Putative mitochondrial exoribonuclease DSS-1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial exoribonuclease DSS-1, putative

Species:

Leishmania major

UniProt:

Q9XZX1_LEIMA

TriTrypDb:

LmjF.04.0330 , LMJLV39_040008200 , LMJSD75_040008400

Length:

857

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000178	exosome (RNase complex)	4	2
GO:0032991	protein-containing complex	1	2
GO:1902494	catalytic complex	2	2
GO:1905354	exoribonuclease complex	3	2

Expansion

Sequence features

Q9XZX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9XZX1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000175	3'-5'-RNA exonuclease activity	7	2
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004527	exonuclease activity	5	6
GO:0004532	RNA exonuclease activity	5	6
GO:0004540	RNA nuclease activity	4	12
GO:0005488	binding	1	12
GO:0008408	3'-5' exonuclease activity	6	6
GO:0008859	exoribonuclease II activity	7	6
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	6
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	6
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.567
CLV_C14_Caspase3-7	423	427	PF00656	0.501
CLV_C14_Caspase3-7	498	502	PF00656	0.525
CLV_C14_Caspase3-7	853	857	PF00656	0.679
CLV_NRD_NRD_1	244	246	PF00675	0.557
CLV_NRD_NRD_1	3	5	PF00675	0.578
CLV_NRD_NRD_1	30	32	PF00675	0.739
CLV_NRD_NRD_1	300	302	PF00675	0.354
CLV_NRD_NRD_1	362	364	PF00675	0.264
CLV_NRD_NRD_1	574	576	PF00675	0.354
CLV_NRD_NRD_1	607	609	PF00675	0.260
CLV_NRD_NRD_1	626	628	PF00675	0.670
CLV_NRD_NRD_1	713	715	PF00675	0.605
CLV_NRD_NRD_1	726	728	PF00675	0.584
CLV_NRD_NRD_1	763	765	PF00675	0.776
CLV_PCSK_FUR_1	242	246	PF00082	0.548
CLV_PCSK_FUR_1	28	32	PF00082	0.525
CLV_PCSK_KEX2_1	2	4	PF00082	0.581
CLV_PCSK_KEX2_1	244	246	PF00082	0.557
CLV_PCSK_KEX2_1	30	32	PF00082	0.739
CLV_PCSK_KEX2_1	300	302	PF00082	0.354
CLV_PCSK_KEX2_1	362	364	PF00082	0.260
CLV_PCSK_KEX2_1	574	576	PF00082	0.354
CLV_PCSK_KEX2_1	607	609	PF00082	0.260
CLV_PCSK_KEX2_1	626	628	PF00082	0.624
CLV_PCSK_KEX2_1	726	728	PF00082	0.575
CLV_PCSK_KEX2_1	763	765	PF00082	0.706
CLV_PCSK_SKI1_1	188	192	PF00082	0.456
CLV_PCSK_SKI1_1	3	7	PF00082	0.612
CLV_PCSK_SKI1_1	300	304	PF00082	0.260
CLV_PCSK_SKI1_1	362	366	PF00082	0.264
DEG_APCC_DBOX_1	1	9	PF00400	0.510
DEG_APCC_DBOX_1	187	195	PF00400	0.512
DEG_Kelch_Keap1_1	342	347	PF01344	0.507
DEG_Nend_UBRbox_1	1	4	PF02207	0.650
DEG_SPOP_SBC_1	36	40	PF00917	0.668
DEG_SPOP_SBC_1	637	641	PF00917	0.715
DEG_SPOP_SBC_1	754	758	PF00917	0.705
DOC_ANK_TNKS_1	243	250	PF00023	0.536
DOC_ANK_TNKS_1	704	711	PF00023	0.488
DOC_CKS1_1	17	22	PF01111	0.726
DOC_CKS1_1	468	473	PF01111	0.507
DOC_CKS1_1	778	783	PF01111	0.617
