Adenylosuccinate lyase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adenylosuccinate lyase, putative

Species:

Leishmania major

UniProt:

Q9U0T7_LEIMA

TriTrypDb:

LmjF.04.0460 , LMJLV39_040009500 , LMJSD75_040009800

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q9U0T7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9U0T7

PDB structure(s): 4mx2_A , 4mx2_B , 4mx2_C , 4mx2_D , 4mx2_E , 4mx2_F , 4mx2_G , 4mx2_H

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006163	purine nucleotide metabolic process	5	12
GO:0006164	purine nucleotide biosynthetic process	6	12
GO:0006167	AMP biosynthetic process	8	11
GO:0006188	IMP biosynthetic process	8	12
GO:0006189	'de novo' IMP biosynthetic process	9	11
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009117	nucleotide metabolic process	5	12
GO:0009123	nucleoside monophosphate metabolic process	5	12
GO:0009124	nucleoside monophosphate biosynthetic process	6	12
GO:0009126	purine nucleoside monophosphate metabolic process	6	12
GO:0009127	purine nucleoside monophosphate biosynthetic process	7	12
GO:0009150	purine ribonucleotide metabolic process	6	12
GO:0009152	purine ribonucleotide biosynthetic process	7	12
GO:0009156	ribonucleoside monophosphate biosynthetic process	7	12
GO:0009161	ribonucleoside monophosphate metabolic process	6	12
GO:0009165	nucleotide biosynthetic process	6	12
GO:0009167	purine ribonucleoside monophosphate metabolic process	7	12
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	8	12
GO:0009259	ribonucleotide metabolic process	5	12
GO:0009260	ribonucleotide biosynthetic process	6	12
GO:0009987	cellular process	1	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0019637	organophosphate metabolic process	3	12
GO:0019693	ribose phosphate metabolic process	4	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034654	nucleobase-containing compound biosynthetic process	4	12
GO:0044208	'de novo' AMP biosynthetic process	9	11
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0044281	small molecule metabolic process	2	12
GO:0046033	AMP metabolic process	7	11
GO:0046040	IMP metabolic process	7	12
GO:0046390	ribose phosphate biosynthetic process	5	12
GO:0046483	heterocycle metabolic process	3	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0072521	purine-containing compound metabolic process	4	12
GO:0072522	purine-containing compound biosynthetic process	5	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901293	nucleoside phosphate biosynthetic process	5	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004018	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity	5	12
GO:0016829	lyase activity	2	12
GO:0016840	carbon-nitrogen lyase activity	3	12
GO:0016842	amidine-lyase activity	4	12
GO:0070626	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity	5	11
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0036094	small molecule binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	362	366	PF00656	0.337
CLV_NRD_NRD_1	266	268	PF00675	0.371
CLV_NRD_NRD_1	420	422	PF00675	0.337
CLV_PCSK_FUR_1	40	44	PF00082	0.310
CLV_PCSK_KEX2_1	266	268	PF00082	0.296
CLV_PCSK_KEX2_1	42	44	PF00082	0.310
CLV_PCSK_KEX2_1	420	422	PF00082	0.337
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.310
CLV_PCSK_SKI1_1	107	111	PF00082	0.364
CLV_PCSK_SKI1_1	162	166	PF00082	0.346
CLV_PCSK_SKI1_1	220	224	PF00082	0.340
CLV_PCSK_SKI1_1	361	365	PF00082	0.337
CLV_PCSK_SKI1_1	392	396	PF00082	0.463
CLV_PCSK_SKI1_1	432	436	PF00082	0.337
CLV_PCSK_SKI1_1	83	87	PF00082	0.302
DEG_APCC_DBOX_1	219	227	PF00400	0.510
DEG_APCC_DBOX_1	460	468	PF00400	0.337
DOC_CYCLIN_RxL_1	388	398	PF00134	0.257
DOC_CYCLIN_yClb5_NLxxxL_5	370	376	PF00134	0.458
DOC_CYCLIN_yCln2_LP_2	372	378	PF00134	0.337
DOC_MAPK_gen_1	59	66	PF00069	0.496
DOC_MAPK_MEF2A_6	59	66	PF00069	0.496
DOC_PP2B_LxvP_1	224	227	PF13499	0.546
DOC_PP2B_LxvP_1	372	375	PF13499	0.337
DOC_USP7_MATH_1	10	14	PF00917	0.490
DOC_USP7_MATH_1	382	386	PF00917	0.326
DOC_WW_Pin1_4	198	203	PF00397	0.485
DOC_WW_Pin1_4	32	37	PF00397	0.463
DOC_WW_Pin1_4	465	470	PF00397	0.337
LIG_14-3-3_CanoR_1	267	277	PF00244	0.486
LIG_14-3-3_CanoR_1	49	58	PF00244	0.518
