RSN1_TM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q9U0Z7_LEIMA

TriTrypDb:

LmjF.04.0860 , LMJLV39_040014000 , LMJSD75_040014300

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q9U0Z7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9U0Z7

PDB structure(s): 7aih_S , 7am2_S , 7ane_S

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.559
CLV_C14_Caspase3-7	31	35	PF00656	0.476
CLV_MEL_PAP_1	60	66	PF00089	0.564
CLV_NRD_NRD_1	149	151	PF00675	0.702
CLV_NRD_NRD_1	2	4	PF00675	0.609
CLV_NRD_NRD_1	205	207	PF00675	0.805
CLV_NRD_NRD_1	252	254	PF00675	0.656
CLV_NRD_NRD_1	297	299	PF00675	0.598
CLV_NRD_NRD_1	362	364	PF00675	0.663
CLV_NRD_NRD_1	72	74	PF00675	0.607
CLV_PCSK_FUR_1	360	364	PF00082	0.667
CLV_PCSK_FUR_1	68	72	PF00082	0.604
CLV_PCSK_KEX2_1	2	4	PF00082	0.609
CLV_PCSK_KEX2_1	205	207	PF00082	0.805
CLV_PCSK_KEX2_1	252	254	PF00082	0.656
CLV_PCSK_KEX2_1	299	301	PF00082	0.634
CLV_PCSK_KEX2_1	362	364	PF00082	0.663
CLV_PCSK_KEX2_1	377	379	PF00082	0.423
CLV_PCSK_KEX2_1	68	70	PF00082	0.596
CLV_PCSK_KEX2_1	71	73	PF00082	0.602
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.634
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.685
CLV_PCSK_PC7_1	68	74	PF00082	0.603
CLV_PCSK_SKI1_1	162	166	PF00082	0.444
CLV_PCSK_SKI1_1	175	179	PF00082	0.580
CLV_PCSK_SKI1_1	377	381	PF00082	0.688
DEG_APCC_DBOX_1	362	370	PF00400	0.662
DEG_Nend_UBRbox_1	1	4	PF02207	0.590
DEG_SPOP_SBC_1	240	244	PF00917	0.769
DEG_SPOP_SBC_1	51	55	PF00917	0.511
DOC_CKS1_1	106	111	PF01111	0.632
DOC_CYCLIN_RxL_1	157	168	PF00134	0.448
DOC_CYCLIN_RxL_1	275	283	PF00134	0.622
DOC_CYCLIN_RxL_1	371	382	PF00134	0.679
DOC_CYCLIN_yClb3_PxF_3	79	85	PF00134	0.551
DOC_MAPK_gen_1	157	166	PF00069	0.453
DOC_MAPK_gen_1	252	259	PF00069	0.620
DOC_MAPK_gen_1	275	284	PF00069	0.626
DOC_MAPK_gen_1	298	310	PF00069	0.634
DOC_MAPK_gen_1	353	361	PF00069	0.672
DOC_MAPK_MEF2A_6	275	284	PF00069	0.626
DOC_PP1_RVXF_1	158	164	PF00149	0.554
DOC_PP1_RVXF_1	279	285	PF00149	0.636
DOC_USP7_MATH_1	32	36	PF00917	0.520
DOC_USP7_MATH_1	50	54	PF00917	0.495
DOC_WW_Pin1_4	105	110	PF00397	0.770
DOC_WW_Pin1_4	177	182	PF00397	0.731
DOC_WW_Pin1_4	191	196	PF00397	0.543
DOC_WW_Pin1_4	62	67	PF00397	0.566
LIG_14-3-3_CanoR_1	162	167	PF00244	0.614
LIG_14-3-3_CanoR_1	175	183	PF00244	0.624
LIG_14-3-3_CanoR_1	88	94	PF00244	0.611
LIG_Actin_WH2_2	352	369	PF00022	0.668
LIG_APCC_ABBAyCdc20_2	367	373	PF00400	0.663
LIG_BRCT_BRCA1_1	167	171	PF00533	0.434
LIG_deltaCOP1_diTrp_1	26	29	PF00928	0.671
LIG_EVH1_2	81	85	PF00568	0.655
LIG_FHA_1	111	117	PF00498	0.526
LIG_FHA_1	241	247	PF00498	0.742
