DNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA helicase

Gene product:

DNA replication licensing factor MCM7, putative

Species:

Leishmania major

UniProt:

Q9U1E0_LEIMA

TriTrypDb:

LmjF.32.2960 , LMJLV39_320037200 , LMJSD75_320037400

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0032991	protein-containing complex	1	11
GO:0042555	MCM complex	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q9U1E0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9U1E0

Function

Biological processes
Term	Name	Level	Count
GO:0000724	double-strand break repair via homologous recombination	7	2
GO:0000725	recombinational repair	6	2
GO:0000727	double-strand break repair via break-induced replication	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006268	DNA unwinding involved in DNA replication	9	2
GO:0006270	DNA replication initiation	5	11
GO:0006271	DNA strand elongation involved in DNA replication	6	2
GO:0006281	DNA repair	5	2
GO:0006302	double-strand break repair	6	2
GO:0006310	DNA recombination	5	2
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0006996	organelle organization	4	2
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	2
GO:0022616	DNA strand elongation	5	2
GO:0032392	DNA geometric change	7	2
GO:0032508	DNA duplex unwinding	8	2
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0050896	response to stimulus	1	2
GO:0051276	chromosome organization	5	2
GO:0051716	cellular response to stimulus	2	2
GO:0071103	DNA conformation change	6	2
GO:0071704	organic substance metabolic process	2	11
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003678	DNA helicase activity	3	11
GO:0003697	single-stranded DNA binding	5	2
GO:0003824	catalytic activity	1	11
GO:0004386	helicase activity	2	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0008094	ATP-dependent activity, acting on DNA	2	11
GO:0016787	hydrolase activity	2	10
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140097	catalytic activity, acting on DNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0016462	pyrophosphatase activity	5	7
GO:0016817	hydrolase activity, acting on acid anhydrides	3	7
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	7
GO:0016887	ATP hydrolysis activity	7	7
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.490
CLV_C14_Caspase3-7	661	665	PF00656	0.416
CLV_NRD_NRD_1	126	128	PF00675	0.209
CLV_PCSK_FUR_1	491	495	PF00082	0.209
CLV_PCSK_KEX2_1	126	128	PF00082	0.209
CLV_PCSK_KEX2_1	28	30	PF00082	0.222
CLV_PCSK_KEX2_1	304	306	PF00082	0.420
CLV_PCSK_KEX2_1	493	495	PF00082	0.209
CLV_PCSK_KEX2_1	573	575	PF00082	0.265
CLV_PCSK_KEX2_1	6	8	PF00082	0.547
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.265
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.463
CLV_PCSK_PC1ET2_1	493	495	PF00082	0.255
CLV_PCSK_PC1ET2_1	573	575	PF00082	0.265
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.547
CLV_PCSK_PC7_1	24	30	PF00082	0.262
CLV_PCSK_SKI1_1	145	149	PF00082	0.198
CLV_PCSK_SKI1_1	223	227	PF00082	0.265
CLV_PCSK_SKI1_1	258	262	PF00082	0.193
CLV_PCSK_SKI1_1	28	32	PF00082	0.222
CLV_PCSK_SKI1_1	349	353	PF00082	0.209
CLV_PCSK_SKI1_1	397	401	PF00082	0.209
CLV_PCSK_SKI1_1	452	456	PF00082	0.209
CLV_PCSK_SKI1_1	494	498	PF00082	0.209
CLV_PCSK_SKI1_1	562	566	PF00082	0.244
CLV_PCSK_SKI1_1	608	612	PF00082	0.242
CLV_PCSK_SKI1_1	651	655	PF00082	0.537
CLV_PCSK_SKI1_1	658	662	PF00082	0.452
CLV_PCSK_SKI1_1	687	691	PF00082	0.420
DEG_APCC_DBOX_1	168	176	PF00400	0.409
DEG_APCC_DBOX_1	451	459	PF00400	0.409
DEG_APCC_DBOX_1	510	518	PF00400	0.455
DEG_APCC_DBOX_1	607	615	PF00400	0.422
DEG_MDM2_SWIB_1	512	519	PF02201	0.409
DEG_SPOP_SBC_1	659	663	PF00917	0.454
DOC_CKS1_1	1	6	PF01111	0.567
DOC_CKS1_1	259	264	PF01111	0.393
DOC_CYCLIN_RxL_1	605	612	PF00134	0.425
DOC_MAPK_gen_1	126	132	PF00069	0.409
DOC_MAPK_gen_1	148	157	PF00069	0.424
DOC_MAPK_gen_1	169	178	PF00069	0.409
DOC_MAPK_gen_1	223	232	PF00069	0.409
DOC_MAPK_gen_1	367	376	PF00069	0.486
DOC_MAPK_gen_1	676	683	PF00069	0.390
DOC_MAPK_gen_1	702	712	PF00069	0.483
DOC_MAPK_MEF2A_6	169	178	PF00069	0.409
DOC_MAPK_MEF2A_6	367	376	PF00069	0.486
DOC_MAPK_MEF2A_6	511	519	PF00069	0.409
DOC_PP1_RVXF_1	620	626	PF00149	0.456
DOC_USP7_MATH_1	11	15	PF00917	0.588
DOC_USP7_MATH_1	113	117	PF00917	0.446
DOC_USP7_MATH_1	274	278	PF00917	0.394
DOC_USP7_MATH_1	477	481	PF00917	0.409
DOC_USP7_MATH_1	599	603	PF00917	0.362
DOC_USP7_UBL2_3	292	296	PF12436	0.389
DOC_WW_Pin1_4	193	198	PF00397	0.409
DOC_WW_Pin1_4	258	263	PF00397	0.363
DOC_WW_Pin1_4	494	499	PF00397	0.409
LIG_14-3-3_CanoR_1	169	175	PF00244	0.395
LIG_14-3-3_CanoR_1	286	291	PF00244	0.430
LIG_14-3-3_CanoR_1	367	376	PF00244	0.409
LIG_14-3-3_CanoR_1	553	560	PF00244	0.592
LIG_14-3-3_CanoR_1	595	604	PF00244	0.422
LIG_14-3-3_CanoR_1	608	614	PF00244	0.422
LIG_14-3-3_CanoR_1	615	623	PF00244	0.323
LIG_14-3-3_CanoR_1	624	630	PF00244	0.389
LIG_14-3-3_CanoR_1	651	660	PF00244	0.555
LIG_14-3-3_CanoR_1	676	682	PF00244	0.523
LIG_14-3-3_CanoR_1	702	708	PF00244	0.376
LIG_Actin_WH2_2	609	626	PF00022	0.424
LIG_APCC_ABBA_1	575	580	PF00400	0.465
LIG_APCC_ABBA_1	58	63	PF00400	0.414
LIG_BRCT_BRCA1_1	54	58	PF00533	0.377
LIG_FHA_1	152	158	PF00498	0.409
LIG_FHA_1	245	251	PF00498	0.395
LIG_FHA_1	333	339	PF00498	0.409
LIG_FHA_1	410	416	PF00498	0.409
LIG_FHA_1	419	425	PF00498	0.409
LIG_FHA_1	477	483	PF00498	0.422
LIG_FHA_1	497	503	PF00498	0.389
LIG_FHA_1	97	103	PF00498	0.465
LIG_FHA_2	495	501	PF00498	0.409
LIG_FHA_2	544	550	PF00498	0.478
LIG_FHA_2	553	559	PF00498	0.492
LIG_FHA_2	659	665	PF00498	0.438
LIG_FHA_2	704	710	PF00498	0.382
LIG_FHA_2	716	722	PF00498	0.377
LIG_LIR_Gen_1	184	195	PF02991	0.409
LIG_LIR_Gen_1	442	451	PF02991	0.409
LIG_LIR_Gen_1	510	519	PF02991	0.409
LIG_LIR_Gen_1	55	66	PF02991	0.475
LIG_LIR_Gen_1	588	599	PF02991	0.422
LIG_LIR_Gen_1	666	675	PF02991	0.474
LIG_LIR_Gen_1	706	715	PF02991	0.367
LIG_LIR_Nem_3	14	20	PF02991	0.439
LIG_LIR_Nem_3	184	190	PF02991	0.409
LIG_LIR_Nem_3	222	227	PF02991	0.422
LIG_LIR_Nem_3	293	298	PF02991	0.306
LIG_LIR_Nem_3	510	515	PF02991	0.409
LIG_LIR_Nem_3	55	61	PF02991	0.512
LIG_LIR_Nem_3	666	671	PF02991	0.465
LIG_LIR_Nem_3	706	710	PF02991	0.373
LIG_LIR_Nem_3	86	92	PF02991	0.456
LIG_NRBOX	513	519	PF00104	0.397
LIG_PCNA_yPIPBox_3	205	216	PF02747	0.409
LIG_PCNA_yPIPBox_3	76	85	PF02747	0.504
LIG_Pex14_2	30	34	PF04695	0.422
LIG_Pex14_2	512	516	PF04695	0.409
LIG_Pex14_2	560	564	PF04695	0.363
LIG_PTB_Apo_2	483	490	PF02174	0.409
LIG_SH2_CRK	295	299	PF00017	0.365
LIG_SH2_GRB2like	20	23	PF00017	0.416
LIG_SH2_NCK_1	9	13	PF00017	0.516
LIG_SH2_PTP2	578	581	PF00017	0.455
LIG_SH2_SRC	307	310	PF00017	0.416
LIG_SH2_SRC	578	581	PF00017	0.455
LIG_SH2_STAP1	128	132	PF00017	0.409
LIG_SH2_STAP1	9	13	PF00017	0.516
LIG_SH2_STAT3	43	46	PF00017	0.455
LIG_SH2_STAT5	20	23	PF00017	0.369
LIG_SH2_STAT5	272	275	PF00017	0.409
LIG_SH2_STAT5	43	46	PF00017	0.504
LIG_SH2_STAT5	559	562	PF00017	0.361
LIG_SH2_STAT5	568	571	PF00017	0.409
LIG_SH2_STAT5	578	581	PF00017	0.409
LIG_SH2_STAT5	591	594	PF00017	0.370
LIG_SH2_STAT5	707	710	PF00017	0.492
LIG_SH3_3	137	143	PF00018	0.360
LIG_SH3_3	268	274	PF00018	0.525
LIG_SH3_3	499	505	PF00018	0.409
LIG_SUMO_SIM_anti_2	154	159	PF11976	0.409
LIG_SUMO_SIM_anti_2	609	615	PF11976	0.422
LIG_SUMO_SIM_par_1	173	180	PF11976	0.409
LIG_TRAF2_1	116	119	PF00917	0.504
LIG_TRAF2_1	306	309	PF00917	0.419
LIG_TYR_ITSM	291	298	PF00017	0.457
MOD_CK1_1	136	142	PF00069	0.489
MOD_CK1_1	398	404	PF00069	0.409
MOD_CK1_1	450	456	PF00069	0.465
MOD_CK1_1	644	650	PF00069	0.418
MOD_CK1_1	663	669	PF00069	0.418
MOD_CK2_1	113	119	PF00069	0.504
MOD_CK2_1	174	180	PF00069	0.409
MOD_CK2_1	303	309	PF00069	0.413
MOD_CK2_1	494	500	PF00069	0.409
MOD_CK2_1	519	525	PF00069	0.409
MOD_CK2_1	552	558	PF00069	0.499
MOD_CK2_1	703	709	PF00069	0.420
MOD_CK2_1	715	721	PF00069	0.439
MOD_GlcNHglycan	115	118	PF01048	0.267
