40S ribosomal protein S8

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

40S ribosomal protein S8, putative

Species:

Leishmania major

UniProt:

RS8_LEIMA

TriTrypDb:

LmjF.24.2070 , LMJLV39_240028500 , LMJSD75_240027900

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0015935	small ribosomal subunit	4	2
GO:0022627	cytosolic small ribosomal subunit	5	2
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0044391	ribosomal subunit	3	2
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005840	ribosome	5	10

Expansion

Sequence features

P25204

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: P25204

PDB structure(s): 6az1_K

Function

Biological processes
Term	Name	Level	Count
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0019538	protein metabolic process	3	12
GO:0030490	maturation of SSU-rRNA	9	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0034660	ncRNA metabolic process	6	2
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.252
CLV_NRD_NRD_1	138	140	PF00675	0.247
CLV_NRD_NRD_1	166	168	PF00675	0.254
CLV_NRD_NRD_1	21	23	PF00675	0.234
CLV_NRD_NRD_1	41	43	PF00675	0.138
CLV_PCSK_FUR_1	164	168	PF00082	0.322
CLV_PCSK_KEX2_1	10	12	PF00082	0.252
CLV_PCSK_KEX2_1	110	112	PF00082	0.335
CLV_PCSK_KEX2_1	164	166	PF00082	0.248
CLV_PCSK_KEX2_1	213	215	PF00082	0.519
CLV_PCSK_KEX2_1	23	25	PF00082	0.234
CLV_PCSK_KEX2_1	41	43	PF00082	0.252
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.232
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.333
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.516
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.232
CLV_PCSK_PC7_1	160	166	PF00082	0.333
CLV_PCSK_PC7_1	37	43	PF00082	0.333
CLV_PCSK_SKI1_1	11	15	PF00082	0.243
CLV_PCSK_SKI1_1	23	27	PF00082	0.235
CLV_Separin_Metazoa	89	93	PF03568	0.434
DEG_APCC_DBOX_1	74	82	PF00400	0.486
DOC_CYCLIN_RxL_1	53	62	PF00134	0.434
DOC_MAPK_RevD_3	27	42	PF00069	0.445
DOC_USP7_MATH_1	192	196	PF00917	0.540
DOC_USP7_MATH_1	66	70	PF00917	0.505
DOC_USP7_UBL2_3	125	129	PF12436	0.444
DOC_USP7_UBL2_3	136	140	PF12436	0.459
DOC_USP7_UBL2_3	153	157	PF12436	0.423
DOC_USP7_UBL2_3	19	23	PF12436	0.432
DOC_USP7_UBL2_3	213	217	PF12436	0.388
DOC_USP7_UBL2_3	94	98	PF12436	0.434
DOC_WW_Pin1_4	152	157	PF00397	0.533
DOC_WW_Pin1_4	41	46	PF00397	0.445
LIG_14-3-3_CanoR_1	92	97	PF00244	0.445
LIG_BIR_III_2	105	109	PF00653	0.434
LIG_FHA_1	91	97	PF00498	0.434
LIG_FHA_2	84	90	PF00498	0.434
LIG_SH2_STAP1	113	117	PF00017	0.434
LIG_SH2_STAT5	211	214	PF00017	0.404
LIG_SUMO_SIM_par_1	100	105	PF11976	0.452
MOD_CDC14_SPxK_1	44	47	PF00782	0.284
MOD_CDK_SPK_2	152	157	PF00069	0.413
MOD_CDK_SPxK_1	41	47	PF00069	0.284
MOD_CK2_1	83	89	PF00069	0.275
MOD_Cter_Amidation	137	140	PF01082	0.446
MOD_GlcNHglycan	140	143	PF01048	0.282
MOD_GlcNHglycan	194	197	PF01048	0.422
MOD_GSK3_1	11	18	PF00069	0.273
MOD_LATS_1	9	15	PF00433	0.272
MOD_N-GLC_1	83	88	PF02516	0.275
MOD_NEK2_1	90	95	PF00069	0.275
MOD_NMyristoyl	1	7	PF02799	0.416
MOD_PKA_1	11	17	PF00069	0.272
MOD_PKA_1	125	131	PF00069	0.338
MOD_PKA_2	138	144	PF00069	0.234
MOD_PKA_2	186	192	PF00069	0.299
MOD_Plk_4	92	98	PF00069	0.290
MOD_ProDKin_1	152	158	PF00069	0.413
MOD_ProDKin_1	41	47	PF00069	0.290
MOD_SUMO_for_1	25	28	PF00179	0.290
MOD_SUMO_rev_2	120	128	PF00179	0.346
TRG_DiLeu_BaLyEn_6	74	79	PF01217	0.320
TRG_ER_diArg_1	164	167	PF00400	0.294
TRG_ER_diArg_1	22	25	PF00400	0.272
TRG_ER_diArg_1	4	7	PF00400	0.379
TRG_ER_diArg_1	41	43	PF00400	0.311
TRG_ER_diArg_1	46	49	PF00400	0.277
TRG_ER_diArg_1	75	78	PF00400	0.275
TRG_ER_diLys_1	217	220	PF00400	0.402
TRG_NLS_Bipartite_1	10	27	PF00514	0.287
TRG_NLS_MonoExtC_3	21	26	PF00514	0.272
TRG_NLS_MonoExtN_4	19	26	PF00514	0.271
TRG_NLS_MonoExtN_4	7	14	PF00514	0.272
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTQ8	Leptomonas seymouri	87%	100%
A0A0S4IUG1	Bodo saltans	71%	100%
A0A1X0NVX8	Trypanosomatidae	77%	100%
A0A3Q8ID68	Leishmania donovani	98%	100%
A0A3R7KLM1	Trypanosoma rangeli	80%	99%
A4HDR9	Leishmania braziliensis	94%	100%
A4I116	Leishmania infantum	97%	100%
C9ZW94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	100%
E9AX53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O14049	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
O76756	Apis mellifera	52%	100%
O81361	Prunus armeniaca	50%	100%
P0CX39	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	100%
P0CX40	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	100%
P25204	Leishmania major	100%	100%
P48156	Caenorhabditis elegans	48%	100%
P49199	Oryza sativa subsp. japonica	53%	100%
P62241	Homo sapiens	47%	100%
P62242	Mus musculus	47%	100%
P62243	Rattus norvegicus	47%	100%
P62247	Danio rerio	48%	100%
Q08069	Zea mays	54%	100%
Q4N3P0	Theileria parva	49%	100%
Q4R6P8	Macaca fascicularis	47%	100%
Q4UFS9	Theileria annulata	47%	100%
Q54E24	Dictyostelium discoideum	48%	100%
Q59T44	Candida albicans (strain SC5314 / ATCC MYA-2876)	49%	100%
Q5E958	Bos taurus	47%	100%
Q7SYU0	Xenopus laevis	47%	100%
Q8MLY8	Drosophila melanogaster	53%	100%
Q8WQI5	Spodoptera frugiperda	52%	100%
Q90YR6	Ictalurus punctatus	49%	100%
Q93VG5	Arabidopsis thaliana	53%	99%
Q9FIF3	Arabidopsis thaliana	51%	100%
Q9P7B2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
Q9ZT56	Griffithsia japonica	48%	100%
V5BJK3	Trypanosoma cruzi	79%	86%