LeishMANIAdb
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Surface antigen-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Surface antigen-like protein
Gene product:
surface antigen-like protein
Species:
Leishmania major
UniProt:
Q9XZX9_LEIMA
TriTrypDb:
LmjF.04.0190 , LMJLV39_040006700 * , LMJSD75_040006700 *
Length:
709

Annotations

LeishMANIAdb annotations

A strange, fast-evolving receptor-like family of parazitic Kinetoplastids. While absent from many species, this family has expanded enormously on the Angomonas and Strigomonas lineages.. Very likely GPI-anchored protein. Very putatively might be involved in interactions with bacteria, explaining its expansion in symbiontic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 80
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 16, no: 6
NetGPI no yes: 0, no: 22
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

Q9XZX9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9XZX9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0008233 peptidase activity 3 3
GO:0016787 hydrolase activity 2 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 108 112 PF00656 0.320
CLV_C14_Caspase3-7 419 423 PF00656 0.314
CLV_PCSK_SKI1_1 192 196 PF00082 0.495
CLV_PCSK_SKI1_1 221 225 PF00082 0.518
CLV_PCSK_SKI1_1 232 236 PF00082 0.596
CLV_PCSK_SKI1_1 285 289 PF00082 0.542
DEG_MDM2_SWIB_1 215 223 PF02201 0.307
DEG_Nend_UBRbox_1 1 4 PF02207 0.629
DEG_SCF_FBW7_1 522 527 PF00400 0.371
DOC_CKS1_1 521 526 PF01111 0.374
DOC_CKS1_1 543 548 PF01111 0.383
DOC_MAPK_gen_1 2 11 PF00069 0.629
DOC_PP1_SILK_1 80 85 PF00149 0.315
DOC_PP2B_PxIxI_1 237 243 PF00149 0.313
DOC_PP2B_PxIxI_1 314 320 PF00149 0.412
DOC_USP7_MATH_1 147 151 PF00917 0.367
DOC_USP7_MATH_1 246 250 PF00917 0.343
DOC_USP7_MATH_1 68 72 PF00917 0.449
DOC_WW_Pin1_4 261 266 PF00397 0.374
DOC_WW_Pin1_4 520 525 PF00397 0.377
DOC_WW_Pin1_4 526 531 PF00397 0.347
DOC_WW_Pin1_4 542 547 PF00397 0.320
DOC_WW_Pin1_4 551 556 PF00397 0.330
DOC_WW_Pin1_4 602 607 PF00397 0.382
LIG_14-3-3_CanoR_1 149 155 PF00244 0.312
LIG_14-3-3_CanoR_1 225 231 PF00244 0.310
LIG_14-3-3_CanoR_1 285 290 PF00244 0.341
LIG_14-3-3_CanoR_1 434 438 PF00244 0.342
LIG_14-3-3_CanoR_1 566 574 PF00244 0.347
LIG_14-3-3_CanoR_1 84 89 PF00244 0.418
LIG_Actin_WH2_2 209 227 PF00022 0.300
LIG_BIR_III_4 111 115 PF00653 0.323
LIG_BRCT_BRCA1_1 164 168 PF00533 0.286
