Uncharacterized protein L1648.04

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q9U1E4_LEIMA

TriTrypDb:

LmjF.32.2920 , LMJLV39_320036800 , LMJSD75_320037000

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 6
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q9U1E4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9U1E4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	202	204	PF00675	0.640
CLV_NRD_NRD_1	256	258	PF00675	0.693
CLV_NRD_NRD_1	297	299	PF00675	0.697
CLV_NRD_NRD_1	309	311	PF00675	0.667
CLV_NRD_NRD_1	355	357	PF00675	0.693
CLV_NRD_NRD_1	358	360	PF00675	0.634
CLV_NRD_NRD_1	538	540	PF00675	0.577
CLV_NRD_NRD_1	561	563	PF00675	0.768
CLV_NRD_NRD_1	603	605	PF00675	0.677
CLV_NRD_NRD_1	717	719	PF00675	0.501
CLV_NRD_NRD_1	81	83	PF00675	0.671
CLV_PCSK_FUR_1	356	360	PF00082	0.717
CLV_PCSK_KEX2_1	202	204	PF00082	0.623
CLV_PCSK_KEX2_1	309	311	PF00082	0.684
CLV_PCSK_KEX2_1	355	357	PF00082	0.709
CLV_PCSK_KEX2_1	358	360	PF00082	0.648
CLV_PCSK_KEX2_1	537	539	PF00082	0.578
CLV_PCSK_KEX2_1	603	605	PF00082	0.663
CLV_PCSK_KEX2_1	719	721	PF00082	0.475
CLV_PCSK_KEX2_1	723	725	PF00082	0.477
CLV_PCSK_KEX2_1	80	82	PF00082	0.661
CLV_PCSK_PC1ET2_1	719	721	PF00082	0.512
CLV_PCSK_PC1ET2_1	723	725	PF00082	0.523
CLV_PCSK_SKI1_1	309	313	PF00082	0.734
CLV_PCSK_SKI1_1	351	355	PF00082	0.742
CLV_PCSK_SKI1_1	48	52	PF00082	0.596
CLV_PCSK_SKI1_1	538	542	PF00082	0.645
CLV_PCSK_SKI1_1	570	574	PF00082	0.625
CLV_PCSK_SKI1_1	60	64	PF00082	0.462
CLV_PCSK_SKI1_1	720	724	PF00082	0.499
DEG_Nend_UBRbox_1	1	4	PF02207	0.474
DEG_SCF_FBW7_1	133	139	PF00400	0.397
DOC_CKS1_1	133	138	PF01111	0.443
DOC_CKS1_1	98	103	PF01111	0.417
DOC_MAPK_DCC_7	634	643	PF00069	0.267
DOC_MAPK_gen_1	2	11	PF00069	0.448
DOC_MAPK_gen_1	332	339	PF00069	0.541
DOC_MAPK_gen_1	355	365	PF00069	0.406
DOC_MAPK_gen_1	586	594	PF00069	0.498
DOC_MAPK_gen_1	623	633	PF00069	0.374
DOC_MAPK_MEF2A_6	2	11	PF00069	0.450
DOC_MAPK_MEF2A_6	332	341	PF00069	0.531
DOC_MAPK_MEF2A_6	497	506	PF00069	0.360
DOC_MAPK_RevD_3	681	697	PF00069	0.475
DOC_PP1_RVXF_1	536	543	PF00149	0.364
DOC_PP4_FxxP_1	32	35	PF00568	0.311
DOC_USP7_MATH_1	300	304	PF00917	0.577
DOC_USP7_MATH_1	54	58	PF00917	0.437
DOC_USP7_MATH_1	552	556	PF00917	0.520
DOC_USP7_MATH_1	561	565	PF00917	0.502
DOC_USP7_UBL2_3	295	299	PF12436	0.480
DOC_USP7_UBL2_3	715	719	PF12436	0.745
DOC_WW_Pin1_4	132	137	PF00397	0.373
DOC_WW_Pin1_4	496	501	PF00397	0.342
DOC_WW_Pin1_4	550	555	PF00397	0.513
DOC_WW_Pin1_4	97	102	PF00397	0.402
LIG_14-3-3_CanoR_1	309	314	PF00244	0.521
LIG_14-3-3_CanoR_1	342	349	PF00244	0.577
LIG_14-3-3_CanoR_1	478	484	PF00244	0.513
LIG_14-3-3_CanoR_1	60	70	PF00244	0.412
LIG_14-3-3_CanoR_1	629	634	PF00244	0.467
LIG_14-3-3_CanoR_1	670	679	PF00244	0.433
LIG_14-3-3_CanoR_1	718	723	PF00244	0.763
LIG_14-3-3_CterR_2	724	727	PF00244	0.677
LIG_Actin_WH2_2	327	344	PF00022	0.490
LIG_BRCT_BRCA1_1	24	28	PF00533	0.385
LIG_BRCT_BRCA1_1	360	364	PF00533	0.458
LIG_deltaCOP1_diTrp_1	260	266	PF00928	0.365
LIG_FHA_1	142	148	PF00498	0.334
LIG_FHA_1	182	188	PF00498	0.360
LIG_FHA_1	40	46	PF00498	0.421
LIG_FHA_1	419	425	PF00498	0.481
LIG_FHA_1	451	457	PF00498	0.443
LIG_FHA_1	480	486	PF00498	0.438
LIG_FHA_1	497	503	PF00498	0.280
LIG_FHA_1	525	531	PF00498	0.364
LIG_FHA_1	605	611	PF00498	0.366
LIG_FHA_1	626	632	PF00498	0.373
LIG_FHA_1	649	655	PF00498	0.402
LIG_FHA_1	705	711	PF00498	0.700
LIG_FHA_1	98	104	PF00498	0.414
LIG_FHA_2	224	230	PF00498	0.556
LIG_FHA_2	263	269	PF00498	0.461
LIG_FHA_2	529	535	PF00498	0.311
LIG_LIR_Apic_2	704	709	PF02991	0.753
LIG_LIR_Gen_1	123	133	PF02991	0.373
LIG_LIR_Gen_1	260	271	PF02991	0.413
LIG_LIR_Gen_1	425	436	PF02991	0.427
LIG_LIR_Gen_1	518	525	PF02991	0.393
LIG_LIR_Gen_1	658	666	PF02991	0.412
LIG_LIR_Gen_1	67	78	PF02991	0.418
LIG_LIR_Gen_1	84	94	PF02991	0.275
LIG_LIR_Nem_3	123	129	PF02991	0.355
LIG_LIR_Nem_3	260	266	PF02991	0.364
LIG_LIR_Nem_3	425	431	PF02991	0.445
LIG_LIR_Nem_3	518	523	PF02991	0.394
LIG_LIR_Nem_3	600	605	PF02991	0.461
LIG_LIR_Nem_3	614	620	PF02991	0.245
LIG_LIR_Nem_3	658	663	PF02991	0.340
LIG_LIR_Nem_3	67	73	PF02991	0.330
LIG_LIR_Nem_3	84	90	PF02991	0.303
LIG_LYPXL_S_1	286	290	PF13949	0.622
LIG_LYPXL_yS_3	287	290	PF13949	0.424
LIG_NRBOX	678	684	PF00104	0.449
LIG_Pex14_2	28	32	PF04695	0.401
LIG_PTB_Apo_2	72	79	PF02174	0.437
LIG_PTB_Phospho_1	72	78	PF10480	0.425
LIG_RPA_C_Fungi	299	311	PF08784	0.650
LIG_SH2_CRK	126	130	PF00017	0.474
LIG_SH2_CRK	428	432	PF00017	0.537
LIG_SH2_CRK	706	710	PF00017	0.719
LIG_SH2_CRK	99	103	PF00017	0.428
LIG_SH2_NCK_1	396	400	PF00017	0.541
LIG_SH2_SRC	278	281	PF00017	0.485
LIG_SH2_SRC	396	399	PF00017	0.528
LIG_SH2_STAP1	278	282	PF00017	0.515
LIG_SH2_STAP1	520	524	PF00017	0.482
LIG_SH2_STAT5	109	112	PF00017	0.515
LIG_SH2_STAT5	206	209	PF00017	0.442
LIG_SH2_STAT5	253	256	PF00017	0.664
LIG_SH2_STAT5	378	381	PF00017	0.438
LIG_SH2_STAT5	608	611	PF00017	0.393
LIG_SH2_STAT5	70	73	PF00017	0.460
LIG_SH2_STAT5	706	709	PF00017	0.720
LIG_SH2_STAT5	99	102	PF00017	0.536
LIG_SH3_1	634	640	PF00018	0.319
LIG_SH3_3	41	47	PF00018	0.498
LIG_SH3_3	634	640	PF00018	0.418
LIG_SH3_3	95	101	PF00018	0.536
LIG_SH3_4	573	580	PF00018	0.480
LIG_SUMO_SIM_anti_2	159	165	PF11976	0.399
LIG_SUMO_SIM_anti_2	482	488	PF11976	0.539
LIG_SUMO_SIM_anti_2	5	10	PF11976	0.460
LIG_SUMO_SIM_anti_2	653	658	PF11976	0.388
LIG_SUMO_SIM_par_1	127	132	PF11976	0.435
LIG_SUMO_SIM_par_1	48	53	PF11976	0.398
LIG_SUMO_SIM_par_1	606	614	PF11976	0.353
LIG_SUMO_SIM_par_1	639	645	PF11976	0.438
LIG_SUMO_SIM_par_1	653	658	PF11976	0.369
LIG_TYR_ITIM	426	431	PF00017	0.565
LIG_TYR_ITIM	68	73	PF00017	0.511
MOD_CK1_1	132	138	PF00069	0.569
MOD_CK1_1	153	159	PF00069	0.477
MOD_CK1_1	381	387	PF00069	0.423
MOD_CK1_1	407	413	PF00069	0.523
MOD_CK1_1	493	499	PF00069	0.458
MOD_CK1_1	64	70	PF00069	0.476
MOD_CK1_1	669	675	PF00069	0.488
MOD_CK2_1	182	188	PF00069	0.589
MOD_CK2_1	223	229	PF00069	0.621
MOD_CK2_1	262	268	PF00069	0.604
MOD_CK2_1	438	444	PF00069	0.594
MOD_CK2_1	629	635	PF00069	0.588
MOD_Cter_Amidation	255	258	PF01082	0.643
MOD_Cter_Amidation	330	333	PF01082	0.471
MOD_GlcNHglycan	183	187	PF01048	0.553
MOD_GlcNHglycan	192	195	PF01048	0.415
MOD_GlcNHglycan	334	337	PF01048	0.700
MOD_GlcNHglycan	440	443	PF01048	0.619
MOD_GlcNHglycan	55	59	PF01048	0.551
MOD_GlcNHglycan	92	95	PF01048	0.463
MOD_GSK3_1	107	114	PF00069	0.530
MOD_GSK3_1	132	139	PF00069	0.497
MOD_GSK3_1	18	25	PF00069	0.551
MOD_GSK3_1	262	269	PF00069	0.591
MOD_GSK3_1	337	344	PF00069	0.622
MOD_GSK3_1	378	385	PF00069	0.467
MOD_GSK3_1	446	453	PF00069	0.438
MOD_GSK3_1	524	531	PF00069	0.375
MOD_GSK3_1	615	622	PF00069	0.440
MOD_GSK3_1	625	632	PF00069	0.505
MOD_GSK3_1	665	672	PF00069	0.432
MOD_GSK3_1	69	76	PF00069	0.374
MOD_GSK3_1	718	725	PF00069	0.667
MOD_LATS_1	297	303	PF00433	0.488
MOD_N-GLC_1	112	117	PF02516	0.531
MOD_N-GLC_1	223	228	PF02516	0.675
MOD_N-GLC_1	351	356	PF02516	0.686
MOD_N-GLC_1	446	451	PF02516	0.430
MOD_N-GLC_1	704	709	PF02516	0.702
MOD_NEK2_1	112	117	PF00069	0.506
MOD_NEK2_1	13	18	PF00069	0.598
MOD_NEK2_1	141	146	PF00069	0.462
MOD_NEK2_1	190	195	PF00069	0.522
MOD_NEK2_1	266	271	PF00069	0.576
MOD_NEK2_1	337	342	PF00069	0.703
MOD_NEK2_1	446	451	PF00069	0.428
MOD_NEK2_1	485	490	PF00069	0.526
MOD_NEK2_1	524	529	PF00069	0.368
MOD_NEK2_1	62	67	PF00069	0.377
MOD_NEK2_1	665	670	PF00069	0.475
MOD_NEK2_2	262	267	PF00069	0.595
MOD_NEK2_2	598	603	PF00069	0.664
MOD_NEK2_2	69	74	PF00069	0.272
MOD_PIKK_1	141	147	PF00454	0.554
MOD_PIKK_1	18	24	PF00454	0.533
MOD_PIKK_1	223	229	PF00454	0.738
MOD_PIKK_1	342	348	PF00454	0.628
MOD_PIKK_1	407	413	PF00454	0.450
MOD_PIKK_1	450	456	PF00454	0.549
MOD_PKA_1	309	315	PF00069	0.675
MOD_PKA_1	332	338	PF00069	0.656
MOD_PKA_1	358	364	PF00069	0.572
MOD_PKA_1	718	724	PF00069	0.726
MOD_PKA_2	266	272	PF00069	0.549
MOD_PKA_2	300	306	PF00069	0.763
MOD_PKA_2	309	315	PF00069	0.684
MOD_PKA_2	341	347	PF00069	0.712
MOD_PKA_2	358	364	PF00069	0.416
MOD_PKA_2	561	567	PF00069	0.700
MOD_PKA_2	587	593	PF00069	0.637
MOD_PKA_2	669	675	PF00069	0.589
MOD_PKB_1	356	364	PF00069	0.523
MOD_Plk_1	112	118	PF00069	0.553
MOD_Plk_1	446	452	PF00069	0.424
MOD_Plk_1	590	596	PF00069	0.561
MOD_Plk_1	615	621	PF00069	0.507
MOD_Plk_1	704	710	PF00069	0.696
MOD_Plk_1	83	89	PF00069	0.562
MOD_Plk_4	112	118	PF00069	0.536
MOD_Plk_4	13	19	PF00069	0.558
MOD_Plk_4	136	142	PF00069	0.480
MOD_Plk_4	266	272	PF00069	0.555
MOD_Plk_4	382	388	PF00069	0.441
MOD_Plk_4	579	585	PF00069	0.523
MOD_Plk_4	590	596	PF00069	0.578
MOD_Plk_4	604	610	PF00069	0.398
MOD_Plk_4	69	75	PF00069	0.442
MOD_Plk_4	83	89	PF00069	0.490
MOD_ProDKin_1	132	138	PF00069	0.457
MOD_ProDKin_1	496	502	PF00069	0.419
MOD_ProDKin_1	550	556	PF00069	0.668
MOD_ProDKin_1	97	103	PF00069	0.502
MOD_SUMO_rev_2	193	199	PF00179	0.530
TRG_DiLeu_BaEn_1	124	129	PF01217	0.488
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.775
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.554
TRG_ENDOCYTIC_2	109	112	PF00928	0.474
TRG_ENDOCYTIC_2	126	129	PF00928	0.450
TRG_ENDOCYTIC_2	192	195	PF00928	0.454
TRG_ENDOCYTIC_2	278	281	PF00928	0.544
TRG_ENDOCYTIC_2	287	290	PF00928	0.486
TRG_ENDOCYTIC_2	396	399	PF00928	0.381
TRG_ENDOCYTIC_2	428	431	PF00928	0.504
TRG_ENDOCYTIC_2	520	523	PF00928	0.483
TRG_ENDOCYTIC_2	581	584	PF00928	0.594
TRG_ENDOCYTIC_2	660	663	PF00928	0.404
TRG_ENDOCYTIC_2	70	73	PF00928	0.405
TRG_ENDOCYTIC_2	99	102	PF00928	0.454
TRG_ER_diArg_1	1	4	PF00400	0.479
TRG_ER_diArg_1	202	204	PF00400	0.558
TRG_ER_diArg_1	355	358	PF00400	0.674
TRG_ER_diArg_1	537	539	PF00400	0.489
TRG_ER_diArg_1	602	604	PF00400	0.628
TRG_ER_diArg_1	80	82	PF00400	0.659
TRG_NLS_MonoExtN_4	295	302	PF00514	0.641
TRG_NLS_MonoExtN_4	715	722	PF00514	0.688
TRG_Pf-PMV_PEXEL_1	236	241	PF00026	0.774
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML4	Leptomonas seymouri	62%	100%
A0A0S4JLI3	Bodo saltans	34%	93%
A0A1X0NRQ2	Trypanosomatidae	42%	100%
A0A3R7KWB9	Trypanosoma rangeli	42%	100%
A0A3S7X607	Leishmania donovani	96%	100%
A4HKT4	Leishmania braziliensis	84%	100%
A4I8B3	Leishmania infantum	96%	100%
D0AAI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B372	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5AXZ0	Trypanosoma cruzi	42%	100%