Putative serine peptidase, Clan S-, family S54

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine peptidase, Clan S-, family S54, putative

Species:

Leishmania major

UniProt:

Q9U0Z8_LEIMA

TriTrypDb:

LmjF.04.0850 , LMJLV39_040013900 , LMJSD75_040014200

Length:

400

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q9U0Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9U0Z8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004175	endopeptidase activity	4	10
GO:0004252	serine-type endopeptidase activity	5	10
GO:0008233	peptidase activity	3	10
GO:0008236	serine-type peptidase activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0017171	serine hydrolase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	137	141	PF00082	0.499
CLV_PCSK_SKI1_1	18	22	PF00082	0.464
CLV_PCSK_SKI1_1	361	365	PF00082	0.276
DEG_Nend_UBRbox_3	1	3	PF02207	0.670
DEG_SPOP_SBC_1	37	41	PF00917	0.707
DEG_SPOP_SBC_1	70	74	PF00917	0.674
DOC_CYCLIN_RxL_1	386	397	PF00134	0.396
DOC_MAPK_gen_1	91	101	PF00069	0.757
DOC_PP1_RVXF_1	333	340	PF00149	0.312
DOC_PP4_FxxP_1	192	195	PF00568	0.615
DOC_USP7_MATH_1	103	107	PF00917	0.674
DOC_USP7_MATH_1	119	123	PF00917	0.729
DOC_USP7_MATH_1	142	146	PF00917	0.744
DOC_USP7_MATH_1	25	29	PF00917	0.751
DOC_USP7_MATH_1	37	41	PF00917	0.694
DOC_USP7_MATH_1	63	67	PF00917	0.713
DOC_USP7_MATH_1	70	74	PF00917	0.646
DOC_WW_Pin1_4	111	116	PF00397	0.712
DOC_WW_Pin1_4	138	143	PF00397	0.747
DOC_WW_Pin1_4	27	32	PF00397	0.723
LIG_14-3-3_CanoR_1	104	108	PF00244	0.650
LIG_14-3-3_CanoR_1	18	27	PF00244	0.741
LIG_14-3-3_CanoR_1	279	283	PF00244	0.337
LIG_14-3-3_CanoR_1	78	87	PF00244	0.755
LIG_BRCT_BRCA1_1	120	124	PF00533	0.678
LIG_Clathr_ClatBox_1	326	330	PF01394	0.312
LIG_deltaCOP1_diTrp_1	221	226	PF00928	0.399
LIG_deltaCOP1_diTrp_1	236	245	PF00928	0.286
LIG_deltaCOP1_diTrp_1	260	267	PF00928	0.267
LIG_deltaCOP1_diTrp_1	358	363	PF00928	0.312
LIG_EH_1	178	182	PF12763	0.638
LIG_EH_1	319	323	PF12763	0.312
LIG_EVH1_1	190	194	PF00568	0.615
LIG_EVH1_2	343	347	PF00568	0.267
LIG_FHA_1	196	202	PF00498	0.472
LIG_FHA_1	349	355	PF00498	0.312
LIG_FHA_1	386	392	PF00498	0.390
LIG_FHA_1	96	102	PF00498	0.689
LIG_FHA_2	363	369	PF00498	0.485
LIG_LIR_Gen_1	236	245	PF02991	0.346
LIG_LIR_Gen_1	281	289	PF02991	0.337
LIG_LIR_Gen_1	351	359	PF02991	0.312
LIG_LIR_Nem_3	221	226	PF02991	0.391
LIG_LIR_Nem_3	236	241	PF02991	0.293
LIG_LIR_Nem_3	281	286	PF02991	0.350
LIG_LIR_Nem_3	351	356	PF02991	0.312
LIG_LIR_Nem_3	358	363	PF02991	0.312
LIG_LYPXL_S_1	241	245	PF13949	0.467
LIG_Pex14_1	238	242	PF04695	0.346
LIG_Pex14_2	192	196	PF04695	0.615
LIG_Pex14_2	245	249	PF04695	0.310
