3-hydroxy-3-methylglutaryl coenzyme A reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3-hydroxy-3-methylglutaryl-CoA reductase

Species:

Leishmania major

UniProt:

Q9Y0F3_LEIMA

TriTrypDb:

LmjF.30.3190 , LMJLV39_300040400 , LMJSD75_300039600

Length:

434

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005778	peroxisomal membrane	6	2
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0031903	microbody membrane	5	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q9Y0F3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9Y0F3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006163	purine nucleotide metabolic process	5	12
GO:0006629	lipid metabolic process	3	12
GO:0006644	phospholipid metabolic process	4	2
GO:0006694	steroid biosynthetic process	5	2
GO:0006720	isoprenoid metabolic process	4	12
GO:0006721	terpenoid metabolic process	5	2
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008202	steroid metabolic process	4	2
GO:0008299	isoprenoid biosynthetic process	4	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	2
GO:0009058	biosynthetic process	2	12
GO:0009117	nucleotide metabolic process	5	12
GO:0009150	purine ribonucleotide metabolic process	6	12
GO:0009259	ribonucleotide metabolic process	5	12
GO:0009987	cellular process	1	12
GO:0010142	farnesyl diphosphate biosynthetic process, mevalonate pathway	6	2
GO:0015936	coenzyme A metabolic process	6	12
GO:0016114	terpenoid biosynthetic process	5	2
GO:0016125	sterol metabolic process	4	2
GO:0016126	sterol biosynthetic process	5	2
GO:0019637	organophosphate metabolic process	3	12
GO:0019693	ribose phosphate metabolic process	4	12
GO:0033865	nucleoside bisphosphate metabolic process	5	12
GO:0033875	ribonucleoside bisphosphate metabolic process	6	12
GO:0034032	purine nucleoside bisphosphate metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0044281	small molecule metabolic process	2	12
GO:0045337	farnesyl diphosphate biosynthetic process	6	2
GO:0045338	farnesyl diphosphate metabolic process	5	2
GO:0046483	heterocycle metabolic process	3	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0072521	purine-containing compound metabolic process	4	12
GO:0090407	organophosphate biosynthetic process	4	2
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901576	organic substance biosynthetic process	3	12
GO:1901615	organic hydroxy compound metabolic process	3	2
GO:1901617	organic hydroxy compound biosynthetic process	4	2
GO:1902767	isoprenoid biosynthetic process via mevalonate	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004420	hydroxymethylglutaryl-CoA reductase (NADPH) activity	5	12
GO:0016491	oxidoreductase activity	2	12
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	12
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	204	210	PF00089	0.297
CLV_NRD_NRD_1	2	4	PF00675	0.385
CLV_NRD_NRD_1	428	430	PF00675	0.407
CLV_NRD_NRD_1	54	56	PF00675	0.208
CLV_PCSK_KEX2_1	2	4	PF00082	0.402
CLV_PCSK_KEX2_1	274	276	PF00082	0.243
CLV_PCSK_KEX2_1	54	56	PF00082	0.235
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.243
CLV_PCSK_SKI1_1	180	184	PF00082	0.219
CLV_PCSK_SKI1_1	240	244	PF00082	0.210
CLV_PCSK_SKI1_1	3	7	PF00082	0.457
CLV_PCSK_SKI1_1	33	37	PF00082	0.326
CLV_PCSK_SKI1_1	373	377	PF00082	0.284
DEG_APCC_DBOX_1	372	380	PF00400	0.402
DEG_Nend_UBRbox_1	1	4	PF02207	0.609
DOC_CYCLIN_yCln2_LP_2	103	109	PF00134	0.470
DOC_MAPK_MEF2A_6	344	353	PF00069	0.405
DOC_PP1_RVXF_1	30	37	PF00149	0.492
DOC_PP2B_LxvP_1	353	356	PF13499	0.443