MOD_GlcNHglycan	406	409	PF01048	0.209
MOD_GlcNHglycan	597	600	PF01048	0.304
MOD_GlcNHglycan	715	718	PF01048	0.447
MOD_GSK3_1	170	177	PF00069	0.409
MOD_GSK3_1	254	261	PF00069	0.363
MOD_GSK3_1	286	293	PF00069	0.412
MOD_GSK3_1	395	402	PF00069	0.409
MOD_GSK3_1	409	416	PF00069	0.409
MOD_GSK3_1	52	59	PF00069	0.432
MOD_GSK3_1	528	535	PF00069	0.409
MOD_GSK3_1	595	602	PF00069	0.440
MOD_GSK3_1	659	666	PF00069	0.492
MOD_GSK3_1	677	684	PF00069	0.564
MOD_GSK3_1	711	718	PF00069	0.448
MOD_N-GLC_1	494	499	PF02516	0.209
MOD_NEK2_1	174	179	PF00069	0.407
MOD_NEK2_1	285	290	PF00069	0.448
MOD_NEK2_1	334	339	PF00069	0.409
MOD_NEK2_1	34	39	PF00069	0.443
MOD_NEK2_1	519	524	PF00069	0.409
MOD_NEK2_1	532	537	PF00069	0.409
MOD_NEK2_1	641	646	PF00069	0.422
MOD_NEK2_2	528	533	PF00069	0.407
MOD_PIKK_1	200	206	PF00454	0.409
MOD_PIKK_1	382	388	PF00454	0.409
MOD_PIKK_1	614	620	PF00454	0.422
MOD_PKA_2	113	119	PF00069	0.504
MOD_PKA_2	266	272	PF00069	0.495
MOD_PKA_2	285	291	PF00069	0.328
MOD_PKA_2	34	40	PF00069	0.469
MOD_PKA_2	477	483	PF00069	0.409
MOD_PKA_2	52	58	PF00069	0.368
MOD_PKA_2	552	558	PF00069	0.614
MOD_PKA_2	599	605	PF00069	0.435
MOD_PKA_2	614	620	PF00069	0.391
MOD_PKA_2	623	629	PF00069	0.428
MOD_PKA_2	677	683	PF00069	0.423
MOD_Plk_1	136	142	PF00069	0.352
MOD_Plk_1	183	189	PF00069	0.409
MOD_Plk_1	254	260	PF00069	0.409
MOD_Plk_1	450	456	PF00069	0.409
MOD_Plk_1	528	534	PF00069	0.409
MOD_Plk_1	663	669	PF00069	0.486
MOD_Plk_2-3	303	309	PF00069	0.413
MOD_Plk_4	153	159	PF00069	0.418
MOD_Plk_4	170	176	PF00069	0.359
MOD_Plk_4	286	292	PF00069	0.422
MOD_Plk_4	477	483	PF00069	0.409
MOD_Plk_4	52	58	PF00069	0.424
MOD_Plk_4	609	615	PF00069	0.422
MOD_Plk_4	663	669	PF00069	0.486
MOD_Plk_4	715	721	PF00069	0.469
MOD_Plk_4	91	97	PF00069	0.490
MOD_ProDKin_1	193	199	PF00069	0.409
MOD_ProDKin_1	258	264	PF00069	0.363
MOD_ProDKin_1	494	500	PF00069	0.409
MOD_SUMO_rev_2	341	351	PF00179	0.409
TRG_DiLeu_BaEn_1	119	124	PF01217	0.490
TRG_DiLeu_BaEn_1	427	432	PF01217	0.409
TRG_DiLeu_BaEn_1	636	641	PF01217	0.422
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.409
TRG_DiLeu_LyEn_5	636	641	PF01217	0.422
TRG_ENDOCYTIC_2	227	230	PF00928	0.440
TRG_ENDOCYTIC_2	295	298	PF00928	0.431
TRG_ENDOCYTIC_2	591	594	PF00928	0.422
TRG_ENDOCYTIC_2	707	710	PF00928	0.377
TRG_ENDOCYTIC_2	89	92	PF00928	0.430
TRG_ER_diArg_1	126	128	PF00400	0.409
TRG_ER_diArg_1	366	369	PF00400	0.409
TRG_ER_diArg_1	622	625	PF00400	0.422
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.209
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.224
TRG_Pf-PMV_PEXEL_1	628	632	PF00026	0.260

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P686	Leptomonas seymouri	34%	84%
A0A0N0P9H0	Leptomonas seymouri	31%	79%
A0A0N1I2J6	Leptomonas seymouri	32%	81%
A0A0N1I371	Leptomonas seymouri	91%	100%
A0A0N1PC47	Leptomonas seymouri	30%	91%
A0A0S4IVB8	Bodo saltans	34%	83%
A0A0S4IW18	Bodo saltans	34%	90%
A0A0S4IYQ3	Bodo saltans	30%	90%
A0A0S4J4D4	Bodo saltans	31%	78%
A0A0S4J5X8	Bodo saltans	32%	96%
A0A0S4JM41	Bodo saltans	35%	92%
A0A1X0NQM5	Trypanosomatidae	32%	82%
A0A1X0NSY3	Trypanosomatidae	36%	85%
A0A1X0NT66	Trypanosomatidae	78%	99%
A0A1X0NVE7	Trypanosomatidae	31%	91%
A0A1X0NZT6	Trypanosomatidae	35%	77%
A0A1X0P1Q1	Trypanosomatidae	30%	100%
A0A3Q8IQ79	Leishmania donovani	30%	80%
A0A3R7K9K0	Trypanosoma rangeli	37%	91%
A0A3R7MUG3	Trypanosoma rangeli	34%	96%
A0A3S5H7J9	Leishmania donovani	32%	82%
A0A3S5H7S8	Leishmania donovani	98%	100%
A0A3S7WY81	Leishmania donovani	29%	91%
A0A3S7X726	Leishmania donovani	34%	82%
A0A422N694	Trypanosoma rangeli	32%	100%
A0A422NDR0	Trypanosoma rangeli	30%	100%
A0A422NHH5	Trypanosoma rangeli	31%	94%
A0A422NZW3	Trypanosoma rangeli	78%	99%
A4FUD9	Bos taurus	38%	90%
A4HDE7	Leishmania braziliensis	30%	90%
A4HGC9	Leishmania braziliensis	32%	75%
A4HGU2	Leishmania braziliensis	33%	82%
A4HKT9	Leishmania braziliensis	94%	100%
A4HLY1	Leishmania braziliensis	34%	83%
A4I0T0	Leishmania infantum	29%	91%
A4I3W9	Leishmania infantum	32%	82%
A4I8B8	Leishmania infantum	98%	100%
A4I9B0	Leishmania infantum	34%	82%
A4IC27	Leishmania infantum	30%	80%
B8AEH3	Oryza sativa subsp. indica	34%	99%
B8AZ14	Oryza sativa subsp. indica	33%	92%
B8AZ99	Oryza sativa subsp. indica	34%	94%
B8AZX3	Oryza sativa subsp. indica	35%	87%
B8B406	Oryza sativa subsp. indica	34%	100%
B8BKI8	Oryza sativa subsp. indica	36%	75%
B8BMI1	Oryza sativa subsp. indica	42%	100%
B9FKM7	Oryza sativa subsp. japonica	33%	92%
C9ZJB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	89%
D0A4I0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0A759	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	94%
D0A936	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	84%
D0A999	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	87%
D0AAI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	99%
D3ZVK1	Rattus norvegicus	33%	87%
E1BPX4	Bos taurus	33%	89%
E9AWT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	91%
E9B059	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	82%
E9B377	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9B4B0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	83%
E9B719	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	80%
F4IFF3	Arabidopsis thaliana	33%	100%
F4KAB8	Arabidopsis thaliana	36%	87%
I0IUP3	Gallus gallus	33%	87%
O75001	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	95%
O80786	Arabidopsis thaliana	35%	100%
P25205	Homo sapiens	38%	90%
P25206	Mus musculus	38%	89%
P29458	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	78%
P29469	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	84%
P29496	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	94%
P30664	Xenopus laevis	37%	84%
P30665	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	78%
P30666	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	82%
P33991	Homo sapiens	38%	84%
P33992	Homo sapiens	35%	99%
P33993	Homo sapiens	42%	100%
P34647	Caenorhabditis elegans	32%	90%
P38132	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	86%
P40377	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	87%
P41389	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
P43299	Arabidopsis thaliana	42%	100%
P49717	Mus musculus	38%	84%
P49718	Mus musculus	31%	99%
P49731	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	81%
P49735	Drosophila melanogaster	37%	82%
P49736	Homo sapiens	36%	80%
P49739	Xenopus laevis	38%	90%
P55861	Xenopus laevis	35%	82%
P55862	Xenopus laevis	35%	99%
P97310	Mus musculus	35%	80%
P97311	Mus musculus	31%	88%
Q0DHC4	Oryza sativa subsp. japonica	34%	94%
Q0V8B7	Bos taurus	35%	99%
Q0V9Q6	Xenopus tropicalis	33%	86%
Q0WVF5	Arabidopsis thaliana	39%	86%
Q14566	Homo sapiens	31%	88%
Q21902	Caenorhabditis elegans	32%	96%
Q26454	Drosophila melanogaster	36%	84%
Q28BS0	Xenopus tropicalis	38%	90%
Q28CM3	Xenopus tropicalis	32%	88%
Q29JI9	Drosophila pseudoobscura pseudoobscura	31%	89%
Q2KIZ8	Bos taurus	31%	88%
Q2QNM1	Oryza sativa subsp. japonica	42%	100%
Q2R482	Oryza sativa subsp. japonica	36%	75%
Q3ZBH9	Bos taurus	42%	100%
Q43704	Zea mays	34%	94%
Q498J7	Xenopus laevis	30%	88%
Q4Q3R6	Leishmania major	34%	82%
Q4Q826	Leishmania major	32%	82%
Q4QAP2	Leishmania major	31%	100%
Q54CP4	Dictyostelium discoideum	32%	96%
Q561P5	Xenopus tropicalis	35%	99%
Q57809	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	30%	96%
Q58371	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	28%	95%
Q58884	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	27%	100%
Q5F310	Xenopus laevis	33%	87%
Q5FWY4	Xenopus laevis	32%	88%
Q5JKB0	Oryza sativa subsp. japonica	37%	84%
Q5R8G6	Pongo abelii	38%	90%
Q5XK83	Xenopus laevis	37%	84%
Q5ZMN2	Gallus gallus	37%	89%
Q61881	Mus musculus	41%	100%
Q61J08	Caenorhabditis briggsae	33%	90%
Q69QA6	Oryza sativa subsp. japonica	34%	100%
Q6DIH3	Xenopus tropicalis	35%	82%
Q6F353	Oryza sativa subsp. japonica	35%	87%
Q6GL41	Xenopus tropicalis	37%	84%
Q6KAJ4	Oryza sativa subsp. japonica	34%	99%
Q6NX31	Xenopus tropicalis	42%	100%
Q6P1V8	Xenopus tropicalis	30%	88%
Q6PCI7	Xenopus laevis	35%	99%
Q7Q0Q1	Anopheles gambiae	30%	89%
Q7ZXB1	Xenopus laevis	42%	100%
Q7ZXZ0	Xenopus laevis	38%	90%
Q7ZY18	Xenopus laevis	30%	88%
Q86B14	Dictyostelium discoideum	31%	84%
Q91876	Xenopus laevis	42%	100%
Q95XQ8	Caenorhabditis elegans	36%	88%
Q9CWV1	Mus musculus	33%	87%
Q9FL33	Arabidopsis thaliana	37%	93%
Q9LPD9	Arabidopsis thaliana	36%	77%
Q9SF37	Arabidopsis thaliana	31%	91%
Q9SX03	Zea mays	34%	94%
Q9SX04	Zea mays	34%	94%
Q9UJA3	Homo sapiens	33%	86%
Q9UXG1	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	31%	100%
Q9V461	Drosophila melanogaster	31%	89%
Q9VGW6	Drosophila melanogaster	36%	99%
Q9XYU0	Drosophila melanogaster	40%	100%
Q9XYU1	Drosophila melanogaster	37%	89%
V5B8T3	Trypanosoma cruzi	31%	100%
V5BAH7	Trypanosoma cruzi	37%	83%
V5BGQ5	Trypanosoma cruzi	33%	85%
V5BHZ8	Trypanosoma cruzi	79%	100%
V5BSG2	Trypanosoma cruzi	34%	83%
V5C0K6	Trypanosoma cruzi	31%	94%