Uncharacterized protein L7836.08

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q9U0V4_LEIMA

TriTrypDb:

LmjF.23.0640 , LMJLV39_230014800 , LMJSD75_230015100

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 0
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q9U0V4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9U0V4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006887	exocytosis	4	2
GO:0009987	cellular process	1	2
GO:0016192	vesicle-mediated transport	4	2
GO:0032940	secretion by cell	3	2
GO:0045055	regulated exocytosis	5	2
GO:0046903	secretion	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0140352	export from cell	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0005515	protein binding	2	5
GO:0019899	enzyme binding	3	5
GO:0031267	small GTPase binding	5	5
GO:0051020	GTPase binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	466	470	PF00656	0.316
CLV_C14_Caspase3-7	476	480	PF00656	0.324
CLV_NRD_NRD_1	10	12	PF00675	0.563
CLV_NRD_NRD_1	101	103	PF00675	0.617
CLV_NRD_NRD_1	109	111	PF00675	0.536
CLV_NRD_NRD_1	121	123	PF00675	0.548
CLV_NRD_NRD_1	129	131	PF00675	0.560
CLV_NRD_NRD_1	141	143	PF00675	0.516
CLV_NRD_NRD_1	149	151	PF00675	0.520
CLV_NRD_NRD_1	161	163	PF00675	0.534
CLV_NRD_NRD_1	169	171	PF00675	0.514
CLV_NRD_NRD_1	176	178	PF00675	0.616
CLV_NRD_NRD_1	186	188	PF00675	0.585
CLV_NRD_NRD_1	195	197	PF00675	0.581
CLV_NRD_NRD_1	89	91	PF00675	0.630
CLV_PCSK_FUR_1	192	196	PF00082	0.683
CLV_PCSK_KEX2_1	101	103	PF00082	0.617
CLV_PCSK_KEX2_1	108	110	PF00082	0.587
CLV_PCSK_KEX2_1	121	123	PF00082	0.544
CLV_PCSK_KEX2_1	128	130	PF00082	0.569
CLV_PCSK_KEX2_1	140	142	PF00082	0.519
CLV_PCSK_KEX2_1	148	150	PF00082	0.643
CLV_PCSK_KEX2_1	160	162	PF00082	0.539
CLV_PCSK_KEX2_1	168	170	PF00082	0.656
CLV_PCSK_KEX2_1	175	177	PF00082	0.571
CLV_PCSK_KEX2_1	186	188	PF00082	0.569
CLV_PCSK_KEX2_1	194	196	PF00082	0.667
CLV_PCSK_KEX2_1	259	261	PF00082	0.562
CLV_PCSK_KEX2_1	89	91	PF00082	0.630
CLV_PCSK_KEX2_1	9	11	PF00082	0.568
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.702
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.562
CLV_PCSK_SKI1_1	11	15	PF00082	0.588
CLV_PCSK_SKI1_1	63	67	PF00082	0.666
DEG_APCC_DBOX_1	9	17	PF00400	0.426
DEG_Nend_UBRbox_1	1	4	PF02207	0.574
DOC_CYCLIN_RxL_1	320	328	PF00134	0.290
DOC_MAPK_gen_1	382	388	PF00069	0.326
DOC_MAPK_gen_1	9	18	PF00069	0.425
DOC_MAPK_MEF2A_6	424	431	PF00069	0.335
DOC_MAPK_MEF2A_6	9	18	PF00069	0.397
