Xanthine_phosphoribosyltransferase/GeneDB:LmjF.21.0850

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

xanthine phosphoribosyltransferase

Species:

Leishmania donovani

UniProt:

Q9U6Y2_LEIDO

TriTrypDb:

LdBPK_210990.1 , LdCL_210014900 , LDHU3_21.1170

Length:

241

Annotations

Annotations by Jardim et al.

Purine metabolism, Xanthine phosphoribosyltransferase XRPT

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0005777	peroxisome	6	1
GO:0005829	cytosol	2	1
GO:0020015	glycosome	7	1
GO:0020022	acidocalcisome	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q9U6Y2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006144	purine nucleobase metabolic process	5	1
GO:0006163	purine nucleotide metabolic process	5	4
GO:0006164	purine nucleotide biosynthetic process	6	4
GO:0006177	GMP biosynthetic process	8	1
GO:0006178	guanine salvage	6	1
GO:0006188	IMP biosynthetic process	8	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006753	nucleoside phosphate metabolic process	4	4
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0009058	biosynthetic process	2	4
GO:0009112	nucleobase metabolic process	4	1
GO:0009113	purine nucleobase biosynthetic process	6	1
GO:0009117	nucleotide metabolic process	5	4
GO:0009123	nucleoside monophosphate metabolic process	5	4
GO:0009124	nucleoside monophosphate biosynthetic process	6	4
GO:0009126	purine nucleoside monophosphate metabolic process	6	4
GO:0009127	purine nucleoside monophosphate biosynthetic process	7	4
GO:0009150	purine ribonucleotide metabolic process	6	4
GO:0009152	purine ribonucleotide biosynthetic process	7	4
GO:0009156	ribonucleoside monophosphate biosynthetic process	7	4
GO:0009161	ribonucleoside monophosphate metabolic process	6	4
GO:0009165	nucleotide biosynthetic process	6	4
GO:0009167	purine ribonucleoside monophosphate metabolic process	7	4
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	8	4
GO:0009259	ribonucleotide metabolic process	5	4
GO:0009260	ribonucleotide biosynthetic process	6	4
GO:0009987	cellular process	1	4
GO:0018130	heterocycle biosynthetic process	4	4
GO:0019438	aromatic compound biosynthetic process	4	4
GO:0019637	organophosphate metabolic process	3	4
GO:0019693	ribose phosphate metabolic process	4	4
GO:0032261	purine nucleotide salvage	5	4
GO:0032263	GMP salvage	7	1
GO:0032264	IMP salvage	7	4
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0034654	nucleobase-containing compound biosynthetic process	4	4
GO:0043094	cellular metabolic compound salvage	3	4
GO:0043096	purine nucleobase salvage	5	1
GO:0043101	purine-containing compound salvage	4	4
GO:0043173	nucleotide salvage	4	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044271	cellular nitrogen compound biosynthetic process	4	4
GO:0044281	small molecule metabolic process	2	4
GO:0046037	GMP metabolic process	7	1
GO:0046040	IMP metabolic process	7	4
GO:0046098	guanine metabolic process	6	1
GO:0046099	guanine biosynthetic process	7	1
GO:0046100	hypoxanthine metabolic process	6	1
GO:0046112	nucleobase biosynthetic process	5	1
GO:0046390	ribose phosphate biosynthetic process	5	4
GO:0046483	heterocycle metabolic process	3	4
GO:0055086	nucleobase-containing small molecule metabolic process	3	4
GO:0071704	organic substance metabolic process	2	4
GO:0072521	purine-containing compound metabolic process	4	4
GO:0072522	purine-containing compound biosynthetic process	5	4
GO:0090407	organophosphate biosynthetic process	4	4
GO:0106380	purine ribonucleotide salvage	6	4
