Ubiquitin-60S ribosomal protein L40

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-fusion protein

Species:

Leishmania major

UniProt:

RL40_LEIMA

TriTrypDb:

LmjF.31.1900 , LMJLV39_000007200 , LMJSD75_310027300

Length:

128

Annotations

Annotations by Jardim et al.

Protein modification, Ubiquitin-fusion

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 8
Forrest at al. (procyclic)	yes	yes: 8
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 18

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0005737	cytoplasm	2	9
GO:0005840	ribosome	5	9
GO:0032991	protein-containing complex	1	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9
GO:1990904	ribonucleoprotein complex	2	9

Phosphorylation

Amastigote: 57

Expansion

Sequence features

P69201

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: P69201

PDB structure(s): 6az3_m

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	9
GO:0006508	proteolysis	4	2
GO:0006518	peptide metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009058	biosynthetic process	2	9
GO:0009059	macromolecule biosynthetic process	4	9
GO:0009987	cellular process	1	9
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	9
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	9
GO:0036211	protein modification process	4	2
GO:0043043	peptide biosynthetic process	5	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	2
GO:0043603	amide metabolic process	3	9
GO:0043604	amide biosynthetic process	4	9
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044248	cellular catabolic process	3	2
GO:0044249	cellular biosynthetic process	3	9
GO:0044260	obsolete cellular macromolecule metabolic process	3	9
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	9
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:1901566	organonitrogen compound biosynthetic process	4	9
GO:1901575	organic substance catabolic process	3	2
GO:1901576	organic substance biosynthetic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	9
GO:0005198	structural molecule activity	1	9
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0019899	enzyme binding	3	2
GO:0031386	protein tag	1	2
GO:0031625	ubiquitin protein ligase binding	5	2
GO:0044389	ubiquitin-like protein ligase binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.343
CLV_NRD_NRD_1	97	99	PF00675	0.352
CLV_PCSK_KEX2_1	97	99	PF00082	0.350
CLV_PCSK_SKI1_1	42	46	PF00082	0.343
CLV_PCSK_SKI1_1	6	10	PF00082	0.359
DEG_Nend_UBRbox_3	1	3	PF02207	0.441
DOC_MAPK_gen_1	97	105	PF00069	0.551
DOC_MAPK_MEF2A_6	63	71	PF00069	0.543
DOC_PP1_RVXF_1	40	46	PF00149	0.543
DOC_USP7_UBL2_3	29	33	PF12436	0.543
LIG_14-3-3_CanoR_1	54	61	PF00244	0.626
LIG_FHA_1	10	16	PF00498	0.543
LIG_FHA_1	64	70	PF00498	0.556
LIG_FHA_2	53	59	PF00498	0.543
LIG_NRP_CendR_1	125	128	PF00754	0.386
LIG_SH2_CRK	100	104	PF00017	0.543
LIG_SH2_STAT3	59	62	PF00017	0.543
LIG_SH3_3	74	80	PF00018	0.371
LIG_SUMO_SIM_par_1	11	16	PF11976	0.543
MOD_NEK2_1	4	9	PF00069	0.543
MOD_PKA_2	105	111	PF00069	0.543
MOD_Plk_1	63	69	PF00069	0.543
MOD_Plk_2-3	52	58	PF00069	0.543
MOD_Plk_4	78	84	PF00069	0.611
TRG_DiLeu_BaEn_4	51	57	PF01217	0.543
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.543
TRG_ENDOCYTIC_2	100	103	PF00928	0.543
TRG_ER_diArg_1	71	74	PF00400	0.543
TRG_ER_diLys_1	124	128	PF00400	0.586
TRG_NLS_Bipartite_1	93	115	PF00514	0.543
TRG_NLS_MonoExtC_3	123	128	PF00514	0.586
TRG_NLS_MonoExtN_4	122	128	PF00514	0.582
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NP39	Trypanosomatidae	96%	100%
A0A3Q8ISR1	Leishmania donovani	100%	100%
A0A3R7JQP6	Trypanosoma rangeli	98%	98%
A4HJH0	Leishmania braziliensis	98%	100%
B9DHA6	Arabidopsis thaliana	80%	100%
E9AHL5	Leishmania infantum	100%	100%
E9AI36	Leishmania braziliensis	62%	100%
E9AMU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9B1Y9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
P0C224	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	81%	100%
P0C273	Macaca fascicularis	83%	100%
P0C275	Pongo pygmaeus	83%	100%
P0C276	Ovis aries	83%	100%
P0CH06	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	84%	100%
P0CH07	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	84%	100%
P0CH08	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	83%	100%
P0CH09	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	83%	100%
P0CH10	Chlamydomonas reinhardtii	83%	100%
P0CH11	Chlamydomonas reinhardtii	83%	100%
P0CH34	Oryza sativa subsp. japonica	80%	99%
P0CH35	Oryza sativa subsp. japonica	80%	99%
P0DJ25	Tetrahymena thermophila (strain SB210)	86%	99%
P14794	Dictyostelium discoideum	83%	100%
P14795	Trypanosoma cruzi	96%	100%
P14797	Dictyostelium discoideum	57%	83%
P18101	Drosophila melanogaster	84%	100%
P21899	Trypanosoma brucei brucei	97%	100%
P33190	Tetrahymena pyriformis	86%	99%
P40909	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	82%	99%
P46575	Eimeria bovis	86%	99%
P49632	Caenorhabditis elegans	84%	100%
P49633	Acanthamoeba castellanii	81%	100%
P49636	Nicotiana sylvestris	80%	100%
P51423	Brassica rapa subsp. pekinensis	80%	100%
P62861	Homo sapiens	32%	96%
P62984	Mus musculus	83%	100%
P62986	Rattus norvegicus	83%	100%
P62987	Homo sapiens	83%	100%
P63048	Bos taurus	83%	100%
P63050	Canis lupus familiaris	83%	100%
P63052	Felis catus	83%	100%
P63053	Sus scrofa	83%	100%
P68205	Ophiophagus hannah	83%	100%
P69200	Leishmania tarentolae	98%	100%
P69201	Leishmania major	100%	100%
Q05120	Orgyia pseudotsugata multicapsid polyhedrosis virus	63%	100%
Q42202	Arabidopsis thaliana	80%	100%