Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q9U191_LEIMA

TriTrypDb:

LmjF.04.0230 , LMJLV39_040007100 , LMJSD75_040007200

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q9U191

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9U191

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.570
CLV_NRD_NRD_1	248	250	PF00675	0.639
CLV_NRD_NRD_1	78	80	PF00675	0.525
CLV_PCSK_KEX2_1	108	110	PF00082	0.570
CLV_PCSK_KEX2_1	247	249	PF00082	0.641
CLV_PCSK_KEX2_1	78	80	PF00082	0.470
CLV_PCSK_SKI1_1	80	84	PF00082	0.520
DEG_SIAH_1	162	170	PF03145	0.808
DEG_SPOP_SBC_1	122	126	PF00917	0.772
DEG_SPOP_SBC_1	186	190	PF00917	0.740
DOC_CKS1_1	133	138	PF01111	0.660
DOC_MAPK_gen_1	247	255	PF00069	0.834
DOC_PP1_RVXF_1	250	256	PF00149	0.722
DOC_PP2B_PxIxI_1	37	43	PF00149	0.584
DOC_USP7_MATH_1	25	29	PF00917	0.464
DOC_WW_Pin1_4	109	114	PF00397	0.744
DOC_WW_Pin1_4	118	123	PF00397	0.650
DOC_WW_Pin1_4	132	137	PF00397	0.664
DOC_WW_Pin1_4	190	195	PF00397	0.824
DOC_WW_Pin1_4	216	221	PF00397	0.857
DOC_WW_Pin1_4	234	239	PF00397	0.649
DOC_WW_Pin1_4	34	39	PF00397	0.588
LIG_14-3-3_CanoR_1	108	116	PF00244	0.721
LIG_14-3-3_CanoR_1	152	160	PF00244	0.696
LIG_14-3-3_CanoR_1	227	235	PF00244	0.813
LIG_DLG_GKlike_1	147	155	PF00625	0.668
LIG_FHA_1	123	129	PF00498	0.707
LIG_FHA_1	35	41	PF00498	0.533
LIG_FHA_2	15	21	PF00498	0.509
LIG_FHA_2	238	244	PF00498	0.805
LIG_LIR_Gen_1	94	103	PF02991	0.603
LIG_LIR_Nem_3	85	91	PF02991	0.617
LIG_LIR_Nem_3	94	98	PF02991	0.570
LIG_PDZ_Class_2	253	258	PF00595	0.829
LIG_Pex14_2	52	56	PF04695	0.435
LIG_PTB_Apo_2	177	184	PF02174	0.819
LIG_PTB_Apo_2	3	10	PF02174	0.552
LIG_PTB_Phospho_1	177	183	PF10480	0.819
LIG_SH2_STAT5	183	186	PF00017	0.815
LIG_SH2_STAT5	195	198	PF00017	0.690
LIG_SH3_2	242	247	PF14604	0.849
LIG_SH3_3	157	163	PF00018	0.714
LIG_SH3_3	166	172	PF00018	0.677
LIG_SH3_3	229	235	PF00018	0.725
LIG_SH3_3	239	245	PF00018	0.770
LIG_SUMO_SIM_anti_2	37	43	PF11976	0.584
LIG_WRC_WIRS_1	72	77	PF05994	0.541
MOD_CK1_1	107	113	PF00069	0.782
MOD_CK1_1	190	196	PF00069	0.834
MOD_CK1_1	219	225	PF00069	0.711
MOD_CK1_1	237	243	PF00069	0.763
MOD_CK1_1	251	257	PF00069	0.702
MOD_CK1_1	34	40	PF00069	0.553
MOD_CK2_1	14	20	PF00069	0.499
MOD_CK2_1	237	243	PF00069	0.809
MOD_CK2_1	24	30	PF00069	0.430
MOD_GlcNHglycan	189	192	PF01048	0.571
MOD_GSK3_1	118	125	PF00069	0.675
MOD_GSK3_1	147	154	PF00069	0.784
MOD_GSK3_1	186	193	PF00069	0.742
MOD_GSK3_1	215	222	PF00069	0.758
MOD_GSK3_1	223	230	PF00069	0.784
MOD_GSK3_1	234	241	PF00069	0.739
MOD_N-GLC_1	42	47	PF02516	0.700
MOD_NEK2_1	151	156	PF00069	0.650
MOD_NEK2_1	91	96	PF00069	0.575
MOD_NEK2_2	204	209	PF00069	0.782
MOD_PIKK_1	151	157	PF00454	0.775
MOD_PIKK_1	219	225	PF00454	0.752
MOD_PK_1	141	147	PF00069	0.780
MOD_PKA_1	248	254	PF00069	0.834
MOD_PKA_2	107	113	PF00069	0.754
MOD_PKA_2	151	157	PF00069	0.830
MOD_PKA_2	223	229	PF00069	0.812
MOD_PKA_2	248	254	PF00069	0.834
MOD_Plk_4	204	210	PF00069	0.782
MOD_Plk_4	251	257	PF00069	0.828
MOD_ProDKin_1	109	115	PF00069	0.748
MOD_ProDKin_1	118	124	PF00069	0.651
MOD_ProDKin_1	132	138	PF00069	0.664
MOD_ProDKin_1	190	196	PF00069	0.826
MOD_ProDKin_1	216	222	PF00069	0.857
MOD_ProDKin_1	234	240	PF00069	0.650
MOD_ProDKin_1	34	40	PF00069	0.587
MOD_SUMO_for_1	82	85	PF00179	0.719
TRG_ENDOCYTIC_2	88	91	PF00928	0.597
TRG_ER_diArg_1	246	249	PF00400	0.842

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H588	Leishmania donovani	91%	100%
A4H444	Leishmania braziliensis	57%	99%
A4HS18	Leishmania infantum	91%	100%
E9AK05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%