LIG_FHA_1	286	292	PF00498	0.650
LIG_FHA_1	53	59	PF00498	0.527
LIG_FHA_2	259	265	PF00498	0.443
LIG_LIR_Gen_1	165	174	PF02991	0.442
LIG_LIR_Nem_3	165	169	PF02991	0.432
LIG_LIR_Nem_3	329	333	PF02991	0.544
LIG_PDZ_Class_1	404	409	PF00595	0.551
LIG_Pex14_2	267	271	PF04695	0.631
LIG_PROFILIN_1	77	83	PF00235	0.542
LIG_SH2_CRK	137	141	PF00017	0.443
LIG_SH2_CRK	251	255	PF00017	0.651
LIG_SH2_STAP1	137	141	PF00017	0.443
LIG_SH2_STAT5	107	110	PF00017	0.634
LIG_SH3_1	71	77	PF00018	0.589
LIG_SH3_3	217	223	PF00018	0.580
LIG_SH3_3	289	295	PF00018	0.647
LIG_SH3_3	344	350	PF00018	0.724
LIG_SH3_3	53	59	PF00018	0.527
LIG_SH3_3	71	77	PF00018	0.579
LIG_TYR_ITIM	135	140	PF00017	0.445
MOD_CDC14_SPxK_1	65	68	PF00782	0.573
MOD_CDK_SPxK_1	62	68	PF00069	0.570
MOD_CDK_SPxxK_3	62	69	PF00069	0.574
MOD_CK1_1	238	244	PF00069	0.635
MOD_Cter_Amidation	66	69	PF01082	0.581
MOD_GlcNHglycan	217	220	PF01048	0.661
MOD_GlcNHglycan	231	234	PF01048	0.785
MOD_GSK3_1	110	117	PF00069	0.695
MOD_GSK3_1	235	242	PF00069	0.796
MOD_N-GLC_1	32	37	PF02516	0.516
MOD_NEK2_1	116	121	PF00069	0.398
MOD_NEK2_1	141	146	PF00069	0.534
MOD_NEK2_1	215	220	PF00069	0.733
MOD_NEK2_1	258	263	PF00069	0.437
MOD_NEK2_1	285	290	PF00069	0.654
MOD_NEK2_1	84	89	PF00069	0.620
MOD_NEK2_1	96	101	PF00069	0.621
MOD_PK_1	343	349	PF00069	0.730
MOD_PKB_1	160	168	PF00069	0.544
MOD_Plk_2-3	326	332	PF00069	0.660
MOD_Plk_4	135	141	PF00069	0.443
MOD_Plk_4	165	171	PF00069	0.435
MOD_Plk_4	210	216	PF00069	0.587
MOD_Plk_4	286	292	PF00069	0.650
MOD_ProDKin_1	105	111	PF00069	0.769
MOD_ProDKin_1	177	183	PF00069	0.729
MOD_ProDKin_1	191	197	PF00069	0.544
MOD_ProDKin_1	62	68	PF00069	0.570
MOD_SUMO_for_1	7	10	PF00179	0.579
MOD_SUMO_rev_2	311	321	PF00179	0.640
TRG_DiLeu_BaEn_1	317	322	PF01217	0.648
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.701
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.682
TRG_ENDOCYTIC_2	137	140	PF00928	0.446
TRG_ENDOCYTIC_2	251	254	PF00928	0.658
TRG_ER_diArg_1	1	3	PF00400	0.617
TRG_ER_diArg_1	160	163	PF00400	0.524
TRG_ER_diArg_1	251	253	PF00400	0.669
TRG_ER_diArg_1	297	300	PF00400	0.641
TRG_ER_diArg_1	302	305	PF00400	0.554
TRG_ER_diArg_1	359	362	PF00400	0.667
TRG_ER_diArg_1	363	366	PF00400	0.592
TRG_ER_diArg_1	38	41	PF00400	0.568
TRG_ER_diArg_1	68	71	PF00400	0.601
TRG_ER_diArg_1	72	74	PF00400	0.587
TRG_NLS_MonoExtN_4	295	302	PF00514	0.646
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.617
TRG_Pf-PMV_PEXEL_1	331	336	PF00026	0.676
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H3Z6	Leishmania braziliensis	65%	100%
E9AK69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%