LIG_BRCT_BRCA1_1 37 41 PF00533 0.411
LIG_Clathr_ClatBox_1 256 260 PF01394 0.310
LIG_eIF4E_1 520 526 PF01652 0.361
LIG_FHA_1 158 164 PF00498 0.359
LIG_FHA_1 211 217 PF00498 0.342
LIG_FHA_1 264 270 PF00498 0.327
LIG_FHA_1 299 305 PF00498 0.414
LIG_FHA_1 330 336 PF00498 0.422
LIG_FHA_1 377 383 PF00498 0.360
LIG_FHA_1 393 399 PF00498 0.404
LIG_FHA_1 521 527 PF00498 0.359
LIG_FHA_1 581 587 PF00498 0.346
LIG_FHA_2 106 112 PF00498 0.318
LIG_FHA_2 304 310 PF00498 0.461
LIG_GBD_Chelix_1 531 539 PF00786 0.575
LIG_LIR_Gen_1 213 223 PF02991 0.308
LIG_LIR_Gen_1 361 370 PF02991 0.344
LIG_LIR_Gen_1 37 47 PF02991 0.449
LIG_LIR_Gen_1 387 394 PF02991 0.359
LIG_LIR_Gen_1 673 684 PF02991 0.342
LIG_LIR_Gen_1 91 102 PF02991 0.305
LIG_LIR_Nem_3 213 218 PF02991 0.304
LIG_LIR_Nem_3 358 363 PF02991 0.330
LIG_LIR_Nem_3 37 42 PF02991 0.505
LIG_LIR_Nem_3 387 391 PF02991 0.376
LIG_LIR_Nem_3 559 564 PF02991 0.346
LIG_LIR_Nem_3 673 679 PF02991 0.361
LIG_LIR_Nem_3 91 97 PF02991 0.300
LIG_Pex14_2 215 219 PF04695 0.303
LIG_PTB_Apo_2 251 258 PF02174 0.306
LIG_PTB_Apo_2 346 353 PF02174 0.371
LIG_PTB_Apo_2 359 366 PF02174 0.323
LIG_PTB_Apo_2 628 635 PF02174 0.375
LIG_PTB_Phospho_1 359 365 PF10480 0.337
LIG_PTB_Phospho_1 628 634 PF10480 0.374
LIG_SH2_CRK 363 367 PF00017 0.344
LIG_SH2_CRK 561 565 PF00017 0.342
LIG_SH2_CRK 676 680 PF00017 0.355
LIG_SH2_GRB2like 360 363 PF00017 0.338
LIG_SH2_NCK_1 676 680 PF00017 0.318
LIG_SH2_PTP2 94 97 PF00017 0.290
LIG_SH2_STAP1 130 134 PF00017 0.300
LIG_SH2_STAP1 360 364 PF00017 0.344
LIG_SH2_STAP1 594 598 PF00017 0.367
LIG_SH2_STAP1 691 695 PF00017 0.316
LIG_SH2_STAT3 130 133 PF00017 0.306
LIG_SH2_STAT5 100 103 PF00017 0.308
LIG_SH2_STAT5 360 363 PF00017 0.346
LIG_SH2_STAT5 365 368 PF00017 0.337
LIG_SH2_STAT5 521 524 PF00017 0.378
LIG_SH2_STAT5 556 559 PF00017 0.343
LIG_SH2_STAT5 629 632 PF00017 0.378
LIG_SH2_STAT5 635 638 PF00017 0.359
LIG_SH2_STAT5 648 651 PF00017 0.317
LIG_SH2_STAT5 670 673 PF00017 0.357
LIG_SH2_STAT5 94 97 PF00017 0.290
LIG_SH3_2 543 548 PF14604 0.377
LIG_SH3_3 152 158 PF00018 0.354
LIG_SH3_3 180 186 PF00018 0.314
LIG_SH3_3 259 265 PF00018 0.330
LIG_SH3_3 540 546 PF00018 0.368
LIG_SUMO_SIM_anti_2 131 142 PF11976 0.300
LIG_SUMO_SIM_anti_2 178 185 PF11976 0.284
LIG_SUMO_SIM_anti_2 316 323 PF11976 0.430
LIG_SUMO_SIM_anti_2 8 13 PF11976 0.294
LIG_TRAF2_1 48 51 PF00917 0.364
LIG_TRFH_1 520 524 PF08558 0.372
