Surface antigen-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen-like protein

Species:

Leishmania major

UniProt:

Q9XZY1_LEIMA

TriTrypDb:

LmjF.04.0210 , LMJLV39_040006900 , LMJSD75_040007000

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 1
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q9XZY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9XZY1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	247	249	PF00675	0.754
CLV_NRD_NRD_1	55	57	PF00675	0.558
CLV_PCSK_KEX2_1	12	14	PF00082	0.677
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.677
DEG_SPOP_SBC_1	155	159	PF00917	0.565
DEG_SPOP_SBC_1	167	171	PF00917	0.442
DOC_MAPK_gen_1	12	20	PF00069	0.635
DOC_MAPK_gen_1	56	63	PF00069	0.409
DOC_MAPK_MEF2A_6	13	22	PF00069	0.533
DOC_USP7_MATH_1	168	172	PF00917	0.572
DOC_USP7_MATH_1	210	214	PF00917	0.439
DOC_USP7_MATH_1	247	251	PF00917	0.469
DOC_USP7_MATH_1	5	9	PF00917	0.539
DOC_WW_Pin1_4	146	151	PF00397	0.510
DOC_WW_Pin1_4	253	258	PF00397	0.494
DOC_WW_Pin1_4	73	78	PF00397	0.418
LIG_14-3-3_CanoR_1	127	135	PF00244	0.434
LIG_14-3-3_CanoR_1	229	237	PF00244	0.384
LIG_FHA_1	106	112	PF00498	0.305
LIG_FHA_1	190	196	PF00498	0.403
LIG_FHA_1	256	262	PF00498	0.322
LIG_FHA_1	27	33	PF00498	0.508
LIG_FHA_1	91	97	PF00498	0.413
LIG_FHA_2	34	40	PF00498	0.499
LIG_LIR_Gen_1	240	247	PF02991	0.413
LIG_LIR_Nem_3	240	246	PF02991	0.457
LIG_LIR_Nem_3	38	43	PF02991	0.399
LIG_LYPXL_yS_3	117	120	PF13949	0.414
LIG_LYPXL_yS_3	40	43	PF13949	0.432
LIG_SH2_CRK	243	247	PF00017	0.409
LIG_SH2_NCK_1	243	247	PF00017	0.409
LIG_SH2_STAP1	191	195	PF00017	0.404
LIG_SH2_STAP1	237	241	PF00017	0.408
LIG_SH2_STAP1	71	75	PF00017	0.359
LIG_SH2_STAT5	123	126	PF00017	0.461
LIG_SH2_STAT5	191	194	PF00017	0.396
LIG_SH2_STAT5	243	246	PF00017	0.404
LIG_SH3_3	108	114	PF00018	0.364
LIG_SH3_3	74	80	PF00018	0.456
LIG_SUMO_SIM_par_1	28	33	PF11976	0.580
LIG_SUMO_SIM_par_1	59	65	PF11976	0.406
LIG_SxIP_EBH_1	239	249	PF03271	0.421
LIG_TYR_ITIM	115	120	PF00017	0.422
LIG_TYR_ITIM	241	246	PF00017	0.414
LIG_UBA3_1	60	68	PF00899	0.400
MOD_CK1_1	138	144	PF00069	0.545
MOD_CK1_1	149	155	PF00069	0.534
MOD_CK1_1	171	177	PF00069	0.460
MOD_CK1_1	181	187	PF00069	0.417
MOD_CK1_1	232	238	PF00069	0.393
MOD_CK1_1	33	39	PF00069	0.485
MOD_CK1_1	62	68	PF00069	0.389
MOD_CK2_1	228	234	PF00069	0.407
MOD_GlcNHglycan	170	173	PF01048	0.689
MOD_GlcNHglycan	197	200	PF01048	0.662
MOD_GlcNHglycan	204	207	PF01048	0.581
MOD_GlcNHglycan	234	237	PF01048	0.577
MOD_GlcNHglycan	249	252	PF01048	0.720
MOD_GlcNHglycan	32	35	PF01048	0.649
MOD_GSK3_1	126	133	PF00069	0.517
MOD_GSK3_1	135	142	PF00069	0.494
MOD_GSK3_1	144	151	PF00069	0.488
MOD_GSK3_1	157	164	PF00069	0.586
MOD_GSK3_1	167	174	PF00069	0.484
MOD_GSK3_1	210	217	PF00069	0.496
MOD_GSK3_1	228	235	PF00069	0.335
MOD_GSK3_1	237	244	PF00069	0.401
MOD_GSK3_1	26	33	PF00069	0.510
MOD_GSK3_1	69	76	PF00069	0.418
MOD_N-GLC_2	228	230	PF02516	0.602
MOD_NEK2_1	202	207	PF00069	0.384
MOD_NEK2_1	239	244	PF00069	0.424
MOD_NEK2_1	30	35	PF00069	0.577
MOD_OFUCOSY	177	182	PF10250	0.621
MOD_OFUCOSY	208	214	PF10250	0.740
MOD_PKA_2	126	132	PF00069	0.422
MOD_PKA_2	228	234	PF00069	0.366
MOD_PKA_2	247	253	PF00069	0.534
MOD_Plk_4	119	125	PF00069	0.433
MOD_ProDKin_1	146	152	PF00069	0.511
MOD_ProDKin_1	253	259	PF00069	0.493
MOD_ProDKin_1	73	79	PF00069	0.423
TRG_DiLeu_BaLyEn_6	256	261	PF01217	0.267
TRG_ENDOCYTIC_2	117	120	PF00928	0.414
TRG_ENDOCYTIC_2	243	246	PF00928	0.404
TRG_ENDOCYTIC_2	40	43	PF00928	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZJ5	Leptomonas seymouri	35%	100%
A0A3S5H586	Leishmania donovani	79%	97%
A4H439	Leishmania braziliensis	29%	88%
A4H440	Leishmania braziliensis	27%	93%
A4H446	Leishmania braziliensis	33%	100%
A4HS16	Leishmania infantum	79%	96%
E9AK03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%