00069 0.396
MOD_Plk_2-3 79 85 PF00069 0.495
MOD_Plk_4 111 117 PF00069 0.369
MOD_Plk_4 180 186 PF00069 0.406
MOD_Plk_4 189 195 PF00069 0.240
MOD_Plk_4 208 214 PF00069 0.167
MOD_Plk_4 21 27 PF00069 0.575
MOD_Plk_4 233 239 PF00069 0.214
MOD_Plk_4 259 265 PF00069 0.328
MOD_Plk_4 407 413 PF00069 0.304
MOD_Plk_4 526 532 PF00069 0.321
MOD_Plk_4 631 637 PF00069 0.319
MOD_Plk_4 67 73 PF00069 0.430
MOD_Plk_4 812 818 PF00069 0.545
MOD_Plk_4 819 825 PF00069 0.516
MOD_Plk_4 826 832 PF00069 0.490
MOD_ProDKin_1 510 516 PF00069 0.297
MOD_ProDKin_1 779 785 PF00069 0.240
MOD_SUMO_rev_2 227 236 PF00179 0.199
MOD_SUMO_rev_2 367 376 PF00179 0.377
TRG_DiLeu_BaEn_1 233 238 PF01217 0.206
TRG_DiLeu_BaLyEn_6 155 160 PF01217 0.491
TRG_DiLeu_BaLyEn_6 383 388 PF01217 0.317
TRG_ENDOCYTIC_2 286 289 PF00928 0.230
TRG_ENDOCYTIC_2 55 58 PF00928 0.442
TRG_ENDOCYTIC_2 551 554 PF00928 0.284
TRG_ENDOCYTIC_2 637 640 PF00928 0.234
TRG_ENDOCYTIC_2 692 695 PF00928 0.218
TRG_ER_diArg_1 306 308 PF00400 0.249
TRG_ER_diArg_1 668 671 PF00400 0.381
TRG_ER_diArg_1 87 89 PF00400 0.470
TRG_ER_diArg_1 886 889 PF00400 0.657
TRG_Pf-PMV_PEXEL_1 16 20 PF00026 0.396
TRG_Pf-PMV_PEXEL_1 214 218 PF00026 0.416
TRG_Pf-PMV_PEXEL_1 386 391 PF00026 0.616
TRG_Pf-PMV_PEXEL_1 832 836 PF00026 0.443

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P867 Leptomonas seymouri 66% 100%
A0A0S4IQA8 Bodo saltans 37% 100%
A0A1X0P6I5 Trypanosomatidae 47% 98%
A0A3R7KQ50 Trypanosoma rangeli 44% 100%
A0A3S7X571 Leishmania donovani 100% 93%
A2EK80 Trichomonas vaginalis 24% 100%
A4HK17 Leishmania braziliensis 79% 99%
A4I7K1 Leishmania infantum 100% 100%
B6K0N7 Schizosaccharomyces japonicus (strain yFS275 / FY16936) 25% 100%
D0A0A4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9B2F8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q388F1 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 44% 100%
Q4DHA1 Trypanosoma cruzi (strain CL Brener) 45% 100%
Q4Q5P8 Leishmania major 92% 100%
Q9SSN0 Arabidopsis thaliana 27% 100%
V5DTG5 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS