p21 antigen protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

p21 antigen protein

Gene product:

Lsm12 protein, putative

Species:

Leishmania major

UniProt:

Q9U8C2_LEIMA

TriTrypDb:

LmjF.35.5290 , LMJLV39_350061100 , LMJSD75_350060400

Length:

191

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q9U8C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9U8C2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	164	168	PF00082	0.538
CLV_PCSK_SKI1_1	91	95	PF00082	0.534
DOC_CKS1_1	160	165	PF01111	0.525
DOC_CKS1_1	53	58	PF01111	0.474
DOC_MAPK_MEF2A_6	34	43	PF00069	0.491
DOC_USP7_MATH_1	75	79	PF00917	0.663
DOC_USP7_UBL2_3	91	95	PF12436	0.616
DOC_WW_Pin1_4	116	121	PF00397	0.453
DOC_WW_Pin1_4	159	164	PF00397	0.489
DOC_WW_Pin1_4	52	57	PF00397	0.467
LIG_BIR_II_1	1	5	PF00653	0.636
LIG_BIR_III_4	8	12	PF00653	0.558
LIG_eIF4E_1	13	19	PF01652	0.486
LIG_FHA_1	13	19	PF00498	0.422
LIG_FHA_1	149	155	PF00498	0.531
LIG_FHA_1	53	59	PF00498	0.434
LIG_FHA_2	15	21	PF00498	0.443
LIG_GBD_Chelix_1	178	186	PF00786	0.519
LIG_LIR_Apic_2	157	163	PF02991	0.465
LIG_LIR_Gen_1	109	120	PF02991	0.594
LIG_LIR_Gen_1	125	135	PF02991	0.522
LIG_LIR_Gen_1	77	87	PF02991	0.668
LIG_LIR_Nem_3	109	115	PF02991	0.589
LIG_LIR_Nem_3	125	130	PF02991	0.340
LIG_LIR_Nem_3	77	82	PF02991	0.676
LIG_LYPXL_S_1	133	137	PF13949	0.443
LIG_LYPXL_yS_3	134	137	PF13949	0.439
LIG_SH2_CRK	13	17	PF00017	0.551
LIG_SH2_STAT5	127	130	PF00017	0.472
LIG_SH2_STAT5	57	60	PF00017	0.551
LIG_SH3_3	152	158	PF00018	0.504
LIG_SUMO_SIM_anti_2	149	157	PF11976	0.501
LIG_SUMO_SIM_anti_2	15	22	PF11976	0.512
LIG_SUMO_SIM_anti_2	35	42	PF11976	0.304
LIG_SUMO_SIM_par_1	14	22	PF11976	0.441
LIG_SUMO_SIM_par_1	149	157	PF11976	0.501
LIG_SUMO_SIM_par_1	35	42	PF11976	0.501
LIG_WRC_WIRS_1	76	81	PF05994	0.685
MOD_CDK_SPK_2	159	164	PF00069	0.570
MOD_CDK_SPxxK_3	52	59	PF00069	0.464
MOD_CK1_1	114	120	PF00069	0.585
MOD_CK2_1	19	25	PF00069	0.524
MOD_CK2_1	61	67	PF00069	0.555
MOD_CK2_1	75	81	PF00069	0.630
MOD_Cter_Amidation	188	191	PF01082	0.697
MOD_GSK3_1	116	123	PF00069	0.556
MOD_NEK2_1	14	19	PF00069	0.461
MOD_NEK2_1	61	66	PF00069	0.546
MOD_PIKK_1	96	102	PF00454	0.528
MOD_PK_1	89	95	PF00069	0.641
MOD_Plk_1	59	65	PF00069	0.520
MOD_Plk_1	89	95	PF00069	0.550
MOD_Plk_2-3	138	144	PF00069	0.499
MOD_Plk_4	14	20	PF00069	0.431
MOD_Plk_4	148	154	PF00069	0.530
MOD_Plk_4	24	30	PF00069	0.387
MOD_Plk_4	89	95	PF00069	0.636
MOD_ProDKin_1	116	122	PF00069	0.446
MOD_ProDKin_1	159	165	PF00069	0.483
MOD_ProDKin_1	52	58	PF00069	0.462
MOD_SUMO_rev_2	20	24	PF00179	0.557
TRG_DiLeu_BaEn_4	67	73	PF01217	0.649
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.342
TRG_ENDOCYTIC_2	127	130	PF00928	0.415
TRG_ENDOCYTIC_2	13	16	PF00928	0.514
TRG_ENDOCYTIC_2	134	137	PF00928	0.389
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ22	Leptomonas seymouri	80%	100%
A0A0S4JPM5	Bodo saltans	35%	99%
A0A1X0P513	Trypanosomatidae	44%	100%
A0A3S7XA44	Leishmania donovani	97%	100%
A0A422N5Z2	Trypanosoma rangeli	44%	100%
A4HNJ0	Leishmania braziliensis	91%	100%
A4IC47	Leishmania infantum	97%	100%
C9ZYC7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B755	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q38E83	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	46%	100%