GO:1901135	carbohydrate derivative metabolic process	3	4
GO:1901137	carbohydrate derivative biosynthetic process	4	4
GO:1901293	nucleoside phosphate biosynthetic process	5	4
GO:1901360	organic cyclic compound metabolic process	3	4
GO:1901362	organic cyclic compound biosynthetic process	4	4
GO:1901564	organonitrogen compound metabolic process	3	4
GO:1901566	organonitrogen compound biosynthetic process	4	4
GO:1901576	organic substance biosynthetic process	3	4
GO:0006166	purine ribonucleoside salvage	5	3
GO:0009116	nucleoside metabolic process	4	3
GO:0009119	ribonucleoside metabolic process	5	3
GO:0009163	nucleoside biosynthetic process	5	3
GO:0034404	nucleobase-containing small molecule biosynthetic process	4	3
GO:0042278	purine nucleoside metabolic process	5	3
GO:0042451	purine nucleoside biosynthetic process	6	3
GO:0042455	ribonucleoside biosynthetic process	6	3
GO:0043174	nucleoside salvage	4	3
GO:0044283	small molecule biosynthetic process	3	3
GO:0046128	purine ribonucleoside metabolic process	6	3
GO:0046129	purine ribonucleoside biosynthetic process	7	3
GO:1901657	glycosyl compound metabolic process	4	3
GO:1901659	glycosyl compound biosynthetic process	5	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0004422	hypoxanthine phosphoribosyltransferase activity	6	8
GO:0016740	transferase activity	2	14
GO:0016757	glycosyltransferase activity	3	14
GO:0016763	pentosyltransferase activity	4	8
GO:0052657	guanine phosphoribosyltransferase activity	6	8
GO:0106130	purine phosphoribosyltransferase activity	5	8
GO:0000287	magnesium ion binding	5	1
GO:0000310	xanthine phosphoribosyltransferase activity	6	3
GO:0005488	binding	1	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0000166	nucleotide binding	3	3
GO:0036094	small molecule binding	2	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	56	60	PF00656	0.319
CLV_NRD_NRD_1	190	192	PF00675	0.218
CLV_PCSK_SKI1_1	147	151	PF00082	0.237
CLV_PCSK_SKI1_1	176	180	PF00082	0.303
CLV_PCSK_SKI1_1	224	228	PF00082	0.363
DOC_ANK_TNKS_1	15	22	PF00023	0.380
DOC_MAPK_gen_1	145	152	PF00069	0.422
DOC_MAPK_gen_1	176	184	PF00069	0.492
DOC_MAPK_gen_1	219	228	PF00069	0.354
DOC_PP1_RVXF_1	158	165	PF00149	0.515
DOC_PP1_RVXF_1	189	196	PF00149	0.460
DOC_PP2B_PxIxI_1	84	90	PF00149	0.429
DOC_USP7_MATH_1	25	29	PF00917	0.467
DOC_USP7_MATH_1	3	7	PF00917	0.344
DOC_USP7_UBL2_3	172	176	PF12436	0.515
DOC_WW_Pin1_4	60	65	PF00397	0.582
LIG_14-3-3_CanoR_1	119	124	PF00244	0.406
LIG_BIR_III_4	12	16	PF00653	0.474
LIG_BRCT_BRCA1_1	94	98	PF00533	0.400
LIG_DLG_GKlike_1	119	127	PF00625	0.500
LIG_FHA_1	128	134	PF00498	0.497
LIG_FHA_1	31	37	PF00498	0.350
LIG_LIR_Apic_2	81	85	PF02991	0.452
LIG_LIR_Gen_1	116	123	PF02991	0.418
LIG_LIR_Nem_3	116	120	PF02991	0.335
LIG_LIR_Nem_3	196	202	PF02991	0.433
LIG_LIR_Nem_3	218	223	PF02991	0.330
LIG_LIR_Nem_3	51	55	PF02991	0.453
LIG_LIR_Nem_3	99	105	PF02991	0.519
LIG_Pex14_2	98	102	PF04695	0.452
LIG_SH2_CRK	52	56	PF00017	0.402
LIG_SH2_CRK	82	86	PF00017	0.452
LIG_SH2_GRB2like	82	85	PF00017	0.452
LIG_SH2_SRC	82	85	PF00017	0.452
LIG_SH2_STAT5	105	108	PF00017	0.429
LIG_SH2_STAT5	168	171	PF00017	0.460
LIG_SH2_STAT5	199	202	PF00017	0.409
LIG_SH2_STAT5	208	211	PF00017	0.391
LIG_SH2_STAT5	96	99	PF00017	0.436
LIG_SUMO_SIM_par_1	148	154	PF11976	0.418
LIG_SUMO_SIM_par_1	225	231	PF11976	0.281
LIG_SUMO_SIM_par_1	83	90	PF11976	0.411
LIG_UBA3_1	86	93	PF00899	0.403
MOD_CK1_1	122	128	PF00069	0.514
MOD_CK1_1	158	164	PF00069	0.428
MOD_CK1_1	177	183	PF00069	0.333
MOD_CK1_1	63	69	PF00069	0.438
MOD_CK2_1	62	68	PF00069	0.567
