C-type lectin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

Q9XZX6_LEIMA

TriTrypDb:

LmjF.04.0390 , LMJLV39_040008700 , LMJSD75_040009000

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 1
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q9XZX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9XZX6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.635
CLV_C14_Caspase3-7	236	240	PF00656	0.639
CLV_NRD_NRD_1	184	186	PF00675	0.396
CLV_NRD_NRD_1	227	229	PF00675	0.433
CLV_NRD_NRD_1	84	86	PF00675	0.490
CLV_PCSK_KEX2_1	184	186	PF00082	0.372
CLV_PCSK_KEX2_1	227	229	PF00082	0.433
CLV_PCSK_KEX2_1	84	86	PF00082	0.476
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.372
CLV_PCSK_SKI1_1	69	73	PF00082	0.513
DEG_SPOP_SBC_1	122	126	PF00917	0.266
DOC_MAPK_RevD_3	169	185	PF00069	0.237
DOC_PP2B_LxvP_1	21	24	PF13499	0.320
DOC_USP7_MATH_1	24	28	PF00917	0.370
DOC_USP7_MATH_1	74	78	PF00917	0.351
DOC_WW_Pin1_4	149	154	PF00397	0.399
DOC_WW_Pin1_4	46	51	PF00397	0.415
LIG_14-3-3_CanoR_1	84	89	PF00244	0.264
LIG_BRCT_BRCA1_1	201	205	PF00533	0.750
LIG_CaM_NSCaTE_8	161	168	PF13499	0.197
LIG_deltaCOP1_diTrp_1	83	89	PF00928	0.277
LIG_FHA_1	173	179	PF00498	0.269
LIG_FHA_1	57	63	PF00498	0.313
LIG_FHA_1	85	91	PF00498	0.249
LIG_FHA_2	132	138	PF00498	0.286
LIG_LIR_Apic_2	149	154	PF02991	0.398
LIG_LIR_Gen_1	83	91	PF02991	0.252
LIG_LIR_Nem_3	134	139	PF02991	0.363
LIG_LIR_Nem_3	202	208	PF02991	0.603
LIG_LIR_Nem_3	32	37	PF02991	0.321
LIG_LIR_Nem_3	83	89	PF02991	0.276
LIG_LYPXL_yS_3	139	142	PF13949	0.269
LIG_SH2_CRK	151	155	PF00017	0.464
LIG_SH2_GRB2like	136	139	PF00017	0.302
LIG_SH2_GRB2like	145	148	PF00017	0.318
LIG_SH2_GRB2like	79	82	PF00017	0.274
LIG_SH2_NCK_1	151	155	PF00017	0.396
LIG_SH2_SRC	79	82	PF00017	0.274
LIG_SH2_STAP1	54	58	PF00017	0.305
LIG_SH2_STAT3	145	148	PF00017	0.328
LIG_SH2_STAT5	54	57	PF00017	0.316
LIG_SH2_STAT5	75	78	PF00017	0.239
LIG_SH2_STAT5	79	82	PF00017	0.257
LIG_SH3_3	105	111	PF00018	0.265
LIG_SUMO_SIM_anti_2	162	167	PF11976	0.238
LIG_SUMO_SIM_par_1	169	175	PF11976	0.210
LIG_Vh1_VBS_1	164	182	PF01044	0.236
LIG_WRC_WIRS_1	31	36	PF05994	0.283
MOD_CDK_SPxxK_3	149	156	PF00069	0.397
MOD_CK1_1	196	202	PF00069	0.647
MOD_CK1_1	204	210	PF00069	0.602
MOD_CK1_1	215	221	PF00069	0.575
MOD_CK1_1	222	228	PF00069	0.595
MOD_CK1_1	229	235	PF00069	0.631
MOD_CK1_1	238	244	PF00069	0.708
MOD_CK2_1	229	235	PF00069	0.677
MOD_Cter_Amidation	154	157	PF01082	0.575
MOD_GlcNHglycan	131	134	PF01048	0.624
MOD_GlcNHglycan	201	204	PF01048	0.448
MOD_GlcNHglycan	231	234	PF01048	0.440
MOD_GlcNHglycan	76	79	PF01048	0.552
MOD_GSK3_1	109	116	PF00069	0.302
MOD_GSK3_1	193	200	PF00069	0.657
MOD_GSK3_1	204	211	PF00069	0.611
MOD_GSK3_1	215	222	PF00069	0.589
MOD_GSK3_1	223	230	PF00069	0.572
MOD_GSK3_1	231	238	PF00069	0.724
MOD_GSK3_1	41	48	PF00069	0.435
MOD_GSK3_1	52	59	PF00069	0.323
MOD_GSK3_1	96	103	PF00069	0.310
MOD_N-GLC_1	101	106	PF02516	0.527
MOD_N-GLC_1	146	151	PF02516	0.663
MOD_N-GLC_1	215	220	PF02516	0.397
MOD_NEK2_1	100	105	PF00069	0.394
MOD_NEK2_1	11	16	PF00069	0.509
MOD_NEK2_1	223	228	PF00069	0.612
MOD_PIKK_1	101	107	PF00454	0.300
MOD_PIKK_1	41	47	PF00454	0.295
MOD_PKA_1	227	233	PF00069	0.632
MOD_PKA_1	69	75	PF00069	0.262
MOD_PKA_1	84	90	PF00069	0.223
MOD_PKA_2	226	232	PF00069	0.653
MOD_PKA_2	84	90	PF00069	0.259
MOD_Plk_1	101	107	PF00069	0.334
MOD_Plk_1	218	224	PF00069	0.581
MOD_Plk_4	219	225	PF00069	0.608
MOD_Plk_4	96	102	PF00069	0.300
MOD_ProDKin_1	149	155	PF00069	0.398
MOD_ProDKin_1	46	52	PF00069	0.411
MOD_SUMO_rev_2	25	30	PF00179	0.275
MOD_SUMO_rev_2	64	72	PF00179	0.278
TRG_ENDOCYTIC_2	139	142	PF00928	0.290
TRG_ER_diArg_1	84	86	PF00400	0.276
TRG_NLS_MonoExtC_3	183	189	PF00514	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRH3	Leptomonas seymouri	27%	88%
A0A0N1PBW5	Leptomonas seymouri	38%	84%
A0A3S7WNP1	Leishmania donovani	91%	100%
A4H3V9	Leishmania braziliensis	68%	94%
A4HS33	Leishmania infantum	92%	100%
E9AK20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%