GRAM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GRAM domain containing protein, putative

Species:

Leishmania major

UniProt:

Q9XZY4_LEIMA

TriTrypDb:

LmjF.04.0240 , LMJLV39_040007200 , LMJSD75_040007300

Length:

290

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q9XZY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9XZY4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	43	45	PF00675	0.646
CLV_NRD_NRD_1	59	61	PF00675	0.476
CLV_PCSK_KEX2_1	43	45	PF00082	0.447
CLV_PCSK_KEX2_1	49	51	PF00082	0.418
CLV_PCSK_KEX2_1	59	61	PF00082	0.404
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.395
CLV_PCSK_SKI1_1	50	54	PF00082	0.640
DEG_Nend_UBRbox_3	1	3	PF02207	0.661
DEG_SPOP_SBC_1	155	159	PF00917	0.368
DOC_CKS1_1	145	150	PF01111	0.229
DOC_MAPK_JIP1_4	229	235	PF00069	0.437
DOC_PP2B_LxvP_1	223	226	PF13499	0.434
DOC_USP7_MATH_1	133	137	PF00917	0.294
DOC_USP7_MATH_1	89	93	PF00917	0.631
DOC_WW_Pin1_4	144	149	PF00397	0.229
DOC_WW_Pin1_4	34	39	PF00397	0.451
LIG_14-3-3_CanoR_1	130	138	PF00244	0.462
LIG_14-3-3_CanoR_1	176	185	PF00244	0.500
LIG_14-3-3_CanoR_1	254	258	PF00244	0.449
LIG_14-3-3_CanoR_1	59	69	PF00244	0.663
LIG_eIF4E_1	12	18	PF01652	0.554
LIG_FHA_1	156	162	PF00498	0.462
LIG_FHA_1	163	169	PF00498	0.473
LIG_FHA_1	254	260	PF00498	0.483
LIG_FHA_1	280	286	PF00498	0.528
LIG_FHA_2	264	270	PF00498	0.507
LIG_FHA_2	35	41	PF00498	0.466
LIG_FHA_2	91	97	PF00498	0.659
LIG_LIR_Gen_1	147	155	PF02991	0.368
LIG_LIR_Gen_1	240	251	PF02991	0.447
LIG_LIR_Gen_1	269	278	PF02991	0.352
LIG_LIR_Nem_3	147	153	PF02991	0.353
LIG_LIR_Nem_3	269	275	PF02991	0.351
LIG_Pex14_2	111	115	PF04695	0.344
LIG_SH2_CRK	22	26	PF00017	0.526
LIG_SH2_PTP2	14	17	PF00017	0.444
LIG_SH2_SRC	12	15	PF00017	0.523
LIG_SH2_SRC	274	277	PF00017	0.365
LIG_SH2_STAT5	14	17	PF00017	0.464
LIG_SH2_STAT5	150	153	PF00017	0.336
LIG_SH2_STAT5	22	25	PF00017	0.565
LIG_SH2_STAT5	236	239	PF00017	0.435
LIG_SH2_STAT5	274	277	PF00017	0.365
LIG_SH3_1	22	28	PF00018	0.450
LIG_SH3_3	22	28	PF00018	0.432
LIG_SUMO_SIM_par_1	194	200	PF11976	0.376
LIG_SUMO_SIM_par_1	255	261	PF11976	0.401
LIG_TRFH_1	220	224	PF08558	0.532
LIG_UBA3_1	69	74	PF00899	0.698
MOD_CK1_1	250	256	PF00069	0.557
MOD_CK1_1	64	70	PF00069	0.719
MOD_CK1_1	72	78	PF00069	0.584
MOD_CK1_1	92	98	PF00069	0.413
MOD_CK2_1	34	40	PF00069	0.477
MOD_CK2_1	90	96	PF00069	0.584
MOD_GlcNHglycan	131	134	PF01048	0.334
MOD_GlcNHglycan	135	138	PF01048	0.325
MOD_GlcNHglycan	179	182	PF01048	0.571
MOD_GlcNHglycan	64	67	PF01048	0.598
MOD_GlcNHglycan	74	77	PF01048	0.597
MOD_GSK3_1	129	136	PF00069	0.357
MOD_GSK3_1	157	164	PF00069	0.525
MOD_GSK3_1	200	207	PF00069	0.379
MOD_GSK3_1	224	231	PF00069	0.550
MOD_GSK3_1	60	67	PF00069	0.639
MOD_GSK3_1	90	97	PF00069	0.562
MOD_NEK2_1	154	159	PF00069	0.345
MOD_NEK2_1	20	25	PF00069	0.497
MOD_NEK2_1	62	67	PF00069	0.710
MOD_NEK2_1	69	74	PF00069	0.688
MOD_PIKK_1	234	240	PF00454	0.434
MOD_PIKK_1	75	81	PF00454	0.638
MOD_PIKK_1	94	100	PF00454	0.558
MOD_PKA_2	129	135	PF00069	0.462
MOD_PKA_2	20	26	PF00069	0.359
MOD_PKA_2	228	234	PF00069	0.480
MOD_PKA_2	253	259	PF00069	0.677
MOD_PKA_2	279	285	PF00069	0.468
MOD_Plk_4	204	210	PF00069	0.411
MOD_Plk_4	247	253	PF00069	0.428
MOD_ProDKin_1	144	150	PF00069	0.229
MOD_ProDKin_1	34	40	PF00069	0.450
TRG_ENDOCYTIC_2	12	15	PF00928	0.500
TRG_ENDOCYTIC_2	150	153	PF00928	0.367
TRG_ENDOCYTIC_2	243	246	PF00928	0.451
TRG_ENDOCYTIC_2	272	275	PF00928	0.344
TRG_ER_diArg_1	185	188	PF00400	0.582
TRG_ER_diArg_1	42	44	PF00400	0.450
TRG_Pf-PMV_PEXEL_1	100	105	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAZ3	Leptomonas seymouri	50%	85%
A0A0S4IUM5	Bodo saltans	33%	98%
A0A1X0NMU9	Trypanosomatidae	44%	100%
A0A3R7NSA7	Trypanosoma rangeli	43%	97%
A0A3S5H589	Leishmania donovani	93%	100%
A4H3U4	Leishmania braziliensis	56%	91%
A4HS19	Leishmania infantum	93%	100%
C9ZY11	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	98%
E9AK06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BA94	Trypanosoma cruzi	24%	80%
V5D9R6	Trypanosoma cruzi	41%	96%