DOC_CYCLIN_RxL_1	185	192	PF00134	0.508
DOC_CYCLIN_yClb5_NLxxxL_5	425	432	PF00134	0.544
DOC_CYCLIN_yCln2_LP_2	748	754	PF00134	0.622
DOC_MAPK_gen_1	2	11	PF00069	0.581
DOC_MAPK_gen_1	330	339	PF00069	0.471
DOC_MAPK_gen_1	607	614	PF00069	0.463
DOC_MAPK_gen_1	714	721	PF00069	0.496
DOC_MAPK_JIP1_4	764	770	PF00069	0.714
DOC_PP2B_LxvP_1	748	751	PF13499	0.681
DOC_PP2B_LxvP_1	752	755	PF13499	0.647
DOC_PP2B_PxIxI_1	479	485	PF00149	0.462
DOC_PP4_FxxP_1	314	317	PF00568	0.460
DOC_PP4_FxxP_1	475	478	PF00568	0.554
DOC_SPAK_OSR1_1	683	687	PF12202	0.489
DOC_USP7_MATH_1	251	255	PF00917	0.478
DOC_USP7_MATH_1	289	293	PF00917	0.524
DOC_USP7_MATH_1	36	40	PF00917	0.750
DOC_USP7_MATH_1	45	49	PF00917	0.801
DOC_USP7_MATH_1	568	572	PF00917	0.534
DOC_USP7_MATH_1	659	663	PF00917	0.519
DOC_USP7_MATH_1	738	742	PF00917	0.649
DOC_USP7_UBL2_3	375	379	PF12436	0.407
DOC_WW_Pin1_4	103	108	PF00397	0.580
DOC_WW_Pin1_4	16	21	PF00397	0.732
DOC_WW_Pin1_4	399	404	PF00397	0.525
DOC_WW_Pin1_4	41	46	PF00397	0.748
DOC_WW_Pin1_4	467	472	PF00397	0.509
DOC_WW_Pin1_4	601	606	PF00397	0.536
DOC_WW_Pin1_4	777	782	PF00397	0.673
DOC_WW_Pin1_4	97	102	PF00397	0.606
LIG_14-3-3_CanoR_1	124	134	PF00244	0.548
LIG_14-3-3_CanoR_1	3	9	PF00244	0.544
LIG_14-3-3_CanoR_1	300	309	PF00244	0.462
LIG_14-3-3_CanoR_1	330	336	PF00244	0.485
LIG_14-3-3_CanoR_1	362	367	PF00244	0.460
LIG_14-3-3_CanoR_1	531	537	PF00244	0.498
LIG_14-3-3_CanoR_1	553	559	PF00244	0.539
LIG_14-3-3_CanoR_1	574	580	PF00244	0.473
LIG_14-3-3_CanoR_1	673	677	PF00244	0.536
LIG_14-3-3_CanoR_1	714	719	PF00244	0.445
LIG_14-3-3_CanoR_1	736	744	PF00244	0.645
LIG_14-3-3_CanoR_1	763	769	PF00244	0.721
LIG_Actin_WH2_1	80	97	PF00022	0.596
LIG_Actin_WH2_2	81	97	PF00022	0.589
LIG_BIR_III_4	262	266	PF00653	0.460
LIG_BRCT_BRCA1_1	560	564	PF00533	0.554
LIG_BRCT_BRCA1_1	680	684	PF00533	0.506
LIG_Clathr_ClatBox_1	555	559	PF01394	0.407
LIG_deltaCOP1_diTrp_1	75	82	PF00928	0.538
LIG_deltaCOP1_diTrp_1	844	851	PF00928	0.597
LIG_EVH1_2	471	475	PF00568	0.557
LIG_FHA_1	109	115	PF00498	0.679
LIG_FHA_1	12	18	PF00498	0.720
LIG_FHA_1	127	133	PF00498	0.494
LIG_FHA_1	19	25	PF00498	0.628
LIG_FHA_1	255	261	PF00498	0.460
LIG_FHA_1	303	309	PF00498	0.476
LIG_FHA_1	332	338	PF00498	0.460
LIG_FHA_1	343	349	PF00498	0.460
LIG_FHA_1	468	474	PF00498	0.565
LIG_FHA_1	485	491	PF00498	0.431
LIG_FHA_1	531	537	PF00498	0.460
LIG_FHA_1	578	584	PF00498	0.477
LIG_FHA_1	601	607	PF00498	0.460
LIG_FHA_1	723	729	PF00498	0.429
LIG_FHA_1	821	827	PF00498	0.456
LIG_FHA_2	137	143	PF00498	0.585
LIG_FHA_2	160	166	PF00498	0.589
LIG_FHA_2	254	260	PF00498	0.482
LIG_FHA_2	323	329	PF00498	0.474
LIG_FHA_2	419	425	PF00498	0.471
LIG_FHA_2	545	551	PF00498	0.557
