Putative mitogen-activated protein kinase kinase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitogen-activated protein kinase kinase 1

Species:

Leishmania major

UniProt:

Q9Y077_LEIMA

TriTrypDb:

LmjF.29.2320 , LMJLV39_290031300 , LMJSD75_290031600

Length:

372

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q9Y077

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9Y077

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0004674	protein serine/threonine kinase activity	4	12
GO:0004707	MAP kinase activity	5	5
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004140	dephospho-CoA kinase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	179	181	PF00082	0.260
CLV_PCSK_KEX2_1	66	68	PF00082	0.249
CLV_PCSK_KEX2_1	91	93	PF00082	0.362
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.250
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.283
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.392
CLV_PCSK_SKI1_1	162	166	PF00082	0.264
CLV_PCSK_SKI1_1	179	183	PF00082	0.268
CLV_PCSK_SKI1_1	184	188	PF00082	0.229
CLV_PCSK_SKI1_1	35	39	PF00082	0.351
CLV_PCSK_SKI1_1	361	365	PF00082	0.568
CLV_PCSK_SKI1_1	4	8	PF00082	0.532
DEG_Nend_UBRbox_1	1	4	PF02207	0.590
DEG_SPOP_SBC_1	214	218	PF00917	0.392
DOC_MAPK_gen_1	184	193	PF00069	0.270
DOC_MAPK_gen_1	2	9	PF00069	0.548
DOC_MAPK_gen_1	81	90	PF00069	0.283
DOC_MAPK_JIP1_4	187	193	PF00069	0.264
DOC_MAPK_MEF2A_6	2	9	PF00069	0.610
DOC_PP1_RVXF_1	160	167	PF00149	0.264
DOC_PP4_FxxP_1	225	228	PF00568	0.264
DOC_USP7_MATH_1	214	218	PF00917	0.392
DOC_USP7_MATH_1	275	279	PF00917	0.325
DOC_USP7_MATH_1	71	75	PF00917	0.383
DOC_USP7_MATH_1	94	98	PF00917	0.249
DOC_USP7_UBL2_3	293	297	PF12436	0.392
DOC_WW_Pin1_4	114	119	PF00397	0.264
DOC_WW_Pin1_4	276	281	PF00397	0.264
LIG_Actin_WH2_2	149	164	PF00022	0.242
LIG_Actin_WH2_2	171	189	PF00022	0.320
LIG_Actin_WH2_2	75	93	PF00022	0.283
LIG_APCC_ABBAyCdc20_2	179	185	PF00400	0.249
LIG_APCC_ABBAyCdc20_2	35	41	PF00400	0.445
LIG_BRCT_BRCA1_1	284	288	PF00533	0.392
LIG_BRCT_BRCA1_1	30	34	PF00533	0.436
LIG_EH1_1	203	211	PF00400	0.249
LIG_FHA_1	194	200	PF00498	0.379
LIG_FHA_1	210	216	PF00498	0.184
LIG_FHA_1	277	283	PF00498	0.264
LIG_FHA_1	337	343	PF00498	0.418
LIG_FHA_2	143	149	PF00498	0.299
LIG_FHA_2	279	285	PF00498	0.235
LIG_FHA_2	307	313	PF00498	0.415
LIG_Integrin_RGD_1	114	116	PF01839	0.325
LIG_IRF3_LxIS_1	188	194	PF10401	0.392
LIG_LIR_Apic_2	222	228	PF02991	0.249
LIG_LIR_Nem_3	140	144	PF02991	0.278
LIG_LIR_Nem_3	31	37	PF02991	0.511
LIG_LIR_Nem_3	76	82	PF02991	0.344
LIG_MAD2	180	188	PF02301	0.392
LIG_NRBOX	266	272	PF00104	0.283
LIG_REV1ctd_RIR_1	76	85	PF16727	0.325
LIG_SH2_CRK	268	272	PF00017	0.276
LIG_SH2_STAT5	119	122	PF00017	0.392
LIG_SH2_STAT5	144	147	PF00017	0.290
LIG_SH2_STAT5	174	177	PF00017	0.288
LIG_SH2_STAT5	219	222	PF00017	0.249
LIG_SH2_STAT5	45	48	PF00017	0.480
LIG_SH3_3	255	261	PF00018	0.249
LIG_SH3_3	277	283	PF00018	0.264
LIG_SUMO_SIM_par_1	211	218	PF11976	0.264
LIG_TRAF2_1	261	264	PF00917	0.283
MOD_CK1_1	278	284	PF00069	0.349
MOD_CK1_1	28	34	PF00069	0.511
MOD_CK1_1	355	361	PF00069	0.551
MOD_CK2_1	278	284	PF00069	0.191
MOD_CK2_1	306	312	PF00069	0.340
MOD_GlcNHglycan	169	172	PF01048	0.300
MOD_GlcNHglycan	284	287	PF01048	0.358
MOD_GlcNHglycan	325	328	PF01048	0.435
MOD_GlcNHglycan	73	76	PF01048	0.249
MOD_GSK3_1	209	216	PF00069	0.253
MOD_GSK3_1	237	244	PF00069	0.256
MOD_GSK3_1	278	285	PF00069	0.299
MOD_N-GLC_1	275	280	PF02516	0.377
MOD_N-GLC_1	28	33	PF02516	0.384
MOD_NEK2_1	204	209	PF00069	0.272
MOD_NEK2_1	213	218	PF00069	0.311
MOD_NEK2_1	245	250	PF00069	0.277
MOD_PIKK_1	352	358	PF00454	0.427
MOD_PK_1	84	90	PF00069	0.180
MOD_PKA_1	83	89	PF00069	0.180
MOD_PKA_2	306	312	PF00069	0.265
MOD_Plk_1	28	34	PF00069	0.394
MOD_Plk_4	215	221	PF00069	0.249
MOD_Plk_4	245	251	PF00069	0.283
MOD_ProDKin_1	114	120	PF00069	0.264
MOD_ProDKin_1	276	282	PF00069	0.264
MOD_SUMO_rev_2	15	23	PF00179	0.547
MOD_SUMO_rev_2	285	295	PF00179	0.325
MOD_SUMO_rev_2	357	365	PF00179	0.579
TRG_DiLeu_BaEn_2	106	112	PF01217	0.325
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.433
TRG_ENDOCYTIC_2	124	127	PF00928	0.392
TRG_ENDOCYTIC_2	268	271	PF00928	0.325
TRG_Pf-PMV_PEXEL_1	180	185	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3N5	Leptomonas seymouri	28%	87%
A0A0N0P3Q8	Leptomonas seymouri	31%	100%
A0A0N0P8X6	Leptomonas seymouri	28%	96%
A0A0N1HVN6	Leptomonas seymouri	84%	99%
A0A0N1HWQ2	Leptomonas seymouri	27%	100%
A0A0N1I0B6	Leptomonas seymouri	32%	69%
A0A0N1I2Z5	Leptomonas seymouri	32%	100%
A0A0N1PEV2	Leptomonas seymouri	29%	69%
A0A0S4IHW4	Bodo saltans	31%	83%
A0A0S4IKC2	Bodo saltans	52%	98%
A0A0S4IKH2	Bodo saltans	27%	75%
A0A0S4IMB7	Bodo saltans	26%	84%
A0A0S4IQX7	Bodo saltans	31%	96%
A0A0S4IRG0	Bodo saltans	29%	100%
A0A0S4IRZ7	Bodo saltans	26%	75%
A0A0S4IX86	Bodo saltans	28%	87%
A0A0S4J3Y5	Bodo saltans	30%	87%
A0A0S4J444	Bodo saltans	29%	93%
A0A0S4J4X4	Bodo saltans	35%	100%
A0A0S4J804	Bodo saltans	28%	71%
A0A0S4J9Q7	Bodo saltans	32%	82%
A0A0S4JBR3	Bodo saltans	29%	100%
A0A0S4JCG2	Bodo saltans	29%	83%
A0A0S4JHA7	Bodo saltans	33%	81%
A0A0S4JK24	Bodo saltans	24%	86%
A0A0S4JNA1	Bodo saltans	31%	75%
A0A0S4JPZ1	Bodo saltans	26%	83%
A0A0S4JU73	Bodo saltans	29%	78%
A0A0S4JUJ2	Bodo saltans	29%	100%
A0A0S4JUT0	Bodo saltans	34%	69%
A0A0S4KHR9	Bodo saltans	31%	100%
A0A0S4KMV7	Bodo saltans	27%	100%
A0A0S4KN74	Bodo saltans	35%	100%
A0A1X0NFW4	Trypanosomatidae	33%	78%
A0A1X0NLC8	Trypanosomatidae	31%	78%
