Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

Q9XZY2_LEIMA

TriTrypDb:

LmjF.04.0220 , LMJLV39_040007000 , LMJSD75_040007100

Length:

354

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26167471
Might belong to a Kinetoplastid-specific lectin domain protein family. Experiments of homologues indicate them to localize to ER (PMID: 26167471). Highly expanded in the Trypanosoma genus, while relatively limited in Leishmaniids.. Localization: ER (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 7, no: 5
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q9XZY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9XZY2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.432
CLV_C14_Caspase3-7	221	225	PF00656	0.526
CLV_NRD_NRD_1	171	173	PF00675	0.642
CLV_NRD_NRD_1	317	319	PF00675	0.471
CLV_NRD_NRD_1	326	328	PF00675	0.438
CLV_PCSK_KEX2_1	171	173	PF00082	0.753
CLV_PCSK_KEX2_1	317	319	PF00082	0.446
CLV_PCSK_KEX2_1	326	328	PF00082	0.462
CLV_PCSK_PC7_1	313	319	PF00082	0.461
DEG_MDM2_SWIB_1	263	270	PF02201	0.330
DOC_CYCLIN_yCln2_LP_2	178	184	PF00134	0.438
DOC_PP4_FxxP_1	182	185	PF00568	0.442
DOC_PP4_FxxP_1	37	40	PF00568	0.400
DOC_USP7_MATH_1	144	148	PF00917	0.443
DOC_USP7_MATH_1	32	36	PF00917	0.420
DOC_USP7_MATH_1	75	79	PF00917	0.365
DOC_WW_Pin1_4	256	261	PF00397	0.377
LIG_14-3-3_CanoR_1	134	138	PF00244	0.492
LIG_14-3-3_CanoR_1	162	168	PF00244	0.444
LIG_14-3-3_CanoR_1	217	223	PF00244	0.413
LIG_14-3-3_CanoR_1	317	325	PF00244	0.669
LIG_BRCT_BRCA1_1	272	276	PF00533	0.299
LIG_BRCT_BRCA1_1	77	81	PF00533	0.374
LIG_deltaCOP1_diTrp_1	114	121	PF00928	0.419
LIG_deltaCOP1_diTrp_1	265	272	PF00928	0.256
LIG_FHA_1	144	150	PF00498	0.459
LIG_FHA_1	154	160	PF00498	0.480
LIG_FHA_1	20	26	PF00498	0.506
LIG_FHA_1	205	211	PF00498	0.448
LIG_FHA_1	63	69	PF00498	0.394
LIG_FHA_2	122	128	PF00498	0.571
LIG_FHA_2	219	225	PF00498	0.521
LIG_FHA_2	234	240	PF00498	0.400
LIG_FHA_2	43	49	PF00498	0.377
LIG_LIR_Apic_2	34	40	PF02991	0.407
LIG_LIR_Gen_1	265	276	PF02991	0.259
LIG_LIR_Gen_1	282	288	PF02991	0.251
LIG_LIR_Gen_1	82	93	PF02991	0.392
LIG_LIR_Nem_3	102	108	PF02991	0.423
LIG_LIR_Nem_3	239	243	PF02991	0.356
LIG_LIR_Nem_3	265	271	PF02991	0.288
LIG_LIR_Nem_3	282	286	PF02991	0.257
LIG_LIR_Nem_3	78	84	PF02991	0.394
LIG_Pex14_1	117	121	PF04695	0.426
LIG_Pex14_1	211	215	PF04695	0.484
LIG_Pex14_1	267	271	PF04695	0.345
LIG_Pex14_2	176	180	PF04695	0.425
LIG_Pex14_2	263	267	PF04695	0.435
LIG_Pex14_2	272	276	PF04695	0.333
LIG_SH2_CRK	28	32	PF00017	0.405
LIG_SH2_CRK	85	89	PF00017	0.413
LIG_SH2_SRC	38	41	PF00017	0.378
LIG_SH2_STAP1	169	173	PF00017	0.451
LIG_SH2_STAT3	161	164	PF00017	0.436
LIG_SH2_STAT3	319	322	PF00017	0.684
LIG_SH2_STAT5	319	322	PF00017	0.691
LIG_SH2_STAT5	38	41	PF00017	0.370
LIG_SH2_STAT5	59	62	PF00017	0.412
LIG_SH3_3	178	184	PF00018	0.444
LIG_Sin3_3	64	71	PF02671	0.401
LIG_SUMO_SIM_anti_2	12	18	PF11976	0.430
LIG_SUMO_SIM_anti_2	282	288	PF11976	0.399
LIG_SUMO_SIM_par_1	6	12	PF11976	0.435
LIG_WRC_WIRS_1	280	285	PF05994	0.299
LIG_WW_1	184	187	PF00397	0.433
MOD_CK1_1	321	327	PF00069	0.693
MOD_CK1_1	328	334	PF00069	0.697
MOD_CK1_1	338	344	PF00069	0.807
MOD_CK2_1	341	347	PF00069	0.690
MOD_CK2_1	42	48	PF00069	0.377
MOD_GlcNHglycan	146	149	PF01048	0.658
MOD_GlcNHglycan	332	335	PF01048	0.534
MOD_GSK3_1	117	124	PF00069	0.487
MOD_GSK3_1	254	261	PF00069	0.450
MOD_GSK3_1	321	328	PF00069	0.721
MOD_GSK3_1	329	336	PF00069	0.765
MOD_GSK3_1	40	47	PF00069	0.342
MOD_GSK3_1	75	82	PF00069	0.436
MOD_N-GLC_1	117	122	PF02516	0.568
MOD_N-GLC_1	341	346	PF02516	0.531
MOD_N-GLC_2	129	131	PF02516	0.630
MOD_NEK2_1	121	126	PF00069	0.420
MOD_NEK2_2	32	37	PF00069	0.339
MOD_PIKK_1	119	125	PF00454	0.452
MOD_PIKK_1	243	249	PF00454	0.497
MOD_PIKK_1	258	264	PF00454	0.429
MOD_PIKK_1	318	324	PF00454	0.692
MOD_PKA_2	133	139	PF00069	0.490
MOD_PKA_2	325	331	PF00069	0.681
MOD_Plk_1	117	123	PF00069	0.450
MOD_Plk_1	233	239	PF00069	0.403
MOD_Plk_1	62	68	PF00069	0.461
MOD_Plk_4	32	38	PF00069	0.377
MOD_Plk_4	80	86	PF00069	0.444
MOD_Plk_4	9	15	PF00069	0.335
MOD_ProDKin_1	256	262	PF00069	0.372
MOD_SUMO_rev_2	147	156	PF00179	0.403
MOD_SUMO_rev_2	234	243	PF00179	0.352
TRG_ENDOCYTIC_2	28	31	PF00928	0.422
TRG_ENDOCYTIC_2	84	87	PF00928	0.407
TRG_ER_diArg_1	171	173	PF00400	0.553
TRG_ER_diArg_1	317	319	PF00400	0.652
TRG_ER_diArg_1	325	327	PF00400	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY91	Leptomonas seymouri	47%	100%
A0A0N1PG18	Leptomonas seymouri	36%	79%
A0A3S5H587	Leishmania donovani	92%	100%
A0A3S5H6P8	Leishmania donovani	35%	84%
A4H3U3	Leishmania braziliensis	81%	99%
A4H7B4	Leishmania braziliensis	34%	84%
A4HS17	Leishmania infantum	93%	100%
A4HVQ9	Leishmania infantum	35%	84%
E9AK04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9APF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	85%
Q4QG23	Leishmania major	33%	100%