Putative spliceosomal U5 snRNP-specific protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

spliceosomal U5 snRNP-specific protein, putative

Species:

Leishmania major

UniProt:

Q9U0V5_LEIMA

TriTrypDb:

LmjF.23.0650 , LMJLV39_230014900 , LMJSD75_230015200

Length:

217

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	2
GO:0005682	U5 snRNP	5	4
GO:0030532	small nuclear ribonucleoprotein complex	3	9
GO:0032991	protein-containing complex	1	9
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	9
GO:0097525	spliceosomal snRNP complex	4	9
GO:0097526	spliceosomal tri-snRNP complex	5	9
GO:0120114	Sm-like protein family complex	2	9
GO:0140513	nuclear protein-containing complex	2	9
GO:1990904	ribonucleoprotein complex	2	9

Expansion

Sequence features

Q9U0V5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9U0V5

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	9
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	9
GO:0000398	mRNA splicing, via spliceosome	8	9
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006396	RNA processing	6	9
GO:0006397	mRNA processing	7	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0008380	RNA splicing	7	9
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0016071	mRNA metabolic process	6	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	78	82	PF00656	0.632
CLV_MEL_PAP_1	26	32	PF00089	0.318
CLV_NRD_NRD_1	122	124	PF00675	0.287
CLV_NRD_NRD_1	207	209	PF00675	0.481
CLV_NRD_NRD_1	72	74	PF00675	0.703
CLV_NRD_NRD_1	75	77	PF00675	0.692
CLV_PCSK_FUR_1	73	77	PF00082	0.629
CLV_PCSK_KEX2_1	48	50	PF00082	0.552
CLV_PCSK_KEX2_1	74	76	PF00082	0.695
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.552
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.695
CLV_PCSK_SKI1_1	134	138	PF00082	0.382
CLV_PCSK_SKI1_1	24	28	PF00082	0.321
CLV_PCSK_SKI1_1	45	49	PF00082	0.555
DEG_ODPH_VHL_1	118	130	PF01847	0.382
DEG_SPOP_SBC_1	52	56	PF00917	0.516
DOC_MAPK_gen_1	121	130	PF00069	0.360
DOC_MAPK_gen_1	159	167	PF00069	0.377
DOC_MAPK_gen_1	208	215	PF00069	0.512
DOC_MAPK_MEF2A_6	159	167	PF00069	0.298
DOC_PP1_RVXF_1	172	178	PF00149	0.318
DOC_USP7_MATH_1	59	63	PF00917	0.535
DOC_USP7_MATH_1	87	91	PF00917	0.627
LIG_14-3-3_CanoR_1	201	210	PF00244	0.377
LIG_14-3-3_CanoR_1	29	34	PF00244	0.348
LIG_14-3-3_CanoR_1	49	58	PF00244	0.454
LIG_AP2alpha_2	150	152	PF02296	0.382
LIG_BIR_II_1	1	5	PF00653	0.472
LIG_BIR_III_4	79	83	PF00653	0.631
LIG_FHA_1	131	137	PF00498	0.288
LIG_FHA_1	210	216	PF00498	0.477
LIG_FHA_1	53	59	PF00498	0.616
LIG_FHA_1	91	97	PF00498	0.507
LIG_FHA_2	55	61	PF00498	0.721
LIG_LIR_Gen_1	137	145	PF02991	0.318
LIG_LIR_Gen_1	150	158	PF02991	0.217
LIG_LIR_Gen_1	181	192	PF02991	0.377
LIG_LIR_Gen_1	207	215	PF02991	0.514
LIG_LIR_Nem_3	137	142	PF02991	0.382
LIG_LIR_Nem_3	181	187	PF02991	0.413
LIG_LIR_Nem_3	207	213	PF02991	0.548
LIG_NRP_CendR_1	216	217	PF00754	0.514
LIG_Pex14_2	152	156	PF04695	0.300
LIG_REV1ctd_RIR_1	154	163	PF16727	0.269
LIG_SH2_CRK	125	129	PF00017	0.345
LIG_SH2_CRK	184	188	PF00017	0.377
LIG_SH2_NCK_1	33	37	PF00017	0.528
LIG_SH2_STAP1	33	37	PF00017	0.506
LIG_SH2_STAP1	43	47	PF00017	0.560
LIG_SH2_STAT3	43	46	PF00017	0.514
LIG_SH2_STAT5	105	108	PF00017	0.434
LIG_SH2_STAT5	125	128	PF00017	0.308
LIG_SH2_STAT5	129	132	PF00017	0.301
LIG_SH2_STAT5	33	36	PF00017	0.538
LIG_SUMO_SIM_anti_2	23	29	PF11976	0.333
LIG_SUMO_SIM_par_1	3	9	PF11976	0.481
LIG_UBA3_1	114	121	PF00899	0.325
LIG_UBA3_1	4	8	PF00899	0.377
MOD_CK1_1	202	208	PF00069	0.377
MOD_CK1_1	31	37	PF00069	0.530
MOD_CK1_1	54	60	PF00069	0.712
MOD_CK1_1	62	68	PF00069	0.552
MOD_CK1_1	90	96	PF00069	0.601
MOD_CK2_1	54	60	PF00069	0.732
MOD_GlcNHglycan	20	23	PF01048	0.494
MOD_GlcNHglycan	34	37	PF01048	0.633
MOD_GlcNHglycan	67	70	PF01048	0.712
MOD_GlcNHglycan	8	11	PF01048	0.383
MOD_GlcNHglycan	83	86	PF01048	0.511
MOD_GlcNHglycan	89	92	PF01048	0.532
MOD_GlcNHglycan	97	100	PF01048	0.554
MOD_GSK3_1	130	137	PF00069	0.382
MOD_GSK3_1	28	35	PF00069	0.388
MOD_GSK3_1	48	55	PF00069	0.512
MOD_GSK3_1	59	66	PF00069	0.712
MOD_GSK3_1	86	93	PF00069	0.576
MOD_N-GLC_1	63	68	PF02516	0.580
MOD_PKA_1	208	214	PF00069	0.418
MOD_PKA_1	48	54	PF00069	0.564
MOD_PKA_2	28	34	PF00069	0.342
MOD_PKA_2	48	54	PF00069	0.413
MOD_Plk_1	134	140	PF00069	0.382
MOD_Plk_4	124	130	PF00069	0.382
MOD_SUMO_rev_2	202	211	PF00179	0.292
TRG_ENDOCYTIC_2	125	128	PF00928	0.288
TRG_ENDOCYTIC_2	184	187	PF00928	0.414
TRG_ER_diArg_1	106	109	PF00400	0.533
TRG_ER_diArg_1	158	161	PF00400	0.382
TRG_ER_diArg_1	215	217	PF00400	0.483
TRG_ER_diArg_1	73	76	PF00400	0.633
TRG_ER_FFAT_2	31	39	PF00635	0.485
TRG_NLS_MonoCore_2	72	77	PF00514	0.629
TRG_NLS_MonoExtC_3	72	78	PF00514	0.693
TRG_NLS_MonoExtN_4	71	77	PF00514	0.657

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILU9	Leptomonas seymouri	71%	100%
A0A1X0NWY8	Trypanosomatidae	49%	100%
A0A3R7KYL3	Trypanosoma rangeli	45%	100%
A0A3S7WXR3	Leishmania donovani	97%	100%
A4HCT6	Leishmania braziliensis	83%	100%
A4I0B6	Leishmania infantum	97%	100%
E9AW80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%