LeishMANIAdb
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Small hydrophilic endoplasmic reticulum-associated protein (Sherp)

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Small hydrophilic endoplasmic reticulum-associated protein (Sherp)
Gene product:
small hydrophilic endoplasmic reticulum-associated protein (sherp)
Species:
Leishmania major
UniProt:
Q9XTN3_LEIMA
TriTrypDb:
LmjF.23.1086
Length:
57

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 3
NetGPI no yes: 0, no: 3
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q9XTN3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9XTN3

PDB structure(s): 2x43_S

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 15 19 PF00656 0.549
CLV_C14_Caspase3-7 37 41 PF00656 0.502
DEG_Nend_UBRbox_2 1 3 PF02207 0.509
DEG_SPOP_SBC_1 41 45 PF00917 0.435
DOC_USP7_MATH_1 41 45 PF00917 0.476
MOD_CK2_1 41 47 PF00069 0.475
MOD_GlcNHglycan 53 56 PF01048 0.616
MOD_GSK3_1 41 48 PF00069 0.477

Homologs

Protein Taxonomy Sequence identity Coverage
E9AH13 Leishmania infantum 79% 100%
E9AWB6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 72% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS