Tyrosine phospatase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

atypical dual specificity phosphatase, putative

Species:

Leishmania major

UniProt:

Q9U0Z9_LEIMA

TriTrypDb:

LmjF.04.0840 , LMJLV39_040013800 , LMJSD75_040014100

Length:

891

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q9U0Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9U0Z9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004721	phosphoprotein phosphatase activity	3	5
GO:0004725	protein tyrosine phosphatase activity	4	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0016791	phosphatase activity	5	5
GO:0042578	phosphoric ester hydrolase activity	4	5
GO:0140096	catalytic activity, acting on a protein	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	67	71	PF00656	0.633
CLV_MEL_PAP_1	808	814	PF00089	0.803
CLV_NRD_NRD_1	128	130	PF00675	0.611
CLV_NRD_NRD_1	14	16	PF00675	0.793
CLV_NRD_NRD_1	282	284	PF00675	0.840
CLV_NRD_NRD_1	426	428	PF00675	0.435
CLV_NRD_NRD_1	508	510	PF00675	0.435
CLV_NRD_NRD_1	785	787	PF00675	0.808
CLV_PCSK_KEX2_1	128	130	PF00082	0.611
CLV_PCSK_KEX2_1	14	16	PF00082	0.793
CLV_PCSK_KEX2_1	282	284	PF00082	0.840
CLV_PCSK_KEX2_1	426	428	PF00082	0.435
CLV_PCSK_KEX2_1	568	570	PF00082	0.664
CLV_PCSK_KEX2_1	785	787	PF00082	0.808
CLV_PCSK_KEX2_1	886	888	PF00082	0.873
CLV_PCSK_PC1ET2_1	568	570	PF00082	0.664
CLV_PCSK_PC1ET2_1	886	888	PF00082	0.873
CLV_PCSK_PC7_1	124	130	PF00082	0.611
CLV_PCSK_SKI1_1	498	502	PF00082	0.375
CLV_PCSK_SKI1_1	509	513	PF00082	0.306
DEG_APCC_DBOX_1	426	434	PF00400	0.636
DEG_SCF_FBW7_1	227	233	PF00400	0.783
DEG_SPOP_SBC_1	758	762	PF00917	0.738
DEG_SPOP_SBC_1	85	89	PF00917	0.652
DOC_CDC14_PxL_1	680	688	PF14671	0.595
DOC_CKS1_1	110	115	PF01111	0.625
DOC_CKS1_1	227	232	PF01111	0.802
DOC_CKS1_1	299	304	PF01111	0.851
DOC_CKS1_1	816	821	PF01111	0.568
DOC_CYCLIN_RxL_1	420	432	PF00134	0.636
DOC_CYCLIN_RxL_1	506	515	PF00134	0.636
DOC_CYCLIN_yClb5_NLxxxL_5	169	176	PF00134	0.599
DOC_CYCLIN_yCln2_LP_2	268	274	PF00134	0.812
DOC_CYCLIN_yCln2_LP_2	398	401	PF00134	0.605
DOC_CYCLIN_yCln2_LP_2	545	548	PF00134	0.636
DOC_MAPK_gen_1	426	436	PF00069	0.636
DOC_MAPK_gen_1	463	470	PF00069	0.636
DOC_MAPK_gen_1	568	576	PF00069	0.662
DOC_MAPK_MEF2A_6	569	578	PF00069	0.665
DOC_PP1_RVXF_1	508	515	PF00149	0.636
DOC_PP2B_LxvP_1	104	107	PF13499	0.799
DOC_PP2B_LxvP_1	398	401	PF13499	0.605
DOC_PP2B_LxvP_1	544	547	PF13499	0.636
DOC_PP2B_LxvP_1	821	824	PF13499	0.722
DOC_USP7_MATH_1	111	115	PF00917	0.691
DOC_USP7_MATH_1	167	171	PF00917	0.649
DOC_USP7_MATH_1	290	294	PF00917	0.664
DOC_USP7_MATH_1	305	309	PF00917	0.711
DOC_USP7_MATH_1	343	347	PF00917	0.722
DOC_USP7_MATH_1	386	390	PF00917	0.661
DOC_USP7_MATH_1	609	613	PF00917	0.714
DOC_USP7_MATH_1	69	73	PF00917	0.766
DOC_USP7_MATH_1	702	706	PF00917	0.728
DOC_USP7_MATH_1	734	738	PF00917	0.749
DOC_USP7_MATH_1	751	755	PF00917	0.520
DOC_USP7_MATH_1	757	761	PF00917	0.659
DOC_USP7_MATH_1	796	800	PF00917	0.791
DOC_USP7_MATH_1	802	806	PF00917	0.719
DOC_USP7_MATH_1	845	849	PF00917	0.807
DOC_USP7_MATH_1	873	877	PF00917	0.735
DOC_USP7_MATH_1	885	889	PF00917	0.717
DOC_WW_Pin1_4	109	114	PF00397	0.509
DOC_WW_Pin1_4	157	162	PF00397	0.773
DOC_WW_Pin1_4	193	198	PF00397	0.847
DOC_WW_Pin1_4	226	231	PF00397	0.837
DOC_WW_Pin1_4	233	238	PF00397	0.744
DOC_WW_Pin1_4	241	246	PF00397	0.573
DOC_WW_Pin1_4	298	303	PF00397	0.853
DOC_WW_Pin1_4	312	317	PF00397	0.594
DOC_WW_Pin1_4	80	85	PF00397	0.783
DOC_WW_Pin1_4	815	820	PF00397	0.565
DOC_WW_Pin1_4	881	886	PF00397	0.759
DOC_WW_Pin1_4	91	96	PF00397	0.581
LIG_14-3-3_CanoR_1	128	135	PF00244	0.628
LIG_14-3-3_CanoR_1	345	351	PF00244	0.802
LIG_14-3-3_CanoR_1	365	370	PF00244	0.782
LIG_14-3-3_CanoR_1	429	434	PF00244	0.627
LIG_14-3-3_CanoR_1	738	746	PF00244	0.723
LIG_14-3-3_CanoR_1	770	776	PF00244	0.756
LIG_14-3-3_CanoR_1	786	792	PF00244	0.550
LIG_14-3-3_CanoR_1	811	819	PF00244	0.777
LIG_14-3-3_CterR_2	887	891	PF00244	0.869
LIG_Actin_WH2_2	673	689	PF00022	0.747
LIG_BIR_II_1	1	5	PF00653	0.741
LIG_BRCT_BRCA1_1	169	173	PF00533	0.702
LIG_BRCT_BRCA1_1	331	335	PF00533	0.776
LIG_CSL_BTD_1	299	302	PF09270	0.616
LIG_CSL_BTD_1	816	819	PF09270	0.565
LIG_deltaCOP1_diTrp_1	768	777	PF00928	0.600
LIG_eIF4E_1	540	546	PF01652	0.636
LIG_EVH1_1	163	167	PF00568	0.603
LIG_EVH1_2	400	404	PF00568	0.636
LIG_FHA_1	294	300	PF00498	0.745
LIG_FHA_1	318	324	PF00498	0.596
LIG_FHA_1	346	352	PF00498	0.705
LIG_FHA_1	362	368	PF00498	0.617
LIG_FHA_1	43	49	PF00498	0.585
LIG_FHA_1	440	446	PF00498	0.636
LIG_FHA_1	499	505	PF00498	0.606
LIG_FHA_1	525	531	PF00498	0.636
LIG_FHA_1	539	545	PF00498	0.475
LIG_FHA_1	571	577	PF00498	0.502
LIG_FHA_1	619	625	PF00498	0.708
LIG_FHA_1	708	714	PF00498	0.732
LIG_FHA_1	718	724	PF00498	0.666
LIG_FHA_1	760	766	PF00498	0.749
LIG_FHA_1	816	822	PF00498	0.723
LIG_FHA_1	87	93	PF00498	0.712
LIG_FHA_2	322	328	PF00498	0.653
LIG_FHA_2	65	71	PF00498	0.694
LIG_LIR_Apic_2	160	166	PF02991	0.677
LIG_LIR_Apic_2	539	543	PF02991	0.636
LIG_LIR_Gen_1	522	530	PF02991	0.636
LIG_LIR_Nem_3	117	122	PF02991	0.677
LIG_LIR_Nem_3	170	176	PF02991	0.697
LIG_LIR_Nem_3	522	526	PF02991	0.636
LIG_LIR_Nem_3	774	780	PF02991	0.757
LIG_LYPXL_yS_3	416	419	PF13949	0.636
LIG_MYND_1	543	547	PF01753	0.636
LIG_NRBOX	507	513	PF00104	0.636
LIG_PTB_Apo_2	418	425	PF02174	0.636
LIG_PTB_Apo_2	517	524	PF02174	0.580
LIG_PTB_Phospho_1	418	424	PF10480	0.636
LIG_SH2_CRK	540	544	PF00017	0.636
LIG_SH2_NCK_1	560	564	PF00017	0.659
LIG_SH2_PTP2	674	677	PF00017	0.811
LIG_SH2_SRC	674	677	PF00017	0.811
LIG_SH2_STAP1	321	325	PF00017	0.590
LIG_SH2_STAT5	119	122	PF00017	0.759
LIG_SH2_STAT5	251	254	PF00017	0.653
LIG_SH2_STAT5	424	427	PF00017	0.636
LIG_SH2_STAT5	491	494	PF00017	0.636
LIG_SH2_STAT5	540	543	PF00017	0.636
LIG_SH2_STAT5	674	677	PF00017	0.811
LIG_SH3_2	164	169	PF14604	0.602
LIG_SH3_3	155	161	PF00018	0.677
LIG_SH3_3	2	8	PF00018	0.655
LIG_SH3_3	243	249	PF00018	0.805
LIG_SH3_3	296	302	PF00018	0.854
LIG_SH3_3	313	319	PF00018	0.533
LIG_SH3_3	435	441	PF00018	0.636
LIG_SH3_3	545	551	PF00018	0.552
LIG_SH3_3	621	627	PF00018	0.813
LIG_SH3_3	678	684	PF00018	0.734
LIG_SH3_3	866	872	PF00018	0.730
LIG_SH3_3	89	95	PF00018	0.727
LIG_SUMO_SIM_anti_2	322	327	PF11976	0.619
LIG_SUMO_SIM_anti_2	432	439	PF11976	0.636
LIG_SUMO_SIM_anti_2	501	507	PF11976	0.636
LIG_SxIP_EBH_1	827	839	PF03271	0.765
LIG_TYR_ITSM	115	122	PF00017	0.638
LIG_UBA3_1	505	510	PF00899	0.392
LIG_WW_1	440	443	PF00397	0.530
MOD_CDK_SPK_2	881	886	PF00069	0.754
MOD_CDK_SPxK_1	881	887	PF00069	0.755
MOD_CK1_1	114	120	PF00069	0.653
MOD_CK1_1	127	133	PF00069	0.575
MOD_CK1_1	159	165	PF00069	0.779
MOD_CK1_1	178	184	PF00069	0.515
MOD_CK1_1	196	202	PF00069	0.775
MOD_CK1_1	203	209	PF00069	0.692
MOD_CK1_1	225	231	PF00069	0.736
MOD_CK1_1	255	261	PF00069	0.730
MOD_CK1_1	293	299	PF00069	0.723
MOD_CK1_1	384	390	PF00069	0.647
MOD_CK1_1	46	52	PF00069	0.625
MOD_CK1_1	473	479	PF00069	0.530
MOD_CK1_1	616	622	PF00069	0.733
MOD_CK1_1	629	635	PF00069	0.568
MOD_CK1_1	709	715	PF00069	0.836
MOD_CK1_1	733	739	PF00069	0.750
MOD_CK1_1	74	80	PF00069	0.596
MOD_CK1_1	741	747	PF00069	0.660
MOD_CK1_1	773	779	PF00069	0.771
MOD_CK1_1	841	847	PF00069	0.846
MOD_CK1_1	881	887	PF00069	0.852
MOD_CK2_1	321	327	PF00069	0.622
MOD_CK2_1	736	742	PF00069	0.759
MOD_Cter_Amidation	280	283	PF01082	0.839
MOD_GlcNHglycan	1	4	PF01048	0.670
MOD_GlcNHglycan	113	116	PF01048	0.499
MOD_GlcNHglycan	129	132	PF01048	0.570
MOD_GlcNHglycan	177	180	PF01048	0.695
MOD_GlcNHglycan	218	221	PF01048	0.804
MOD_GlcNHglycan	284	287	PF01048	0.719
MOD_GlcNHglycan	292	295	PF01048	0.787
MOD_GlcNHglycan	307	310	PF01048	0.742
MOD_GlcNHglycan	351	354	PF01048	0.777
MOD_GlcNHglycan	383	386	PF01048	0.713
MOD_GlcNHglycan	390	393	PF01048	0.565
MOD_GlcNHglycan	408	411	PF01048	0.507
MOD_GlcNHglycan	582	585	PF01048	0.789
MOD_GlcNHglycan	587	590	PF01048	0.733
MOD_GlcNHglycan	607	610	PF01048	0.534
MOD_GlcNHglycan	611	614	PF01048	0.756
MOD_GlcNHglycan	628	631	PF01048	0.580
MOD_GlcNHglycan	646	649	PF01048	0.537
MOD_GlcNHglycan	700	703	PF01048	0.761
MOD_GlcNHglycan	704	707	PF01048	0.733
MOD_GlcNHglycan	713	716	PF01048	0.695
MOD_GlcNHglycan	717	720	PF01048	0.620
MOD_GlcNHglycan	732	735	PF01048	0.545
MOD_GlcNHglycan	753	756	PF01048	0.732
MOD_GlcNHglycan	804	807	PF01048	0.828
MOD_GlcNHglycan	812	815	PF01048	0.654
MOD_GlcNHglycan	824	827	PF01048	0.509
MOD_GlcNHglycan	831	834	PF01048	0.530
MOD_GlcNHglycan	836	839	PF01048	0.583
MOD_GlcNHglycan	840	843	PF01048	0.582
MOD_GlcNHglycan	847	850	PF01048	0.578
MOD_GlcNHglycan	880	883	PF01048	0.785
MOD_GlcNHglycan	95	98	PF01048	0.772
MOD_GSK3_1	138	145	PF00069	0.783
MOD_GSK3_1	196	203	PF00069	0.809
MOD_GSK3_1	222	229	PF00069	0.741
MOD_GSK3_1	289	296	PF00069	0.805
MOD_GSK3_1	3	10	PF00069	0.601
MOD_GSK3_1	305	312	PF00069	0.620
MOD_GSK3_1	317	324	PF00069	0.533
MOD_GSK3_1	345	352	PF00069	0.799
MOD_GSK3_1	361	368	PF00069	0.621
MOD_GSK3_1	384	391	PF00069	0.749
MOD_GSK3_1	42	49	PF00069	0.686
MOD_GSK3_1	576	583	PF00069	0.715
MOD_GSK3_1	585	592	PF00069	0.668
MOD_GSK3_1	605	612	PF00069	0.550
MOD_GSK3_1	614	621	PF00069	0.670
MOD_GSK3_1	698	705	PF00069	0.819
MOD_GSK3_1	707	714	PF00069	0.718
MOD_GSK3_1	715	722	PF00069	0.567
MOD_GSK3_1	729	736	PF00069	0.613
MOD_GSK3_1	737	744	PF00069	0.659
MOD_GSK3_1	76	83	PF00069	0.778
MOD_GSK3_1	766	773	PF00069	0.752
MOD_GSK3_1	834	841	PF00069	0.801
MOD_GSK3_1	84	91	PF00069	0.675
MOD_GSK3_1	874	881	PF00069	0.771
MOD_GSK3_1	93	100	PF00069	0.616
MOD_LATS_1	140	146	PF00433	0.706
MOD_NEK2_1	200	205	PF00069	0.718
MOD_NEK2_1	207	212	PF00069	0.756
MOD_NEK2_1	576	581	PF00069	0.616
MOD_NEK2_1	59	64	PF00069	0.661
MOD_NEK2_1	686	691	PF00069	0.757
MOD_NEK2_1	727	732	PF00069	0.754
MOD_NEK2_1	787	792	PF00069	0.756
MOD_NEK2_2	555	560	PF00069	0.617
MOD_NEK2_2	639	644	PF00069	0.690
MOD_PIKK_1	201	207	PF00454	0.833
MOD_PIKK_1	3	9	PF00454	0.598
MOD_PIKK_1	365	371	PF00454	0.773
MOD_PIKK_1	649	655	PF00454	0.602
MOD_PIKK_1	71	77	PF00454	0.763
MOD_PIKK_1	874	880	PF00454	0.615
MOD_PKA_1	282	288	PF00069	0.835
MOD_PKA_2	127	133	PF00069	0.653
MOD_PKA_2	282	288	PF00069	0.759
MOD_PKA_2	344	350	PF00069	0.694
MOD_PKA_2	353	359	PF00069	0.728
MOD_PKA_2	524	530	PF00069	0.530
MOD_PKA_2	576	582	PF00069	0.631
MOD_PKA_2	59	65	PF00069	0.650
MOD_PKA_2	686	692	PF00069	0.722
MOD_PKA_2	730	736	PF00069	0.750
MOD_PKA_2	737	743	PF00069	0.673
MOD_PKA_2	810	816	PF00069	0.796
MOD_PKA_2	838	844	PF00069	0.850
MOD_PKB_1	427	435	PF00069	0.530
MOD_PKB_1	575	583	PF00069	0.676
MOD_Plk_1	69	75	PF00069	0.592
MOD_Plk_2-3	439	445	PF00069	0.530
MOD_Plk_4	321	327	PF00069	0.739
MOD_Plk_4	330	336	PF00069	0.684
MOD_Plk_4	394	400	PF00069	0.666
MOD_Plk_4	43	49	PF00069	0.585
MOD_Plk_4	432	438	PF00069	0.530
MOD_Plk_4	555	561	PF00069	0.618
MOD_Plk_4	7	13	PF00069	0.754
MOD_Plk_4	787	793	PF00069	0.740
MOD_ProDKin_1	109	115	PF00069	0.494
MOD_ProDKin_1	157	163	PF00069	0.775
MOD_ProDKin_1	193	199	PF00069	0.847
MOD_ProDKin_1	226	232	PF00069	0.838
MOD_ProDKin_1	233	239	PF00069	0.743
MOD_ProDKin_1	241	247	PF00069	0.570
MOD_ProDKin_1	298	304	PF00069	0.852
MOD_ProDKin_1	312	318	PF00069	0.594
MOD_ProDKin_1	80	86	PF00069	0.783
MOD_ProDKin_1	815	821	PF00069	0.567
MOD_ProDKin_1	881	887	PF00069	0.761
MOD_ProDKin_1	91	97	PF00069	0.583
MOD_SUMO_for_1	464	467	PF00179	0.530
MOD_SUMO_rev_2	439	448	PF00179	0.530
TRG_DiLeu_BaEn_1	477	482	PF01217	0.530
TRG_DiLeu_BaLyEn_6	540	545	PF01217	0.530
TRG_ENDOCYTIC_2	119	122	PF00928	0.759
TRG_ENDOCYTIC_2	416	419	PF00928	0.369
TRG_ENDOCYTIC_2	674	677	PF00928	0.811
TRG_ER_diArg_1	13	15	PF00400	0.621
TRG_ER_diArg_1	425	427	PF00400	0.530
TRG_ER_diArg_1	428	431	PF00400	0.480
TRG_ER_diArg_1	574	577	PF00400	0.649
TRG_ER_diArg_1	785	787	PF00400	0.808
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.780
TRG_Pf-PMV_PEXEL_1	509	513	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5D1	Leishmania donovani	88%	100%
A4H3Z4	Leishmania braziliensis	65%	100%
A4HS81	Leishmania infantum	89%	100%
E9AK67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%