LeishMANIAdb
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Protein SEY1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein SEY1 homolog
Gene product:
root hair defective 3 GTP-binding protein (RHD3), putative
Species:
Leishmania braziliensis
UniProt:
SEY1_LEIBR
TriTrypDb:
LbrM.32.0440 , LBRM2903_320009100 * , LBRM2903_320009200 *
Length:
891

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005789 endoplasmic reticulum membrane 4 11
GO:0016020 membrane 2 12
GO:0031090 organelle membrane 3 11
GO:0110165 cellular anatomical entity 1 12
GO:0005737 cytoplasm 2 1
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0005783 endoplasmic reticulum 5 1

Expansion

Sequence features

A4HK17
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HK17

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 11
GO:0003924 GTPase activity 7 11
GO:0005488 binding 1 12
GO:0005525 GTP binding 5 12
GO:0016462 pyrophosphatase activity 5 11
GO:0016787 hydrolase activity 2 11
GO:0016817 hydrolase activity, acting on acid anhydrides 3 11
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 11
GO:0017076 purine nucleotide binding 4 12
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 11
GO:0019001 guanyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032561 guanyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 160 164 PF00656 0.406
CLV_C14_Caspase3-7 271 275 PF00656 0.181
CLV_C14_Caspase3-7 428 432 PF00656 0.348
CLV_C14_Caspase3-7 675 679 PF00656 0.284
CLV_NRD_NRD_1 251 253 PF00675 0.447
CLV_NRD_NRD_1 302 304 PF00675 0.449
CLV_NRD_NRD_1 663 665 PF00675 0.535
CLV_NRD_NRD_1 88 90 PF00675 0.243
CLV_PCSK_KEX2_1 302 304 PF00082 0.449
CLV_PCSK_KEX2_1 663 665 PF00082 0.534
CLV_PCSK_KEX2_1 88 90 PF00082 0.246
CLV_PCSK_SKI1_1 16 20 PF00082 0.359
CLV_PCSK_SKI1_1 209 213 PF00082 0.406
CLV_PCSK_SKI1_1 237 241 PF00082 0.413
CLV_PCSK_SKI1_1 352 356 PF00082 0.508
CLV_PCSK_SKI1_1 361 365 PF00082 0.484
CLV_PCSK_SKI1_1 465 469 PF00082 0.501
CLV_PCSK_SKI1_1 593 597 PF00082 0.574
CLV_PCSK_SKI1_1 793 797 PF00082 0.247
CLV_PCSK_SKI1_1 827 831 PF00082 0.400
CLV_PCSK_SKI1_1 94 98 PF00082 0.236
DEG_MDM2_SWIB_1 255 262 PF02201 0.230
DEG_MDM2_SWIB_1 764 772 PF02201 0.250
DEG_Nend_UBRbox_3 1 3 PF02207 0.453
DOC_CYCLIN_RxL_1 172 183 PF00134 0.416
DOC_CYCLIN_RxL_1 824 832 PF00134 0.572
DOC_CYCLIN_yCln2_LP_2 775 781 PF00134 0.273
DOC_MAPK_gen_1 381 391 PF00069 0.316
DOC_MAPK_gen_1 666 674 PF00069 0.355