LIG_WRC_WIRS_1 701 706 PF05994 0.264
MOD_CDK_SPxK_1 542 548 PF00069 0.379
MOD_CK1_1 141 147 PF00069 0.403
MOD_CK1_1 150 156 PF00069 0.309
MOD_CK1_1 172 178 PF00069 0.292
MOD_CK1_1 187 193 PF00069 0.317
MOD_CK1_1 227 233 PF00069 0.378
MOD_CK1_1 263 269 PF00069 0.355
MOD_CK1_1 37 43 PF00069 0.522
MOD_CK1_1 45 51 PF00069 0.409
MOD_CK1_1 473 479 PF00069 0.396
MOD_CK1_1 505 511 PF00069 0.351
MOD_CK1_1 602 608 PF00069 0.387
MOD_CK1_1 674 680 PF00069 0.327
MOD_CK1_1 70 76 PF00069 0.405
MOD_CK2_1 176 182 PF00069 0.300
MOD_CK2_1 45 51 PF00069 0.382
MOD_GlcNHglycan 111 115 PF01048 0.557
MOD_GlcNHglycan 149 152 PF01048 0.617
MOD_GlcNHglycan 192 195 PF01048 0.525
MOD_GlcNHglycan 244 247 PF01048 0.672
MOD_GlcNHglycan 368 371 PF01048 0.520
MOD_GlcNHglycan 45 48 PF01048 0.705
MOD_GlcNHglycan 596 599 PF01048 0.544
MOD_GlcNHglycan 685 688 PF01048 0.619
MOD_GSK3_1 1 8 PF00069 0.635
MOD_GSK3_1 124 131 PF00069 0.328
MOD_GSK3_1 132 139 PF00069 0.339
MOD_GSK3_1 157 164 PF00069 0.324
MOD_GSK3_1 172 179 PF00069 0.369
MOD_GSK3_1 242 249 PF00069 0.443
MOD_GSK3_1 260 267 PF00069 0.431
MOD_GSK3_1 288 295 PF00069 0.406
MOD_GSK3_1 331 338 PF00069 0.381
MOD_GSK3_1 366 373 PF00069 0.342
MOD_GSK3_1 392 399 PF00069 0.384
MOD_GSK3_1 45 52 PF00069 0.386
MOD_GSK3_1 473 480 PF00069 0.396
MOD_GSK3_1 520 527 PF00069 0.370
MOD_GSK3_1 565 572 PF00069 0.345
MOD_GSK3_1 594 601 PF00069 0.362
MOD_GSK3_1 657 664 PF00069 0.377
MOD_GSK3_1 670 677 PF00069 0.334
MOD_GSK3_1 70 77 PF00069 0.496
MOD_GSK3_1 84 91 PF00069 0.335
MOD_N-GLC_1 105 110 PF02516 0.514
MOD_N-GLC_1 260 265 PF02516 0.534
MOD_N-GLC_1 376 381 PF02516 0.545
MOD_N-GLC_2 351 353 PF02516 0.597
MOD_N-GLC_2 448 450 PF02516 0.516
MOD_N-GLC_2 462 464 PF02516 0.534
MOD_N-GLC_2 511 513 PF02516 0.536
MOD_N-GLC_2 617 619 PF02516 0.566
MOD_NEK2_1 1 6 PF00069 0.651
MOD_NEK2_1 163 168 PF00069 0.356
MOD_NEK2_1 170 175 PF00069 0.382
MOD_NEK2_1 224 229 PF00069 0.393
MOD_NEK2_1 296 301 PF00069 0.364
MOD_NEK2_1 366 371 PF00069 0.339
MOD_NEK2_1 376 381 PF00069 0.359
MOD_NEK2_1 394 399 PF00069 0.411
MOD_NEK2_1 426 431 PF00069 0.337
MOD_NEK2_1 657 662 PF00069 0.386
MOD_NEK2_1 671 676 PF00069 0.326
MOD_NEK2_1 700 705 PF00069 0.316
MOD_NEK2_1 83 88 PF00069 0.418
MOD_NEK2_2 280 285 PF00069 0.336
MOD_NEK2_2 371 376 PF00069 0.321
MOD_OFUCOSY 368 375 PF10250 0.523
MOD_OFUCOSY 474 481 PF10250 0.593
MOD_PIKK_1 172 178 PF00454 0.332
