DUF4217 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q9XZX5_LEIMA

TriTrypDb:

LmjF.04.0370 , LMJLV39_040008500 , LMJSD75_040008700

Length:

268

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q9XZX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9XZX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.655
CLV_NRD_NRD_1	169	171	PF00675	0.430
CLV_NRD_NRD_1	184	186	PF00675	0.477
CLV_NRD_NRD_1	258	260	PF00675	0.562
CLV_NRD_NRD_1	4	6	PF00675	0.395
CLV_NRD_NRD_1	98	100	PF00675	0.540
CLV_PCSK_KEX2_1	169	171	PF00082	0.430
CLV_PCSK_KEX2_1	183	185	PF00082	0.470
CLV_PCSK_KEX2_1	258	260	PF00082	0.562
CLV_PCSK_KEX2_1	4	6	PF00082	0.395
CLV_PCSK_KEX2_1	89	91	PF00082	0.497
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.481
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.562
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.548
CLV_PCSK_SKI1_1	100	104	PF00082	0.511
CLV_PCSK_SKI1_1	164	168	PF00082	0.441
CLV_PCSK_SKI1_1	169	173	PF00082	0.432
CLV_PCSK_SKI1_1	250	254	PF00082	0.598
CLV_PCSK_SKI1_1	4	8	PF00082	0.394
CLV_PCSK_SKI1_1	89	93	PF00082	0.470
DOC_CYCLIN_yCln2_LP_2	10	13	PF00134	0.399
DOC_MAPK_gen_1	89	98	PF00069	0.477
DOC_PP2B_LxvP_1	10	13	PF13499	0.399
DOC_PP2B_LxvP_1	81	84	PF13499	0.556
DOC_PP4_FxxP_1	9	12	PF00568	0.425
DOC_USP7_MATH_1	236	240	PF00917	0.606
DOC_USP7_UBL2_3	183	187	PF12436	0.574
DOC_USP7_UBL2_3	85	89	PF12436	0.511
DOC_WW_Pin1_4	201	206	PF00397	0.633
DOC_WW_Pin1_4	68	73	PF00397	0.423
LIG_14-3-3_CanoR_1	21	25	PF00244	0.449
LIG_14-3-3_CanoR_1	42	49	PF00244	0.437
LIG_14-3-3_CanoR_1	66	72	PF00244	0.417
LIG_BRCT_BRCA1_1	141	145	PF00533	0.509
LIG_BRCT_BRCA1_1	34	38	PF00533	0.431
LIG_FHA_1	158	164	PF00498	0.503
LIG_FHA_2	170	176	PF00498	0.520
LIG_FHA_2	92	98	PF00498	0.576
LIG_MAD2	241	249	PF02301	0.573
LIG_Pex14_2	252	256	PF04695	0.599
LIG_REV1ctd_RIR_1	250	259	PF16727	0.597
LIG_SH2_STAP1	115	119	PF00017	0.505
LIG_SH2_STAT5	49	52	PF00017	0.451
LIG_TRFH_1	9	13	PF08558	0.399
LIG_WRC_WIRS_1	158	163	PF05994	0.477
MOD_CDK_SPK_2	201	206	PF00069	0.630
MOD_CDK_SPxxK_3	68	75	PF00069	0.411
MOD_CK1_1	20	26	PF00069	0.575
MOD_CK2_1	169	175	PF00069	0.520
MOD_CK2_1	91	97	PF00069	0.571
MOD_GlcNHglycan	238	241	PF01048	0.659
MOD_GlcNHglycan	34	37	PF01048	0.427
MOD_GSK3_1	100	107	PF00069	0.572
MOD_GSK3_1	228	235	PF00069	0.531
MOD_GSK3_1	41	48	PF00069	0.754
MOD_GSK3_1	49	56	PF00069	0.606
MOD_NEK2_1	113	118	PF00069	0.582
MOD_NEK2_1	128	133	PF00069	0.673
MOD_NEK2_1	19	24	PF00069	0.573
MOD_NEK2_1	67	72	PF00069	0.471
MOD_PKA_1	169	175	PF00069	0.520
MOD_PKA_2	169	175	PF00069	0.508
MOD_PKA_2	17	23	PF00069	0.442
MOD_PKA_2	32	38	PF00069	0.420
MOD_PKA_2	41	47	PF00069	0.430
MOD_PKB_1	230	238	PF00069	0.624
MOD_ProDKin_1	201	207	PF00069	0.636
MOD_ProDKin_1	68	74	PF00069	0.423
TRG_ER_diArg_1	168	170	PF00400	0.435
TRG_ER_diArg_1	3	5	PF00400	0.396
TRG_ER_diArg_1	74	77	PF00400	0.419
TRG_NLS_Bipartite_1	169	187	PF00514	0.505
TRG_NLS_MonoCore_2	182	187	PF00514	0.476
TRG_NLS_MonoCore_2	256	261	PF00514	0.568
TRG_NLS_MonoExtC_3	182	187	PF00514	0.532
TRG_NLS_MonoExtC_3	256	262	PF00514	0.625
TRG_NLS_MonoExtN_4	255	261	PF00514	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC96	Leptomonas seymouri	79%	100%
A0A3R7MRB1	Trypanosoma rangeli	57%	100%
A0A3S7WNN7	Leishmania donovani	98%	100%
A4H3V5	Leishmania braziliensis	89%	92%
A4HS31	Leishmania infantum	97%	100%
C9ZY23	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AK18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%