LIG_PTB_Apo_2	244	251	PF02174	0.285
LIG_PTB_Phospho_1	244	250	PF10480	0.285
LIG_REV1ctd_RIR_1	4	14	PF16727	0.650
LIG_SH2_STAT5	189	192	PF00017	0.620
LIG_SH2_STAT5	213	216	PF00017	0.312
LIG_SH2_STAT5	381	384	PF00017	0.312
LIG_SH3_3	188	194	PF00018	0.621
LIG_SH3_3	340	346	PF00018	0.267
LIG_SUMO_SIM_par_1	325	330	PF11976	0.371
LIG_UBA3_1	390	395	PF00899	0.399
LIG_Vh1_VBS_1	69	87	PF01044	0.605
MOD_CDC14_SPxK_1	141	144	PF00782	0.738
MOD_CDK_SPK_2	138	143	PF00069	0.746
MOD_CDK_SPxK_1	138	144	PF00069	0.735
MOD_CK1_1	39	45	PF00069	0.729
MOD_CK1_1	73	79	PF00069	0.736
MOD_CK2_1	362	368	PF00069	0.485
MOD_CMANNOS	262	265	PF00535	0.467
MOD_GlcNHglycan	147	151	PF01048	0.542
MOD_GlcNHglycan	184	187	PF01048	0.464
MOD_GlcNHglycan	56	59	PF01048	0.500
MOD_GlcNHglycan	65	68	PF01048	0.435
MOD_GlcNHglycan	80	83	PF01048	0.507
MOD_GSK3_1	111	118	PF00069	0.748
MOD_GSK3_1	138	145	PF00069	0.738
MOD_GSK3_1	14	21	PF00069	0.649
MOD_GSK3_1	23	30	PF00069	0.588
MOD_GSK3_1	285	292	PF00069	0.320
MOD_GSK3_1	36	43	PF00069	0.666
MOD_GSK3_1	50	57	PF00069	0.715
MOD_GSK3_1	65	72	PF00069	0.609
MOD_GSK3_1	78	85	PF00069	0.661
MOD_N-GLC_1	236	241	PF02516	0.613
MOD_N-GLC_1	78	83	PF02516	0.404
MOD_NEK2_1	267	272	PF00069	0.267
MOD_NEK2_1	275	280	PF00069	0.267
MOD_NEK2_1	285	290	PF00069	0.298
MOD_NEK2_1	348	353	PF00069	0.312
MOD_NEK2_1	38	43	PF00069	0.790
MOD_NEK2_1	83	88	PF00069	0.723
MOD_NEK2_2	103	108	PF00069	0.651
MOD_NEK2_2	119	124	PF00069	0.584
MOD_NEK2_2	50	55	PF00069	0.637
MOD_NEK2_2	89	94	PF00069	0.762
MOD_PIKK_1	73	79	PF00454	0.678
MOD_PKA_2	103	109	PF00069	0.651
MOD_PKA_2	133	139	PF00069	0.723
MOD_PKA_2	14	20	PF00069	0.714
MOD_PKA_2	278	284	PF00069	0.337
MOD_Plk_1	236	242	PF00069	0.411
MOD_Plk_1	78	84	PF00069	0.604
MOD_Plk_4	103	109	PF00069	0.631
MOD_Plk_4	119	125	PF00069	0.660
MOD_Plk_4	267	273	PF00069	0.285
MOD_Plk_4	278	284	PF00069	0.312
MOD_Plk_4	289	295	PF00069	0.225
MOD_Plk_4	95	101	PF00069	0.673
MOD_ProDKin_1	111	117	PF00069	0.711
MOD_ProDKin_1	138	144	PF00069	0.749
MOD_ProDKin_1	27	33	PF00069	0.725
TRG_ENDOCYTIC_2	189	192	PF00928	0.627
TRG_ENDOCYTIC_2	213	216	PF00928	0.314
TRG_ENDOCYTIC_2	242	245	PF00928	0.267
TRG_ENDOCYTIC_2	304	307	PF00928	0.485
TRG_ER_diArg_1	312	315	PF00400	0.467
TRG_Pf-PMV_PEXEL_1	389	394	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA30	Leptomonas seymouri	81%	100%
A0A1X0NLI4	Trypanosomatidae	76%	100%
A0A3R7RFZ5	Trypanosoma rangeli	65%	100%
A0A3S7WNU2	Leishmania donovani	96%	100%
A4H3Z5	Leishmania braziliensis	92%	100%
A4HS82	Leishmania infantum	96%	100%
C9ZY76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AK68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%