Putative beta-fructofuranosidase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta-fructofuranosidase, putative

Species:

Leishmania major

UniProt:

Q9XTP3_LEIMA

TriTrypDb:

LmjF.04.0310 , LMJLV39_040007900 , LMJSD75_350011600

Length:

640

Annotations

LeishMANIAdb annotations

An expanded and variable family of glycosidases. Some Leishmaniid members even incorporate an extra N-terminal fructofuronidase domain after the signal peptide.. Seems to be evolving rapidly for unclear reasons

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 4
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 11, no: 6
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q9XTP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9XTP3

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	18
GO:0008152	metabolic process	1	18
GO:0044238	primary metabolic process	2	18
GO:0071704	organic substance metabolic process	2	18

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	18
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	18
GO:0004564	beta-fructofuranosidase activity	5	10
GO:0016787	hydrolase activity	2	18
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	316	318	PF00675	0.534
CLV_PCSK_KEX2_1	149	151	PF00082	0.415
CLV_PCSK_KEX2_1	316	318	PF00082	0.473
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.397
CLV_PCSK_SKI1_1	157	161	PF00082	0.335
CLV_PCSK_SKI1_1	293	297	PF00082	0.506
CLV_PCSK_SKI1_1	354	358	PF00082	0.453
CLV_PCSK_SKI1_1	624	628	PF00082	0.711
DEG_APCC_DBOX_1	520	528	PF00400	0.530
DEG_COP1_1	417	427	PF00400	0.432
DOC_MAPK_gen_1	365	375	PF00069	0.537
DOC_MAPK_gen_1	87	97	PF00069	0.489
DOC_MAPK_HePTP_8	594	606	PF00069	0.458
DOC_MAPK_MEF2A_6	157	164	PF00069	0.354
DOC_MAPK_MEF2A_6	597	606	PF00069	0.458
DOC_MAPK_MEF2A_6	7	14	PF00069	0.662
DOC_PP1_RVXF_1	499	505	PF00149	0.501
DOC_PP4_FxxP_1	178	181	PF00568	0.369
DOC_PP4_FxxP_1	243	246	PF00568	0.533
DOC_PP4_FxxP_1	309	312	PF00568	0.534
DOC_USP7_MATH_1	291	295	PF00917	0.498
DOC_USP7_MATH_1	419	423	PF00917	0.540
DOC_USP7_MATH_1	454	458	PF00917	0.578
DOC_USP7_MATH_1	471	475	PF00917	0.481
DOC_USP7_MATH_1	476	480	PF00917	0.526
DOC_USP7_MATH_1	508	512	PF00917	0.382
DOC_USP7_UBL2_3	501	505	PF12436	0.518
DOC_WW_Pin1_4	380	385	PF00397	0.634
DOC_WW_Pin1_4	548	553	PF00397	0.532
DOC_WW_Pin1_4	616	621	PF00397	0.717
DOC_WW_Pin1_4	90	95	PF00397	0.518
LIG_14-3-3_CanoR_1	150	156	PF00244	0.301
LIG_14-3-3_CanoR_1	293	298	PF00244	0.429
LIG_14-3-3_CanoR_1	403	407	PF00244	0.496
LIG_Actin_WH2_2	244	262	PF00022	0.388
LIG_APCC_ABBA_1	557	562	PF00400	0.396
LIG_APCC_ABBA_1	566	571	PF00400	0.396
LIG_BRCT_BRCA1_1	293	297	PF00533	0.470
LIG_BRCT_BRCA1_1	305	309	PF00533	0.470
LIG_BRCT_BRCA1_1	489	493	PF00533	0.496
LIG_deltaCOP1_diTrp_1	100	106	PF00928	0.518
LIG_FHA_1	356	362	PF00498	0.453
LIG_FHA_1	383	389	PF00498	0.567
LIG_FHA_1	440	446	PF00498	0.531
LIG_FHA_1	456	462	PF00498	0.518
LIG_FHA_1	497	503	PF00498	0.460
LIG_FHA_1	536	542	PF00498	0.487
LIG_FHA_1	54	60	PF00498	0.481
LIG_FHA_1	576	582	PF00498	0.410
LIG_FHA_1	587	593	PF00498	0.410
LIG_FHA_1	599	605	PF00498	0.505
LIG_FHA_1	625	631	PF00498	0.688
LIG_FHA_2	124	130	PF00498	0.451
LIG_FHA_2	294	300	PF00498	0.401
LIG_FHA_2	306	312	PF00498	0.388
LIG_FHA_2	321	327	PF00498	0.534
LIG_FHA_2	403	409	PF00498	0.494
LIG_FHA_2	517	523	PF00498	0.509
LIG_FHA_2	79	85	PF00498	0.369
LIG_FHA_2	87	93	PF00498	0.369
LIG_LIR_Apic_2	176	181	PF02991	0.385
LIG_LIR_Apic_2	182	188	PF02991	0.333
LIG_LIR_Apic_2	240	246	PF02991	0.528
LIG_LIR_Apic_2	306	312	PF02991	0.534
LIG_LIR_Apic_2	612	618	PF02991	0.633
LIG_LIR_Gen_1	256	265	PF02991	0.430
LIG_LIR_Gen_1	282	292	PF02991	0.534
LIG_LIR_Gen_1	294	303	PF02991	0.536
LIG_LIR_Gen_1	395	404	PF02991	0.532
LIG_LIR_Gen_1	438	448	PF02991	0.380
LIG_LIR_Gen_1	628	639	PF02991	0.535
LIG_LIR_Nem_3	104	109	PF02991	0.474
LIG_LIR_Nem_3	247	251	PF02991	0.403
LIG_LIR_Nem_3	256	261	PF02991	0.401
LIG_LIR_Nem_3	269	273	PF02991	0.409
LIG_LIR_Nem_3	282	288	PF02991	0.385
LIG_LIR_Nem_3	294	300	PF02991	0.327
LIG_LIR_Nem_3	308	313	PF02991	0.364
LIG_LIR_Nem_3	395	400	PF02991	0.532
LIG_LIR_Nem_3	438	443	PF02991	0.439
LIG_LIR_Nem_3	462	467	PF02991	0.513
LIG_LIR_Nem_3	628	634	PF02991	0.548
LIG_LIR_Nem_3	74	80	PF02991	0.384
LIG_LYPXL_yS_3	464	467	PF13949	0.496
LIG_NRBOX	629	635	PF00104	0.660
LIG_PCNA_yPIPBox_3	341	355	PF02747	0.496
LIG_PDZ_Class_2	635	640	PF00595	0.623
LIG_Pex14_1	194	198	PF04695	0.380
LIG_PTB_Apo_2	112	119	PF02174	0.430
LIG_PTB_Phospho_1	112	118	PF10480	0.430
LIG_REV1ctd_RIR_1	246	256	PF16727	0.406
LIG_SH2_CRK	310	314	PF00017	0.397
LIG_SH2_CRK	440	444	PF00017	0.533
LIG_SH2_NCK_1	31	35	PF00017	0.570
LIG_SH2_NCK_1	440	444	PF00017	0.533
LIG_SH2_PTP2	285	288	PF00017	0.533
LIG_SH2_SRC	31	34	PF00017	0.575
LIG_SH2_SRC	310	313	PF00017	0.413
LIG_SH2_STAP1	595	599	PF00017	0.526
LIG_SH2_STAT5	125	128	PF00017	0.366
LIG_SH2_STAT5	233	236	PF00017	0.530
LIG_SH2_STAT5	258	261	PF00017	0.389
LIG_SH2_STAT5	270	273	PF00017	0.392
LIG_SH2_STAT5	285	288	PF00017	0.331
LIG_SH2_STAT5	440	443	PF00017	0.396
LIG_SH2_STAT5	491	494	PF00017	0.512
LIG_SH2_STAT5	526	529	PF00017	0.530
LIG_SH2_STAT5	582	585	PF00017	0.396
LIG_SH2_STAT5	609	612	PF00017	0.583
LIG_SH2_STAT5	85	88	PF00017	0.369
LIG_SH3_2	188	193	PF14604	0.513
LIG_SH3_2	47	52	PF14604	0.382
LIG_SH3_3	185	191	PF00018	0.520
LIG_SH3_3	27	33	PF00018	0.511
LIG_SH3_3	285	291	PF00018	0.532
LIG_SH3_3	44	50	PF00018	0.318
LIG_SH3_3	442	448	PF00018	0.390
LIG_SH3_3	517	523	PF00018	0.404
LIG_SH3_3	64	70	PF00018	0.231
LIG_SH3_3	88	94	PF00018	0.518
LIG_SUMO_SIM_par_1	600	605	PF11976	0.561
LIG_TYR_ITIM	29	34	PF00017	0.601
LIG_TYR_ITSM	306	313	PF00017	0.515
LIG_TYR_ITSM	393	400	PF00017	0.532
MOD_CK1_1	221	227	PF00069	0.485
MOD_CK1_1	438	444	PF00069	0.486
MOD_CK2_1	123	129	PF00069	0.478
MOD_CK2_1	320	326	PF00069	0.534
