Uncharacterized protein L1648.06

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q9U1E2_LEIMA

TriTrypDb:

LmjF.32.2940 , LMJLV39_320037000 , LMJSD75_320037200

Length:

604

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q9U1E2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9U1E2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	475	479	PF00656	0.276
CLV_C14_Caspase3-7	484	488	PF00656	0.481
CLV_NRD_NRD_1	129	131	PF00675	0.594
CLV_NRD_NRD_1	284	286	PF00675	0.362
CLV_NRD_NRD_1	397	399	PF00675	0.501
CLV_NRD_NRD_1	464	466	PF00675	0.376
CLV_NRD_NRD_1	567	569	PF00675	0.626
CLV_NRD_NRD_1	75	77	PF00675	0.526
CLV_PCSK_KEX2_1	210	212	PF00082	0.319
CLV_PCSK_KEX2_1	276	278	PF00082	0.301
CLV_PCSK_KEX2_1	284	286	PF00082	0.340
CLV_PCSK_KEX2_1	396	398	PF00082	0.500
CLV_PCSK_KEX2_1	48	50	PF00082	0.554
CLV_PCSK_KEX2_1	536	538	PF00082	0.430
CLV_PCSK_KEX2_1	569	571	PF00082	0.683
CLV_PCSK_KEX2_1	75	77	PF00082	0.550
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.319
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.301
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.629
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.430
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.683
CLV_PCSK_SKI1_1	110	114	PF00082	0.532
CLV_PCSK_SKI1_1	134	138	PF00082	0.390
CLV_PCSK_SKI1_1	152	156	PF00082	0.427
CLV_PCSK_SKI1_1	16	20	PF00082	0.568
CLV_PCSK_SKI1_1	277	281	PF00082	0.406
CLV_PCSK_SKI1_1	33	37	PF00082	0.511
CLV_PCSK_SKI1_1	521	525	PF00082	0.475
DEG_APCC_DBOX_1	276	284	PF00400	0.307
DEG_Nend_UBRbox_1	1	4	PF02207	0.537
DEG_ODPH_VHL_1	257	270	PF01847	0.224
DOC_CYCLIN_RxL_1	238	246	PF00134	0.279
DOC_CYCLIN_RxL_1	274	282	PF00134	0.401
DOC_CYCLIN_yCln2_LP_2	14	20	PF00134	0.669
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.279
DOC_MAPK_DCC_7	10	20	PF00069	0.588
DOC_MAPK_gen_1	167	176	PF00069	0.412
DOC_MAPK_gen_1	440	449	PF00069	0.271
DOC_MAPK_gen_1	465	472	PF00069	0.348
DOC_MAPK_gen_1	536	543	PF00069	0.389
DOC_MAPK_gen_1	75	83	PF00069	0.531
DOC_MAPK_JIP1_4	598	604	PF00069	0.682
DOC_MAPK_MEF2A_6	152	160	PF00069	0.351
DOC_MAPK_MEF2A_6	536	545	PF00069	0.392
DOC_MAPK_MEF2A_6	87	95	PF00069	0.572
DOC_MAPK_RevD_3	93	107	PF00069	0.393
DOC_PP1_RVXF_1	508	515	PF00149	0.465
DOC_PP1_SILK_1	223	228	PF00149	0.349
DOC_PP1_SILK_1	431	436	PF00149	0.292
DOC_PP2B_LxvP_1	410	413	PF13499	0.515
DOC_PP4_FxxP_1	495	498	PF00568	0.425
DOC_SPAK_OSR1_1	66	70	PF12202	0.577
DOC_USP7_MATH_1	306	310	PF00917	0.579
DOC_USP7_MATH_1	367	371	PF00917	0.702
DOC_USP7_MATH_1	506	510	PF00917	0.481
DOC_USP7_MATH_2	498	504	PF00917	0.469
DOC_USP7_UBL2_3	102	106	PF12436	0.400
DOC_USP7_UBL2_3	167	171	PF12436	0.348
DOC_USP7_UBL2_3	507	511	PF12436	0.596
DOC_WW_Pin1_4	228	233	PF00397	0.271
DOC_WW_Pin1_4	350	355	PF00397	0.462
DOC_WW_Pin1_4	442	447	PF00397	0.271
LIG_14-3-3_CanoR_1	177	183	PF00244	0.431
LIG_14-3-3_CanoR_1	227	232	PF00244	0.289
LIG_14-3-3_CanoR_1	556	562	PF00244	0.551
LIG_14-3-3_CanoR_1	576	586	PF00244	0.623
LIG_14-3-3_CanoR_1	66	72	PF00244	0.511
LIG_14-3-3_CanoR_1	75	83	PF00244	0.497
LIG_Actin_WH2_2	86	104	PF00022	0.331
LIG_BIR_III_2	478	482	PF00653	0.324
LIG_BIR_III_4	289	293	PF00653	0.421
LIG_BRCT_BRCA1_1	63	67	PF00533	0.581
LIG_FHA_1	22	28	PF00498	0.630
LIG_FHA_1	260	266	PF00498	0.271
LIG_FHA_1	360	366	PF00498	0.601
LIG_FHA_1	434	440	PF00498	0.335
LIG_FHA_1	582	588	PF00498	0.574
LIG_FHA_2	473	479	PF00498	0.294
LIG_LIR_Apic_2	493	498	PF02991	0.410
LIG_LIR_Apic_2	593	599	PF02991	0.564
LIG_LIR_Gen_1	323	334	PF02991	0.364
LIG_LIR_Gen_1	406	417	PF02991	0.646
LIG_LIR_Nem_3	294	299	PF02991	0.377
LIG_LIR_Nem_3	323	329	PF02991	0.368
LIG_LIR_Nem_3	487	492	PF02991	0.379
LIG_LIR_Nem_3	517	523	PF02991	0.452
LIG_NRBOX	140	146	PF00104	0.408
LIG_Pex14_2	386	390	PF04695	0.432
LIG_PTB_Apo_2	40	47	PF02174	0.514
LIG_SH2_CRK	229	233	PF00017	0.289
LIG_SH2_CRK	341	345	PF00017	0.496
LIG_SH2_CRK	596	600	PF00017	0.561
LIG_SH2_GRB2like	242	245	PF00017	0.404
LIG_SH2_GRB2like	399	402	PF00017	0.501
LIG_SH2_NCK_1	596	600	PF00017	0.561
LIG_SH2_PTP2	469	472	PF00017	0.404
LIG_SH2_STAP1	341	345	PF00017	0.441
LIG_SH2_STAP1	63	67	PF00017	0.649
LIG_SH2_STAT3	578	581	PF00017	0.591
LIG_SH2_STAT5	229	232	PF00017	0.290
LIG_SH2_STAT5	242	245	PF00017	0.369
LIG_SH2_STAT5	409	412	PF00017	0.583
LIG_SH2_STAT5	469	472	PF00017	0.404
LIG_SH2_STAT5	531	534	PF00017	0.508
LIG_SH2_STAT5	596	599	PF00017	0.541
LIG_SH3_3	253	259	PF00018	0.286
LIG_SH3_3	267	273	PF00018	0.343
LIG_SH3_3	402	408	PF00018	0.447
LIG_SH3_3	446	452	PF00018	0.182
LIG_SH3_3	66	72	PF00018	0.516
LIG_SH3_3	78	84	PF00018	0.463
LIG_SUMO_SIM_anti_2	267	272	PF11976	0.357
LIG_SUMO_SIM_par_1	172	178	PF11976	0.444
LIG_SUMO_SIM_par_1	264	269	PF11976	0.250
LIG_TRAF2_1	147	150	PF00917	0.540
LIG_TRAF2_1	370	373	PF00917	0.466
LIG_TRAF2_1	481	484	PF00917	0.577
LIG_UBA3_1	501	507	PF00899	0.482
LIG_WRC_WIRS_1	434	439	PF05994	0.349
MOD_CK1_1	178	184	PF00069	0.459
MOD_CK1_1	343	349	PF00069	0.577
MOD_CK1_1	39	45	PF00069	0.570
MOD_CK1_1	563	569	PF00069	0.542
MOD_CK1_1	580	586	PF00069	0.472
MOD_CK1_1	594	600	PF00069	0.562
MOD_CK1_1	74	80	PF00069	0.485
MOD_CK2_1	355	361	PF00069	0.632
MOD_CK2_1	367	373	PF00069	0.594
MOD_CK2_1	541	547	PF00069	0.395
MOD_CK2_1	548	554	PF00069	0.480
MOD_Cter_Amidation	208	211	PF01082	0.271
MOD_Cter_Amidation	382	385	PF01082	0.555
MOD_GlcNHglycan	121	124	PF01048	0.414
MOD_GlcNHglycan	177	180	PF01048	0.505
MOD_GlcNHglycan	357	360	PF01048	0.668
MOD_GlcNHglycan	550	553	PF01048	0.486
MOD_GSK3_1	33	40	PF00069	0.552
MOD_GSK3_1	339	346	PF00069	0.443
MOD_GSK3_1	355	362	PF00069	0.378
MOD_GSK3_1	429	436	PF00069	0.292
MOD_GSK3_1	53	60	PF00069	0.345
MOD_GSK3_1	556	563	PF00069	0.508
MOD_GSK3_1	577	584	PF00069	0.601
MOD_GSK3_1	590	597	PF00069	0.571
MOD_GSK3_1	67	74	PF00069	0.472
MOD_N-GLC_1	259	264	PF02516	0.289
MOD_N-GLC_2	546	548	PF02516	0.463
MOD_NEK2_1	119	124	PF00069	0.427
MOD_NEK2_1	264	269	PF00069	0.250
MOD_NEK2_1	355	360	PF00069	0.603
MOD_NEK2_1	365	370	PF00069	0.549
MOD_NEK2_1	37	42	PF00069	0.603
MOD_NEK2_1	515	520	PF00069	0.439
MOD_NEK2_1	541	546	PF00069	0.408
MOD_NEK2_1	577	582	PF00069	0.602
MOD_NEK2_1	62	67	PF00069	0.652
MOD_NEK2_2	531	536	PF00069	0.514
MOD_NEK2_2	591	596	PF00069	0.573
MOD_PIKK_1	577	583	PF00454	0.589
MOD_PIKK_1	67	73	PF00454	0.630
MOD_PK_1	429	435	PF00069	0.292
MOD_PKA_2	346	352	PF00069	0.424
MOD_PKA_2	74	80	PF00069	0.504
MOD_PKB_1	568	576	PF00069	0.696
MOD_Plk_1	33	39	PF00069	0.537
MOD_Plk_1	429	435	PF00069	0.384
MOD_Plk_4	266	272	PF00069	0.467
MOD_Plk_4	27	33	PF00069	0.553
MOD_Plk_4	340	346	PF00069	0.572
MOD_Plk_4	429	435	PF00069	0.384
MOD_Plk_4	500	506	PF00069	0.451
MOD_Plk_4	557	563	PF00069	0.556
MOD_Plk_4	591	597	PF00069	0.570
MOD_ProDKin_1	228	234	PF00069	0.271
MOD_ProDKin_1	350	356	PF00069	0.467
MOD_ProDKin_1	442	448	PF00069	0.271
MOD_SUMO_for_1	496	499	PF00179	0.478
MOD_SUMO_rev_2	105	112	PF00179	0.484
TRG_DiLeu_BaEn_3	150	156	PF01217	0.484
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.536
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.437
TRG_DiLeu_BaLyEn_6	421	426	PF01217	0.335
TRG_ENDOCYTIC_2	242	245	PF00928	0.438
TRG_ENDOCYTIC_2	341	344	PF00928	0.504
TRG_ENDOCYTIC_2	409	412	PF00928	0.638
TRG_ENDOCYTIC_2	469	472	PF00928	0.438
TRG_ER_diArg_1	283	285	PF00400	0.341
TRG_ER_diArg_1	396	398	PF00400	0.493
TRG_NLS_MonoExtN_4	130	135	PF00514	0.469
TRG_Pf-PMV_PEXEL_1	152	157	PF00026	0.366
TRG_Pf-PMV_PEXEL_1	277	282	PF00026	0.322

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBK1	Leptomonas seymouri	70%	100%
A0A1X0NRN7	Trypanosomatidae	58%	99%
A0A3R7NSK8	Trypanosoma rangeli	60%	100%
A0A3S7X5W5	Leishmania donovani	95%	100%
A4HKT6	Leishmania braziliensis	87%	100%
A4I8B5	Leishmania infantum	95%	100%
D0AAI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	99%
E9B374	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5DE73	Trypanosoma cruzi	57%	100%