PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tir chaperone protein (CesT) family/PDZ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q9U110_LEIMA

TriTrypDb:

LmjF.04.0710 , LMJLV39_040012300 , LMJSD75_040012700

Length:

794

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q9U110

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9U110

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0008104	protein localization	4	9
GO:0009306	protein secretion	4	9
GO:0009987	cellular process	1	9
GO:0015031	protein transport	4	9
GO:0030254	protein secretion by the type III secretion system	4	9
GO:0032940	secretion by cell	3	9
GO:0033036	macromolecule localization	2	9
GO:0035592	establishment of protein localization to extracellular region	4	9
GO:0045184	establishment of protein localization	3	9
GO:0046903	secretion	4	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0051641	cellular localization	2	9
GO:0055085	transmembrane transport	2	9
GO:0070727	cellular macromolecule localization	3	9
GO:0071692	protein localization to extracellular region	5	9
GO:0071702	organic substance transport	4	9
GO:0071705	nitrogen compound transport	4	9
GO:0071806	protein transmembrane transport	3	9
GO:0140352	export from cell	2	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.576
CLV_C14_Caspase3-7	446	450	PF00656	0.655
CLV_NRD_NRD_1	152	154	PF00675	0.543
CLV_NRD_NRD_1	167	169	PF00675	0.526
CLV_NRD_NRD_1	248	250	PF00675	0.492
CLV_NRD_NRD_1	333	335	PF00675	0.471
CLV_NRD_NRD_1	464	466	PF00675	0.325
CLV_NRD_NRD_1	758	760	PF00675	0.391
CLV_NRD_NRD_1	98	100	PF00675	0.637
CLV_PCSK_FUR_1	150	154	PF00082	0.550
CLV_PCSK_KEX2_1	152	154	PF00082	0.545
CLV_PCSK_KEX2_1	248	250	PF00082	0.492
CLV_PCSK_KEX2_1	27	29	PF00082	0.469
CLV_PCSK_KEX2_1	333	335	PF00082	0.468
CLV_PCSK_KEX2_1	464	466	PF00082	0.325
CLV_PCSK_KEX2_1	696	698	PF00082	0.553
CLV_PCSK_KEX2_1	758	760	PF00082	0.415
CLV_PCSK_KEX2_1	98	100	PF00082	0.637
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.449
CLV_PCSK_PC1ET2_1	696	698	PF00082	0.553
CLV_PCSK_PC7_1	94	100	PF00082	0.534
CLV_PCSK_SKI1_1	152	156	PF00082	0.499
CLV_PCSK_SKI1_1	272	276	PF00082	0.442
CLV_Separin_Metazoa	165	169	PF03568	0.497
DEG_APCC_DBOX_1	14	22	PF00400	0.512
DEG_APCC_DBOX_1	223	231	PF00400	0.474
DEG_SPOP_SBC_1	137	141	PF00917	0.614
DEG_SPOP_SBC_1	686	690	PF00917	0.610
DOC_CKS1_1	33	38	PF01111	0.464
DOC_CKS1_1	614	619	PF01111	0.628
DOC_CYCLIN_RxL_1	149	159	PF00134	0.599
DOC_CYCLIN_RxL_1	301	312	PF00134	0.519
DOC_CYCLIN_yCln2_LP_2	142	148	PF00134	0.590
DOC_MAPK_DCC_7	696	704	PF00069	0.474
DOC_MAPK_gen_1	150	157	PF00069	0.539
DOC_MAPK_gen_1	222	229	PF00069	0.475
DOC_MAPK_gen_1	27	33	PF00069	0.467
DOC_MAPK_gen_1	464	472	PF00069	0.525
DOC_MAPK_gen_1	696	704	PF00069	0.474
DOC_MAPK_gen_1	774	784	PF00069	0.391
DOC_MAPK_MEF2A_6	696	704	PF00069	0.517
DOC_MAPK_MEF2A_6	777	786	PF00069	0.366
DOC_PP2B_LxvP_1	142	145	PF13499	0.528
DOC_PP2B_LxvP_1	563	566	PF13499	0.525
DOC_PP2B_LxvP_1	683	686	PF13499	0.730
DOC_USP7_MATH_1	137	141	PF00917	0.614
DOC_USP7_MATH_1	50	54	PF00917	0.512
DOC_USP7_MATH_1	633	637	PF00917	0.719
DOC_USP7_MATH_1	651	655	PF00917	0.645
DOC_USP7_MATH_1	660	664	PF00917	0.736
DOC_USP7_MATH_1	672	676	PF00917	0.728
DOC_USP7_MATH_1	686	690	PF00917	0.579
DOC_USP7_MATH_1	729	733	PF00917	0.412
DOC_USP7_MATH_1	790	794	PF00917	0.570
DOC_USP7_MATH_1	9	13	PF00917	0.662
DOC_WW_Pin1_4	113	118	PF00397	0.763
DOC_WW_Pin1_4	122	127	PF00397	0.761
DOC_WW_Pin1_4	133	138	PF00397	0.589
DOC_WW_Pin1_4	140	145	PF00397	0.535
DOC_WW_Pin1_4	32	37	PF00397	0.470
DOC_WW_Pin1_4	429	434	PF00397	0.689
DOC_WW_Pin1_4	613	618	PF00397	0.687
DOC_WW_Pin1_4	621	626	PF00397	0.689
DOC_WW_Pin1_4	635	640	PF00397	0.744
DOC_WW_Pin1_4	654	659	PF00397	0.482
DOC_WW_Pin1_4	663	668	PF00397	0.691
DOC_WW_Pin1_4	678	683	PF00397	0.535
DOC_WW_Pin1_4	763	768	PF00397	0.330
LIG_14-3-3_CanoR_1	179	183	PF00244	0.625
LIG_14-3-3_CanoR_1	237	245	PF00244	0.581
LIG_14-3-3_CanoR_1	28	34	PF00244	0.565
LIG_14-3-3_CanoR_1	409	413	PF00244	0.728
LIG_14-3-3_CanoR_1	427	433	PF00244	0.750
LIG_14-3-3_CanoR_1	588	598	PF00244	0.498
LIG_BIR_II_1	1	5	PF00653	0.714
LIG_BRCT_BRCA1_1	142	146	PF00533	0.611
LIG_eIF4E_1	506	512	PF01652	0.483
LIG_eIF4E_1	719	725	PF01652	0.297
LIG_FHA_1	481	487	PF00498	0.458
LIG_FHA_1	491	497	PF00498	0.458
LIG_FHA_1	500	506	PF00498	0.458
LIG_FHA_1	590	596	PF00498	0.493
LIG_FHA_1	608	614	PF00498	0.563
LIG_FHA_1	705	711	PF00498	0.427
LIG_FHA_1	783	789	PF00498	0.391
LIG_FHA_1	86	92	PF00498	0.436
LIG_FHA_2	368	374	PF00498	0.552
LIG_FHA_2	444	450	PF00498	0.658
LIG_LIR_Gen_1	489	500	PF02991	0.458
LIG_LIR_Gen_1	555	564	PF02991	0.483
LIG_LIR_LC3C_4	721	726	PF02991	0.332
LIG_LIR_Nem_3	489	495	PF02991	0.458
LIG_LIR_Nem_3	756	760	PF02991	0.391
LIG_PCNA_PIPBox_1	526	535	PF02747	0.408
LIG_Rb_pABgroove_1	492	500	PF01858	0.519
LIG_SH2_CRK	344	348	PF00017	0.482
LIG_SH2_CRK	492	496	PF00017	0.458
LIG_SH2_CRK	508	512	PF00017	0.458
LIG_SH2_NCK_1	498	502	PF00017	0.525
LIG_SH2_NCK_1	630	634	PF00017	0.597
LIG_SH2_SRC	506	509	PF00017	0.534
LIG_SH2_SRC	719	722	PF00017	0.391
LIG_SH2_STAP1	492	496	PF00017	0.458
LIG_SH2_STAP1	508	512	PF00017	0.458
LIG_SH2_STAP1	530	534	PF00017	0.458
LIG_SH2_STAP1	630	634	PF00017	0.623
LIG_SH2_STAT3	343	346	PF00017	0.521
LIG_SH2_STAT5	492	495	PF00017	0.481
LIG_SH2_STAT5	506	509	PF00017	0.485
LIG_SH2_STAT5	630	633	PF00017	0.686
LIG_SH3_2	93	98	PF14604	0.606
LIG_SH3_3	141	147	PF00018	0.652
LIG_SH3_3	346	352	PF00018	0.429
LIG_SH3_3	611	617	PF00018	0.683
LIG_SH3_3	8	14	PF00018	0.613
LIG_SH3_3	90	96	PF00018	0.559
LIG_SUMO_SIM_anti_2	225	231	PF11976	0.471
LIG_SUMO_SIM_anti_2	493	499	PF11976	0.519
LIG_SUMO_SIM_anti_2	721	727	PF11976	0.299
LIG_SUMO_SIM_par_1	153	159	PF11976	0.625
LIG_SUMO_SIM_par_1	483	489	PF11976	0.460
LIG_SUMO_SIM_par_1	87	92	PF11976	0.435
LIG_TRAF2_1	205	208	PF00917	0.554
LIG_TRAF2_1	254	257	PF00917	0.456
LIG_TYR_ITAM	489	511	PF00017	0.458
LIG_UBA3_1	264	272	PF00899	0.515
LIG_WW_3	95	99	PF00397	0.686
MOD_CDK_SPK_2	113	118	PF00069	0.651
MOD_CDK_SPxxK_3	113	120	PF00069	0.652
MOD_CDK_SPxxK_3	32	39	PF00069	0.471
MOD_CDK_SPxxK_3	654	661	PF00069	0.689
MOD_CK1_1	136	142	PF00069	0.697
MOD_CK1_1	32	38	PF00069	0.549
MOD_CK1_1	397	403	PF00069	0.713
MOD_CK1_1	432	438	PF00069	0.635
MOD_CK1_1	572	578	PF00069	0.481
MOD_CK1_1	632	638	PF00069	0.786
MOD_CK1_1	650	656	PF00069	0.625
MOD_CK1_1	663	669	PF00069	0.658
MOD_CK2_1	202	208	PF00069	0.555
MOD_Cter_Amidation	25	28	PF01082	0.472
MOD_GlcNHglycan	1	4	PF01048	0.709
MOD_GlcNHglycan	204	207	PF01048	0.627
MOD_GlcNHglycan	388	391	PF01048	0.748
MOD_GlcNHglycan	559	562	PF01048	0.319
MOD_GlcNHglycan	631	634	PF01048	0.783
MOD_GlcNHglycan	643	646	PF01048	0.773
MOD_GlcNHglycan	649	652	PF01048	0.554
MOD_GlcNHglycan	662	665	PF01048	0.586
MOD_GlcNHglycan	674	677	PF01048	0.674
MOD_GlcNHglycan	693	696	PF01048	0.559
MOD_GSK3_1	133	140	PF00069	0.738
MOD_GSK3_1	382	389	PF00069	0.668
MOD_GSK3_1	408	415	PF00069	0.619
MOD_GSK3_1	423	430	PF00069	0.602
MOD_GSK3_1	480	487	PF00069	0.458
MOD_GSK3_1	507	514	PF00069	0.564
MOD_GSK3_1	565	572	PF00069	0.469
MOD_GSK3_1	628	635	PF00069	0.645
MOD_GSK3_1	637	644	PF00069	0.724
MOD_GSK3_1	647	654	PF00069	0.533
MOD_GSK3_1	659	666	PF00069	0.705
MOD_GSK3_1	687	694	PF00069	0.722
MOD_N-GLC_1	381	386	PF02516	0.664
MOD_N-GLC_1	691	696	PF02516	0.638
MOD_N-GLC_1	746	751	PF02516	0.304
MOD_N-GLC_2	482	484	PF02516	0.267
MOD_NEK2_1	178	183	PF00069	0.584
MOD_NEK2_1	297	302	PF00069	0.521
MOD_NEK2_1	399	404	PF00069	0.719
MOD_NEK2_1	423	428	PF00069	0.663
MOD_NEK2_1	478	483	PF00069	0.482
MOD_NEK2_1	507	512	PF00069	0.469
MOD_NEK2_1	534	539	PF00069	0.588
MOD_NEK2_1	559	564	PF00069	0.482
MOD_NEK2_1	641	646	PF00069	0.711
MOD_NEK2_1	670	675	PF00069	0.576
MOD_NEK2_1	691	696	PF00069	0.719
MOD_NEK2_1	704	709	PF00069	0.453
MOD_NEK2_1	746	751	PF00069	0.304
