LeishMANIAdb
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Surface antigen-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Surface antigen-like protein
Gene product:
surface antigen-like protein
Species:
Leishmania major
UniProt:
Q9XZX8_LEIMA
TriTrypDb:
LmjF.04.0180 , LMJLV39_000014000 * , LMJSD75_040006800 *
Length:
504

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 35
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 6, no: 4
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q9XZX8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9XZX8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 121 123 PF00082 0.563
CLV_PCSK_PC1ET2_1 121 123 PF00082 0.563
CLV_PCSK_SKI1_1 154 158 PF00082 0.538
CLV_PCSK_SKI1_1 4 8 PF00082 0.716
DEG_APCC_DBOX_1 121 129 PF00400 0.339
DEG_APCC_DBOX_1 3 11 PF00400 0.532
DEG_Nend_UBRbox_1 1 4 PF02207 0.557
DEG_SCF_FBW7_1 317 322 PF00400 0.444
DOC_ANK_TNKS_1 33 40 PF00023 0.411
DOC_CKS1_1 316 321 PF01111 0.449
DOC_CKS1_1 338 343 PF01111 0.448
DOC_MAPK_gen_1 2 10 PF00069 0.628
DOC_MAPK_MEF2A_6 2 10 PF00069 0.533
DOC_PP1_RVXF_1 152 158 PF00149 0.340
DOC_USP7_MATH_1 146 150 PF00917 0.439
DOC_USP7_MATH_1 156 160 PF00917 0.328
DOC_USP7_MATH_1 177 181 PF00917 0.366
DOC_USP7_MATH_1 220 224 PF00917 0.374
DOC_WW_Pin1_4 16 21 PF00397 0.658
DOC_WW_Pin1_4 315 320 PF00397 0.453
DOC_WW_Pin1_4 321 326 PF00397 0.397
DOC_WW_Pin1_4 337 342 PF00397 0.320
DOC_WW_Pin1_4 346 351 PF00397 0.362
DOC_WW_Pin1_4 397 402 PF00397 0.444
LIG_14-3-3_CanoR_1 361 369 PF00244 0.406
LIG_BRCT_BRCA1_1 179 183 PF00533 0.376
LIG_eIF4E_1 315 321 PF01652 0.425
LIG_FHA_1 229 235 PF00498 0.346
LIG_FHA_1 316 322 PF00498 0.411
LIG_FHA_1 376 382 PF00498 0.409
LIG_FHA_1 55 61 PF00498 0.460
LIG_FHA_1 91 97 PF00498 0.418
LIG_GBD_Chelix_1 326 334 PF00786 0.637
LIG_LIR_Apic_2 251 257 PF02991 0.369
LIG_LIR_Gen_1 468 479 PF02991 0.359
LIG_LIR_Nem_3 127 133 PF02991 0.408
LIG_LIR_Nem_3 354 359 PF02991 0.422
LIG_LIR_Nem_3 468 474 PF02991 0.429
LIG_Pex14_2 41 45 PF04695 0.340
LIG_PTB_Apo_2 423 430 PF02174 0.432
LIG_PTB_Phospho_1 423 429 PF10480 0.433
LIG_SH2_CRK 254 258 PF00017 0.364
LIG_SH2_CRK 356 360 PF00017 0.418
LIG_SH2_CRK 471 475 PF00017 0.421
LIG_SH2_NCK_1 471 475 PF00017 0.334
LIG_SH2_STAP1 248 252 PF00017 0.392
LIG_SH2_STAP1 389 393 PF00017 0.439
LIG_SH2_STAP1 486 490 PF00017 0.404
LIG_SH2_STAT5 197 200 PF00017 0.392
LIG_SH2_STAT5 24 27 PF00017 0.410
LIG_SH2_STAT5 248 251 PF00017 0.383
LIG_SH2_STAT5 254 257 PF00017 0.344
LIG_SH2_STAT5 316 319 PF00017 0.457
LIG_SH2_STAT5 351 354 PF00017 0.406
LIG_SH2_STAT5 424 427 PF00017 0.446
LIG_SH2_STAT5 430 433 PF00017 0.403
LIG_SH2_STAT5 443 446 PF00017 0.318
LIG_SH2_STAT5 465 468 PF00017 0.426
LIG_SH2_STAT5 95 98 PF00017 0.447
LIG_SH3_2 338 343 PF14604 0.448
LIG_SH3_3 335 341 PF00018 0.442
LIG_SH3_3 47 53 PF00018 0.451
