Peptide deformylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Peptide deformylase

Gene product:

Peptide deformylase 2, putative

Species:

Leishmania major

UniProt:

Q9U112_LEIMA

TriTrypDb:

LmjF.04.0820 , LMJLV39_040013600 , LMJSD75_040013900

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q9U112

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9U112

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	6
GO:0006518	peptide metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009058	biosynthetic process	2	6
GO:0009059	macromolecule biosynthetic process	4	6
GO:0009987	cellular process	1	6
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018206	peptidyl-methionine modification	6	2
GO:0019538	protein metabolic process	3	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	6
GO:0036211	protein modification process	4	2
GO:0043043	peptide biosynthetic process	5	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	2
GO:0043603	amide metabolic process	3	6
GO:0043604	amide biosynthetic process	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044249	cellular biosynthetic process	3	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	6
GO:0044271	cellular nitrogen compound biosynthetic process	4	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:1901566	organonitrogen compound biosynthetic process	4	6
GO:1901576	organic substance biosynthetic process	3	6
GO:0006508	proteolysis	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	6
GO:0016787	hydrolase activity	2	6
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	6
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	6
GO:0042586	peptide deformylase activity	5	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0008233	peptidase activity	3	1
GO:0008237	metallopeptidase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.544
CLV_NRD_NRD_1	233	235	PF00675	0.274
CLV_NRD_NRD_1	34	36	PF00675	0.561
CLV_NRD_NRD_1	379	381	PF00675	0.274
CLV_NRD_NRD_1	39	41	PF00675	0.518
CLV_NRD_NRD_1	435	437	PF00675	0.518
CLV_NRD_NRD_1	467	469	PF00675	0.510
CLV_NRD_NRD_1	473	475	PF00675	0.554
CLV_NRD_NRD_1	51	53	PF00675	0.616
CLV_NRD_NRD_1	91	93	PF00675	0.486
CLV_PCSK_KEX2_1	233	235	PF00082	0.274
CLV_PCSK_KEX2_1	379	381	PF00082	0.274
CLV_PCSK_KEX2_1	39	41	PF00082	0.513
CLV_PCSK_KEX2_1	473	475	PF00082	0.601
CLV_PCSK_KEX2_1	90	92	PF00082	0.486
CLV_PCSK_PC1ET2_1	473	475	PF00082	0.497
CLV_PCSK_PC7_1	35	41	PF00082	0.502
CLV_PCSK_SKI1_1	337	341	PF00082	0.274
CLV_PCSK_SKI1_1	351	355	PF00082	0.274
CLV_PCSK_SKI1_1	363	367	PF00082	0.228
CLV_PCSK_SKI1_1	40	44	PF00082	0.488
DEG_APCC_DBOX_1	362	370	PF00400	0.274
DEG_APCC_DBOX_1	452	460	PF00400	0.551
DOC_ANK_TNKS_1	200	207	PF00023	0.477
DOC_CKS1_1	416	421	PF01111	0.344
DOC_CYCLIN_RxL_1	35	48	PF00134	0.491
DOC_CYCLIN_RxL_1	89	97	PF00134	0.480
DOC_MAPK_DCC_7	39	49	PF00069	0.485
DOC_MAPK_gen_1	35	46	PF00069	0.493
DOC_MAPK_gen_1	359	366	PF00069	0.274
DOC_MAPK_gen_1	90	98	PF00069	0.672
DOC_MAPK_MEF2A_6	39	46	PF00069	0.486
DOC_MAPK_MEF2A_6	90	98	PF00069	0.672
DOC_MAPK_NFAT4_5	39	47	PF00069	0.486
DOC_MAPK_NFAT4_5	91	99	PF00069	0.648
DOC_MAPK_RevD_3	364	380	PF00069	0.274
DOC_PP2B_LxvP_1	146	149	PF13499	0.585
DOC_PP2B_LxvP_1	42	45	PF13499	0.478
DOC_PP2B_LxvP_1	47	50	PF13499	0.469
DOC_PP2B_LxvP_1	96	99	PF13499	0.655
DOC_PP4_FxxP_1	279	282	PF00568	0.274
DOC_PP4_FxxP_1	417	420	PF00568	0.340
DOC_USP7_MATH_1	126	130	PF00917	0.618
DOC_USP7_MATH_1	197	201	PF00917	0.502
DOC_USP7_MATH_1	219	223	PF00917	0.346
DOC_USP7_MATH_1	257	261	PF00917	0.308
DOC_USP7_MATH_1	324	328	PF00917	0.274
DOC_USP7_MATH_1	38	42	PF00917	0.497
DOC_USP7_MATH_1	79	83	PF00917	0.487
DOC_USP7_MATH_1	8	12	PF00917	0.541
DOC_USP7_UBL2_3	469	473	PF12436	0.454
DOC_WW_Pin1_4	130	135	PF00397	0.610
DOC_WW_Pin1_4	3	8	PF00397	0.498
DOC_WW_Pin1_4	415	420	PF00397	0.378
DOC_WW_Pin1_4	82	87	PF00397	0.473
DOC_WW_Pin1_4	9	14	PF00397	0.574
LIG_14-3-3_CanoR_1	101	108	PF00244	0.563
LIG_14-3-3_CanoR_1	117	125	PF00244	0.588
LIG_14-3-3_CanoR_1	135	139	PF00244	0.552
LIG_14-3-3_CanoR_1	153	162	PF00244	0.564
LIG_14-3-3_CanoR_1	164	169	PF00244	0.436
LIG_14-3-3_CanoR_1	296	302	PF00244	0.234
LIG_14-3-3_CanoR_1	337	342	PF00244	0.274
LIG_14-3-3_CanoR_1	39	45	PF00244	0.552
LIG_14-3-3_CanoR_1	409	413	PF00244	0.348
LIG_BIR_II_1	1	5	PF00653	0.547
LIG_BIR_III_2	426	430	PF00653	0.425
LIG_BRCT_BRCA1_1	157	161	PF00533	0.563
LIG_BRCT_BRCA1_1	192	196	PF00533	0.508
LIG_BRCT_BRCA1_1	326	330	PF00533	0.274
LIG_EVH1_2	419	423	PF00568	0.381
LIG_FHA_1	210	216	PF00498	0.401
LIG_FHA_1	352	358	PF00498	0.321
LIG_FHA_1	376	382	PF00498	0.274
LIG_FHA_1	41	47	PF00498	0.482
LIG_FHA_2	270	276	PF00498	0.274
LIG_FHA_2	393	399	PF00498	0.416
LIG_FHA_2	455	461	PF00498	0.420
LIG_FHA_2	485	491	PF00498	0.597
LIG_Integrin_RGD_1	483	485	PF01839	0.588
LIG_LIR_Apic_2	277	282	PF02991	0.347
LIG_LIR_Apic_2	415	420	PF02991	0.329
LIG_LIR_Gen_1	300	309	PF02991	0.308
LIG_LIR_Gen_1	391	398	PF02991	0.406
LIG_LIR_Gen_1	411	421	PF02991	0.407
LIG_LIR_Nem_3	211	216	PF02991	0.424
LIG_LIR_Nem_3	239	243	PF02991	0.316
LIG_LIR_Nem_3	300	304	PF02991	0.366
LIG_LIR_Nem_3	400	406	PF02991	0.434
LIG_LIR_Nem_3	411	417	PF02991	0.391
LIG_LIR_Nem_3	418	424	PF02991	0.430
LIG_LIR_Nem_3	48	54	PF02991	0.673
LIG_LYPXL_yS_3	213	216	PF13949	0.356
LIG_LYPXL_yS_3	256	259	PF13949	0.274
LIG_LYPXL_yS_3	403	406	PF13949	0.360
LIG_Pex14_1	224	228	PF04695	0.274
LIG_Pex14_1	399	403	PF04695	0.396
LIG_PTB_Apo_2	273	280	PF02174	0.268
LIG_Rb_pABgroove_1	268	276	PF01858	0.274
LIG_SH2_CRK	240	244	PF00017	0.372
LIG_SH2_CRK	254	258	PF00017	0.214
LIG_SH2_CRK	421	425	PF00017	0.379
LIG_SH2_SRC	203	206	PF00017	0.476
LIG_SH2_SRC	254	257	PF00017	0.274
LIG_SH2_STAP1	228	232	PF00017	0.268
LIG_SH2_STAT5	203	206	PF00017	0.476
LIG_SH2_STAT5	334	337	PF00017	0.274
LIG_SH2_STAT5	414	417	PF00017	0.386
LIG_SH2_STAT5	93	96	PF00017	0.635
LIG_SH3_2	10	15	PF14604	0.478
LIG_SH3_3	135	141	PF00018	0.561
LIG_SH3_3	199	205	PF00018	0.491
LIG_SH3_3	4	10	PF00018	0.499
LIG_SH3_3	81	87	PF00018	0.523
LIG_SUMO_SIM_par_1	353	358	PF11976	0.345
LIG_TRAF2_1	208	211	PF00917	0.440
LIG_TRAF2_1	303	306	PF00917	0.299
LIG_TRAF2_1	458	461	PF00917	0.440
LIG_UBA3_1	46	53	PF00899	0.481
LIG_WRC_WIRS_1	148	153	PF05994	0.519
LIG_WW_3	12	16	PF00397	0.478
MOD_CDC14_SPxK_1	12	15	PF00782	0.474
MOD_CDK_SPK_2	130	135	PF00069	0.557
MOD_CDK_SPxK_1	9	15	PF00069	0.482
MOD_CK1_1	144	150	PF00069	0.580
MOD_CK1_1	189	195	PF00069	0.563
MOD_CK1_1	2	8	PF00069	0.517
MOD_CK1_1	397	403	PF00069	0.426
MOD_CK1_1	82	88	PF00069	0.527
MOD_CK2_1	454	460	PF00069	0.397
MOD_CK2_1	484	490	PF00069	0.564
MOD_GlcNHglycan	102	105	PF01048	0.531
MOD_GlcNHglycan	143	146	PF01048	0.569
MOD_GlcNHglycan	157	160	PF01048	0.552
MOD_GlcNHglycan	192	195	PF01048	0.546
MOD_GlcNHglycan	259	262	PF01048	0.274
MOD_GlcNHglycan	327	330	PF01048	0.274
MOD_GlcNHglycan	491	497	PF01048	0.590
MOD_GSK3_1	126	133	PF00069	0.612
MOD_GSK3_1	160	167	PF00069	0.531
MOD_GSK3_1	182	189	PF00069	0.560
MOD_GSK3_1	192	199	PF00069	0.516
MOD_GSK3_1	257	264	PF00069	0.347
MOD_GSK3_1	408	415	PF00069	0.336
MOD_LATS_1	349	355	PF00433	0.299
MOD_N-GLC_1	190	195	PF02516	0.524
MOD_N-GLC_2	128	130	PF02516	0.584
MOD_NEK2_1	100	105	PF00069	0.536
MOD_NEK2_1	182	187	PF00069	0.567
MOD_NEK2_1	196	201	PF00069	0.469
MOD_NEK2_1	274	279	PF00069	0.274
MOD_NEK2_1	412	417	PF00069	0.359
MOD_NEK2_1	94	99	PF00069	0.526
MOD_PIKK_1	242	248	PF00454	0.274
MOD_PK_1	164	170	PF00069	0.536
MOD_PKA_2	100	106	PF00069	0.560
MOD_PKA_2	134	140	PF00069	0.589
MOD_PKA_2	38	44	PF00069	0.492
MOD_PKA_2	408	414	PF00069	0.340
MOD_Plk_1	274	280	PF00069	0.309
MOD_Plk_1	454	460	PF00069	0.406
MOD_Plk_1	484	490	PF00069	0.713
MOD_Plk_2-3	402	408	PF00069	0.364
MOD_Plk_4	274	280	PF00069	0.347
MOD_Plk_4	297	303	PF00069	0.434
MOD_Plk_4	408	414	PF00069	0.340
MOD_ProDKin_1	130	136	PF00069	0.610
MOD_ProDKin_1	3	9	PF00069	0.498
MOD_ProDKin_1	415	421	PF00069	0.389
MOD_ProDKin_1	82	88	PF00069	0.472
MOD_SUMO_rev_2	300	309	PF00179	0.285
MOD_SUMO_rev_2	430	438	PF00179	0.431
TRG_DiLeu_BaEn_1	239	244	PF01217	0.274
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.482
TRG_ENDOCYTIC_2	213	216	PF00928	0.356
TRG_ENDOCYTIC_2	240	243	PF00928	0.274
TRG_ENDOCYTIC_2	256	259	PF00928	0.274
TRG_ENDOCYTIC_2	403	406	PF00928	0.407
TRG_ENDOCYTIC_2	414	417	PF00928	0.423
TRG_ENDOCYTIC_2	421	424	PF00928	0.550
TRG_ENDOCYTIC_2	93	96	PF00928	0.635
TRG_ER_diArg_1	233	235	PF00400	0.277
TRG_ER_diArg_1	341	344	PF00400	0.269
TRG_ER_diArg_1	360	363	PF00400	0.342
TRG_ER_diArg_1	379	381	PF00400	0.180
TRG_ER_diArg_1	89	92	PF00400	0.484
TRG_Pf-PMV_PEXEL_1	310	315	PF00026	0.299
TRG_Pf-PMV_PEXEL_1	344	348	PF00026	0.268
TRG_Pf-PMV_PEXEL_1	52	56	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P349	Leptomonas seymouri	66%	100%
A0A3S7WNT3	Leishmania donovani	92%	100%
A4HS79	Leishmania infantum	92%	100%
E9AK65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%