A0A1X0NM94	Trypanosomatidae	29%	73%
A0A1X0NNE5	Trypanosomatidae	31%	74%
A0A1X0NRZ9	Trypanosomatidae	30%	100%
A0A1X0NUQ4	Trypanosomatidae	26%	98%
A0A1X0NVR3	Trypanosomatidae	29%	87%
A0A1X0NW24	Trypanosomatidae	35%	100%
A0A1X0NWB9	Trypanosomatidae	31%	77%
A0A1X0NYK8	Trypanosomatidae	26%	100%
A0A1X0NYS1	Trypanosomatidae	30%	72%
A0A1X0P4Z7	Trypanosomatidae	29%	67%
A0A1X0P6F5	Trypanosomatidae	30%	100%
A0A1X0P6Y5	Trypanosomatidae	29%	100%
A0A1X0P919	Trypanosomatidae	31%	100%
A0A1X0P935	Trypanosomatidae	68%	100%
A0A1X0P963	Trypanosomatidae	28%	77%
A0A1X0P9C4	Trypanosomatidae	28%	74%
A0A1X0PAW2	Trypanosomatidae	28%	100%
A0A3Q8IBT5	Leishmania donovani	26%	100%
A0A3Q8IEH3	Leishmania donovani	27%	100%
A0A3Q8IFK8	Leishmania donovani	26%	84%
A0A3Q8IFW0	Leishmania donovani	26%	87%
A0A3Q8IHH8	Leishmania donovani	26%	74%
A0A3Q8IIH5	Leishmania donovani	27%	67%
A0A3Q8IND3	Leishmania donovani	37%	71%
A0A3R7K109	Trypanosoma rangeli	32%	79%
A0A3R7KMF0	Trypanosoma rangeli	27%	100%
A0A3R7KRP1	Trypanosoma rangeli	30%	78%
A0A3R7M1U6	Trypanosoma rangeli	64%	100%
A0A3R7M819	Trypanosoma rangeli	31%	100%
A0A3R7NKI8	Trypanosoma rangeli	26%	100%
A0A3R7NLI6	Trypanosoma rangeli	28%	100%
A0A3R7RIN5	Trypanosoma rangeli	27%	74%
A0A3S5H789	Leishmania donovani	27%	100%
A0A3S5H7M0	Leishmania donovani	28%	71%
A0A3S5IRC3	Trypanosoma rangeli	35%	99%
A0A3S7WUE7	Leishmania donovani	29%	67%
A0A3S7WVE9	Leishmania donovani	31%	100%
A0A3S7WYP4	Leishmania donovani	30%	100%
A0A3S7X2W3	Leishmania donovani	99%	100%
A0A3S7X6T8	Leishmania donovani	24%	83%
A0A3S7X7Y2	Leishmania donovani	28%	97%
A0A3S7XA45	Leishmania donovani	27%	95%
A0A422N3Y6	Trypanosoma rangeli	31%	84%
A0A422NCP0	Trypanosoma rangeli	26%	75%
A0A422NCU3	Trypanosoma rangeli	30%	100%
A0A422NFN4	Trypanosoma rangeli	31%	73%
A0A422NU88	Trypanosoma rangeli	27%	67%
A0A422P0N6	Trypanosoma rangeli	33%	100%
A0A422P4L8	Trypanosoma rangeli	31%	87%
A0A8I3S724	Canis lupus familiaris	28%	92%
A2BD05	Sus scrofa	28%	100%
A2XFF4	Oryza sativa subsp. indica	30%	73%
A3B529	Oryza sativa subsp. japonica	29%	86%
A4H7W1	Leishmania braziliensis	27%	68%
A4H9X2	Leishmania braziliensis	31%	100%
A4HAS1	Leishmania braziliensis	26%	97%
A4HDJ5	Leishmania braziliensis	30%	69%
A4HDU3	Leishmania braziliensis	32%	100%
A4HG92	Leishmania braziliensis	27%	100%
A4HHN1	Leishmania braziliensis	95%	100%
A4HHQ5	Leishmania braziliensis	27%	74%
A4HHR5	Leishmania braziliensis	29%	72%
A4HJT5	Leishmania braziliensis	26%	84%
A4HJW2	Leishmania braziliensis	26%	87%
A4HNU6	Leishmania braziliensis	35%	71%
A4HP12	Leishmania braziliensis	26%	73%
A4HW88	Leishmania infantum	27%	67%
A4HX71	Leishmania infantum	29%	67%
A4HYX6	Leishmania infantum	27%	100%
A4I140	Leishmania infantum	30%	100%
