LeishMANIAdb
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40S ribosomal protein S25

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
40S ribosomal protein S25
Gene product:
ribosomal protein S25
Species:
Leishmania infantum
UniProt:
RS25_LEIIN
TriTrypDb:
LINF_340009500
Length:
120

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 40S ribosomal S25 RPS25 PE=2 SV=1 - [RS25_LEIIN]

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 13
GO:0032991 protein-containing complex 1 15
GO:0043226 organelle 2 13
GO:0043228 non-membrane-bounded organelle 3 13
GO:0043229 intracellular organelle 3 13
GO:0043232 intracellular non-membrane-bounded organelle 4 13
GO:0110165 cellular anatomical entity 1 13
GO:1990904 ribonucleoprotein complex 2 15
GO:0015935 small ribosomal subunit 4 2
GO:0022627 cytosolic small ribosomal subunit 5 2
GO:0044391 ribosomal subunit 3 2

Expansion

Sequence features

Q9N9V4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9N9V4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 2
GO:0005198 structural molecule activity 1 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 18 22 PF00082 0.293
CLV_PCSK_SKI1_1 33 37 PF00082 0.338
CLV_PCSK_SKI1_1 58 62 PF00082 0.360
CLV_PCSK_SKI1_1 9 13 PF00082 0.378
DEG_APCC_DBOX_1 84 92 PF00400 0.395
DOC_CKS1_1 59 64 PF01111 0.338
DOC_MAPK_gen_1 68 75 PF00069 0.338
DOC_MAPK_MEF2A_6 68 75 PF00069 0.338
DOC_USP7_UBL2_3 18 22 PF12436 0.338
DOC_USP7_UBL2_3 25 29 PF12436 0.338
DOC_WW_Pin1_4 58 63 PF00397 0.338
LIG_FHA_1 100 106 PF00498 0.459
LIG_FHA_1 59 65 PF00498 0.341
LIG_LIR_Gen_1 45 55 PF02991 0.484
LIG_LIR_Gen_1 98 109 PF02991 0.633
LIG_LIR_Nem_3 45 50 PF02991 0.484
LIG_LIR_Nem_3 98 104 PF02991 0.367
LIG_SH2_CRK 101 105 PF00017 0.484
LIG_SH2_CRK 47 51 PF00017 0.395
LIG_SH2_CRK 57 61 PF00017 0.279
LIG_SH2_STAP1 101 105 PF00017 0.395
LIG_SH2_STAT5 101 104 PF00017 0.354
MOD_CK1_1 63 69 PF00069 0.338
MOD_CK1_1 93 99 PF00069 0.338
MOD_GSK3_1 21 28 PF00069 0.350
MOD_GSK3_1 95 102 PF00069 0.436
MOD_PKA_1 21 27 PF00069 0.350
MOD_Plk_2-3 43 49 PF00069 0.337
MOD_Plk_4 60 66 PF00069 0.333
MOD_ProDKin_1 58 64 PF00069 0.338
MOD_SUMO_for_1 11 14 PF00179 0.459
TRG_ENDOCYTIC_2 101 104 PF00928 0.423
TRG_ENDOCYTIC_2 47 50 PF00928 0.395
TRG_ENDOCYTIC_2 57 60 PF00928 0.279
TRG_NLS_MonoExtC_3 8 14 PF00514 0.354

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4KIW3 Bodo saltans 72% 100%
A0A1D8PNQ6 Candida albicans (strain SC5314 / ATCC MYA-2876) 45% 100%
A0A1X0P8I6 Trypanosomatidae 72% 100%
A0A3Q8INE9 Leishmania donovani 100% 100%
A0A3R7MV32 Trypanosoma rangeli 67% 100%
A4HAF8 Leishmania braziliensis 98% 100%
A4HE62 Leishmania braziliensis 99% 100%
C9ZK09 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 72% 100%
D0A1X6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 73% 100%
E9AXJ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
E9B4L2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
P62851 Homo sapiens 51% 96%
P62852 Mus musculus 51% 96%
P62853 Rattus norvegicus 51% 96%
Q03409 Dictyostelium discoideum 43% 100%
Q4Q3G4 Leishmania major 100% 100%
Q4Q9X4 Leishmania major 100% 100%
Q56JX5 Bos taurus 51% 96%
Q6PBI5 Danio rerio 48% 97%
Q6Q311 Ovis aries 51% 96%
Q7SC06 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 45% 100%
Q8STD9 Encephalitozoon cuniculi (strain GB-M1) 27% 100%
Q9N9V4 Leishmania infantum 100% 100%
V5BRV7 Trypanosoma cruzi 70% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS