60S ribosomal protein L18

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L18, putative

Species:

Leishmania major

UniProt:

RL18_LEIMA

TriTrypDb:

LmjF.13.0560 , LMJLV39_130009600 , LMJSD75_130009700

Length:

198

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S ribosomal L18 RPL18

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	yes	yes: 6
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	4
GO:0015934	large ribosomal subunit	4	2
GO:0022625	cytosolic large ribosomal subunit	5	2
GO:0032991	protein-containing complex	1	13
GO:0043226	organelle	2	13
GO:0043228	non-membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043232	intracellular non-membrane-bounded organelle	4	13
GO:0044391	ribosomal subunit	3	2
GO:0110165	cellular anatomical entity	1	13
GO:1990904	ribonucleoprotein complex	2	13
GO:0005840	ribosome	5	11
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QG98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG98

PDB structure(s): 6az3_P

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	13
GO:0006518	peptide metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009058	biosynthetic process	2	13
GO:0009059	macromolecule biosynthetic process	4	13
GO:0009987	cellular process	1	13
GO:0019538	protein metabolic process	3	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	13
GO:0043043	peptide biosynthetic process	5	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043603	amide metabolic process	3	13
GO:0043604	amide biosynthetic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044249	cellular biosynthetic process	3	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0044271	cellular nitrogen compound biosynthetic process	4	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:1901566	organonitrogen compound biosynthetic process	4	13
GO:1901576	organic substance biosynthetic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003735	structural constituent of ribosome	2	13
GO:0005198	structural molecule activity	1	13
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	148	150	PF00675	0.301
CLV_NRD_NRD_1	184	186	PF00675	0.308
CLV_NRD_NRD_1	191	193	PF00675	0.503
CLV_NRD_NRD_1	72	74	PF00675	0.302
CLV_PCSK_FUR_1	182	186	PF00082	0.389
CLV_PCSK_KEX2_1	181	183	PF00082	0.316
CLV_PCSK_KEX2_1	184	186	PF00082	0.295
CLV_PCSK_KEX2_1	191	193	PF00082	0.485
CLV_PCSK_KEX2_1	38	40	PF00082	0.390
CLV_PCSK_KEX2_1	72	74	PF00082	0.301
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.397
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.619
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.390
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.333
CLV_PCSK_SKI1_1	192	196	PF00082	0.555
CLV_PCSK_SKI1_1	51	55	PF00082	0.301
CLV_PCSK_SKI1_1	74	78	PF00082	0.406
DOC_MAPK_gen_1	56	64	PF00069	0.508
DOC_MAPK_gen_1	80	88	PF00069	0.532
DOC_MAPK_gen_1	98	107	PF00069	0.495
DOC_MAPK_MEF2A_6	82	90	PF00069	0.501
DOC_MAPK_RevD_3	60	74	PF00069	0.501
DOC_USP7_MATH_1	116	120	PF00917	0.595
DOC_USP7_UBL2_3	27	31	PF12436	0.501
DOC_USP7_UBL2_3	34	38	PF12436	0.501
LIG_14-3-3_CanoR_1	111	121	PF00244	0.482
LIG_14-3-3_CanoR_1	16	21	PF00244	0.501
LIG_14-3-3_CanoR_1	185	191	PF00244	0.585
LIG_14-3-3_CanoR_1	39	47	PF00244	0.589
LIG_14-3-3_CanoR_1	59	65	PF00244	0.387
LIG_Actin_WH2_2	95	113	PF00022	0.501
LIG_BRCT_BRCA1_1	40	44	PF00533	0.595
LIG_BRCT_BRCA1_2	40	46	PF00533	0.595
LIG_CtBP_PxDLS_1	61	65	PF00389	0.501
LIG_FHA_1	141	147	PF00498	0.482
LIG_IBAR_NPY_1	23	25	PF08397	0.501
LIG_LIR_Gen_1	129	138	PF02991	0.501
LIG_LIR_Gen_1	22	33	PF02991	0.501
LIG_LIR_Gen_1	41	52	PF02991	0.501
LIG_LIR_Nem_3	129	133	PF02991	0.501
LIG_LIR_Nem_3	22	28	PF02991	0.501
LIG_LIR_Nem_3	41	47	PF02991	0.501
LIG_SH2_CRK	33	37	PF00017	0.501
LIG_SH2_CRK	49	53	PF00017	0.501
LIG_SH2_PTP2	25	28	PF00017	0.501
LIG_SH2_STAT5	144	147	PF00017	0.595
LIG_SH2_STAT5	25	28	PF00017	0.501
LIG_SUMO_SIM_anti_2	65	71	PF11976	0.631
LIG_SUMO_SIM_par_1	60	65	PF11976	0.501
LIG_TYR_ITIM	47	52	PF00017	0.595
LIG_UBA3_1	28	34	PF00899	0.501
MOD_CK1_1	9	15	PF00069	0.595
MOD_CK2_1	148	154	PF00069	0.515
MOD_Cter_Amidation	147	150	PF01082	0.301
MOD_Cter_Amidation	182	185	PF01082	0.389
MOD_GlcNHglycan	114	117	PF01048	0.282
MOD_GlcNHglycan	150	153	PF01048	0.315
MOD_GlcNHglycan	161	164	PF01048	0.315
MOD_GlcNHglycan	41	44	PF01048	0.356
MOD_GSK3_1	112	119	PF00069	0.540
MOD_GSK3_1	136	143	PF00069	0.501
MOD_GSK3_1	148	155	PF00069	0.501
MOD_NEK2_1	110	115	PF00069	0.501
MOD_NEK2_1	159	164	PF00069	0.595
MOD_NEK2_1	52	57	PF00069	0.501
MOD_NEK2_2	152	157	PF00069	0.515
MOD_NMyristoyl	1	7	PF02799	0.366
MOD_PKA_1	38	44	PF00069	0.595
MOD_PKA_2	110	116	PF00069	0.546
MOD_PKA_2	148	154	PF00069	0.515
MOD_PKA_2	183	189	PF00069	0.532
MOD_PKA_2	38	44	PF00069	0.595
MOD_Plk_2-3	126	132	PF00069	0.501
MOD_Plk_4	116	122	PF00069	0.595
MOD_Plk_4	140	146	PF00069	0.501
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.501
TRG_ENDOCYTIC_2	25	28	PF00928	0.501
TRG_ENDOCYTIC_2	33	36	PF00928	0.501
TRG_ENDOCYTIC_2	49	52	PF00928	0.501
TRG_ER_diArg_1	146	149	PF00400	0.501
TRG_ER_diArg_1	182	185	PF00400	0.523
TRG_NLS_Bipartite_1	181	195	PF00514	0.595
TRG_NLS_MonoExtC_3	180	185	PF00514	0.595
TRG_NLS_MonoExtN_4	178	185	PF00514	0.597
TRG_NLS_MonoExtN_4	188	195	PF00514	0.701

