TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q9XZY6_LEIMA

TriTrypDb:

LmjF.04.0260 , LMJLV39_040007400 , LMJSD75_040007500

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q9XZY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9XZY6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.696
CLV_NRD_NRD_1	199	201	PF00675	0.372
CLV_NRD_NRD_1	221	223	PF00675	0.504
CLV_NRD_NRD_1	251	253	PF00675	0.488
CLV_NRD_NRD_1	99	101	PF00675	0.589
CLV_PCSK_KEX2_1	199	201	PF00082	0.367
CLV_PCSK_KEX2_1	221	223	PF00082	0.504
CLV_PCSK_KEX2_1	99	101	PF00082	0.612
CLV_PCSK_SKI1_1	161	165	PF00082	0.445
CLV_PCSK_SKI1_1	173	177	PF00082	0.432
CLV_PCSK_SKI1_1	195	199	PF00082	0.386
CLV_PCSK_SKI1_1	221	225	PF00082	0.477
CLV_PCSK_SKI1_1	264	268	PF00082	0.500
DOC_MAPK_gen_1	199	207	PF00069	0.447
DOC_MAPK_gen_1	258	267	PF00069	0.523
DOC_MAPK_gen_1	51	57	PF00069	0.429
DOC_MAPK_MEF2A_6	258	267	PF00069	0.523
DOC_MAPK_NFAT4_5	260	268	PF00069	0.530
DOC_PP1_RVXF_1	262	268	PF00149	0.493
DOC_USP7_MATH_1	118	122	PF00917	0.719
DOC_USP7_MATH_1	6	10	PF00917	0.759
DOC_WW_Pin1_4	2	7	PF00397	0.723
DOC_WW_Pin1_4	67	72	PF00397	0.603
LIG_14-3-3_CanoR_1	221	226	PF00244	0.549
LIG_14-3-3_CanoR_1	44	49	PF00244	0.481
LIG_BIR_II_1	1	5	PF00653	0.723
LIG_BIR_III_4	83	87	PF00653	0.571
LIG_BRCT_BRCA1_1	184	188	PF00533	0.621
LIG_FHA_1	162	168	PF00498	0.385
LIG_FHA_1	243	249	PF00498	0.521
LIG_FHA_2	110	116	PF00498	0.705
LIG_FHA_2	120	126	PF00498	0.666
LIG_LIR_Nem_3	47	53	PF02991	0.435
LIG_PCNA_PIPBox_1	132	141	PF02747	0.526
LIG_PCNA_yPIPBox_3	128	139	PF02747	0.491
LIG_PCNA_yPIPBox_3	87	101	PF02747	0.664
LIG_SH2_CRK	50	54	PF00017	0.453
LIG_SH2_PTP2	204	207	PF00017	0.529
LIG_SH2_SRC	156	159	PF00017	0.513
LIG_SH2_SRC	60	63	PF00017	0.521
LIG_SH2_STAP1	139	143	PF00017	0.528
LIG_SH2_STAT3	22	25	PF00017	0.562
LIG_SH2_STAT5	204	207	PF00017	0.457
LIG_SH2_STAT5	22	25	PF00017	0.526
LIG_SH2_STAT5	54	57	PF00017	0.379
LIG_SH2_STAT5	60	63	PF00017	0.394
LIG_TRAF2_1	122	125	PF00917	0.637
MOD_CK1_1	189	195	PF00069	0.383
MOD_CK1_1	5	11	PF00069	0.692
MOD_CK2_1	109	115	PF00069	0.746
MOD_CK2_1	118	124	PF00069	0.695
MOD_Cter_Amidation	250	253	PF01082	0.553
MOD_GlcNHglycan	115	119	PF01048	0.716
MOD_GlcNHglycan	184	187	PF01048	0.636
MOD_GlcNHglycan	190	194	PF01048	0.564
MOD_GlcNHglycan	231	234	PF01048	0.682
MOD_GlcNHglycan	67	70	PF01048	0.569
MOD_GlcNHglycan	8	11	PF01048	0.761
MOD_GlcNHglycan	87	90	PF01048	0.379
MOD_GSK3_1	109	116	PF00069	0.733
MOD_GSK3_1	182	189	PF00069	0.619
MOD_GSK3_1	2	9	PF00069	0.653
MOD_NEK2_1	138	143	PF00069	0.439
MOD_NEK2_1	188	193	PF00069	0.568
MOD_PIKK_1	133	139	PF00454	0.560
MOD_PIKK_1	242	248	PF00454	0.511
MOD_PKA_1	221	227	PF00069	0.378
MOD_PKA_2	113	119	PF00069	0.710
MOD_PKA_2	186	192	PF00069	0.561
MOD_PKA_2	221	227	PF00069	0.471
MOD_Plk_1	114	120	PF00069	0.729
MOD_Plk_1	133	139	PF00069	0.496
MOD_ProDKin_1	2	8	PF00069	0.725
MOD_ProDKin_1	67	73	PF00069	0.601
MOD_SUMO_rev_2	255	263	PF00179	0.554
MOD_SUMO_rev_2	47	53	PF00179	0.440
TRG_DiLeu_BaEn_4	124	130	PF01217	0.565
TRG_DiLeu_BaEn_4	133	139	PF01217	0.368
TRG_ENDOCYTIC_2	204	207	PF00928	0.500
TRG_ENDOCYTIC_2	50	53	PF00928	0.428
TRG_ENDOCYTIC_2	54	57	PF00928	0.424
TRG_ER_diArg_1	198	200	PF00400	0.376
TRG_ER_diArg_1	220	222	PF00400	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZG7	Leptomonas seymouri	52%	86%
A0A0S4J1V3	Bodo saltans	32%	100%
A0A1X0NLP6	Trypanosomatidae	32%	100%
A0A3R7L3M0	Trypanosoma rangeli	31%	100%
A0A3S5H590	Leishmania donovani	93%	100%
A4H3U6	Leishmania braziliensis	73%	97%
A4HS21	Leishmania infantum	93%	100%
C9ZY14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AK08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%