60S acidic ribosomal protein P2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S acidic ribosomal protein P2, putative

Species:

Leishmania braziliensis

UniProt:

RLA2_LEIBR

TriTrypDb:

LbrM.30.3760 , LBRM2903_300045000

Length:

105

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	12
GO:0022625	cytosolic large ribosomal subunit	5	12
GO:0032991	protein-containing complex	1	12
GO:0044391	ribosomal subunit	3	12
GO:1990904	ribonucleoprotein complex	2	12

Expansion

Sequence features

O44010

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: O44010

PDB structure(s): 1s4h_A

Function

Biological processes
Term	Name	Level	Count
GO:0002182	cytoplasmic translational elongation	6	12
GO:0006414	translational elongation	5	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.538
DEG_Nend_UBRbox_3	1	3	PF02207	0.509
DOC_MAPK_MEF2A_6	27	35	PF00069	0.376
DOC_USP7_MATH_1	71	75	PF00917	0.517
DOC_USP7_UBL2_3	15	19	PF12436	0.368
DOC_WW_Pin1_4	13	18	PF00397	0.459
LIG_LIR_Gen_1	39	50	PF02991	0.490
LIG_LIR_Nem_3	39	45	PF02991	0.465
LIG_LIR_Nem_3	49	53	PF02991	0.457
LIG_LIR_Nem_3	98	104	PF02991	0.479
LIG_SH2_CRK	7	11	PF00017	0.401
LIG_SH2_NCK_1	7	11	PF00017	0.411
LIG_SH2_STAP1	7	11	PF00017	0.493
LIG_SH2_STAT5	3	6	PF00017	0.400
LIG_SUMO_SIM_par_1	8	13	PF11976	0.429
LIG_TRAF2_1	90	93	PF00917	0.458
LIG_UBA3_1	41	48	PF00899	0.432
MOD_CDK_SPxK_1	13	19	PF00069	0.458
MOD_CK1_1	13	19	PF00069	0.458
MOD_CK2_1	46	52	PF00069	0.429
MOD_CK2_1	88	94	PF00069	0.497
MOD_GlcNHglycan	12	15	PF01048	0.471
MOD_GlcNHglycan	63	66	PF01048	0.326
MOD_GSK3_1	52	59	PF00069	0.546
MOD_NEK2_1	61	66	PF00069	0.530
MOD_Plk_1	33	39	PF00069	0.479
MOD_Plk_2-3	46	52	PF00069	0.545
MOD_ProDKin_1	13	19	PF00069	0.458
MOD_SUMO_for_1	86	89	PF00179	0.537
MOD_SUMO_rev_2	44	50	PF00179	0.484
TRG_ENDOCYTIC_2	7	10	PF00928	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZR2	Leptomonas seymouri	68%	98%
A0A0S4JJB8	Bodo saltans	37%	97%
A0A1X0P2R9	Trypanosomatidae	63%	100%
A0A3Q8ICC2	Leishmania donovani	46%	95%
A0A3Q8IG52	Leishmania donovani	83%	100%
A0A422NR90	Trypanosoma rangeli	44%	95%
A4H3L0	Leishmania braziliensis	40%	100%
A4H3L1	Leishmania braziliensis	44%	100%
A4H884	Leishmania braziliensis	47%	100%
A4I5Z9	Leishmania infantum	83%	100%
A4I600	Leishmania infantum	83%	100%
C9ZRI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	98%
E9AGM1	Leishmania infantum	46%	95%
E9AJS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AJS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9AQB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	95%
E9B1E6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	85%
E9B1E7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
O01504	Caenorhabditis elegans	40%	98%
O01725	Branchiostoma floridae	38%	91%
O14317	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	95%
O24415	Zea mays	37%	93%
O43940	Leishmania donovani	83%	100%
O44010	Leishmania braziliensis	100%	100%
O61463	Cryptochiton stelleri	45%	95%
P02399	Artemia salina	39%	95%
P02400	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	95%
P05319	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	99%
P08094	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	95%
P17478	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	95%
P22683	Dictyostelium discoideum	43%	99%
P23632	Trypanosoma cruzi	63%	98%
P42037	Alternaria alternata	45%	93%
P42899	Bos taurus	34%	91%
P46252	Zea mays	36%	94%
P50879	Taenia solium	33%	87%
P51407	Arabidopsis thaliana	34%	91%
P51408	Trypanosoma brucei brucei	59%	98%
P90703	Brugia malayi	38%	92%
Q06382	Leishmania infantum	44%	95%
Q06383	Leishmania infantum	75%	99%
Q29315	Sus scrofa	33%	91%
Q4Q6R5	Leishmania major	82%	100%
Q4Q6R6	Leishmania major	82%	100%
Q4QF62	Leishmania major	45%	100%
Q8TFM9	Fusarium culmorum	44%	96%
Q96UQ7	Rhodotorula glutinis	45%	95%
Q9C3Z5	Podospora anserina	51%	95%
Q9HFQ4	Candida albicans	43%	95%
Q9HFQ5	Candida albicans	48%	97%
Q9LH85	Arabidopsis thaliana	31%	91%
Q9UUZ6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	45%	95%