MOD_NEK2_1	77	82	PF00069	0.564
MOD_NEK2_1	782	787	PF00069	0.332
MOD_NEK2_2	29	34	PF00069	0.464
MOD_OFUCOSY	48	55	PF10250	0.444
MOD_PIKK_1	565	571	PF00454	0.525
MOD_PIKK_1	9	15	PF00454	0.594
MOD_PKA_2	178	184	PF00069	0.636
MOD_PKA_2	202	208	PF00069	0.542
MOD_PKA_2	236	242	PF00069	0.513
MOD_PKA_2	38	44	PF00069	0.427
MOD_PKA_2	408	414	PF00069	0.664
MOD_PKB_1	425	433	PF00069	0.665
MOD_Plk_1	490	496	PF00069	0.501
MOD_Plk_1	534	540	PF00069	0.525
MOD_Plk_2-3	367	373	PF00069	0.549
MOD_Plk_4	490	496	PF00069	0.458
MOD_Plk_4	507	513	PF00069	0.458
MOD_Plk_4	534	540	PF00069	0.556
MOD_Plk_4	559	565	PF00069	0.458
MOD_Plk_4	706	712	PF00069	0.449
MOD_Plk_4	729	735	PF00069	0.391
MOD_ProDKin_1	113	119	PF00069	0.761
MOD_ProDKin_1	122	128	PF00069	0.755
MOD_ProDKin_1	133	139	PF00069	0.588
MOD_ProDKin_1	140	146	PF00069	0.532
MOD_ProDKin_1	32	38	PF00069	0.471
MOD_ProDKin_1	429	435	PF00069	0.688
MOD_ProDKin_1	613	619	PF00069	0.690
MOD_ProDKin_1	621	627	PF00069	0.688
MOD_ProDKin_1	635	641	PF00069	0.747
MOD_ProDKin_1	654	660	PF00069	0.477
MOD_ProDKin_1	663	669	PF00069	0.684
MOD_ProDKin_1	678	684	PF00069	0.535
MOD_ProDKin_1	763	769	PF00069	0.330
MOD_SUMO_for_1	265	268	PF00179	0.489
MOD_SUMO_rev_2	268	274	PF00179	0.522
MOD_SUMO_rev_2	366	370	PF00179	0.503
TRG_DiLeu_BaEn_1	358	363	PF01217	0.529
TRG_DiLeu_BaEn_1	491	496	PF01217	0.525
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.632
TRG_ENDOCYTIC_2	344	347	PF00928	0.439
TRG_ENDOCYTIC_2	492	495	PF00928	0.481
TRG_ENDOCYTIC_2	508	511	PF00928	0.487
TRG_ENDOCYTIC_2	530	533	PF00928	0.458
TRG_ER_diArg_1	117	120	PF00400	0.647
TRG_ER_diArg_1	150	153	PF00400	0.559
TRG_ER_diArg_1	308	311	PF00400	0.454
TRG_ER_diArg_1	333	335	PF00400	0.510
TRG_ER_diArg_1	424	427	PF00400	0.683
TRG_ER_diArg_1	463	465	PF00400	0.525
TRG_ER_diArg_1	757	759	PF00400	0.391
TRG_ER_diArg_1	97	99	PF00400	0.562
TRG_NES_CRM1_1	461	474	PF08389	0.332
TRG_NES_CRM1_1	61	74	PF08389	0.510
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	197	202	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	327	332	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	353	358	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	464	468	PF00026	0.325
TRG_Pf-PMV_PEXEL_1	574	579	PF00026	0.319
TRG_Pf-PMV_PEXEL_1	759	763	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I193	Leptomonas seymouri	58%	100%
A0A1X0NMQ4	Trypanosomatidae	36%	100%
A0A3R7NDD0	Trypanosoma rangeli	35%	100%
A0A3S5H5C1	Leishmania donovani	93%	100%
A4H405	Leishmania braziliensis	77%	100%
A4HS67	Leishmania infantum	93%	100%
E9AK54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%