DOC_MAPK_JIP1_4 229 235 PF00069 0.208
DOC_MAPK_MEF2A_6 209 218 PF00069 0.206
DOC_MAPK_MEF2A_6 229 236 PF00069 0.121
DOC_MAPK_MEF2A_6 384 391 PF00069 0.328
DOC_MAPK_NFAT4_5 384 392 PF00069 0.242
DOC_PP2B_LxvP_1 346 349 PF13499 0.206
DOC_USP7_MATH_1 125 129 PF00917 0.485
DOC_USP7_MATH_1 244 248 PF00917 0.272
DOC_USP7_MATH_1 640 644 PF00917 0.338
DOC_USP7_MATH_1 868 872 PF00917 0.588
DOC_WW_Pin1_4 149 154 PF00397 0.443
DOC_WW_Pin1_4 28 33 PF00397 0.634
DOC_WW_Pin1_4 774 779 PF00397 0.240
LIG_14-3-3_CanoR_1 175 180 PF00244 0.406
LIG_14-3-3_CanoR_1 252 256 PF00244 0.237
LIG_14-3-3_CanoR_1 309 317 PF00244 0.287
LIG_14-3-3_CanoR_1 34 43 PF00244 0.716
LIG_14-3-3_CanoR_1 455 461 PF00244 0.311
LIG_14-3-3_CanoR_1 575 580 PF00244 0.276
LIG_14-3-3_CanoR_1 593 598 PF00244 0.241
LIG_14-3-3_CanoR_1 604 612 PF00244 0.285
LIG_14-3-3_CanoR_1 88 98 PF00244 0.417
LIG_14-3-3_CanoR_1 883 890 PF00244 0.666
LIG_Actin_WH2_2 453 471 PF00022 0.313
LIG_Actin_WH2_2 620 638 PF00022 0.306
LIG_Clathr_ClatBox_1 154 158 PF01394 0.386
LIG_DLG_GKlike_1 175 182 PF00625 0.406
LIG_eIF4E_1 632 638 PF01652 0.344
LIG_FHA_1 160 166 PF00498 0.474
LIG_FHA_1 17 23 PF00498 0.641
LIG_FHA_1 185 191 PF00498 0.287
LIG_FHA_1 229 235 PF00498 0.206
LIG_FHA_1 425 431 PF00498 0.320
LIG_FHA_1 444 450 PF00498 0.196
LIG_FHA_1 519 525 PF00498 0.288
LIG_FHA_1 553 559 PF00498 0.345
LIG_FHA_1 607 613 PF00498 0.287
LIG_FHA_1 651 657 PF00498 0.412
LIG_FHA_1 738 744 PF00498 0.234
LIG_FHA_1 885 891 PF00498 0.748
LIG_FHA_2 208 214 PF00498 0.206
LIG_FHA_2 238 244 PF00498 0.213
LIG_FHA_2 255 261 PF00498 0.306
LIG_FHA_2 269 275 PF00498 0.244
LIG_FHA_2 340 346 PF00498 0.250
LIG_FHA_2 348 354 PF00498 0.309
LIG_FHA_2 368 374 PF00498 0.184
LIG_FHA_2 862 868 PF00498 0.722
LIG_GBD_Chelix_1 184 192 PF00786 0.240
LIG_LIR_Gen_1 254 262 PF02991 0.221
LIG_LIR_Gen_1 316 325 PF02991 0.342
LIG_LIR_Gen_1 566 577 PF02991 0.280
LIG_LIR_Gen_1 686 694 PF02991 0.423
LIG_LIR_Gen_1 78 87 PF02991 0.402
LIG_LIR_Gen_1 798 808 PF02991 0.520
LIG_LIR_LC3C_4 231 235 PF02991 0.152
LIG_LIR_Nem_3 254 258 PF02991 0.242
LIG_LIR_Nem_3 319 324 PF02991 0.182
LIG_LIR_Nem_3 334 340 PF02991 0.225
LIG_LIR_Nem_3 370 374 PF02991 0.317
LIG_LIR_Nem_3 566 572 PF02991 0.287
LIG_LIR_Nem_3 629 635 PF02991 0.326
LIG_LIR_Nem_3 686 690 PF02991 0.385
LIG_LIR_Nem_3 78 83 PF02991 0.506
LIG_LIR_Nem_3 798 803 PF02991 0.526
LIG_MYND_1 118 122 PF01753 0.345
LIG_NRBOX 463 469 PF00104 0.369
LIG_PCNA_PIPBox_1 512 521 PF02747 0.356
LIG_PCNA_yPIPBox_3 505 519 PF02747 0.324
LIG_Pex14_2 255 259 PF04695 0.230
LIG_Pex14_2 76 80 PF04695 0.402
LIG_Pex14_2 764 768 PF04695 0.250
LIG_Pex14_2 791 795 PF04695 0.254
LIG_Pex14_2 796 800 PF04695 0.416
LIG_PTB_Apo_2 70 77 PF02174 0.402
LIG_REV1ctd_RIR_1 566 575 PF16727 0.190
LIG_REV1ctd_RIR_1 789 797 PF16727 0.333
LIG_SH2_CRK 546 550 PF00017 0.215
LIG_SH2_CRK 55 59 PF00017 0.443
LIG_SH2_GRB2like 421 424 PF00017 0.310
LIG_SH2_PTP2 282 285 PF00017 0.309
LIG_SH2_STAP1 378 382 PF00017 0.288
LIG_SH2_STAP1 413 417 PF00017 0.370
LIG_SH2_STAP1 421 425 PF00017 0.371
LIG_SH2_STAP1 546 550 PF00017 0.219
LIG_SH2_STAT3 287 290 PF00017 0.247
LIG_SH2_STAT5 21 24 PF00017 0.552
LIG_SH2_STAT5 282 285 PF00017 0.309
LIG_SH2_STAT5 313 316 PF00017 0.246
LIG_SH2_STAT5 332 335 PF00017 0.220
LIG_SH2_STAT5 632 635 PF00017 0.327
LIG_SH2_STAT5 684 687 PF00017 0.278
LIG_SH2_STAT5 773 776 PF00017 0.240
LIG_SH3_3 112 118 PF00018 0.438
LIG_SH3_3 548 554 PF00018 0.356
LIG_SH3_3 691 697 PF00018 0.271
LIG_SH3_3 808 814 PF00018 0.602
LIG_SUMO_SIM_anti_2 111 117 PF11976 0.345
LIG_SUMO_SIM_anti_2 152 158 PF11976 0.393
LIG_SUMO_SIM_anti_2 231 238 PF11976 0.216
LIG_SUMO_SIM_par_1 152 158 PF11976 0.473
LIG_SUMO_SIM_par_1 231 238 PF11976 0.206
LIG_SUMO_SIM_par_1 547 553 PF11976 0.203
LIG_SUMO_SIM_par_1 623 629 PF11976 0.316
LIG_TRAF2_1 459 462 PF00917 0.308
LIG_TRAF2_1 802 805 PF00917 0.581
LIG_TRAF2_2 265 270 PF00917 0.212
LIG_TYR_ITIM 53 58 PF00017 0.472
LIG_TYR_ITIM 630 635 PF00017 0.246
LIG_TYR_ITIM 685 690 PF00017 0.273
LIG_UBA3_1 276 280 PF00899 0.309
LIG_WW_3 536 540 PF00397 0.334
MOD_CDC14_SPxK_1 31 34 PF00782 0.544
MOD_CDK_SPxK_1 28 34 PF00069 0.531
MOD_CK1_1 247 253 PF00069 0.272
MOD_CK1_1 254 260 PF00069 0.304
MOD_CK1_1 297 303 PF00069 0.274
MOD_CK1_1 308 314 PF00069 0.276
MOD_CK1_1 316 322 PF00069 0.168
MOD_CK1_1 33 39 PF00069 0.739
MOD_CK1_1 470 476 PF00069 0.396
MOD_CK1_1 482 488 PF00069 0.533
MOD_CK1_1 599 605 PF00069 0.408
MOD_CK1_1 66 72 PF00069 0.402
MOD_CK1_1 686 692 PF00069 0.401
MOD_CK1_1 871 877 PF00069 0.614
MOD_CK2_1 207 213 PF00069 0.206
MOD_CK2_1 219 225 PF00069 0.206
MOD_CK2_1 254 260 PF00069 0.328
MOD_CK2_1 347 353 PF00069 0.363
MOD_CK2_1 447 453 PF00069 0.327
MOD_CK2_1 456 462 PF00069 0.287
MOD_CK2_1 474 480 PF00069 0.330
MOD_CK2_1 586 592 PF00069 0.257
MOD_CK2_1 833 839 PF00069 0.604
MOD_GlcNHglycan 122 125 PF01048 0.292
MOD_GlcNHglycan 35 38 PF01048 0.492
MOD_GlcNHglycan 414 417 PF01048 0.520
