Anaphase promoting complex, subunit 10-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

anaphase promoting complex, subunit 10-like protein

Species:

Leishmania major

UniProt:

Q9U198_LEIMA

TriTrypDb:

LmjF.04.0400 , LMJLV39_040008800 , LMJSD75_040009100

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	12
GO:0000152	nuclear ubiquitin ligase complex	3	12
GO:0005680	anaphase-promoting complex	4	12
GO:0031461	cullin-RING ubiquitin ligase complex	4	12
GO:0032991	protein-containing complex	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12

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Expansion

Sequence features

Q9U198

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9U198

Function

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Biological processes
Term	Name	Level	Count
GO:0000209	protein polyubiquitination	8	2
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0007049	cell cycle	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0010498	proteasomal protein catabolic process	5	12

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.613
DEG_APCC_DBOX_1	109	117	PF00400	0.539
DEG_Nend_UBRbox_2	1	3	PF02207	0.610
DEG_SPOP_SBC_1	261	265	PF00917	0.523
DEG_SPOP_SBC_1	34	38	PF00917	0.724
DOC_CKS1_1	115	120	PF01111	0.539
DOC_MAPK_gen_1	60	67	PF00069	0.423
DOC_USP7_MATH_1	221	225	PF00917	0.549
DOC_USP7_MATH_1	244	248	PF00917	0.539
DOC_USP7_MATH_1	34	38	PF00917	0.728

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2G0	Leptomonas seymouri	58%	99%
A0A0S4JNN0	Bodo saltans	30%	100%
A0A1X0P6H6	Trypanosomatidae	35%	100%
A0A3R7LQ45	Trypanosoma rangeli	37%	100%
A0A3S5H5A1	Leishmania donovani	91%	100%
A4H3W0	Leishmania braziliensis	74%	100%
A4HS34	Leishmania infantum	91%	100%
D0A0Q1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AK21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BNI3	Trypanosoma cruzi	39%	100%

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