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JJ16	Bodo saltans	73%	100%
A0A1D8PK43	Candida albicans (strain SC5314 / ATCC MYA-2876)	47%	100%
A0A1X0P1J6	Trypanosomatidae	77%	100%
A0A3S7XBN1	Leishmania donovani	100%	100%
A0A422P5B7	Trypanosoma rangeli	75%	100%
A3F4S0	Taenia asiatica	48%	100%
A4H745	Leishmania braziliensis	96%	100%
A4HPW8	Leishmania braziliensis	96%	100%
A4HVI5	Leishmania infantum	100%	100%
D0A4B6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	100%
D0VWQ3	Canis lupus familiaris	49%	100%
E9AP80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9ATN5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O22254	Arabidopsis thaliana	50%	100%
O45946	Caenorhabditis elegans	45%	100%
O65729	Cicer arietinum	47%	100%
P02412	Xenopus laevis	46%	100%
P09897	Xenopus laevis	46%	100%
P0CX49	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
P0CX50	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
P0DJ17	Tetrahymena thermophila	46%	100%
P12001	Rattus norvegicus	49%	100%
P24558	Salmo salar	38%	100%
P35980	Mus musculus	49%	100%
P42791	Arabidopsis thaliana	51%	100%
P50885	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	74%	100%
P69090	Oreochromis mossambicus	47%	100%
P69091	Oreochromis niloticus	47%	100%
Q07020	Homo sapiens	48%	100%
Q0PXY6	Diaphorina citri	47%	100%
Q10192	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
Q1HR62	Aedes aegypti	45%	100%
Q2M0G4	Drosophila pseudoobscura pseudoobscura	44%	100%
Q4DZP2	Trypanosoma cruzi (strain CL Brener)	83%	100%
Q4GXG7	Timarcha balearica	44%	100%
Q4N438	Theileria parva	45%	100%
Q4PM04	Ixodes scapularis	46%	100%
Q4QG98	Leishmania major	100%	100%
Q4R5H8	Macaca fascicularis	48%	100%
Q4UFD5	Theileria annulata	44%	100%
Q54VZ4	Dictyostelium discoideum	49%	100%
Q56FG8	Lysiphlebus testaceipes	45%	100%
Q5E973	Bos taurus	49%	100%
Q5UAS1	Bombyx mori	49%	100%
Q60P81	Caenorhabditis briggsae	43%	100%
Q6F442	Plutella xylostella	47%	100%
Q7QJM5	Anopheles gambiae	44%	100%
Q8TFH1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
Q90YV0	Ictalurus punctatus	47%	100%
Q940B0	Arabidopsis thaliana	49%	100%
Q95342	Sus scrofa	49%	100%
Q962Y8	Spodoptera frugiperda	49%	100%
Q9VS34	Drosophila melanogaster	45%	100%
V5BKK2	Trypanosoma cruzi	83%	69%