MOD_GlcNHglycan	124	127	PF01048	0.271
MOD_GlcNHglycan	157	160	PF01048	0.229
MOD_GlcNHglycan	27	30	PF01048	0.401
MOD_GSK3_1	122	129	PF00069	0.470
MOD_GSK3_1	62	69	PF00069	0.504
MOD_GSK3_1	92	99	PF00069	0.400
MOD_NEK2_1	44	49	PF00069	0.448
MOD_NEK2_1	92	97	PF00069	0.400
MOD_NEK2_2	3	8	PF00069	0.343
MOD_Plk_1	232	238	PF00069	0.411
MOD_Plk_4	177	183	PF00069	0.433
MOD_Plk_4	92	98	PF00069	0.401
MOD_ProDKin_1	60	66	PF00069	0.584
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.429
TRG_ENDOCYTIC_2	199	202	PF00928	0.515
TRG_ENDOCYTIC_2	220	223	PF00928	0.273
TRG_ENDOCYTIC_2	52	55	PF00928	0.379
TRG_Pf-PMV_PEXEL_1	104	108	PF00026	0.200
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.197
TRG_PTS1	238	241	PF00515	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHW3	Leptomonas seymouri	66%	100%
A0A0N1PCR6	Leptomonas seymouri	32%	100%
A0A1X0NZ20	Trypanosomatidae	34%	100%
A0A1X0NZ92	Trypanosomatidae	57%	100%
A0A422N3N7	Trypanosoma rangeli	55%	100%
A0A422N3S1	Trypanosoma rangeli	37%	100%
A4HBT6	Leishmania braziliensis	34%	100%
A4HBT7	Leishmania braziliensis	80%	100%
A4II60	Xenopus tropicalis	32%	100%
D0A1D6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
D0A1D7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
D0A1E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AGU6	Leishmania infantum	34%	94%
E9AGU7	Leishmania infantum	100%	100%
E9AV58	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AV59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	99%
O66821	Aquifex aeolicus (strain VF5)	33%	100%
O69537	Mycobacterium leprae (strain TN)	31%	100%
P07833	Plasmodium falciparum (isolate K1 / Thailand)	29%	100%
P09383	Schistosoma mansoni	30%	85%
P0A5T1	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	31%	100%
P0DD40	Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)	34%	100%
P0DD41	Streptococcus pyogenes serotype M3 (strain SSI-1)	34%	100%
P20035	Plasmodium falciparum (isolate FCR-3 / Gambia)	29%	100%
P37171	Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)	32%	100%
P43152	Leishmania donovani	34%	100%
P45078	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	29%	100%
P51900	Tritrichomonas foetus	36%	100%
P96794	Mycobacterium avium	34%	100%
P9WHQ8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	31%	100%
P9WHQ9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	31%	100%
Q07010	Trypanosoma brucei brucei	39%	100%
Q26997	Toxoplasma gondii	31%	100%
Q27541	Crithidia fasciculata	33%	100%
Q4QCC2	Leishmania major	94%	99%
Q4QCC3	Leishmania major	33%	94%
Q54NJ8	Dictyostelium discoideum	28%	100%
Q5HRP4	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	28%	100%
Q5M216	Streptococcus thermophilus (strain CNRZ 1066)	32%	100%
Q5M6K8	Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)	32%	100%
Q5XEL6	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	34%	100%
Q6DCP3	Xenopus laevis	32%	100%
Q7CNQ9	Streptococcus pyogenes serotype M18 (strain MGAS8232)	34%	100%
Q7KLF3	Leishmania donovani	34%	94%
Q839B2	Enterococcus faecalis (strain ATCC 700802 / V583)	33%	100%
Q8CQV4	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	28%	100%
Q8DRP8	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	34%	100%
Q8E2H3	Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)	35%	100%
Q8E7Y1	Streptococcus agalactiae serotype III (strain NEM316)	35%	100%
Q8K9U8	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	31%	100%
Q97TC4	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	34%	100%
V5DEL0	Trypanosoma cruzi	55%	78%