Putative oxidoreductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase-like protein

Species:

Leishmania major

UniProt:

Q9U0V7_LEIMA

TriTrypDb:

LmjF.23.0670 , LMJLV39_230015200 , LMJSD75_230015500

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q9U0V7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9U0V7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	22
GO:0005488	binding	1	22
GO:0036094	small molecule binding	2	22
GO:0097159	organic cyclic compound binding	2	22
GO:1901265	nucleoside phosphate binding	3	22
GO:1901363	heterocyclic compound binding	2	22

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	334	336	PF00675	0.451
CLV_PCSK_KEX2_1	138	140	PF00082	0.348
CLV_PCSK_KEX2_1	334	336	PF00082	0.419
CLV_PCSK_KEX2_1	47	49	PF00082	0.209
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.364
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.178
CLV_PCSK_PC7_1	43	49	PF00082	0.166
CLV_PCSK_SKI1_1	138	142	PF00082	0.433
CLV_PCSK_SKI1_1	155	159	PF00082	0.511
CLV_PCSK_SKI1_1	195	199	PF00082	0.318
CLV_PCSK_SKI1_1	212	216	PF00082	0.407
CLV_PCSK_SKI1_1	334	338	PF00082	0.497
CLV_Separin_Metazoa	112	116	PF03568	0.215
DEG_APCC_DBOX_1	194	202	PF00400	0.328
DOC_MAPK_gen_1	47	55	PF00069	0.356
DOC_PP4_FxxP_1	203	206	PF00568	0.377
DOC_USP7_MATH_1	238	242	PF00917	0.501
DOC_USP7_MATH_1	271	275	PF00917	0.560
DOC_USP7_MATH_1	347	351	PF00917	0.468
DOC_USP7_MATH_1	62	66	PF00917	0.456
DOC_USP7_UBL2_3	215	219	PF12436	0.313
LIG_14-3-3_CanoR_1	344	350	PF00244	0.373
LIG_BIR_II_1	1	5	PF00653	0.544
LIG_Clathr_ClatBox_1	126	130	PF01394	0.296
LIG_FHA_1	208	214	PF00498	0.367
LIG_FHA_1	228	234	PF00498	0.332
LIG_FHA_1	251	257	PF00498	0.388
LIG_FHA_1	351	357	PF00498	0.352
LIG_FHA_2	107	113	PF00498	0.390
LIG_FHA_2	174	180	PF00498	0.393
LIG_FHA_2	255	261	PF00498	0.443
LIG_LIR_Apic_2	202	206	PF02991	0.431
LIG_LIR_Gen_1	241	250	PF02991	0.351
LIG_LIR_Gen_1	286	293	PF02991	0.556
LIG_LIR_Gen_1	65	73	PF02991	0.296
LIG_LIR_Gen_1	76	86	PF02991	0.301
LIG_LIR_Nem_3	188	194	PF02991	0.320
LIG_LIR_Nem_3	241	246	PF02991	0.309
LIG_LIR_Nem_3	277	283	PF02991	0.404
LIG_LIR_Nem_3	286	291	PF02991	0.429
LIG_LIR_Nem_3	315	321	PF02991	0.370
LIG_LIR_Nem_3	343	349	PF02991	0.420
LIG_LIR_Nem_3	65	69	PF02991	0.296
LIG_LIR_Nem_3	76	82	PF02991	0.285
LIG_MYND_1	178	182	PF01753	0.403
LIG_PCNA_yPIPBox_3	352	361	PF02747	0.314
LIG_Pex14_2	242	246	PF04695	0.369
LIG_PTB_Apo_2	282	289	PF02174	0.334
LIG_PTB_Phospho_1	282	288	PF10480	0.332
LIG_SH2_CRK	288	292	PF00017	0.642
LIG_SH2_GRB2like	288	291	PF00017	0.367
LIG_SH2_PTP2	79	82	PF00017	0.278
LIG_SH2_SRC	288	291	PF00017	0.367
LIG_SH2_SRC	326	329	PF00017	0.341
LIG_SH2_STAP1	196	200	PF00017	0.345
LIG_SH2_STAP1	66	70	PF00017	0.254
LIG_SH2_STAT5	192	195	PF00017	0.294
LIG_SH2_STAT5	79	82	PF00017	0.278
LIG_SUMO_SIM_anti_2	236	241	PF11976	0.211
LIG_SUMO_SIM_anti_2	74	79	PF11976	0.328
LIG_TRAF2_1	338	341	PF00917	0.486
