Tubulin-specific chaperone A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin binding cofactor A-like protein

Species:

Leishmania major

UniProt:

Q9U1D9_LEIMA

TriTrypDb:

LmjF.32.2970 , LMJLV39_320037300 , LMJSD75_320037500

Length:

125

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005856	cytoskeleton	5	2
GO:0005874	microtubule	6	10
GO:0015630	microtubule cytoskeleton	6	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	10
GO:0099081	supramolecular polymer	3	10

Previous1 2Next

Expansion

Sequence features

Q9U1D9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9U1D9

PDB structure(s): 4cqi_A

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	10
GO:0007021	tubulin complex assembly	6	10
GO:0007023	post-chaperonin tubulin folding pathway	3	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0022607	cellular component assembly	4	10
GO:0043933	protein-containing complex organization	4	10
GO:0065003	protein-containing complex assembly	5	10
GO:0071840	cellular component organization or biogenesis	2	10

Previous1Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0008092	cytoskeletal protein binding	3	10
GO:0015631	tubulin binding	4	10
GO:0048487	beta-tubulin binding	5	10

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.442
CLV_PCSK_KEX2_1	34	36	PF00082	0.209
CLV_PCSK_KEX2_1	44	46	PF00082	0.209
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.209
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.209
CLV_PCSK_SKI1_1	35	39	PF00082	0.209
DOC_MAPK_gen_1	34	42	PF00069	0.451
DOC_PP1_RVXF_1	36	43	PF00149	0.451
DOC_USP7_UBL2_3	34	38	PF12436	0.409
LIG_14-3-3_CanoR_1	114	118	PF00244	0.397

Previous1 2 3 4Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE53	Leptomonas seymouri	67%	100%
A0A1X0NSC9	Trypanosomatidae	52%	98%
A0A3R7KPE6	Trypanosoma rangeli	44%	99%
A0A3S7X5X5	Leishmania donovani	98%	100%
A4HKU0	Leishmania braziliensis	88%	100%
A4I8B9	Leishmania infantum	98%	100%
D0AAJ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	98%
E9B378	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O04350	Arabidopsis thaliana	32%	100%

Previous1Next