Potential member of the thioredoxin family

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP binding protein-like protein

Species:

Leishmania major

UniProt:

Q9U1D8_LEIMA

TriTrypDb:

LmjF.32.2980 , LMJLV39_320037400 , LMJSD75_320037600

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q9U1D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9U1D8

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	52	54	PF00675	0.281
CLV_NRD_NRD_1	57	59	PF00675	0.313
CLV_NRD_NRD_1	89	91	PF00675	0.239
CLV_PCSK_FUR_1	39	43	PF00082	0.226
CLV_PCSK_KEX2_1	41	43	PF00082	0.230
CLV_PCSK_KEX2_1	52	54	PF00082	0.255
CLV_PCSK_KEX2_1	89	91	PF00082	0.230
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.226
CLV_PCSK_SKI1_1	179	183	PF00082	0.249
CLV_PCSK_SKI1_1	41	45	PF00082	0.246
CLV_PCSK_SKI1_1	71	75	PF00082	0.259
DOC_SPAK_OSR1_1	128	132	PF12202	0.426
DOC_WW_Pin1_4	89	94	PF00397	0.518
LIG_14-3-3_CanoR_1	89	93	PF00244	0.440
LIG_Actin_WH2_2	31	49	PF00022	0.518
LIG_BIR_II_1	1	5	PF00653	0.601
LIG_Clathr_ClatBox_1	137	141	PF01394	0.426
LIG_FHA_1	134	140	PF00498	0.447
LIG_FHA_1	161	167	PF00498	0.440
LIG_LIR_Gen_1	111	122	PF02991	0.426
LIG_LIR_Gen_1	127	137	PF02991	0.427
LIG_LIR_Gen_1	145	152	PF02991	0.427
LIG_LIR_Gen_1	72	81	PF02991	0.482
LIG_LIR_Nem_3	111	117	PF02991	0.426
LIG_LIR_Nem_3	145	149	PF02991	0.427
LIG_LIR_Nem_3	72	77	PF02991	0.457
LIG_Pex14_2	110	114	PF04695	0.426
LIG_SH2_CRK	173	177	PF00017	0.457
LIG_SH2_PTP2	116	119	PF00017	0.439
LIG_SH2_SRC	116	119	PF00017	0.455
LIG_SH2_SRC	64	67	PF00017	0.482
LIG_SH2_STAT5	116	119	PF00017	0.455
LIG_SH2_STAT5	64	67	PF00017	0.518
LIG_SH3_2	123	128	PF14604	0.518
LIG_SH3_3	120	126	PF00018	0.496
LIG_SUMO_SIM_anti_2	136	141	PF11976	0.426
LIG_SUMO_SIM_par_1	135	141	PF11976	0.435
LIG_UBA3_1	133	142	PF00899	0.442
LIG_UBA3_1	35	41	PF00899	0.439
MOD_CDK_SPK_2	89	94	PF00069	0.518
MOD_CK1_1	2	8	PF00069	0.479
MOD_CK2_1	121	127	PF00069	0.439
MOD_GSK3_1	155	162	PF00069	0.464
MOD_N-GLC_1	2	7	PF02516	0.458
MOD_NEK2_1	88	93	PF00069	0.457
MOD_PIKK_1	164	170	PF00454	0.452
MOD_PKA_2	88	94	PF00069	0.434
MOD_Plk_4	133	139	PF00069	0.443
MOD_Plk_4	145	151	PF00069	0.426
MOD_ProDKin_1	89	95	PF00069	0.518
MOD_SUMO_rev_2	66	73	PF00179	0.445
TRG_ENDOCYTIC_2	116	119	PF00928	0.461
TRG_ENDOCYTIC_2	173	176	PF00928	0.440
TRG_ENDOCYTIC_2	64	67	PF00928	0.501
TRG_ER_diArg_1	88	90	PF00400	0.429
TRG_NLS_MonoExtN_4	39	45	PF00514	0.426
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.226

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8C3	Leptomonas seymouri	85%	100%
A0A0S4IMY4	Bodo saltans	64%	99%
A0A0S4J4Q7	Bodo saltans	32%	77%
A0A1X0NR32	Trypanosomatidae	34%	77%
A0A1X0NRR1	Trypanosomatidae	72%	100%
A0A3R7KUG1	Trypanosoma rangeli	31%	77%
A0A3S7X0Z3	Leishmania donovani	34%	79%
A0A3S7X612	Leishmania donovani	98%	100%
A0A422NZU0	Trypanosoma rangeli	70%	100%
A4HFZ7	Leishmania braziliensis	31%	78%
A4HKU1	Leishmania braziliensis	91%	100%
A4I316	Leishmania infantum	34%	79%
A4I8C0	Leishmania infantum	98%	100%
C9ZJI5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	75%
D0AAJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9ACT7	Leishmania major	35%	79%
E9AZC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	79%
E9B379	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O14095	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	68%
O14530	Homo sapiens	42%	84%
O18883	Bos taurus	42%	84%
O64628	Arabidopsis thaliana	37%	90%
Q04004	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	82%
Q0VCW8	Bos taurus	27%	79%
Q11183	Caenorhabditis elegans	38%	91%
Q32LN3	Bos taurus	26%	78%
Q4KLJ8	Rattus norvegicus	28%	79%
Q6NPL9	Arabidopsis thaliana	33%	82%
Q71A37	Dictyostelium discoideum	32%	100%
Q8K581	Rattus norvegicus	42%	84%
Q8LCV1	Arabidopsis thaliana	31%	82%
Q8N4E4	Homo sapiens	25%	78%
Q9CQ79	Mus musculus	41%	84%
Q9H2J4	Homo sapiens	26%	79%
V5DF31	Trypanosoma cruzi	33%	77%