MOD_PIKK_1 187 193 PF00454 0.364
MOD_PIKK_1 28 34 PF00454 0.407
MOD_PIKK_1 479 485 PF00454 0.358
MOD_PIKK_1 511 517 PF00454 0.337
MOD_PIKK_1 605 611 PF00454 0.408
MOD_PIKK_1 677 683 PF00454 0.368
MOD_PKA_2 1 7 PF00069 0.633
MOD_PKA_2 102 108 PF00069 0.289
MOD_PKA_2 224 230 PF00069 0.376
MOD_PKA_2 384 390 PF00069 0.372
MOD_PKA_2 433 439 PF00069 0.342
MOD_PKA_2 565 571 PF00069 0.345
MOD_PKA_2 83 89 PF00069 0.378
MOD_Plk_1 105 111 PF00069 0.319
MOD_Plk_1 139 145 PF00069 0.400
MOD_Plk_1 219 225 PF00069 0.398
MOD_Plk_1 252 258 PF00069 0.427
MOD_Plk_1 49 55 PF00069 0.415
MOD_Plk_1 74 80 PF00069 0.365
MOD_Plk_4 132 138 PF00069 0.344
MOD_Plk_4 150 156 PF00069 0.342
MOD_Plk_4 163 169 PF00069 0.273
MOD_Plk_4 176 182 PF00069 0.436
MOD_Plk_4 252 258 PF00069 0.377
MOD_Plk_4 689 695 PF00069 0.316
MOD_Plk_4 84 90 PF00069 0.372
MOD_ProDKin_1 261 267 PF00069 0.370
MOD_ProDKin_1 520 526 PF00069 0.375
MOD_ProDKin_1 542 548 PF00069 0.379
MOD_ProDKin_1 551 557 PF00069 0.330
MOD_ProDKin_1 602 608 PF00069 0.390
TRG_DiLeu_BaEn_2 252 258 PF01217 0.313
TRG_DiLeu_BaLyEn_6 235 240 PF01217 0.334
TRG_DiLeu_BaLyEn_6 521 526 PF01217 0.362
TRG_ENDOCYTIC_2 363 366 PF00928 0.340
TRG_ENDOCYTIC_2 388 391 PF00928 0.380
TRG_ENDOCYTIC_2 488 491 PF00928 0.340
TRG_ENDOCYTIC_2 561 564 PF00928 0.347
TRG_ENDOCYTIC_2 676 679 PF00928 0.352
TRG_ENDOCYTIC_2 94 97 PF00928 0.290
TRG_NES_CRM1_1 207 220 PF08389 0.299

Homologs

Protein Taxonomy Sequence identity Coverage
A0A381M9M8 Leishmania infantum 24% 100%
A0A3S5H581 Leishmania donovani 24% 100%
A0A3S5H583 Leishmania donovani 24% 100%
A0A3S5H584 Leishmania donovani 70% 100%
A0A451EJW1 Leishmania donovani 24% 100%
A0A451EJW4 Leishmania donovani 24% 100%
A0A451EJW6 Leishmania donovani 93% 100%
A4H3T8 Leishmania braziliensis 23% 100%
A4H3T9 Leishmania braziliensis 24% 100%
A4H3U0 Leishmania braziliensis 24% 100%
A4H3U1 Leishmania braziliensis 24% 100%
A4H3Y2 Leishmania braziliensis 30% 100%
A4HS13 Leishmania infantum 70% 100%
A4HS14 Leishmania infantum 93% 100%
E9AJZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9AK00 Leishmania mexicana (strain MHOM/GT/2001/U1103) 69% 100%
E9AK01 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q9N852 Leishmania major 23% 100%
Q9N853 Leishmania major 23% 100%
Q9N856 Leishmania major 23% 100%
Q9XZX8 Leishmania major 73% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS