Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q9U1D2_LEIMA

TriTrypDb:

LmjF.04.0970 , LMJLV39_040015300 , LMJSD75_040015600

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0035869	ciliary transition zone	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q9U1D2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9U1D2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.603
CLV_C14_Caspase3-7	328	332	PF00656	0.537
CLV_C14_Caspase3-7	335	339	PF00656	0.610
CLV_C14_Caspase3-7	45	49	PF00656	0.649
CLV_NRD_NRD_1	128	130	PF00675	0.685
CLV_NRD_NRD_1	272	274	PF00675	0.548
CLV_NRD_NRD_1	458	460	PF00675	0.621
CLV_NRD_NRD_1	66	68	PF00675	0.640
CLV_NRD_NRD_1	99	101	PF00675	0.687
CLV_PCSK_FUR_1	57	61	PF00082	0.729
CLV_PCSK_KEX2_1	123	125	PF00082	0.746
CLV_PCSK_KEX2_1	128	130	PF00082	0.718
CLV_PCSK_KEX2_1	272	274	PF00082	0.551
CLV_PCSK_KEX2_1	458	460	PF00082	0.621
CLV_PCSK_KEX2_1	59	61	PF00082	0.729
CLV_PCSK_KEX2_1	66	68	PF00082	0.652
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.710
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.729
CLV_PCSK_PC7_1	124	130	PF00082	0.635
CLV_PCSK_SKI1_1	212	216	PF00082	0.635
CLV_PCSK_SKI1_1	378	382	PF00082	0.565
CLV_PCSK_SKI1_1	70	74	PF00082	0.696
DEG_SCF_TRCP1_1	403	409	PF00400	0.600
DEG_SPOP_SBC_1	203	207	PF00917	0.625
DEG_SPOP_SBC_1	231	235	PF00917	0.722
DEG_SPOP_SBC_1	90	94	PF00917	0.733
DOC_CYCLIN_RxL_1	209	217	PF00134	0.635
DOC_MAPK_DCC_7	272	281	PF00069	0.614
DOC_MAPK_DCC_7	378	388	PF00069	0.543
DOC_MAPK_MEF2A_6	272	281	PF00069	0.614
DOC_MAPK_MEF2A_6	374	383	PF00069	0.569
DOC_PP2B_LxvP_1	156	159	PF13499	0.674
DOC_PP2B_PxIxI_1	276	282	PF00149	0.595
DOC_USP7_MATH_1	138	142	PF00917	0.593
DOC_USP7_MATH_1	232	236	PF00917	0.716
DOC_USP7_MATH_1	312	316	PF00917	0.589
DOC_USP7_MATH_1	475	479	PF00917	0.538
DOC_USP7_MATH_1	90	94	PF00917	0.732
DOC_WW_Pin1_4	134	139	PF00397	0.736
DOC_WW_Pin1_4	149	154	PF00397	0.577
DOC_WW_Pin1_4	157	162	PF00397	0.602
DOC_WW_Pin1_4	284	289	PF00397	0.587
DOC_WW_Pin1_4	38	43	PF00397	0.669
DOC_WW_Pin1_4	406	411	PF00397	0.602
DOC_WW_Pin1_4	95	100	PF00397	0.692
LIG_14-3-3_CanoR_1	10	14	PF00244	0.624
LIG_14-3-3_CanoR_1	174	179	PF00244	0.652
LIG_14-3-3_CanoR_1	196	200	PF00244	0.704
LIG_14-3-3_CanoR_1	202	210	PF00244	0.659
LIG_14-3-3_CanoR_1	367	376	PF00244	0.583
LIG_14-3-3_CanoR_1	438	445	PF00244	0.534
LIG_14-3-3_CanoR_1	57	63	PF00244	0.682
LIG_Actin_WH2_2	437	454	PF00022	0.585
LIG_APCC_ABBA_1	437	442	PF00400	0.579
LIG_FHA_1	158	164	PF00498	0.710
LIG_FHA_1	205	211	PF00498	0.656
LIG_FHA_1	276	282	PF00498	0.565
LIG_FHA_2	477	483	PF00498	0.622
LIG_LIR_Apic_2	12	16	PF02991	0.619
LIG_LIR_Apic_2	283	288	PF02991	0.633
LIG_LIR_Apic_2	490	496	PF02991	0.633
LIG_PDZ_Wminus1_1	506	508	PF00595	0.549
LIG_Pex14_1	13	17	PF04695	0.622
LIG_SH2_CRK	285	289	PF00017	0.647
LIG_SH2_CRK	493	497	PF00017	0.599
LIG_SH2_STAT5	421	424	PF00017	0.583
LIG_SH3_1	101	107	PF00018	0.607
LIG_SH3_2	104	109	PF14604	0.603
LIG_SH3_3	101	107	PF00018	0.716
LIG_SH3_3	110	116	PF00018	0.656
LIG_SH3_3	156	162	PF00018	0.705
LIG_SH3_3	197	203	PF00018	0.693
LIG_SH3_3	404	410	PF00018	0.606
LIG_SH3_3	433	439	PF00018	0.662
LIG_SH3_3	75	81	PF00018	0.712
LIG_TRAF2_1	360	363	PF00917	0.574
LIG_TRAF2_1	479	482	PF00917	0.596
LIG_TRFH_1	258	262	PF08558	0.671
MOD_CDC14_SPxK_1	98	101	PF00782	0.689
MOD_CDK_SPK_2	95	100	PF00069	0.692
MOD_CDK_SPxK_1	95	101	PF00069	0.693
MOD_CK1_1	134	140	PF00069	0.696
MOD_CK1_1	177	183	PF00069	0.698
MOD_CK1_1	188	194	PF00069	0.637
MOD_CK1_1	204	210	PF00069	0.537
MOD_CK1_1	217	223	PF00069	0.677
MOD_CK1_1	233	239	PF00069	0.659
MOD_CK1_1	41	47	PF00069	0.705
MOD_CK2_1	357	363	PF00069	0.614
MOD_CK2_1	412	418	PF00069	0.602
MOD_CK2_1	476	482	PF00069	0.609
MOD_Cter_Amidation	126	129	PF01082	0.689
MOD_GlcNHglycan	140	143	PF01048	0.724
MOD_GlcNHglycan	170	173	PF01048	0.716
MOD_GlcNHglycan	176	179	PF01048	0.646
MOD_GlcNHglycan	226	229	PF01048	0.696
MOD_GlcNHglycan	30	33	PF01048	0.670
MOD_GlcNHglycan	318	321	PF01048	0.622
MOD_GlcNHglycan	403	406	PF01048	0.595
MOD_GlcNHglycan	414	417	PF01048	0.480
MOD_GSK3_1	134	141	PF00069	0.681
MOD_GSK3_1	174	181	PF00069	0.632
MOD_GSK3_1	185	192	PF00069	0.651
MOD_GSK3_1	226	233	PF00069	0.679
MOD_GSK3_1	235	242	PF00069	0.682
MOD_GSK3_1	256	263	PF00069	0.671
MOD_GSK3_1	312	319	PF00069	0.600
MOD_GSK3_1	338	345	PF00069	0.632
MOD_GSK3_1	40	47	PF00069	0.667
MOD_GSK3_1	401	408	PF00069	0.564
MOD_GSK3_1	88	95	PF00069	0.731
MOD_NEK2_1	214	219	PF00069	0.623
MOD_NEK2_2	256	261	PF00069	0.657
MOD_PIKK_1	226	232	PF00454	0.672
MOD_PKA_1	123	129	PF00069	0.712
MOD_PKA_2	123	129	PF00069	0.712
MOD_PKA_2	195	201	PF00069	0.668
MOD_PKA_2	217	223	PF00069	0.714
MOD_PKA_2	224	230	PF00069	0.734
MOD_PKA_2	260	266	PF00069	0.628
MOD_PKA_2	9	15	PF00069	0.622
MOD_Plk_2-3	338	344	PF00069	0.633
MOD_Plk_4	325	331	PF00069	0.428
MOD_ProDKin_1	134	140	PF00069	0.734
MOD_ProDKin_1	149	155	PF00069	0.579
MOD_ProDKin_1	157	163	PF00069	0.603
MOD_ProDKin_1	284	290	PF00069	0.580
MOD_ProDKin_1	38	44	PF00069	0.670
MOD_ProDKin_1	406	412	PF00069	0.599
MOD_ProDKin_1	95	101	PF00069	0.693
TRG_ENDOCYTIC_2	349	352	PF00928	0.634
TRG_ER_diArg_1	128	130	PF00400	0.685
TRG_ER_diArg_1	222	225	PF00400	0.657
TRG_ER_diArg_1	271	273	PF00400	0.578
TRG_ER_diArg_1	294	297	PF00400	0.570
TRG_ER_diArg_1	458	460	PF00400	0.621
TRG_ER_diArg_1	65	67	PF00400	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5D8	Leishmania donovani	84%	97%
A4H411	Leishmania braziliensis	68%	100%
A4HS94	Leishmania infantum	84%	100%
E9AK78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%