LIG_14-3-3_CanoR_1	83	90	PF00244	0.510
LIG_14-3-3_CanoR_1	94	99	PF00244	0.510
LIG_Actin_RPEL_3	381	400	PF02755	0.360
LIG_Actin_WH2_2	69	85	PF00022	0.499
LIG_BIR_II_1	1	5	PF00653	0.757
LIG_FHA_1	219	225	PF00498	0.501
LIG_FHA_1	269	275	PF00498	0.490
LIG_FHA_1	43	49	PF00498	0.496
LIG_FHA_1	455	461	PF00498	0.482
LIG_FHA_2	114	120	PF00498	0.375
LIG_FHA_2	146	152	PF00498	0.488
LIG_FHA_2	270	276	PF00498	0.485
LIG_FHA_2	94	100	PF00498	0.572
LIG_GBD_Chelix_1	411	419	PF00786	0.337
LIG_IRF3_LxIS_1	350	357	PF10401	0.401
LIG_LIR_Apic_2	186	190	PF02991	0.498
LIG_LIR_Apic_2	422	427	PF02991	0.337
LIG_LIR_Gen_1	139	147	PF02991	0.499
LIG_LIR_Gen_1	275	283	PF02991	0.493
LIG_LIR_Gen_1	300	310	PF02991	0.485
LIG_LIR_Gen_1	405	415	PF02991	0.337
LIG_LIR_Gen_1	468	477	PF02991	0.353
LIG_LIR_Gen_1	53	62	PF02991	0.506
LIG_LIR_Gen_1	96	106	PF02991	0.572
LIG_LIR_Nem_3	139	145	PF02991	0.499
LIG_LIR_Nem_3	253	257	PF02991	0.510
LIG_LIR_Nem_3	260	265	PF02991	0.512
LIG_LIR_Nem_3	275	280	PF02991	0.421
LIG_LIR_Nem_3	300	305	PF02991	0.485
LIG_LIR_Nem_3	405	411	PF02991	0.338
LIG_LIR_Nem_3	468	473	PF02991	0.339
LIG_LIR_Nem_3	53	58	PF02991	0.496
LIG_LIR_Nem_3	96	101	PF02991	0.572
LIG_LYPXL_yS_3	246	249	PF13949	0.485
LIG_PCNA_yPIPBox_3	387	397	PF02747	0.257
LIG_Pex14_2	254	258	PF04695	0.485
LIG_PTB_Apo_2	26	33	PF02174	0.487
LIG_PTB_Phospho_1	26	32	PF10480	0.388
LIG_SH2_CRK	277	281	PF00017	0.510
LIG_SH2_GRB2like	277	280	PF00017	0.522
LIG_SH2_PTP2	304	307	PF00017	0.590
LIG_SH2_STAP1	270	274	PF00017	0.493
LIG_SH2_STAP1	277	281	PF00017	0.475
LIG_SH2_STAT3	270	273	PF00017	0.510
LIG_SH2_STAT3	309	312	PF00017	0.546
LIG_SH2_STAT3	60	63	PF00017	0.571
LIG_SH2_STAT5	126	129	PF00017	0.499
LIG_SH2_STAT5	169	172	PF00017	0.485
LIG_SH2_STAT5	262	265	PF00017	0.489
LIG_SH2_STAT5	270	273	PF00017	0.479
LIG_SH2_STAT5	304	307	PF00017	0.485
LIG_SH2_STAT5	309	312	PF00017	0.485
LIG_SH2_STAT5	472	475	PF00017	0.403
LIG_SH2_STAT5	51	54	PF00017	0.508
LIG_SH2_STAT5	68	71	PF00017	0.450
LIG_SH3_3	196	202	PF00018	0.485
LIG_SUMO_SIM_par_1	463	468	PF11976	0.347
LIG_TRAF2_1	5	8	PF00917	0.731
LIG_TRFH_1	32	36	PF08558	0.484
LIG_UBA3_1	176	183	PF00899	0.510
LIG_UBA3_1	222	231	PF00899	0.547
LIG_UBA3_1	293	299	PF00899	0.547
MOD_CK1_1	13	19	PF00069	0.606
MOD_CK1_1	2	8	PF00069	0.738
MOD_CK2_1	2	8	PF00069	0.751
MOD_CK2_1	269	275	PF00069	0.485
MOD_CK2_1	93	99	PF00069	0.555
MOD_GlcNHglycan	131	134	PF01048	0.397
MOD_GlcNHglycan	321	324	PF01048	0.291
MOD_GlcNHglycan	350	353	PF01048	0.464
MOD_GlcNHglycan	4	7	PF01048	0.733
MOD_GSK3_1	10	17	PF00069	0.646
MOD_GSK3_1	218	225	PF00069	0.559
MOD_N-GLC_1	152	157	PF02516	0.296
MOD_N-GLC_1	99	104	PF02516	0.384
MOD_NEK2_1	145	150	PF00069	0.485
MOD_NEK2_1	192	197	PF00069	0.470
MOD_NEK2_1	222	227	PF00069	0.590
MOD_NEK2_1	257	262	PF00069	0.513
MOD_NEK2_1	340	345	PF00069	0.411
MOD_NEK2_1	363	368	PF00069	0.360
MOD_NEK2_1	93	98	PF00069	0.543
MOD_PIKK_1	146	152	PF00454	0.496
MOD_PIKK_1	23	29	PF00454	0.586
MOD_PIKK_1	269	275	PF00454	0.485
MOD_PIKK_1	77	83	PF00454	0.590
MOD_PKA_1	42	48	PF00069	0.510
MOD_PKA_2	268	274	PF00069	0.574
MOD_PKA_2	42	48	PF00069	0.493
MOD_PKA_2	93	99	PF00069	0.540
MOD_PKB_1	267	275	PF00069	0.590
MOD_Plk_1	152	158	PF00069	0.491
MOD_Plk_1	364	370	PF00069	0.326
MOD_Plk_1	442	448	PF00069	0.403
MOD_Plk_1	99	105	PF00069	0.547
MOD_Plk_2-3	454	460	PF00069	0.484
MOD_Plk_2-3	99	105	PF00069	0.559
MOD_Plk_4	289	295	PF00069	0.571
MOD_Plk_4	364	370	PF00069	0.339
MOD_Plk_4	414	420	PF00069	0.337
MOD_ProDKin_1	198	204	PF00069	0.485
MOD_ProDKin_1	32	38	PF00069	0.462
MOD_ProDKin_1	465	471	PF00069	0.337
MOD_SUMO_rev_2	113	123	PF00179	0.496
MOD_SUMO_rev_2	306	314	PF00179	0.501
TRG_DiLeu_BaEn_3	217	223	PF01217	0.577
TRG_ENDOCYTIC_2	246	249	PF00928	0.485
TRG_ENDOCYTIC_2	262	265	PF00928	0.485
TRG_ENDOCYTIC_2	277	280	PF00928	0.460
TRG_ENDOCYTIC_2	304	307	PF00928	0.485
TRG_ENDOCYTIC_2	428	431	PF00928	0.337
TRG_ENDOCYTIC_2	55	58	PF00928	0.496
TRG_ER_diArg_1	265	267	PF00400	0.571
TRG_ER_diArg_1	419	421	PF00400	0.337
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.257
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.337
TRG_Pf-PMV_PEXEL_1	448	452	PF00026	0.257

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0H3AL67	Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)	49%	100%
A0A0N1I0W7	Leptomonas seymouri	83%	100%
A0A0S4JC64	Bodo saltans	70%	100%
A0A1X0NMR7	Trypanosomatidae	72%	100%
A0A3R7N1M2	Trypanosoma rangeli	73%	100%
A4H3W5	Leishmania braziliensis	90%	100%
A4HS40	Leishmania infantum	96%	100%
A5IGB3	Legionella pneumophila (strain Corby)	47%	100%
A7LBL3	Leishmania donovani	96%	100%
C9ZY37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AK27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	99%
O28041	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	31%	100%
P0AB89	Escherichia coli (strain K12)	50%	100%
P0AB90	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	50%	100%
P12047	Bacillus subtilis (strain 168)	26%	100%
P44797	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	49%	100%
P56468	Helicobacter pylori (strain ATCC 700392 / 26695)	26%	100%
P57351	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	43%	100%
P72478	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	27%	100%
Q2FFI7	Staphylococcus aureus (strain USA300)	24%	100%
Q2G2S0	Staphylococcus aureus (strain NCTC 8325 / PS 47)	24%	100%
Q2YU66	Staphylococcus aureus (strain bovine RF122 / ET3-1)	24%	100%
Q49YV3	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	24%	100%
Q4L7M3	Staphylococcus haemolyticus (strain JCSC1435)	24%	100%
Q54J34	Dictyostelium discoideum	56%	100%
Q58339	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	26%	100%
Q5HEL4	Staphylococcus aureus (strain COL)	24%	100%
Q5HN26	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	24%	100%
Q5ZXD1	Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)	47%	100%
Q6G825	Staphylococcus aureus (strain MSSA476)	24%	100%
Q6GFE9	Staphylococcus aureus (strain MRSA252)	24%	100%
Q7A0G9	Staphylococcus aureus (strain MW2)	24%	100%
Q7A4Q3	Staphylococcus aureus (strain N315)	24%	100%
Q89AM3	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	41%	100%
Q8CRT6	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	24%	100%
Q8K9Q7	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	42%	100%
Q99SX9	Staphylococcus aureus (strain Mu50 / ATCC 700699)	24%	100%
Q9I0K9	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	50%	100%
Q9RSE6	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	26%	100%
Q9X0I0	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	27%	100%
Q9ZKA2	Helicobacter pylori (strain J99 / ATCC 700824)	26%	100%
V5BE01	Trypanosoma cruzi	71%	100%