DOC_PP2B_PxIxI_1	355	361	PF00149	0.394
DOC_SPAK_OSR1_1	175	179	PF12202	0.410
DOC_USP7_MATH_1	18	22	PF00917	0.503
DOC_USP7_MATH_1	182	186	PF00917	0.394
DOC_USP7_UBL2_3	223	227	PF12436	0.394
DOC_USP7_UBL2_3	426	430	PF12436	0.261
DOC_WW_Pin1_4	62	67	PF00397	0.354
LIG_14-3-3_CanoR_1	2	6	PF00244	0.605
LIG_14-3-3_CanoR_1	240	245	PF00244	0.410
LIG_14-3-3_CanoR_1	263	268	PF00244	0.394
LIG_Actin_WH2_2	192	209	PF00022	0.346
LIG_Actin_WH2_2	270	285	PF00022	0.394
LIG_BIR_III_4	214	218	PF00653	0.394
LIG_BRCT_BRCA1_1	244	248	PF00533	0.497
LIG_FHA_1	142	148	PF00498	0.405
LIG_FHA_1	293	299	PF00498	0.497
LIG_FHA_1	67	73	PF00498	0.452
LIG_FHA_2	323	329	PF00498	0.398
LIG_FHA_2	338	344	PF00498	0.474
LIG_LIR_Gen_1	15	25	PF02991	0.571
LIG_LIR_Gen_1	173	183	PF02991	0.445
LIG_LIR_Gen_1	81	86	PF02991	0.380
LIG_LIR_Nem_3	173	179	PF02991	0.432
LIG_LIR_Nem_3	186	192	PF02991	0.373
LIG_LIR_Nem_3	81	85	PF02991	0.410
LIG_PCNA_yPIPBox_3	372	386	PF02747	0.497
LIG_RPA_C_Fungi	50	62	PF08784	0.278
LIG_SH2_PTP2	96	99	PF00017	0.244
LIG_SH2_SRC	96	99	PF00017	0.244
LIG_SH2_STAP1	47	51	PF00017	0.425
LIG_SH2_STAT5	322	325	PF00017	0.390
LIG_SH2_STAT5	96	99	PF00017	0.230
LIG_SH3_3	111	117	PF00018	0.244
LIG_SH3_3	428	434	PF00018	0.589
LIG_SH3_3	94	100	PF00018	0.244
LIG_SUMO_SIM_anti_2	163	170	PF11976	0.298
LIG_SUMO_SIM_anti_2	408	413	PF11976	0.230
LIG_SUMO_SIM_par_1	105	110	PF11976	0.323
LIG_SUMO_SIM_par_1	155	161	PF11976	0.301
LIG_SUMO_SIM_par_1	240	245	PF11976	0.244
LIG_TYR_ITIM	94	99	PF00017	0.230
LIG_UBA3_1	192	196	PF00899	0.356
LIG_WRC_WIRS_1	159	164	PF05994	0.374
MOD_CK1_1	16	22	PF00069	0.386
MOD_CK1_1	209	215	PF00069	0.374
MOD_CK1_1	288	294	PF00069	0.293
MOD_CK1_1	410	416	PF00069	0.209
MOD_CK2_1	158	164	PF00069	0.260
MOD_CK2_1	18	24	PF00069	0.383
MOD_CK2_1	381	387	PF00069	0.265
MOD_GlcNHglycan	127	130	PF01048	0.302
MOD_GlcNHglycan	138	141	PF01048	0.202
MOD_GlcNHglycan	208	211	PF01048	0.385
MOD_GlcNHglycan	244	247	PF01048	0.230
MOD_GlcNHglycan	254	257	PF01048	0.230
MOD_GlcNHglycan	300	303	PF01048	0.230
MOD_GlcNHglycan	334	337	PF01048	0.374
MOD_GlcNHglycan	412	415	PF01048	0.221
MOD_GlcNHglycan	421	424	PF01048	0.244
MOD_GlcNHglycan	9	12	PF01048	0.547
MOD_GSK3_1	16	23	PF00069	0.445
MOD_GSK3_1	288	295	PF00069	0.364
MOD_GSK3_1	334	341	PF00069	0.233
MOD_GSK3_1	364	371	PF00069	0.356
MOD_GSK3_1	62	69	PF00069	0.394
MOD_N-GLC_1	136	141	PF02516	0.374
MOD_N-GLC_1	292	297	PF02516	0.374
MOD_N-GLC_2	247	249	PF02516	0.230
MOD_NEK2_1	1	6	PF00069	0.529
MOD_NEK2_1	125	130	PF00069	0.230
MOD_NEK2_1	183	188	PF00069	0.230
MOD_NEK2_1	206	211	PF00069	0.294
MOD_NEK2_1	242	247	PF00069	0.285
MOD_NEK2_1	292	297	PF00069	0.297
MOD_NEK2_1	298	303	PF00069	0.242
MOD_NEK2_1	349	354	PF00069	0.240
MOD_NEK2_1	7	12	PF00069	0.454
MOD_PIKK_1	368	374	PF00454	0.374
MOD_PK_1	191	197	PF00069	0.374
MOD_PK_1	263	269	PF00069	0.264
MOD_PKA_1	252	258	PF00069	0.230
MOD_PKA_2	1	7	PF00069	0.550
MOD_PKA_2	206	212	PF00069	0.252
MOD_PKA_2	298	304	PF00069	0.374
MOD_Plk_1	407	413	PF00069	0.250
MOD_Plk_1	80	86	PF00069	0.252
MOD_Plk_2-3	158	164	PF00069	0.263
MOD_Plk_4	263	269	PF00069	0.230
MOD_Plk_4	277	283	PF00069	0.230
MOD_Plk_4	285	291	PF00069	0.253
MOD_Plk_4	407	413	PF00069	0.250
MOD_Plk_4	81	87	PF00069	0.252
MOD_ProDKin_1	62	68	PF00069	0.174
MOD_SUMO_for_1	12	15	PF00179	0.376
MOD_SUMO_rev_2	24	34	PF00179	0.512
MOD_SUMO_rev_2	245	255	PF00179	0.230
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.298
TRG_ENDOCYTIC_2	96	99	PF00928	0.230
TRG_ER_diArg_1	1	3	PF00400	0.528
TRG_ER_diArg_1	53	55	PF00400	0.252