MOD_CK2_1	516	522	PF00069	0.567
MOD_CK2_1	561	567	PF00069	0.533
MOD_CK2_1	86	92	PF00069	0.515
MOD_Cter_Amidation	147	150	PF01082	0.397
MOD_DYRK1A_RPxSP_1	90	94	PF00069	0.515
MOD_GlcNHglycan	109	112	PF01048	0.382
MOD_GlcNHglycan	157	160	PF01048	0.454
MOD_GlcNHglycan	223	226	PF01048	0.492
MOD_GlcNHglycan	337	340	PF01048	0.388
MOD_GlcNHglycan	452	455	PF01048	0.563
MOD_GlcNHglycan	473	476	PF01048	0.537
MOD_GlcNHglycan	478	481	PF01048	0.549
MOD_GlcNHglycan	516	519	PF01048	0.433
MOD_GlcNHglycan	531	534	PF01048	0.395
MOD_GSK3_1	151	158	PF00069	0.367
MOD_GSK3_1	214	221	PF00069	0.479
MOD_GSK3_1	224	231	PF00069	0.492
MOD_GSK3_1	259	266	PF00069	0.399
MOD_GSK3_1	378	385	PF00069	0.602
MOD_GSK3_1	435	442	PF00069	0.378
MOD_GSK3_1	450	457	PF00069	0.459
MOD_GSK3_1	527	534	PF00069	0.437
MOD_GSK3_1	86	93	PF00069	0.508
MOD_N-GLC_1	116	121	PF02516	0.518
MOD_N-GLC_1	278	283	PF02516	0.421
MOD_N-GLC_1	392	397	PF02516	0.476
MOD_N-GLC_1	435	440	PF02516	0.491
MOD_N-GLC_1	476	481	PF02516	0.477
MOD_N-GLC_1	496	501	PF02516	0.301
MOD_N-GLC_1	624	629	PF02516	0.708
MOD_N-GLC_2	498	500	PF02516	0.430
MOD_NEK2_1	123	128	PF00069	0.363
MOD_NEK2_1	155	160	PF00069	0.354
MOD_NEK2_1	228	233	PF00069	0.398
MOD_NEK2_1	259	264	PF00069	0.388
MOD_NEK2_1	278	283	PF00069	0.388
MOD_NEK2_1	303	308	PF00069	0.480
MOD_NEK2_1	343	348	PF00069	0.544
MOD_NEK2_1	470	475	PF00069	0.539
MOD_NEK2_1	487	492	PF00069	0.403
MOD_NEK2_1	527	532	PF00069	0.403
MOD_NEK2_1	633	638	PF00069	0.575
MOD_NEK2_2	305	310	PF00069	0.534
MOD_PIKK_1	280	286	PF00454	0.558
MOD_PIKK_1	355	361	PF00454	0.542
MOD_PIKK_1	382	388	PF00454	0.599
MOD_PIKK_1	435	441	PF00454	0.525
MOD_PIKK_1	527	533	PF00454	0.464
MOD_PIKK_1	79	85	PF00454	0.288
MOD_PKA_2	402	408	PF00069	0.496
MOD_Plk_1	392	398	PF00069	0.506
MOD_Plk_1	435	441	PF00069	0.532
MOD_Plk_1	561	567	PF00069	0.396
MOD_Plk_2-3	607	613	PF00069	0.483
MOD_Plk_4	109	115	PF00069	0.518
MOD_Plk_4	151	157	PF00069	0.341
MOD_Plk_4	228	234	PF00069	0.455
MOD_Plk_4	305	311	PF00069	0.536
MOD_Plk_4	392	398	PF00069	0.532
MOD_Plk_4	489	495	PF00069	0.462
MOD_Plk_4	561	567	PF00069	0.410
MOD_Plk_4	610	616	PF00069	0.483
MOD_Plk_4	633	639	PF00069	0.596
MOD_ProDKin_1	380	386	PF00069	0.637
MOD_ProDKin_1	548	554	PF00069	0.532
MOD_ProDKin_1	616	622	PF00069	0.717
MOD_ProDKin_1	90	96	PF00069	0.518
MOD_SUMO_for_1	569	572	PF00179	0.486
MOD_SUMO_rev_2	350	356	PF00179	0.505
TRG_DiLeu_BaEn_2	555	561	PF01217	0.486
TRG_DiLeu_BaLyEn_6	520	525	PF01217	0.532
TRG_ENDOCYTIC_2	258	261	PF00928	0.427
TRG_ENDOCYTIC_2	285	288	PF00928	0.523
TRG_ENDOCYTIC_2	300	303	PF00928	0.334
TRG_ENDOCYTIC_2	31	34	PF00928	0.575
TRG_ENDOCYTIC_2	310	313	PF00928	0.342
TRG_ENDOCYTIC_2	397	400	PF00928	0.396
TRG_ENDOCYTIC_2	440	443	PF00928	0.396
TRG_ENDOCYTIC_2	464	467	PF00928	0.545
TRG_ENDOCYTIC_2	631	634	PF00928	0.678
TRG_NES_CRM1_1	572	584	PF08389	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT6	Leptomonas seymouri	76%	99%