LIG_TRAF2_1	65	68	PF00917	0.422
LIG_TYR_ITIM	77	82	PF00017	0.286
LIG_TYR_ITSM	276	283	PF00017	0.577
LIG_WRC_WIRS_1	222	227	PF05994	0.326
LIG_WRC_WIRS_1	239	244	PF05994	0.326
MOD_CK1_1	312	318	PF00069	0.396
MOD_CK1_1	350	356	PF00069	0.409
MOD_CK2_1	106	112	PF00069	0.367
MOD_CK2_1	113	119	PF00069	0.356
MOD_CK2_1	173	179	PF00069	0.283
MOD_CK2_1	254	260	PF00069	0.438
MOD_CK2_1	271	277	PF00069	0.374
MOD_CK2_1	62	68	PF00069	0.293
MOD_CMANNOS	18	21	PF00535	0.417
MOD_Cter_Amidation	136	139	PF01082	0.311
MOD_GlcNHglycan	1	4	PF01048	0.594
MOD_GlcNHglycan	362	365	PF01048	0.438
MOD_GlcNHglycan	70	73	PF01048	0.217
MOD_GSK3_1	238	245	PF00069	0.397
MOD_GSK3_1	250	257	PF00069	0.362
MOD_GSK3_1	271	278	PF00069	0.519
MOD_N-GLC_1	159	164	PF02516	0.430
MOD_N-GLC_1	284	289	PF02516	0.510
MOD_N-GLC_2	290	292	PF02516	0.395
MOD_NEK2_1	1	6	PF00069	0.500
MOD_NEK2_1	113	118	PF00069	0.397
MOD_NEK2_1	129	134	PF00069	0.337
MOD_NEK2_1	250	255	PF00069	0.443
MOD_NEK2_1	29	34	PF00069	0.425
MOD_NEK2_1	360	365	PF00069	0.370
MOD_NEK2_2	238	243	PF00069	0.406
MOD_PIKK_1	309	315	PF00454	0.497
MOD_PIKK_1	350	356	PF00454	0.322
MOD_Plk_1	159	165	PF00069	0.258
MOD_Plk_1	227	233	PF00069	0.372
MOD_Plk_1	250	256	PF00069	0.386
MOD_Plk_1	284	290	PF00069	0.449
MOD_Plk_1	340	346	PF00069	0.319
MOD_Plk_4	129	135	PF00069	0.303
MOD_Plk_4	238	244	PF00069	0.326
MOD_Plk_4	275	281	PF00069	0.565
MOD_SUMO_for_1	338	341	PF00179	0.329
MOD_SUMO_rev_2	294	304	PF00179	0.511
TRG_ENDOCYTIC_2	280	283	PF00928	0.478
TRG_ENDOCYTIC_2	288	291	PF00928	0.636
TRG_ENDOCYTIC_2	66	69	PF00928	0.294
TRG_ENDOCYTIC_2	79	82	PF00928	0.272
TRG_ER_diArg_1	334	336	PF00400	0.438
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	323	328	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P740	Leptomonas seymouri	33%	81%
A0A0N1I5Z7	Leptomonas seymouri	40%	100%
A0A0N1I7E8	Leptomonas seymouri	57%	100%
A0A0S4IRH3	Bodo saltans	39%	100%
A0A1X0NWZ0	Trypanosomatidae	23%	77%
A0A1X0NX10	Trypanosomatidae	50%	100%
A0A1X0NX22	Trypanosomatidae	37%	81%
A0A1X0NXP4	Trypanosomatidae	42%	100%
A0A3Q8IM07	Leishmania donovani	39%	100%
A0A3S7WXP2	Leishmania donovani	32%	80%
A0A3S7WXT7	Leishmania donovani	95%	100%
A4HCS3	Leishmania braziliensis	32%	80%
A4I097	Leishmania infantum	32%	80%
A4I0B8	Leishmania infantum	96%	100%
B3TMR8	Actinomadura kijaniata	24%	100%
D4GP30	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	24%	100%
E9AH12	Leishmania infantum	39%	87%
E9AW61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	80%
E9AW62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AW82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QBB6	Leishmania major	40%	100%
Q4QBB7	Leishmania major	32%	100%
Q6DKE0	Xenopus laevis	26%	100%
Q9RR32	Streptomyces antibioticus	24%	100%
Q9SZ83	Arabidopsis thaliana	27%	100%
Q9ZA33	Streptomyces violaceoruber	24%	100%
V5BB31	Trypanosoma cruzi	28%	86%
V5BH08	Trypanosoma cruzi	37%	93%