DOC_MAPK_NFAT4_5	424	432	PF00069	0.283
DOC_PP1_RVXF_1	314	320	PF00149	0.295
DOC_PP2B_LxvP_1	373	376	PF13499	0.291
DOC_USP7_MATH_1	299	303	PF00917	0.375
DOC_USP7_MATH_1	447	451	PF00917	0.333
DOC_USP7_MATH_1	526	530	PF00917	0.741
DOC_USP7_UBL2_3	345	349	PF12436	0.317
DOC_WW_Pin1_4	338	343	PF00397	0.351
DOC_WW_Pin1_4	35	40	PF00397	0.435
LIG_14-3-3_CanoR_1	204	211	PF00244	0.364
LIG_14-3-3_CanoR_1	229	236	PF00244	0.465
LIG_14-3-3_CanoR_1	316	326	PF00244	0.439
LIG_14-3-3_CanoR_1	528	537	PF00244	0.600
LIG_14-3-3_CanoR_1	9	14	PF00244	0.481
LIG_FHA_1	339	345	PF00498	0.344
LIG_FHA_1	346	352	PF00498	0.306
LIG_FHA_1	64	70	PF00498	0.600
LIG_FHA_2	295	301	PF00498	0.307
LIG_FHA_2	36	42	PF00498	0.464
LIG_FHA_2	55	61	PF00498	0.637
LIG_LIR_Gen_1	359	368	PF02991	0.345
LIG_LIR_Gen_1	459	468	PF02991	0.366
LIG_LIR_Gen_1	501	507	PF02991	0.328
LIG_LIR_Nem_3	338	343	PF02991	0.351
LIG_LIR_Nem_3	359	365	PF02991	0.339
LIG_LIR_Nem_3	428	433	PF02991	0.311
LIG_LIR_Nem_3	459	463	PF02991	0.364
LIG_LIR_Nem_3	481	486	PF02991	0.380
LIG_LIR_Nem_3	501	505	PF02991	0.240
LIG_NRBOX	467	473	PF00104	0.293
LIG_PCNA_TLS_4	424	431	PF02747	0.283
LIG_Pex14_1	426	430	PF04695	0.287
LIG_Pex14_2	315	319	PF04695	0.279
LIG_Pex14_2	502	506	PF04695	0.377
LIG_REV1ctd_RIR_1	312	320	PF16727	0.304
LIG_SH2_CRK	340	344	PF00017	0.357
LIG_SH2_CRK	390	394	PF00017	0.451
LIG_SH2_CRK	483	487	PF00017	0.393
LIG_SH2_NCK_1	390	394	PF00017	0.283
LIG_SH2_SRC	419	422	PF00017	0.267
LIG_SH2_STAP1	347	351	PF00017	0.318
LIG_SH2_STAP1	362	366	PF00017	0.290
LIG_SH2_STAP1	419	423	PF00017	0.335
LIG_SH2_STAT3	271	274	PF00017	0.292
LIG_SH2_STAT5	221	224	PF00017	0.315
LIG_SH2_STAT5	313	316	PF00017	0.332
LIG_SH2_STAT5	326	329	PF00017	0.402
LIG_SH2_STAT5	340	343	PF00017	0.417
LIG_SH2_STAT5	347	350	PF00017	0.353
LIG_SH2_STAT5	354	357	PF00017	0.262
LIG_SH2_STAT5	421	424	PF00017	0.336
LIG_SH2_STAT5	434	437	PF00017	0.440
LIG_SH2_STAT5	490	493	PF00017	0.387
LIG_SH3_3	245	251	PF00018	0.341
LIG_SH3_4	45	52	PF00018	0.489
LIG_Sin3_3	405	412	PF02671	0.386
LIG_SUMO_SIM_anti_2	494	499	PF11976	0.283
LIG_SUMO_SIM_par_1	469	479	PF11976	0.329
LIG_TRAF2_1	206	209	PF00917	0.373
LIG_TRAF2_1	217	220	PF00917	0.301
LIG_TRAF2_1	57	60	PF00917	0.478
LIG_TYR_ITIM	388	393	PF00017	0.283
LIG_TYR_ITIM	417	422	PF00017	0.259
LIG_UBA3_1	377	383	PF00899	0.416
LIG_WRC_WIRS_1	26	31	PF05994	0.429
MOD_CDK_SPxxK_3	338	345	PF00069	0.370
MOD_CK1_1	302	308	PF00069	0.395
MOD_CK1_1	52	58	PF00069	0.660
MOD_CK2_1	203	209	PF00069	0.441
MOD_CK2_1	214	220	PF00069	0.377
MOD_CK2_1	300	306	PF00069	0.392
MOD_CK2_1	54	60	PF00069	0.621
MOD_Cter_Amidation	515	518	PF01082	0.520
MOD_GlcNHglycan	205	208	PF01048	0.444
MOD_GlcNHglycan	358	361	PF01048	0.365
MOD_GlcNHglycan	368	371	PF01048	0.349
MOD_GlcNHglycan	511	514	PF01048	0.446
MOD_GlcNHglycan	528	531	PF01048	0.511
MOD_GlcNHglycan	532	537	PF01048	0.570
MOD_GSK3_1	279	286	PF00069	0.462
MOD_GSK3_1	343	350	PF00069	0.399
MOD_GSK3_1	443	450	PF00069	0.394
MOD_GSK3_1	459	466	PF00069	0.300
MOD_GSK3_1	48	55	PF00069	0.823
MOD_GSK3_1	5	12	PF00069	0.495
MOD_GSK3_1	505	512	PF00069	0.356
MOD_GSK3_1	524	531	PF00069	0.628
MOD_NEK2_1	315	320	PF00069	0.376
MOD_NEK2_1	325	330	PF00069	0.346
MOD_NEK2_1	336	341	PF00069	0.354
MOD_NEK2_1	491	496	PF00069	0.342
MOD_NEK2_1	505	510	PF00069	0.500
MOD_OFUCOSY	504	509	PF10250	0.283
MOD_PIKK_1	294	300	PF00454	0.412
MOD_PK_1	196	202	PF00069	0.527
MOD_PKA_1	9	15	PF00069	0.481
MOD_PKA_2	203	209	PF00069	0.441
MOD_PKA_2	315	321	PF00069	0.543
MOD_PKA_2	9	15	PF00069	0.481
MOD_Plk_1	299	305	PF00069	0.396
MOD_Plk_2-3	300	306	PF00069	0.392
MOD_Plk_2-3	473	479	PF00069	0.359
MOD_Plk_4	25	31	PF00069	0.516
MOD_Plk_4	463	469	PF00069	0.391
MOD_Plk_4	498	504	PF00069	0.328
MOD_ProDKin_1	338	344	PF00069	0.421
MOD_ProDKin_1	35	41	PF00069	0.542
MOD_SUMO_rev_2	107	117	PF00179	0.414
MOD_SUMO_rev_2	127	137	PF00179	0.437
MOD_SUMO_rev_2	147	157	PF00179	0.350
MOD_SUMO_rev_2	91	97	PF00179	0.482
TRG_DiLeu_BaEn_4	111	117	PF01217	0.495
TRG_DiLeu_BaEn_4	131	137	PF01217	0.373
TRG_DiLeu_BaEn_4	151	157	PF01217	0.346
TRG_DiLeu_BaEn_4	179	185	PF01217	0.415
TRG_DiLeu_BaEn_4	91	97	PF01217	0.521
TRG_ENDOCYTIC_2	340	343	PF00928	0.433
TRG_ENDOCYTIC_2	362	365	PF00928	0.408
TRG_ENDOCYTIC_2	390	393	PF00928	0.332
TRG_ENDOCYTIC_2	419	422	PF00928	0.322
TRG_ENDOCYTIC_2	483	486	PF00928	0.559
TRG_ER_diArg_1	108	110	PF00400	0.694
TRG_ER_diArg_1	128	130	PF00400	0.471
TRG_ER_diArg_1	139	142	PF00400	0.413
TRG_ER_diArg_1	148	150	PF00400	0.358
TRG_ER_diArg_1	159	162	PF00400	0.374
TRG_ER_diArg_1	168	170	PF00400	0.418
TRG_ER_diArg_1	175	177	PF00400	0.489
TRG_ER_diArg_1	195	197	PF00400	0.675
TRG_ER_diArg_1	9	11	PF00400	0.443
TRG_ER_diLys_1	552	555	PF00400	0.527
TRG_Pf-PMV_PEXEL_1	80	85	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD68	Leptomonas seymouri	44%	100%
A0A3Q8ICI9	Leishmania donovani	82%	100%
A4H6H3	Leishmania braziliensis	62%	100%
A4I0B5	Leishmania infantum	80%	100%