MOD_GlcNHglycan 469 472 PF01048 0.566
MOD_GlcNHglycan 476 479 PF01048 0.658
MOD_GlcNHglycan 507 510 PF01048 0.567
MOD_GlcNHglycan 581 584 PF01048 0.527
MOD_GlcNHglycan 588 591 PF01048 0.505
MOD_GlcNHglycan 638 641 PF01048 0.506
MOD_GlcNHglycan 65 68 PF01048 0.202
MOD_GlcNHglycan 660 663 PF01048 0.592
MOD_GlcNHglycan 822 825 PF01048 0.299
MOD_GlcNHglycan 850 853 PF01048 0.506
MOD_GSK3_1 137 144 PF00069 0.415
MOD_GSK3_1 16 23 PF00069 0.579
MOD_GSK3_1 180 187 PF00069 0.287
MOD_GSK3_1 203 210 PF00069 0.195
MOD_GSK3_1 247 254 PF00069 0.242
MOD_GSK3_1 26 33 PF00069 0.668
MOD_GSK3_1 407 414 PF00069 0.343
MOD_GSK3_1 443 450 PF00069 0.285
MOD_GSK3_1 456 463 PF00069 0.330
MOD_GSK3_1 470 477 PF00069 0.288
MOD_GSK3_1 571 578 PF00069 0.324
MOD_GSK3_1 579 586 PF00069 0.330
MOD_GSK3_1 62 69 PF00069 0.438
MOD_GSK3_1 636 643 PF00069 0.345
MOD_GSK3_1 685 692 PF00069 0.360
MOD_GSK3_1 719 726 PF00069 0.285
MOD_GSK3_1 803 810 PF00069 0.579
MOD_GSK3_1 870 877 PF00069 0.595
MOD_LATS_1 858 864 PF00433 0.557
MOD_N-GLC_1 140 145 PF02516 0.269
MOD_N-GLC_1 203 208 PF02516 0.395
MOD_N-GLC_1 843 848 PF02516 0.351
MOD_N-GLC_1 871 876 PF02516 0.369
MOD_N-GLC_2 668 670 PF02516 0.442
MOD_NEK2_1 100 105 PF00069 0.532
MOD_NEK2_1 180 185 PF00069 0.240
MOD_NEK2_1 207 212 PF00069 0.206
MOD_NEK2_1 219 224 PF00069 0.206
MOD_NEK2_1 268 273 PF00069 0.161
MOD_NEK2_1 305 310 PF00069 0.248
MOD_NEK2_1 412 417 PF00069 0.294
MOD_NEK2_1 467 472 PF00069 0.350
MOD_NEK2_1 518 523 PF00069 0.301
MOD_NEK2_1 579 584 PF00069 0.362
MOD_NEK2_1 591 596 PF00069 0.282
MOD_NEK2_1 605 610 PF00069 0.253
MOD_NEK2_1 683 688 PF00069 0.280
MOD_NEK2_1 75 80 PF00069 0.357
MOD_NEK2_1 795 800 PF00069 0.424
MOD_NEK2_1 803 808 PF00069 0.483
MOD_NEK2_1 825 830 PF00069 0.588
MOD_NEK2_1 83 88 PF00069 0.373
MOD_NEK2_2 583 588 PF00069 0.263
MOD_NEK2_2 878 883 PF00069 0.641
MOD_PIKK_1 347 353 PF00454 0.307
MOD_PIKK_1 719 725 PF00454 0.224
MOD_PIKK_1 738 744 PF00454 0.159
MOD_PIKK_1 795 801 PF00454 0.419
MOD_PK_1 520 526 PF00069 0.185
MOD_PKA_1 16 22 PF00069 0.424
MOD_PKA_2 126 132 PF00069 0.469
MOD_PKA_2 251 257 PF00069 0.216
MOD_PKA_2 308 314 PF00069 0.145
MOD_PKA_2 33 39 PF00069 0.571
MOD_PKA_2 340 346 PF00069 0.243
MOD_PKA_2 389 395 PF00069 0.410
MOD_PKA_2 401 407 PF00069 0.316
MOD_PKA_2 438 444 PF00069 0.312
MOD_PKA_2 884 890 PF00069 0.732
MOD_Plk_1 203 209 PF00069 0.195
MOD_Plk_1 268 274 PF00069 0.152
MOD_Plk_1 430 436 PF00069 0.366
MOD_Plk_1 460 466 PF00069 0.328