A4I3C6	Leishmania infantum	27%	100%
A4I4U6	Leishmania infantum	98%	100%
A4I4X0	Leishmania infantum	26%	74%
A4I4X5	Leishmania infantum	28%	71%
A4I7A1	Leishmania infantum	26%	84%
A4I7C4	Leishmania infantum	26%	87%
A4I9Y5	Leishmania infantum	28%	97%
A4IC54	Leishmania infantum	27%	95%
A4ICP8	Leishmania infantum	38%	71%
A4K2M3	Papio anubis	35%	76%
A4K2P5	Colobus guereza	36%	76%
A4K2Q5	Otolemur garnettii	35%	76%
A4K2S1	Lemur catta	35%	76%
A4K2T0	Macaca mulatta	35%	76%
A4K2W5	Aotus nancymaae	35%	76%
A4K2Y1	Chlorocebus aethiops	35%	76%
A5GFW1	Sus scrofa	29%	93%
A8XJW8	Caenorhabditis briggsae	32%	75%
A9RWC9	Physcomitrium patens	35%	100%
A9S5R3	Physcomitrium patens	35%	100%
A9SR33	Physcomitrium patens	35%	100%
B0LT89	Rattus norvegicus	35%	86%
B0XPE4	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	35%	74%
B8BBT7	Oryza sativa subsp. indica	30%	73%
C6K3W8	Leptomonas seymouri	28%	70%
C9ZIN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	75%
C9ZK98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	86%
C9ZKX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	74%
C9ZLJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
C9ZW46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	79%
C9ZW68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZWG7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	86%
C9ZWI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	86%
D0A0D3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0A2R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	98%
D0A820	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D3ZBE5	Rattus norvegicus	29%	100%
D3ZHP7	Rattus norvegicus	28%	79%
E9AEB9	Leishmania major	26%	74%
E9AEC9	Leishmania major	28%	71%
E9AGR7	Leishmania infantum	31%	100%
E9AII8	Leishmania braziliensis	26%	100%
E9ALF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	71%
E9ALG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	74%
E9ALJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9APY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	67%
E9ARW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ASK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	71%
E9AUS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AX78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AZL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B296	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	84%
E9B2B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	87%
E9B436	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	83%
E9B4Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	97%
G4NEB8	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	34%	90%
G5EDF7	Caenorhabditis elegans	29%	100%
G5EDT6	Caenorhabditis elegans	30%	86%
G5EFM9	Caenorhabditis elegans	29%	100%
O00506	Homo sapiens	35%	87%
O01427	Caenorhabditis elegans	27%	100%
O04160	Brassica napus	28%	79%
O09110	Mus musculus	34%	100%
O14047	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
O14305	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	79%
O14733	Homo sapiens	32%	89%
O14965	Homo sapiens	27%	92%
O15530	Homo sapiens	31%	67%
O22932	Arabidopsis thaliana	34%	86%
O22971	Arabidopsis thaliana	28%	74%
O23082	Arabidopsis thaliana	27%	98%
O23145	Arabidopsis thaliana	27%	86%
O23304	Arabidopsis thaliana	30%	76%
O54748	Rattus norvegicus	36%	76%
O55173	Rattus norvegicus	30%	67%
O61122	Dictyostelium discoideum	33%	78%
O61125	Dictyostelium discoideum	30%	81%
O64629	Arabidopsis thaliana	28%	100%
O65554	Arabidopsis thaliana	28%	84%
O70126	Mus musculus	29%	100%
O70150	Rattus norvegicus	32%	100%
O75914	Homo sapiens	30%	67%
O80396	Arabidopsis thaliana	34%	72%
O80397	Arabidopsis thaliana	31%	100%
O80888	Arabidopsis thaliana	34%	100%
O88445	Mus musculus	27%	100%
O88506	Rattus norvegicus	34%	67%
O88643	Mus musculus	29%	68%
O95747	Homo sapiens	32%	71%
O96017	Homo sapiens	31%	69%
O96821	Plasmodium knowlesi (strain H)	28%	100%
P06784	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	72%
P08458	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	76%
P10506	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
P29678	Oryctolagus cuniculus	34%	95%
P31938	Mus musculus	34%	95%
P32490	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	73%
P32491	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	74%
P35465	Rattus norvegicus	29%	68%
P36506	Rattus norvegicus	34%	93%
P36507	Homo sapiens	33%	93%
P45985	Homo sapiens	32%	93%
P46734	Homo sapiens	34%	100%
P47809	Mus musculus	32%	94%
P49101	Zea mays	29%	73%
P51138	Medicago sativa	27%	91%
P51139	Medicago sativa	26%	91%
P51956	Homo sapiens	27%	74%
P52564	Homo sapiens	34%	100%
P59241	Rattus norvegicus	28%	94%
P59895	Rattus norvegicus	28%	100%
P61075	Plasmodium falciparum (isolate 3D7)	27%	100%
P70236	Mus musculus	35%	100%
P92937	Arabidopsis thaliana	31%	88%
P92958	Arabidopsis thaliana	31%	73%
P97477	Mus musculus	27%	94%
Q01986	Rattus norvegicus	34%	95%
Q02750	Homo sapiens	34%	95%
Q03428	Trypanosoma brucei brucei	28%	86%
Q05116	Xenopus laevis	33%	94%
Q07192	Xenopus laevis	33%	83%
Q07785	Plasmodium falciparum (isolate K1 / Thailand)	27%	100%
Q08942	Trypanosoma brucei brucei	28%	86%
Q08E52	Bos taurus	29%	68%
Q09170	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	81%
Q0JI49	Oryza sativa subsp. japonica	29%	74%
Q0PKV7	Leishmania mexicana	37%	71%
Q10664	Caenorhabditis elegans	35%	96%
Q10LQ2	Oryza sativa subsp. japonica	29%	82%