LIG_FHA_2	70	76	PF00498	0.642
LIG_Integrin_RGD_1	705	707	PF01839	0.490
LIG_LIR_Apic_2	127	133	PF02991	0.512
LIG_LIR_Apic_2	474	478	PF02991	0.557
LIG_LIR_Gen_1	236	246	PF02991	0.455
LIG_LIR_Gen_1	334	341	PF02991	0.554
LIG_LIR_Gen_1	365	373	PF02991	0.467
LIG_LIR_Gen_1	70	77	PF02991	0.620
LIG_LIR_Gen_1	717	722	PF02991	0.497
LIG_LIR_Gen_1	780	791	PF02991	0.472
LIG_LIR_Gen_1	840	851	PF02991	0.540
LIG_LIR_Nem_3	236	241	PF02991	0.427
LIG_LIR_Nem_3	285	290	PF02991	0.512
LIG_LIR_Nem_3	310	316	PF02991	0.461
LIG_LIR_Nem_3	334	338	PF02991	0.555
LIG_LIR_Nem_3	365	369	PF02991	0.462
LIG_LIR_Nem_3	426	432	PF02991	0.540
LIG_LIR_Nem_3	681	687	PF02991	0.365
LIG_LIR_Nem_3	70	76	PF02991	0.622
LIG_LIR_Nem_3	717	721	PF02991	0.481
LIG_LIR_Nem_3	780	786	PF02991	0.453
LIG_LIR_Nem_3	840	846	PF02991	0.533
LIG_NRBOX	83	89	PF00104	0.464
LIG_PCNA_yPIPBox_3	80	88	PF02747	0.572
LIG_PDZ_Class_2	852	857	PF00595	0.676
LIG_Pex14_1	685	689	PF04695	0.412
LIG_Pex14_1	78	82	PF04695	0.467
LIG_Pex14_1	847	851	PF04695	0.596
LIG_Pex14_2	335	339	PF04695	0.460
LIG_SH2_CRK	366	370	PF00017	0.524
LIG_SH2_CRK	91	95	PF00017	0.598
LIG_SH2_NCK_1	366	370	PF00017	0.452
LIG_SH2_NCK_1	546	550	PF00017	0.502
LIG_SH2_PTP2	196	199	PF00017	0.462
LIG_SH2_SRC	196	199	PF00017	0.462
LIG_SH2_SRC	73	76	PF00017	0.529
LIG_SH2_SRC	96	99	PF00017	0.695
LIG_SH2_STAP1	351	355	PF00017	0.502
LIG_SH2_STAP1	609	613	PF00017	0.443
LIG_SH2_STAP1	734	738	PF00017	0.579
LIG_SH2_STAP1	843	847	PF00017	0.613
LIG_SH2_STAT3	214	217	PF00017	0.537
LIG_SH2_STAT5	196	199	PF00017	0.438
LIG_SH2_STAT5	276	279	PF00017	0.471
LIG_SH2_STAT5	280	283	PF00017	0.462
LIG_SH2_STAT5	287	290	PF00017	0.458
LIG_SH2_STAT5	307	310	PF00017	0.462
LIG_SH2_STAT5	430	433	PF00017	0.554
LIG_SH2_STAT5	546	549	PF00017	0.498
LIG_SH2_STAT5	599	602	PF00017	0.546
LIG_SH2_STAT5	689	692	PF00017	0.433
LIG_SH2_STAT5	718	721	PF00017	0.501
LIG_SH2_STAT5	73	76	PF00017	0.469
LIG_SH2_STAT5	785	788	PF00017	0.406
LIG_SH2_STAT5	790	793	PF00017	0.412
LIG_SH3_1	95	101	PF00018	0.629
LIG_SH3_3	130	136	PF00018	0.531
LIG_SH3_3	14	20	PF00018	0.721
LIG_SH3_3	172	178	PF00018	0.464
LIG_SH3_3	283	289	PF00018	0.460
LIG_SH3_3	465	471	PF00018	0.552
LIG_SH3_3	645	651	PF00018	0.614
LIG_SH3_3	726	732	PF00018	0.584
LIG_SH3_3	759	765	PF00018	0.767
LIG_SH3_3	786	792	PF00018	0.521
LIG_SH3_3	95	101	PF00018	0.662
LIG_SUMO_SIM_par_1	487	494	PF11976	0.464
LIG_TRAF2_1	669	672	PF00917	0.447
LIG_TYR_ITIM	364	369	PF00017	0.311
MOD_CDC14_SPxK_1	44	47	PF00782	0.722
MOD_CDC14_SPxK_1	604	607	PF00782	0.315
MOD_CDK_SPxK_1	41	47	PF00069	0.735
MOD_CDK_SPxK_1	601	607	PF00069	0.315
MOD_CDK_SPxxK_3	601	608	PF00069	0.306
MOD_CK1_1	106	112	PF00069	0.597