LIG_SH3_3 70 76 PF00018 0.404
LIG_SH3_3 93 99 PF00018 0.391
LIG_TRFH_1 315 319 PF08558 0.446
LIG_TRFH_1 95 99 PF08558 0.390
LIG_TYR_ITIM 128 133 PF00017 0.348
LIG_WRC_WIRS_1 496 501 PF05994 0.298
MOD_CDK_SPxK_1 337 343 PF00069 0.444
MOD_CK1_1 144 150 PF00069 0.434
MOD_CK1_1 268 274 PF00069 0.459
MOD_CK1_1 300 306 PF00069 0.417
MOD_CK1_1 397 403 PF00069 0.445
MOD_CK1_1 469 475 PF00069 0.344
MOD_CK1_1 74 80 PF00069 0.375
MOD_CK2_1 113 119 PF00069 0.395
MOD_CK2_1 131 137 PF00069 0.322
MOD_Cter_Amidation 119 122 PF01082 0.593
MOD_GlcNHglycan 133 136 PF01048 0.583
MOD_GlcNHglycan 207 210 PF01048 0.544
MOD_GlcNHglycan 213 216 PF01048 0.535
MOD_GlcNHglycan 218 221 PF01048 0.502
MOD_GlcNHglycan 222 225 PF01048 0.521
MOD_GlcNHglycan 391 394 PF01048 0.578
MOD_GlcNHglycan 45 48 PF01048 0.594
MOD_GlcNHglycan 480 483 PF01048 0.640
MOD_GlcNHglycan 67 70 PF01048 0.634
MOD_GSK3_1 156 163 PF00069 0.355
MOD_GSK3_1 195 202 PF00069 0.354
MOD_GSK3_1 205 212 PF00069 0.336
MOD_GSK3_1 216 223 PF00069 0.333
MOD_GSK3_1 236 243 PF00069 0.292
MOD_GSK3_1 268 275 PF00069 0.465
MOD_GSK3_1 315 322 PF00069 0.445
MOD_GSK3_1 360 367 PF00069 0.393
MOD_GSK3_1 389 396 PF00069 0.422
MOD_GSK3_1 452 459 PF00069 0.441
MOD_GSK3_1 465 472 PF00069 0.363
MOD_N-GLC_1 199 204 PF02516 0.526
MOD_N-GLC_2 101 103 PF02516 0.560
MOD_N-GLC_2 104 106 PF02516 0.565
MOD_N-GLC_2 27 29 PF02516 0.549
MOD_N-GLC_2 306 308 PF02516 0.589
MOD_N-GLC_2 412 414 PF02516 0.636
MOD_NEK2_1 157 162 PF00069 0.388
MOD_NEK2_1 195 200 PF00069 0.370
MOD_NEK2_1 452 457 PF00069 0.454
MOD_NEK2_1 466 471 PF00069 0.343
MOD_NEK2_1 495 500 PF00069 0.404
MOD_OFUCOSY 269 276 PF10250 0.653
MOD_OFUCOSY 72 78 PF10250 0.580
MOD_PIKK_1 141 147 PF00454 0.433
MOD_PIKK_1 274 280 PF00454 0.423
MOD_PIKK_1 306 312 PF00454 0.393
MOD_PIKK_1 400 406 PF00454 0.459
MOD_PIKK_1 472 478 PF00454 0.423
MOD_PKA_2 360 366 PF00069 0.404
MOD_Plk_4 37 43 PF00069 0.408
MOD_Plk_4 484 490 PF00069 0.420
MOD_ProDKin_1 16 22 PF00069 0.653
MOD_ProDKin_1 315 321 PF00069 0.451
MOD_ProDKin_1 337 343 PF00069 0.444
MOD_ProDKin_1 346 352 PF00069 0.362
MOD_ProDKin_1 397 403 PF00069 0.452
TRG_DiLeu_BaLyEn_6 316 321 PF01217 0.414
TRG_ENDOCYTIC_2 130 133 PF00928 0.418
TRG_ENDOCYTIC_2 283 286 PF00928 0.408
TRG_ENDOCYTIC_2 356 359 PF00928 0.424
TRG_ENDOCYTIC_2 471 474 PF00928 0.420
TRG_ER_diArg_1 1 4 PF00400 0.652

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H584 Leishmania donovani 93% 100%
A0A451EJW6 Leishmania donovani 71% 71%
A4H3U2 Leishmania braziliensis 65% 100%
A4H3Y2 Leishmania braziliensis 31% 88%
A4HS13 Leishmania infantum 94% 100%
A4HS14 Leishmania infantum 71% 71%
E9AK00 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9AK01 Leishmania mexicana (strain MHOM/GT/2001/U1103) 67% 71%
Q9XZX9 Leishmania major 73% 71%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS