Mitochondrial ribosomal protein L47

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial 39-S ribosomal protein L47 (MRP-L47), putative

Species:

Leishmania major

UniProt:

Q9XZY7_LEIMA

TriTrypDb:

LmjF.04.0270 , LMJLV39_040007500 , LMJSD75_040007600

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000315	organellar large ribosomal subunit	5	2
GO:0005737	cytoplasm	2	2
GO:0005762	mitochondrial large ribosomal subunit	3	2
GO:0015934	large ribosomal subunit	4	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0032991	protein-containing complex	1	2
GO:0043233	organelle lumen	3	2
GO:0044391	ribosomal subunit	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	2
GO:0000313	organellar ribosome	6	10
GO:0005761	mitochondrial ribosome	7	10
GO:0005840	ribosome	5	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10

Expansion

Sequence features

Q9XZY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9XZY7

PDB structure(s): 7aih_R , 7am2_R , 7ane_R

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0032543	mitochondrial translation	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.308
CLV_C14_Caspase3-7	250	254	PF00656	0.682
CLV_C14_Caspase3-7	337	341	PF00656	0.402
CLV_C14_Caspase3-7	351	355	PF00656	0.376
CLV_NRD_NRD_1	147	149	PF00675	0.420
CLV_NRD_NRD_1	199	201	PF00675	0.563
CLV_NRD_NRD_1	384	386	PF00675	0.423
CLV_NRD_NRD_1	40	42	PF00675	0.403
CLV_NRD_NRD_1	6	8	PF00675	0.524
CLV_PCSK_KEX2_1	147	149	PF00082	0.420
CLV_PCSK_KEX2_1	185	187	PF00082	0.509
CLV_PCSK_KEX2_1	199	201	PF00082	0.466
CLV_PCSK_KEX2_1	25	27	PF00082	0.172
CLV_PCSK_KEX2_1	384	386	PF00082	0.472
CLV_PCSK_KEX2_1	40	42	PF00082	0.274
CLV_PCSK_KEX2_1	465	467	PF00082	0.561
CLV_PCSK_KEX2_1	6	8	PF00082	0.524
CLV_PCSK_KEX2_1	95	97	PF00082	0.240
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.521
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.289
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.561
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.256
CLV_PCSK_PC7_1	2	8	PF00082	0.541
CLV_PCSK_SKI1_1	111	115	PF00082	0.383
CLV_PCSK_SKI1_1	116	120	PF00082	0.243
CLV_PCSK_SKI1_1	142	146	PF00082	0.469
CLV_PCSK_SKI1_1	155	159	PF00082	0.354
CLV_PCSK_SKI1_1	288	292	PF00082	0.449
CLV_PCSK_SKI1_1	431	435	PF00082	0.367
CLV_PCSK_SKI1_1	466	470	PF00082	0.559
CLV_PCSK_SKI1_1	58	62	PF00082	0.274
CLV_PCSK_SKI1_1	96	100	PF00082	0.318
DEG_APCC_DBOX_1	276	284	PF00400	0.576
DEG_APCC_DBOX_1	40	48	PF00400	0.393
DEG_APCC_DBOX_1	57	65	PF00400	0.195
DEG_Nend_UBRbox_1	1	4	PF02207	0.668
DEG_SIAH_1	370	378	PF03145	0.413
DEG_SPOP_SBC_1	209	213	PF00917	0.559
DOC_MAPK_MEF2A_6	168	175	PF00069	0.364
DOC_MAPK_RevD_3	171	186	PF00069	0.404
DOC_PP2B_LxvP_1	264	267	PF13499	0.549
DOC_SPAK_OSR1_1	160	164	PF12202	0.531
DOC_USP7_MATH_1	209	213	PF00917	0.609
DOC_USP7_MATH_1	242	246	PF00917	0.686
DOC_USP7_MATH_1	35	39	PF00917	0.276
DOC_USP7_MATH_1	79	83	PF00917	0.310
DOC_USP7_UBL2_3	168	172	PF12436	0.416
DOC_USP7_UBL2_3	95	99	PF12436	0.308
DOC_WW_Pin1_4	440	445	PF00397	0.528
LIG_14-3-3_CanoR_1	2	10	PF00244	0.633
LIG_14-3-3_CanoR_1	333	337	PF00244	0.430
LIG_14-3-3_CanoR_1	40	45	PF00244	0.289
LIG_14-3-3_CanoR_1	466	475	PF00244	0.507
LIG_14-3-3_CanoR_1	58	68	PF00244	0.289
LIG_Actin_WH2_2	71	87	PF00022	0.289
LIG_APCC_ABBA_1	110	115	PF00400	0.409
LIG_DLG_GKlike_1	40	47	PF00625	0.289
LIG_EVH1_1	264	268	PF00568	0.594
LIG_FHA_1	136	142	PF00498	0.408
LIG_FHA_1	172	178	PF00498	0.591
LIG_FHA_1	238	244	PF00498	0.564