Q13043	Homo sapiens	35%	76%
Q13153	Homo sapiens	29%	68%
Q13163	Homo sapiens	35%	83%
Q13177	Homo sapiens	30%	71%
Q13188	Homo sapiens	36%	76%
Q1HG70	Canis lupus familiaris	29%	93%
Q20347	Caenorhabditis elegans	32%	100%
Q21307	Caenorhabditis elegans	32%	100%
Q24324	Drosophila melanogaster	36%	94%
Q29502	Oryctolagus cuniculus	30%	71%
Q2QY53	Oryza sativa subsp. japonica	30%	85%
Q2RAX3	Oryza sativa subsp. japonica	30%	82%
Q2TA06	Bos taurus	28%	93%
Q38997	Arabidopsis thaliana	31%	73%
Q39010	Arabidopsis thaliana	27%	90%
Q39011	Arabidopsis thaliana	28%	98%
Q39012	Arabidopsis thaliana	28%	91%
Q3SWY6	Bos taurus	35%	87%
Q3TZA2	Mus musculus	28%	100%
Q40518	Nicotiana tabacum	28%	91%
Q4KSH7	Rattus norvegicus	32%	89%
Q4Q1Z0	Leishmania major	37%	72%
Q4Q2Z2	Leishmania major	28%	97%
Q4Q3Y9	Leishmania major	25%	83%
Q4Q5T9	Leishmania major	26%	87%
Q4Q5W2	Leishmania major	26%	100%
Q4Q9K2	Leishmania major	26%	96%
Q4QA98	Leishmania major	30%	100%
Q4QCR2	Leishmania major	26%	100%
Q4QCR3	Leishmania major	27%	100%
Q4QDK6	Leishmania major	31%	98%
Q4QFJ2	Leishmania major	28%	67%
Q4V7Q6	Xenopus laevis	28%	79%
Q4WJJ0	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	35%	74%
Q54EY4	Dictyostelium discoideum	29%	66%
Q54PB4	Dictyostelium discoideum	28%	77%
Q54WX4	Dictyostelium discoideum	27%	97%
Q556S2	Dictyostelium discoideum	31%	73%
Q55GV3	Dictyostelium discoideum	31%	78%
Q5E9L6	Bos taurus	35%	76%
Q5E9X2	Bos taurus	34%	100%
Q5JLD8	Oryza sativa subsp. japonica	32%	83%
Q5MAI5	Homo sapiens	26%	98%
Q5QN75	Oryza sativa subsp. japonica	34%	100%
Q5R495	Pongo abelii	30%	71%
Q5XIT0	Rattus norvegicus	29%	73%
Q5Z6X0	Oryza sativa subsp. japonica	31%	72%
Q5Z7J0	Oryza sativa subsp. japonica	26%	92%
Q5ZJK4	Gallus gallus	35%	77%
Q60EZ2	Oryza sativa subsp. japonica	27%	93%
Q61036	Mus musculus	30%	67%
Q61XD3	Caenorhabditis briggsae	27%	100%
Q62829	Rattus norvegicus	29%	68%
Q62862	Rattus norvegicus	34%	83%
Q63932	Mus musculus	34%	93%
Q63980	Cricetulus griseus	34%	95%
Q64303	Rattus norvegicus	31%	71%
Q683C9	Arabidopsis thaliana	27%	100%
Q6A1A2	Homo sapiens	30%	94%
Q6BVA0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	25%	90%
Q6FV07	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	31%	100%
Q6H7U5	Oryza sativa subsp. japonica	28%	75%
Q6IP06	Xenopus laevis	35%	75%
Q6P2M8	Homo sapiens	32%	100%
Q6P3Q4	Xenopus tropicalis	32%	77%
Q6P9R2	Mus musculus	32%	71%
Q6PA14	Xenopus laevis	34%	77%
Q6PHR2	Homo sapiens	29%	79%
Q6SA08	Homo sapiens	26%	100%
Q6YY75	Oryza sativa subsp. japonica	30%	70%
Q7YQL3	Pongo pygmaeus	30%	67%
Q7YQL4	Pan troglodytes	30%	67%
Q7YRC6	Bos taurus	27%	100%
Q7ZUQ3	Danio rerio	37%	76%
Q802A6	Squalus acanthias	34%	76%
Q852Q0	Oryza sativa subsp. japonica	30%	73%
