Ribokinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Ribokinase

Gene product:

ribokinase

Species:

Leishmania major

UniProt:

RBSK_LEIMA

TriTrypDb:

LmjF.27.0420 , LMJLV39_270009200 , LMJSD75_270009200

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005777	peroxisome	6	2
GO:0020015	glycosome	7	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	10

Expansion

Sequence features

E9AD19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AD19

PDB structure(s): 6a8a_A , 6a8a_B , 6a8b_A , 6a8b_B , 6a8c_A , 6a8c_B

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0005996	monosaccharide metabolic process	3	12
GO:0006014	D-ribose metabolic process	5	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0016052	carbohydrate catabolic process	4	12
GO:0019303	D-ribose catabolic process	6	12
GO:0019321	pentose metabolic process	4	12
GO:0019323	pentose catabolic process	5	12
GO:0044238	primary metabolic process	2	12
GO:0044281	small molecule metabolic process	2	12
GO:0044282	small molecule catabolic process	3	12
GO:0046365	monosaccharide catabolic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004747	ribokinase activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0019200	carbohydrate kinase activity	5	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	77	81	PF00656	0.503
CLV_NRD_NRD_1	310	312	PF00675	0.286
CLV_PCSK_KEX2_1	299	301	PF00082	0.290
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.320
CLV_PCSK_SKI1_1	197	201	PF00082	0.274
CLV_PCSK_SKI1_1	229	233	PF00082	0.331
CLV_PCSK_SKI1_1	266	270	PF00082	0.336
CLV_PCSK_SKI1_1	292	296	PF00082	0.352
CLV_Separin_Metazoa	135	139	PF03568	0.504
DOC_CKS1_1	131	136	PF01111	0.520
DOC_CYCLIN_RxL_1	289	296	PF00134	0.504
DOC_MAPK_DCC_7	197	205	PF00069	0.501
DOC_MAPK_gen_1	229	239	PF00069	0.465
DOC_MAPK_MEF2A_6	197	205	PF00069	0.501
DOC_PP2B_PxIxI_1	15	21	PF00149	0.426
DOC_USP7_MATH_1	139	143	PF00917	0.418
DOC_USP7_MATH_1	201	205	PF00917	0.500
DOC_USP7_MATH_1	319	323	PF00917	0.611
DOC_USP7_MATH_1	70	74	PF00917	0.477
DOC_WW_Pin1_4	130	135	PF00397	0.562
LIG_14-3-3_CanoR_1	100	110	PF00244	0.542
LIG_14-3-3_CanoR_1	138	147	PF00244	0.409
LIG_14-3-3_CanoR_1	176	182	PF00244	0.475
LIG_BRCT_BRCA1_1	43	47	PF00533	0.452
LIG_BRCT_BRCA1_2	43	49	PF00533	0.460
LIG_eIF4E_1	131	137	PF01652	0.435
LIG_eIF4E_1	14	20	PF01652	0.350
LIG_FHA_1	131	137	PF00498	0.565
LIG_FHA_2	163	169	PF00498	0.470
LIG_FHA_2	220	226	PF00498	0.458
LIG_FHA_2	75	81	PF00498	0.552
LIG_HP1_1	201	205	PF01393	0.539
LIG_LIR_Apic_2	129	134	PF02991	0.520
LIG_LIR_Apic_2	317	321	PF02991	0.494
LIG_LIR_Gen_1	141	152	PF02991	0.460
LIG_LIR_LC3C_4	17	21	PF02991	0.549
LIG_LIR_Nem_3	141	147	PF02991	0.453
LIG_LIR_Nem_3	225	231	PF02991	0.554
LIG_LIR_Nem_3	23	28	PF02991	0.460
LIG_PCNA_yPIPBox_3	229	243	PF02747	0.496
LIG_Pex14_2	47	51	PF04695	0.450
LIG_SH2_PTP2	202	205	PF00017	0.492
LIG_SH2_SRC	31	34	PF00017	0.488
LIG_SH2_STAP1	144	148	PF00017	0.504
LIG_SH2_STAT5	131	134	PF00017	0.529
LIG_SH2_STAT5	154	157	PF00017	0.517
LIG_SH2_STAT5	179	182	PF00017	0.478
LIG_SH2_STAT5	202	205	PF00017	0.479
LIG_SH2_STAT5	28	31	PF00017	0.456
LIG_SH2_STAT5	286	289	PF00017	0.518
LIG_SH2_STAT5	84	87	PF00017	0.489
LIG_SH3_3	120	126	PF00018	0.450
LIG_SH3_3	195	201	PF00018	0.485
LIG_SUMO_SIM_anti_2	17	23	PF11976	0.472
LIG_SUMO_SIM_par_1	109	115	PF11976	0.504
LIG_SUMO_SIM_par_1	17	23	PF11976	0.470
LIG_TYR_ITIM	200	205	PF00017	0.492
LIG_UBA3_1	215	220	PF00899	0.421
MOD_CK2_1	115	121	PF00069	0.461
MOD_CK2_1	139	145	PF00069	0.418
MOD_CK2_1	166	172	PF00069	0.570
MOD_CK2_1	219	225	PF00069	0.465
MOD_GlcNHglycan	183	186	PF01048	0.266
MOD_GlcNHglycan	225	228	PF01048	0.252
MOD_GSK3_1	126	133	PF00069	0.475
MOD_GSK3_1	162	169	PF00069	0.565
MOD_GSK3_1	177	184	PF00069	0.402
MOD_GSK3_1	219	226	PF00069	0.491
MOD_GSK3_1	307	314	PF00069	0.490
MOD_GSK3_1	70	77	PF00069	0.517
MOD_GSK3_1	98	105	PF00069	0.552
MOD_N-GLC_1	126	131	PF02516	0.270
MOD_N-GLC_2	302	304	PF02516	0.260
MOD_NEK2_1	112	117	PF00069	0.416
MOD_NEK2_1	280	285	PF00069	0.464
MOD_NEK2_1	98	103	PF00069	0.519
MOD_NEK2_2	177	182	PF00069	0.450
MOD_NEK2_2	201	206	PF00069	0.501
MOD_PIKK_1	311	317	PF00454	0.450
MOD_PKA_1	311	317	PF00069	0.460
MOD_Plk_4	177	183	PF00069	0.450
MOD_Plk_4	201	207	PF00069	0.449
MOD_Plk_4	280	286	PF00069	0.484
MOD_Plk_4	70	76	PF00069	0.478
MOD_ProDKin_1	130	136	PF00069	0.562
TRG_ENDOCYTIC_2	144	147	PF00928	0.489
TRG_ENDOCYTIC_2	179	182	PF00928	0.450
TRG_ENDOCYTIC_2	202	205	PF00928	0.492
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.292

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H2WZY4	Staphylococcus aureus (strain COL)	32%	100%
A0A0N0P5S6	Leptomonas seymouri	81%	100%
A0A0S4JY74	Bodo saltans	57%	99%
A0A1X0P4P4	Trypanosomatidae	63%	98%
A0A3R7NMP1	Trypanosoma rangeli	66%	100%
A0A3S7X0F5	Leishmania donovani	96%	100%
A0A422P4V2	Trypanosoma rangeli	28%	96%
A1A6H3	Arabidopsis thaliana	29%	87%
A1AV12	Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1)	25%	67%
A2WXV8	Oryza sativa subsp. indica	27%	100%
A4HFG6	Leishmania braziliensis	91%	100%
A4HI44	Leishmania braziliensis	27%	95%
A4I2M8	Leishmania infantum	95%	100%
A4VR47	Pseudomonas stutzeri (strain A1501)	23%	70%
A5UCC3	Haemophilus influenzae (strain PittEE)	23%	69%
A6Q4Z6	Nitratiruptor sp. (strain SB155-2)	27%	71%
A6WJS7	Shewanella baltica (strain OS185)	21%	69%
A7H2L7	Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)	23%	71%
A7HUC7	Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)	26%	67%
A7MP93	Cronobacter sakazakii (strain ATCC BAA-894)	24%	69%
A7ZE26	Campylobacter concisus (strain 13826)	24%	70%
A8FMK8	Campylobacter jejuni subsp. jejuni serotype O:6 (strain 81116 / NCTC 11828)	24%	71%
A8FZZ3	Shewanella sediminis (strain HAW-EB3)	23%	69%
B3E5M9	Trichlorobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)	25%	67%
B4EW46	Proteus mirabilis (strain HI4320)	24%	69%
B5EEZ1	Citrifermentans bemidjiense (strain ATCC BAA-1014 / DSM 16622 / JCM 12645 / Bem)	26%	68%
B8CVJ1	Shewanella piezotolerans (strain WP3 / JCM 13877)	22%	69%
C9ZQQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	95%
D0A5P3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	99%
E9AD19	Leishmania major	100%	100%
E9AYU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B0L7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	95%
O05074	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	23%	69%
O27587	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	25%	100%
O29891	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	26%	100%
O59128	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	25%	100%
O60116	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
O82616	Arabidopsis thaliana	27%	100%
P0A9J6	Escherichia coli (strain K12)	36%	100%
P0A9J7	Escherichia coli O157:H7	36%	100%
P0AEW9	Escherichia coli (strain K12)	24%	100%
P0AEX0	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	24%	100%
P0AEX1	Escherichia coli O157:H7	24%	100%
P0AEX2	Shigella flexneri	24%	100%
P22824	Vibrio alginolyticus	27%	100%
P25332	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	99%
P30235	Escherichia coli (strain K12)	22%	100%
P32143	Escherichia coli (strain K12)	30%	100%
P33020	Escherichia coli (strain K12)	26%	91%
P36945	Bacillus subtilis (strain 168)	34%	100%
P37829	Solanum tuberosum	29%	100%
P44330	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	24%	100%
P44331	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	35%	100%
P45416	Dickeya dadantii (strain 3937)	22%	100%
P50053	Homo sapiens	23%	100%
P77493	Escherichia coli (strain K12)	25%	100%
P78825	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	97%
P97328	Mus musculus	23%	100%
Q07Y78	Shewanella frigidimarina (strain NCIMB 400)	23%	69%
Q0A4T7	Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)	25%	69%
Q0I1X5	Haemophilus somnus (strain 129Pt)	21%	69%
Q0JGZ6	Oryza sativa subsp. japonica	27%	100%
Q30T22	Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251)	24%	69%
Q31IC2	Hydrogenovibrio crunogenus (strain DSM 25203 / XCL-2)	24%	69%
Q39X60	Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)	27%	67%
Q3J7Y0	Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / JCM 30415 / NCIMB 11848 / C-107)	25%	70%
Q42896	Solanum lycopersicum	30%	100%
Q48P39	Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6)	24%	69%
Q493X3	Blochmannia pennsylvanicus (strain BPEN)	24%	69%
Q4Q7L5	Leishmania major	27%	95%
Q4QKN8	Haemophilus influenzae (strain 86-028NP)	23%	69%
Q4ZZ15	Pseudomonas syringae pv. syringae (strain B728a)	25%	69%
Q54UQ4	Dictyostelium discoideum	31%	100%
Q5HTW1	Campylobacter jejuni (strain RM1221)	23%	71%
Q5JDG9	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	27%	100%
Q6TG09	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	23%	71%
Q6XZ78	Zea mays	27%	98%
Q6XZ79	Zea mays	28%	100%
Q74BF6	Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)	25%	67%
Q7N0C3	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	23%	69%
Q7VQQ6	Blochmannia floridanus	22%	69%
Q7XJ81	Solanum habrochaites	29%	100%
Q87VF4	Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)	24%	69%
Q8KA54	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	23%	100%
Q8R1Q9	Mus musculus	42%	100%
Q8ZKR2	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	27%	100%
Q9CF42	Lactococcus lactis subsp. lactis (strain IL1403)	31%	100%
Q9H477	Homo sapiens	41%	100%
Q9K6K1	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	34%	100%
Q9KM71	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	25%	100%
Q9LNE3	Arabidopsis thaliana	29%	100%
Q9LNE4	Arabidopsis thaliana	29%	95%
Q9M1B9	Arabidopsis thaliana	28%	100%
Q9SID0	Arabidopsis thaliana	28%	100%
Q9ZKZ0	Helicobacter pylori (strain J99 / ATCC 700824)	25%	71%
V5B941	Trypanosoma cruzi	24%	95%
V5BXE5	Trypanosoma cruzi	67%	100%