LIG_FHA_1	467	473	PF00498	0.556
LIG_FHA_2	223	229	PF00498	0.541
LIG_FHA_2	310	316	PF00498	0.493
LIG_FHA_2	349	355	PF00498	0.451
LIG_FHA_2	61	67	PF00498	0.417
LIG_LIR_Apic_2	203	209	PF02991	0.491
LIG_LIR_Apic_2	439	444	PF02991	0.392
LIG_LIR_Nem_3	189	195	PF02991	0.433
LIG_NRBOX	153	159	PF00104	0.436
LIG_PDZ_Class_1	475	480	PF00595	0.401
LIG_Pex14_1	402	406	PF04695	0.347
LIG_SH2_CRK	122	126	PF00017	0.437
LIG_SH2_CRK	422	426	PF00017	0.348
LIG_SH2_GRB2like	422	425	PF00017	0.354
LIG_SH2_NCK_1	372	376	PF00017	0.403
LIG_SH2_SRC	379	382	PF00017	0.442
LIG_SH2_STAP1	222	226	PF00017	0.567
LIG_SH2_STAP1	422	426	PF00017	0.362
LIG_SH2_STAT5	300	303	PF00017	0.448
LIG_SH2_STAT5	344	347	PF00017	0.430
LIG_SH2_STAT5	409	412	PF00017	0.368
LIG_SH2_STAT5	428	431	PF00017	0.275
LIG_SH2_STAT5	68	71	PF00017	0.274
LIG_SH3_1	122	128	PF00018	0.442
LIG_SH3_1	270	276	PF00018	0.524
LIG_SH3_2	265	270	PF14604	0.514
LIG_SH3_3	122	128	PF00018	0.442
LIG_SH3_3	24	30	PF00018	0.274
LIG_SH3_3	262	268	PF00018	0.463
LIG_SH3_3	270	276	PF00018	0.460
LIG_SH3_3	314	320	PF00018	0.433
LIG_SH3_3	394	400	PF00018	0.388
LIG_SUMO_SIM_par_1	357	364	PF11976	0.445
LIG_SUMO_SIM_par_1	442	448	PF11976	0.397
LIG_TRAF2_1	360	363	PF00917	0.460
LIG_TRAF2_1	388	391	PF00917	0.385
LIG_UBA3_1	60	65	PF00899	0.346
LIG_WW_3	274	278	PF00397	0.599
MOD_CK1_1	212	218	PF00069	0.500
MOD_CK1_1	289	295	PF00069	0.511
MOD_CK1_1	349	355	PF00069	0.323
MOD_CK2_1	222	228	PF00069	0.514
MOD_CK2_1	238	244	PF00069	0.693
MOD_CK2_1	357	363	PF00069	0.530
MOD_CK2_1	436	442	PF00069	0.390
MOD_CK2_1	60	66	PF00069	0.274
MOD_GlcNHglycan	214	217	PF01048	0.564
MOD_GlcNHglycan	234	237	PF01048	0.660
MOD_GlcNHglycan	240	243	PF01048	0.671
MOD_GlcNHglycan	3	6	PF01048	0.613
MOD_GSK3_1	208	215	PF00069	0.524
MOD_GSK3_1	238	245	PF00069	0.656
MOD_GSK3_1	344	351	PF00069	0.421
MOD_GSK3_1	436	443	PF00069	0.480
MOD_N-GLC_1	302	307	PF02516	0.389
MOD_N-GLC_1	420	425	PF02516	0.351
MOD_NEK2_1	1	6	PF00069	0.595
MOD_NEK2_1	143	148	PF00069	0.521
MOD_NEK2_1	348	353	PF00069	0.396
MOD_NEK2_1	60	65	PF00069	0.297
MOD_NEK2_2	137	142	PF00069	0.433
MOD_NEK2_2	35	40	PF00069	0.286
MOD_PIKK_1	180	186	PF00454	0.467
MOD_PKA_1	40	46	PF00069	0.403
MOD_PKA_2	1	7	PF00069	0.668
MOD_PKA_2	237	243	PF00069	0.586
MOD_PKA_2	309	315	PF00069	0.490
MOD_PKA_2	332	338	PF00069	0.503
MOD_PKA_2	40	46	PF00069	0.403
MOD_Plk_1	222	228	PF00069	0.496
MOD_Plk_1	389	395	PF00069	0.398
MOD_Plk_1	87	93	PF00069	0.368
MOD_Plk_2-3	217	223	PF00069	0.526
MOD_Plk_4	217	223	PF00069	0.591
MOD_Plk_4	389	395	PF00069	0.398
MOD_Plk_4	50	56	PF00069	0.417
MOD_ProDKin_1	440	446	PF00069	0.532
TRG_ENDOCYTIC_2	14	17	PF00928	0.287
TRG_ENDOCYTIC_2	372	375	PF00928	0.389
TRG_ENDOCYTIC_2	422	425	PF00928	0.354
TRG_ER_diArg_1	147	149	PF00400	0.420
TRG_ER_diArg_1	383	385	PF00400	0.411
TRG_ER_diArg_1	39	41	PF00400	0.400
TRG_NES_CRM1_1	152	165	PF08389	0.470
TRG_NES_CRM1_1	340	354	PF08389	0.517
TRG_NLS_MonoCore_2	461	466	PF00514	0.547
TRG_NLS_MonoExtC_3	461	466	PF00514	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA99	Leptomonas seymouri	79%	98%
A0A0S4IZC9	Bodo saltans	53%	99%
A0A1X0NLD2	Trypanosomatidae	62%	98%
A0A3S5H591	Leishmania donovani	97%	100%
A0A422NNG2	Trypanosoma rangeli	65%	97%
A4H3U7	Leishmania braziliensis	91%	100%
A4HS22	Leishmania infantum	97%	100%
C9ZY15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AK09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5B964	Trypanosoma cruzi	62%	98%