Q852Q1	Oryza sativa subsp. japonica	30%	73%
Q852Q2	Oryza sativa subsp. japonica	33%	74%
Q863I2	Sus scrofa	31%	70%
Q8BGW6	Mus musculus	30%	93%
Q8CE90	Mus musculus	32%	70%
Q8CIN4	Mus musculus	31%	71%
Q8LIG4	Oryza sativa subsp. japonica	29%	84%
Q8RXG3	Arabidopsis thaliana	34%	100%
Q8RXT4	Arabidopsis thaliana	26%	67%
Q8SRL5	Encephalitozoon cuniculi (strain GB-M1)	29%	100%
Q8SWM6	Encephalitozoon cuniculi (strain GB-M1)	30%	79%
Q8TDX7	Homo sapiens	29%	100%
Q8WU08	Homo sapiens	27%	94%
Q90321	Cyprinus carpio	30%	94%
Q90891	Gallus gallus	30%	93%
Q91447	Serinus canaria	34%	96%
Q91819	Xenopus laevis	27%	91%
Q91820	Xenopus laevis	27%	91%
Q94A06	Arabidopsis thaliana	36%	100%
Q96287	Arabidopsis thaliana	28%	79%
Q99JT2	Mus musculus	33%	89%
Q99KH8	Mus musculus	35%	86%
Q9DGE0	Danio rerio	34%	100%
Q9ES70	Mus musculus	28%	100%
Q9ES74	Mus musculus	29%	100%
Q9FJ54	Arabidopsis thaliana	30%	85%
Q9FJV0	Arabidopsis thaliana	33%	100%
Q9FLZ3	Arabidopsis thaliana	28%	75%
Q9FVS6	Arabidopsis thaliana	26%	89%
Q9FX43	Arabidopsis thaliana	36%	100%
Q9GRT1	Leishmania mexicana	31%	100%
Q9HC98	Homo sapiens	28%	100%
Q9JI10	Mus musculus	36%	75%
Q9JI11	Mus musculus	35%	76%
Q9LGV5	Oryza sativa subsp. japonica	31%	81%
Q9LP51	Arabidopsis thaliana	27%	72%
Q9LPQ3	Arabidopsis thaliana	34%	100%
Q9LQM8	Arabidopsis thaliana	31%	100%
Q9LT35	Arabidopsis thaliana	30%	89%
Q9LWM4	Oryza sativa subsp. japonica	29%	81%
Q9M077	Arabidopsis thaliana	26%	100%
Q9M8J5	Arabidopsis thaliana	34%	100%
Q9N0X0	Sus scrofa	27%	100%
Q9N2N1	Leishmania major	28%	100%
Q9NB31	Caenorhabditis elegans	32%	75%
Q9P289	Homo sapiens	33%	89%
Q9QYK9	Mus musculus	32%	100%
Q9S7U9	Arabidopsis thaliana	37%	100%
Q9STV4	Arabidopsis thaliana	33%	84%
Q9TXJ0	Caenorhabditis elegans	29%	100%
Q9UEW8	Homo sapiens	34%	68%
Q9UQB9	Homo sapiens	27%	100%
Q9WVS7	Mus musculus	34%	83%
Q9XT09	Pan troglodytes	33%	95%
Q9XTR1	Caenorhabditis elegans	30%	92%
Q9Y6E0	Homo sapiens	35%	84%
Q9Y884	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q9Z1W9	Mus musculus	34%	67%
Q9Z265	Mus musculus	30%	68%
Q9Z2A0	Mus musculus	30%	67%
Q9Z2W1	Mus musculus	34%	87%
Q9ZVP5	Arabidopsis thaliana	32%	100%
V5B141	Trypanosoma cruzi	32%	78%
V5B9R6	Trypanosoma cruzi	33%	100%
V5BB60	Trypanosoma cruzi	29%	90%
V5BFI8	Trypanosoma cruzi	32%	84%
V5BG98	Trypanosoma cruzi	25%	100%
V5BKJ3	Trypanosoma cruzi	29%	100%
V5BMH5	Trypanosoma cruzi	30%	100%
V5BP88	Trypanosoma cruzi	31%	80%
V5BQF4	Trypanosoma cruzi	34%	100%
V5BX61	Trypanosoma cruzi	66%	100%
V5C1S0	Trypanosoma cruzi	30%	100%
V5C224	Trypanosoma cruzi	27%	74%
V5D9M1	Trypanosoma cruzi	29%	100%
V5DC40	Trypanosoma cruzi	33%	68%
V5DUH0	Trypanosoma cruzi	29%	68%
W0LYS5	Macrobrachium nipponense	30%	100%