MOD_CK1_1	160	166	PF00069	0.497
MOD_CK1_1	254	260	PF00069	0.314
MOD_CK1_1	282	288	PF00069	0.306
MOD_CK1_1	35	41	PF00069	0.743
MOD_CK1_1	46	52	PF00069	0.795
MOD_CK1_1	577	583	PF00069	0.343
MOD_CK1_1	632	638	PF00069	0.636
MOD_CK1_1	662	668	PF00069	0.331
MOD_CK1_1	756	762	PF00069	0.704
MOD_CK1_1	99	105	PF00069	0.705
MOD_CK2_1	136	142	PF00069	0.564
MOD_CK2_1	159	165	PF00069	0.590
MOD_CK2_1	253	259	PF00069	0.306
MOD_CK2_1	289	295	PF00069	0.346
MOD_CK2_1	322	328	PF00069	0.324
MOD_CK2_1	341	347	PF00069	0.406
MOD_CK2_1	544	550	PF00069	0.374
MOD_CK2_1	737	743	PF00069	0.644
MOD_GlcNHglycan	116	119	PF01048	0.546
MOD_GlcNHglycan	253	256	PF01048	0.314
MOD_GlcNHglycan	34	37	PF01048	0.585
MOD_GlcNHglycan	386	389	PF01048	0.438
MOD_GlcNHglycan	411	414	PF01048	0.421
MOD_GlcNHglycan	635	638	PF01048	0.681
MOD_GlcNHglycan	640	643	PF01048	0.668
MOD_GlcNHglycan	667	670	PF01048	0.435
MOD_GlcNHglycan	69	72	PF01048	0.560
MOD_GlcNHglycan	696	699	PF01048	0.584
MOD_GlcNHglycan	740	743	PF01048	0.636
MOD_GSK3_1	251	258	PF00069	0.311
MOD_GSK3_1	32	39	PF00069	0.756
MOD_GSK3_1	394	401	PF00069	0.386
MOD_GSK3_1	41	48	PF00069	0.775
MOD_GSK3_1	484	491	PF00069	0.358
MOD_GSK3_1	49	56	PF00069	0.683
MOD_GSK3_1	530	537	PF00069	0.307
MOD_GSK3_1	554	561	PF00069	0.357
MOD_GSK3_1	593	600	PF00069	0.315
MOD_GSK3_1	628	635	PF00069	0.633
MOD_GSK3_1	738	745	PF00069	0.686
MOD_GSK3_1	746	753	PF00069	0.658
MOD_GSK3_1	754	761	PF00069	0.533
MOD_GSK3_1	777	784	PF00069	0.633
MOD_GSK3_1	96	103	PF00069	0.570
MOD_N-GLC_1	349	354	PF02516	0.335
MOD_N-GLC_1	679	684	PF02516	0.414
MOD_NEK2_1	114	119	PF00069	0.580
MOD_NEK2_1	125	130	PF00069	0.503
MOD_NEK2_1	159	164	PF00069	0.619
MOD_NEK2_1	302	307	PF00069	0.318
MOD_NEK2_1	530	535	PF00069	0.438
MOD_NEK2_1	558	563	PF00069	0.400
MOD_NEK2_1	569	574	PF00069	0.318
MOD_NEK2_1	594	599	PF00069	0.441
MOD_NEK2_1	69	74	PF00069	0.516
MOD_NEK2_1	737	742	PF00069	0.602
MOD_NEK2_1	796	801	PF00069	0.503
MOD_PIKK_1	119	125	PF00454	0.594
MOD_PIKK_1	496	502	PF00454	0.472
MOD_PIKK_1	742	748	PF00454	0.621
MOD_PIKK_1	820	826	PF00454	0.398
MOD_PIKK_1	850	856	PF00454	0.656
MOD_PK_1	349	355	PF00069	0.321
MOD_PK_1	488	494	PF00069	0.240
MOD_PKA_1	300	306	PF00069	0.438
MOD_PKA_1	362	368	PF00069	0.306
MOD_PKA_1	574	580	PF00069	0.438
MOD_PKA_1	714	720	PF00069	0.487
MOD_PKA_2	11	17	PF00069	0.648
MOD_PKA_2	300	306	PF00069	0.405
MOD_PKA_2	362	368	PF00069	0.306
MOD_PKA_2	530	536	PF00069	0.306
MOD_PKA_2	574	580	PF00069	0.438
MOD_PKA_2	672	678	PF00069	0.538
MOD_PKA_2	694	700	PF00069	0.577
MOD_PKB_1	2	10	PF00069	0.547
MOD_Plk_1	160	166	PF00069	0.507
MOD_Plk_1	282	288	PF00069	0.306
MOD_Plk_1	290	296	PF00069	0.306