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0A1C3I2	Panax ginseng	53%	76%
A0A0A1C930	Panax ginseng	52%	73%
A0A0N1HYY3	Leptomonas seymouri	82%	100%
A0A0S4JI16	Bodo saltans	66%	100%
A0A1X0P1N0	Trypanosomatidae	64%	100%
A0A3S5ISH8	Trypanosoma rangeli	63%	100%
A0A3S7X3U0	Leishmania donovani	97%	100%
A2X8W3	Oryza sativa subsp. indica	55%	81%
A4HIQ3	Leishmania braziliensis	91%	100%
A4I602	Leishmania infantum	97%	100%
B0R6J9	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	46%	100%
C8VN86	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	49%	100%
C9ZRC5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9B193	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O08424	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	42%	100%
O24594	Zea mays	52%	75%
O26662	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	43%	100%
O59469	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	45%	100%
O64966	Gossypium hirsutum	54%	74%
O64967	Gossypium hirsutum	54%	69%
P14891	Arabidopsis thaliana	52%	73%
P29057	Hevea brasiliensis	53%	75%
P34135	Dictyostelium discoideum	49%	79%
P34136	Dictyostelium discoideum	52%	83%
P43256	Arabidopsis thaliana	53%	77%
P48020	Solanum tuberosum	51%	73%
P48021	Camptotheca acuminata	53%	73%
P48022	Solanum lycopersicum	50%	72%
Q00583	Hevea brasiliensis	52%	74%
Q01559	Nicotiana sylvestris	51%	72%
Q03163	Catharanthus roseus	52%	72%
Q0DY59	Oryza sativa subsp. japonica	55%	82%
Q41437	Solanum tuberosum	50%	73%
Q41438	Solanum tuberosum	50%	76%
Q58116	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	39%	100%
Q59468	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	44%	100%
Q9V1R3	Pyrococcus abyssi (strain GE5 / Orsay)	44%	100%
Q9XEL8	Capsicum annuum	51%	72%
Q9XHL5	Oryza sativa subsp. japonica	54%	77%
Q9YAS4	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	51%	100%
U5JCC6	Panax ginseng	52%	74%
V5B780	Trypanosoma cruzi	65%	100%