A0A0S4J9J2	Bodo saltans	31%	100%
A0A1X0NFY9	Trypanosomatidae	42%	100%
A0A1X0NTL0	Trypanosomatidae	40%	100%
A0A1X0NTM3	Trypanosomatidae	41%	100%
A0A1X0NY19	Trypanosomatidae	41%	100%
A0A1X0NYR4	Trypanosomatidae	38%	100%
A0A1X0P322	Trypanosomatidae	38%	100%
A0A1X0P5Y7	Trypanosomatidae	41%	100%
A0A3Q8IB13	Leishmania donovani	27%	100%
A0A3Q8IFU7	Leishmania donovani	26%	100%
A0A3S5H595	Leishmania donovani	94%	100%
A0A3S5H596	Leishmania donovani	93%	100%
A0A3S5H7I4	Leishmania donovani	23%	100%
A0A3S7WXQ4	Leishmania donovani	27%	100%
A0A3S7WXS2	Leishmania donovani	26%	100%
A2YZ01	Oryza sativa subsp. indica	28%	100%
A4H3V1	Leishmania braziliensis	83%	100%
A4HCV9	Leishmania braziliensis	24%	100%
A4HCW0	Leishmania braziliensis	26%	100%
A4HG14	Leishmania braziliensis	24%	100%
A4HS26	Leishmania infantum	94%	100%
A4HS27	Leishmania infantum	93%	100%
A4I0D9	Leishmania infantum	27%	100%
A4I0E0	Leishmania infantum	26%	100%
A4IAW1	Leishmania infantum	65%	91%
B6DXP5	Leymus chinensis	28%	100%
B6DZC8	Triticum aestivum	29%	100%
B6DZD0	Triticum urartu	29%	100%
B6DZD1	Aegilops speltoides	30%	100%
B6DZD2	Aegilops tauschii	29%	100%
D2IGW7	Bromus pictus	29%	100%
E8NHF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E8NHF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ACV4	Leishmania major	23%	100%
E9AK13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
H2DF88	Rosa hybrid cultivar	29%	100%
O07003	Bacillus subtilis (strain 168)	21%	100%
O24509	Phaseolus vulgaris	26%	98%
P05656	Bacillus subtilis (strain 168)	24%	95%
P10596	Saccharomyces cerevisiae	25%	100%
P26792	Daucus carota	28%	100%
P29000	Solanum lycopersicum	28%	100%
P29001	Vigna radiata var. radiata	27%	99%
P49174	Zea mays	28%	100%
P49175	Zea mays	30%	96%
P80065	Daucus carota	28%	97%
P92916	Allium cepa	26%	100%
P93761	Capsicum annuum	27%	100%
Q01IS7	Oryza sativa subsp. indica	30%	100%
Q01IS8	Oryza sativa subsp. indica	30%	100%
Q0J360	Oryza sativa subsp. japonica	28%	100%
Q0JDC5	Oryza sativa subsp. japonica	30%	100%
Q0JDC6	Oryza sativa subsp. japonica	30%	100%
Q1PEF8	Arabidopsis thaliana	30%	100%
Q2UXF7	Triticum aestivum	30%	100%
Q39041	Arabidopsis thaliana	26%	96%
Q39693	Daucus carota	30%	100%
Q43089	Pisum sativum	29%	100%
Q43857	Vicia faba	30%	100%
Q43866	Arabidopsis thaliana	32%	100%
Q4QB75	Leishmania major	27%	100%
Q4QB76	Leishmania major	25%	100%
Q56UD0	Oryza sativa subsp. japonica	28%	100%
Q56UD1	Oryza sativa subsp. japonica	25%	100%
Q5FC15	Asparagus officinalis	29%	100%
Q5JJV0	Oryza sativa subsp. japonica	30%	100%
Q67XZ3	Arabidopsis thaliana	31%	100%
Q70AT7	Hordeum vulgare	28%	100%
Q70XE6	Beta vulgaris	27%	100%
Q84LA1	Triticum aestivum	28%	100%
Q84PN8	Triticum aestivum	29%	100%
Q8W413	Arabidopsis thaliana	29%	100%
Q8W4S6	Arabidopsis thaliana	27%	100%
Q9LIB9	Arabidopsis thaliana	28%	100%
Q9XZX0	Leishmania major	98%	100%