MOD_Plk_1	349	355	PF00069	0.316
MOD_Plk_1	473	479	PF00069	0.417
MOD_Plk_1	558	564	PF00069	0.438
MOD_Plk_1	594	600	PF00069	0.438
MOD_Plk_1	679	685	PF00069	0.432
MOD_Plk_1	742	748	PF00069	0.621
MOD_Plk_1	781	787	PF00069	0.543
MOD_Plk_2-3	322	328	PF00069	0.341
MOD_Plk_4	282	288	PF00069	0.326
MOD_Plk_4	303	309	PF00069	0.306
MOD_Plk_4	594	600	PF00069	0.438
MOD_Plk_4	617	623	PF00069	0.437
MOD_Plk_4	662	668	PF00069	0.367
MOD_Plk_4	672	678	PF00069	0.458
MOD_Plk_4	69	75	PF00069	0.511
MOD_Plk_4	714	720	PF00069	0.504
MOD_Plk_4	83	89	PF00069	0.482
MOD_ProDKin_1	16	22	PF00069	0.734
MOD_ProDKin_1	399	405	PF00069	0.397
MOD_ProDKin_1	41	47	PF00069	0.752
MOD_ProDKin_1	467	473	PF00069	0.375
MOD_ProDKin_1	601	607	PF00069	0.413
MOD_ProDKin_1	777	783	PF00069	0.658
MOD_ProDKin_1	97	103	PF00069	0.607
MOD_SUMO_for_1	669	672	PF00179	0.516
MOD_SUMO_rev_2	479	487	PF00179	0.372
TRG_AP2beta_CARGO_1	426	436	PF09066	0.372
TRG_DiLeu_BaEn_1	121	126	PF01217	0.584
TRG_DiLeu_BaEn_1	672	677	PF01217	0.469
TRG_DiLeu_BaEn_1	743	748	PF01217	0.650
TRG_DiLeu_BaEn_2	309	315	PF01217	0.306
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.399
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.442
TRG_DiLeu_BaLyEn_6	477	482	PF01217	0.330
TRG_DiLeu_LyEn_5	121	126	PF01217	0.584
TRG_ENDOCYTIC_2	276	279	PF00928	0.332
TRG_ENDOCYTIC_2	287	290	PF00928	0.309
TRG_ENDOCYTIC_2	366	369	PF00928	0.315
TRG_ENDOCYTIC_2	584	587	PF00928	0.442
TRG_ENDOCYTIC_2	609	612	PF00928	0.306
TRG_ENDOCYTIC_2	718	721	PF00928	0.449
TRG_ENDOCYTIC_2	73	76	PF00928	0.606
TRG_ENDOCYTIC_2	734	737	PF00928	0.489
TRG_ENDOCYTIC_2	843	846	PF00928	0.609
TRG_ENDOCYTIC_2	91	94	PF00928	0.497
TRG_ER_diArg_1	1	4	PF00400	0.615
TRG_ER_diArg_1	28	31	PF00400	0.526
TRG_ER_diArg_1	300	302	PF00400	0.438
TRG_ER_diArg_1	361	363	PF00400	0.306
TRG_ER_diArg_1	436	439	PF00400	0.312
TRG_ER_diArg_1	440	443	PF00400	0.312
TRG_ER_diArg_1	573	575	PF00400	0.439
TRG_ER_diArg_1	606	608	PF00400	0.306
TRG_ER_diArg_1	726	728	PF00400	0.550
TRG_ER_diArg_1	762	764	PF00400	0.781
TRG_ER_diArg_1	9	12	PF00400	0.690
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	534	539	PF00026	0.306
TRG_Pf-PMV_PEXEL_1	688	692	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA76	Leptomonas seymouri	69%	100%
A0A0S4J212	Bodo saltans	42%	100%
A0A1X0NLV5	Trypanosomatidae	53%	100%
A0A3S5H597	Leishmania donovani	95%	100%
A0A422NN62	Trypanosoma rangeli	52%	100%
A4H3V2	Leishmania braziliensis	82%	100%
A4HS28	Leishmania infantum	95%	100%
C9ZY19	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AK15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q86MA2	Trypanosoma brucei brucei	51%	100%
V5B958	Trypanosoma cruzi	52%	100%