MOD_Plk_1 591 597 PF00069 0.388
MOD_Plk_1 83 89 PF00069 0.362
MOD_Plk_1 871 877 PF00069 0.570
MOD_Plk_2-3 269 275 PF00069 0.145
MOD_Plk_2-3 367 373 PF00069 0.205
MOD_Plk_4 175 181 PF00069 0.406
MOD_Plk_4 184 190 PF00069 0.240
MOD_Plk_4 203 209 PF00069 0.167
MOD_Plk_4 21 27 PF00069 0.577
MOD_Plk_4 228 234 PF00069 0.214
MOD_Plk_4 254 260 PF00069 0.328
MOD_Plk_4 316 322 PF00069 0.166
MOD_Plk_4 626 632 PF00069 0.319
MOD_Plk_4 67 73 PF00069 0.430
MOD_Plk_4 807 813 PF00069 0.541
MOD_ProDKin_1 149 155 PF00069 0.443
MOD_ProDKin_1 28 34 PF00069 0.639
MOD_ProDKin_1 774 780 PF00069 0.240
MOD_SUMO_rev_2 222 231 PF00179 0.199
MOD_SUMO_rev_2 9 19 PF00179 0.501
TRG_DiLeu_BaEn_1 228 233 PF01217 0.206
TRG_DiLeu_BaLyEn_6 150 155 PF01217 0.491
TRG_DiLeu_BaLyEn_6 378 383 PF01217 0.315
TRG_DiLeu_BaLyEn_6 496 501 PF01217 0.332
TRG_ENDOCYTIC_2 281 284 PF00928 0.230
TRG_ENDOCYTIC_2 317 320 PF00928 0.298
TRG_ENDOCYTIC_2 371 374 PF00928 0.206
TRG_ENDOCYTIC_2 546 549 PF00928 0.278
TRG_ENDOCYTIC_2 55 58 PF00928 0.445
TRG_ENDOCYTIC_2 632 635 PF00928 0.234
TRG_ENDOCYTIC_2 687 690 PF00928 0.266
TRG_ER_diArg_1 301 303 PF00400 0.249
TRG_ER_diArg_1 663 666 PF00400 0.360
TRG_ER_diArg_1 87 89 PF00400 0.470
TRG_ER_diArg_1 882 885 PF00400 0.657
TRG_NES_CRM1_1 512 528 PF08389 0.191
TRG_Pf-PMV_PEXEL_1 16 20 PF00026 0.395
TRG_Pf-PMV_PEXEL_1 209 213 PF00026 0.416
TRG_Pf-PMV_PEXEL_1 381 386 PF00026 0.610
TRG_Pf-PMV_PEXEL_1 499 504 PF00026 0.507
TRG_Pf-PMV_PEXEL_1 520 525 PF00026 0.424
TRG_Pf-PMV_PEXEL_1 827 832 PF00026 0.446

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P867 Leptomonas seymouri 65% 100%
A0A0S4IQA8 Bodo saltans 38% 100%
A0A1X0P6I5 Trypanosomatidae 45% 97%
A0A3R7KQ50 Trypanosoma rangeli 46% 100%
A0A3S7X571 Leishmania donovani 79% 93%
A2EK80 Trichomonas vaginalis 27% 100%
A4HK17 Leishmania braziliensis 100% 100%
A4I7K1 Leishmania infantum 79% 100%
B0EKR0 Entamoeba dispar (strain ATCC PRA-260 / SAW760) 25% 100%
C4M6U3 Entamoeba histolytica 24% 100%
C5DTA7 Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) 26% 100%
D0A0A4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9B2F8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 100%
Q0JLS6 Oryza sativa subsp. japonica 26% 100%
Q388F1 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 44% 100%
Q4DHA1 Trypanosoma cruzi (strain CL Brener) 45% 100%
Q4Q5P8 Leishmania major 79% 100%
V5DTG5 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS