Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q9NFA7_LEIMA

TriTrypDb:

LmjF.04.0410 , LMJLV39_040008900 , LMJSD75_040009200

Length:

1125

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q9NFA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9NFA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.783
CLV_C14_Caspase3-7	389	393	PF00656	0.791
CLV_C14_Caspase3-7	709	713	PF00656	0.859
CLV_C14_Caspase3-7	911	915	PF00656	0.773
CLV_NRD_NRD_1	104	106	PF00675	0.866
CLV_NRD_NRD_1	110	112	PF00675	0.756
CLV_NRD_NRD_1	135	137	PF00675	0.779
CLV_NRD_NRD_1	213	215	PF00675	0.744
CLV_NRD_NRD_1	233	235	PF00675	0.547
CLV_NRD_NRD_1	242	244	PF00675	0.719
CLV_NRD_NRD_1	246	248	PF00675	0.750
CLV_NRD_NRD_1	355	357	PF00675	0.669
CLV_NRD_NRD_1	370	372	PF00675	0.864
CLV_NRD_NRD_1	426	428	PF00675	0.799
CLV_NRD_NRD_1	437	439	PF00675	0.674
CLV_NRD_NRD_1	586	588	PF00675	0.604
CLV_NRD_NRD_1	755	757	PF00675	0.840
CLV_PCSK_FUR_1	367	371	PF00082	0.866
CLV_PCSK_KEX2_1	104	106	PF00082	0.866
CLV_PCSK_KEX2_1	109	111	PF00082	0.779
CLV_PCSK_KEX2_1	135	137	PF00082	0.779
CLV_PCSK_KEX2_1	213	215	PF00082	0.832
CLV_PCSK_KEX2_1	233	235	PF00082	0.545
CLV_PCSK_KEX2_1	246	248	PF00082	0.767
CLV_PCSK_KEX2_1	355	357	PF00082	0.669
CLV_PCSK_KEX2_1	369	371	PF00082	0.536
CLV_PCSK_KEX2_1	426	428	PF00082	0.727
CLV_PCSK_KEX2_1	437	439	PF00082	0.667
CLV_PCSK_KEX2_1	586	588	PF00082	0.765
CLV_PCSK_KEX2_1	755	757	PF00082	0.843
CLV_PCSK_PC7_1	105	111	PF00082	0.744
CLV_PCSK_PC7_1	365	371	PF00082	0.865
CLV_PCSK_PC7_1	751	757	PF00082	0.842
CLV_PCSK_SKI1_1	344	348	PF00082	0.677
CLV_PCSK_SKI1_1	756	760	PF00082	0.837
CLV_PCSK_SKI1_1	89	93	PF00082	0.734
DEG_Nend_UBRbox_1	1	4	PF02207	0.738
DEG_SCF_FBW7_1	70	77	PF00400	0.598
DEG_SCF_FBW7_1	775	781	PF00400	0.840
DEG_SPOP_SBC_1	689	693	PF00917	0.587
DEG_SPOP_SBC_1	812	816	PF00917	0.697
DOC_CKS1_1	1047	1052	PF01111	0.803
DOC_CKS1_1	350	355	PF01111	0.773
DOC_CKS1_1	775	780	PF01111	0.839
DOC_CKS1_1	952	957	PF01111	0.748
DOC_MAPK_gen_1	755	761	PF00069	0.839
DOC_MAPK_MEF2A_6	471	478	PF00069	0.601
DOC_PP1_RVXF_1	585	592	PF00149	0.582
DOC_PP2B_LxvP_1	476	479	PF13499	0.644
DOC_PP4_FxxP_1	311	314	PF00568	0.713
DOC_PP4_MxPP_1	573	576	PF00568	0.578
DOC_USP7_MATH_1	113	117	PF00917	0.825
DOC_USP7_MATH_1	120	124	PF00917	0.768
DOC_USP7_MATH_1	191	195	PF00917	0.835
DOC_USP7_MATH_1	209	213	PF00917	0.528
DOC_USP7_MATH_1	21	25	PF00917	0.788
DOC_USP7_MATH_1	259	263	PF00917	0.761
DOC_USP7_MATH_1	342	346	PF00917	0.790
DOC_USP7_MATH_1	351	355	PF00917	0.751
DOC_USP7_MATH_1	377	381	PF00917	0.833
DOC_USP7_MATH_1	382	386	PF00917	0.748
DOC_USP7_MATH_1	49	53	PF00917	0.793
DOC_USP7_MATH_1	514	518	PF00917	0.774
DOC_USP7_MATH_1	557	561	PF00917	0.787
DOC_USP7_MATH_1	600	604	PF00917	0.674
DOC_USP7_MATH_1	689	693	PF00917	0.695
DOC_USP7_MATH_1	72	76	PF00917	0.775
DOC_USP7_MATH_1	825	829	PF00917	0.653
DOC_USP7_MATH_1	936	940	PF00917	0.758
DOC_WW_Pin1_4	1046	1051	PF00397	0.806
DOC_WW_Pin1_4	193	198	PF00397	0.772
DOC_WW_Pin1_4	25	30	PF00397	0.802
DOC_WW_Pin1_4	310	315	PF00397	0.729
DOC_WW_Pin1_4	349	354	PF00397	0.846
DOC_WW_Pin1_4	370	375	PF00397	0.856
DOC_WW_Pin1_4	378	383	PF00397	0.701
DOC_WW_Pin1_4	42	47	PF00397	0.552
DOC_WW_Pin1_4	627	632	PF00397	0.773
DOC_WW_Pin1_4	638	643	PF00397	0.602
DOC_WW_Pin1_4	651	656	PF00397	0.638
DOC_WW_Pin1_4	68	73	PF00397	0.790
DOC_WW_Pin1_4	685	690	PF00397	0.777
DOC_WW_Pin1_4	698	703	PF00397	0.606
DOC_WW_Pin1_4	717	722	PF00397	0.856
DOC_WW_Pin1_4	724	729	PF00397	0.613
DOC_WW_Pin1_4	768	773	PF00397	0.834
DOC_WW_Pin1_4	774	779	PF00397	0.689
DOC_WW_Pin1_4	813	818	PF00397	0.761
DOC_WW_Pin1_4	828	833	PF00397	0.571
DOC_WW_Pin1_4	862	867	PF00397	0.845
DOC_WW_Pin1_4	932	937	PF00397	0.801
DOC_WW_Pin1_4	940	945	PF00397	0.720
DOC_WW_Pin1_4	946	951	PF00397	0.626
LIG_14-3-3_CanoR_1	1045	1050	PF00244	0.776
LIG_14-3-3_CanoR_1	1055	1064	PF00244	0.683
LIG_14-3-3_CanoR_1	1116	1124	PF00244	0.714
LIG_14-3-3_CanoR_1	62	72	PF00244	0.606
LIG_14-3-3_CanoR_1	665	672	PF00244	0.757
LIG_14-3-3_CanoR_1	674	679	PF00244	0.612
LIG_14-3-3_CanoR_1	755	761	PF00244	0.762
LIG_14-3-3_CanoR_1	867	874	PF00244	0.637
LIG_14-3-3_CanoR_1	927	931	PF00244	0.770
LIG_14-3-3_CanoR_1	953	959	PF00244	0.751
LIG_BIR_III_4	1000	1004	PF00653	0.800
LIG_BIR_III_4	392	396	PF00653	0.800
LIG_BRCT_BRCA1_1	965	969	PF00533	0.721
LIG_DLG_GKlike_1	965	973	PF00625	0.703
LIG_EVH1_1	502	506	PF00568	0.603
LIG_EVH1_2	128	132	PF00568	0.603
LIG_FHA_1	10	16	PF00498	0.596
LIG_FHA_1	1030	1036	PF00498	0.623
LIG_FHA_1	1065	1071	PF00498	0.735
LIG_FHA_1	176	182	PF00498	0.738
LIG_FHA_1	336	342	PF00498	0.750
LIG_FHA_1	401	407	PF00498	0.757
LIG_FHA_1	491	497	PF00498	0.669
LIG_FHA_1	599	605	PF00498	0.669
LIG_FHA_1	689	695	PF00498	0.685
LIG_FHA_1	71	77	PF00498	0.600
LIG_FHA_1	718	724	PF00498	0.757
LIG_FHA_1	849	855	PF00498	0.655
LIG_FHA_2	152	158	PF00498	0.751
LIG_FHA_2	180	186	PF00498	0.822
LIG_FHA_2	709	715	PF00498	0.858
LIG_FHA_2	892	898	PF00498	0.610
LIG_Integrin_isoDGR_2	307	309	PF01839	0.618
LIG_LIR_Gen_1	232	239	PF02991	0.718
LIG_LIR_Gen_1	897	906	PF02991	0.784
LIG_LIR_Nem_3	232	238	PF02991	0.836
LIG_LIR_Nem_3	897	903	PF02991	0.779
LIG_LYPXL_yS_3	845	848	PF13949	0.823
LIG_PCNA_yPIPBox_3	741	755	PF02747	0.610
LIG_SH2_SRC	1099	1102	PF00017	0.720
LIG_SH2_STAP1	1099	1103	PF00017	0.707
LIG_SH2_STAT3	78	81	PF00017	0.670
LIG_SH2_STAT5	78	81	PF00017	0.670
LIG_SH3_1	371	377	PF00018	0.842
LIG_SH3_1	571	577	PF00018	0.589
LIG_SH3_1	838	844	PF00018	0.739
LIG_SH3_2	130	135	PF14604	0.692
LIG_SH3_2	425	430	PF14604	0.765
LIG_SH3_2	721	726	PF14604	0.848
LIG_SH3_3	1070	1076	PF00018	0.800
LIG_SH3_3	122	128	PF00018	0.837
LIG_SH3_3	23	29	PF00018	0.800
LIG_SH3_3	371	377	PF00018	0.681
LIG_SH3_3	422	428	PF00018	0.769
LIG_SH3_3	443	449	PF00018	0.794
LIG_SH3_3	476	482	PF00018	0.704
LIG_SH3_3	500	506	PF00018	0.667
LIG_SH3_3	542	548	PF00018	0.693
LIG_SH3_3	571	577	PF00018	0.609
LIG_SH3_3	592	598	PF00018	0.784
LIG_SH3_3	625	631	PF00018	0.822
LIG_SH3_3	691	697	PF00018	0.756
LIG_SH3_3	718	724	PF00018	0.850
LIG_SH3_3	772	778	PF00018	0.833
LIG_SH3_3	838	844	PF00018	0.817
LIG_SH3_3	949	955	PF00018	0.755
LIG_SUMO_SIM_anti_2	601	606	PF11976	0.574
LIG_TRAF2_1	277	280	PF00917	0.826
LIG_TRAF2_1	293	296	PF00917	0.606
LIG_TRAF2_1	322	325	PF00917	0.757
LIG_TRAF2_1	577	580	PF00917	0.540
MOD_CDC14_SPxK_1	641	644	PF00782	0.754
MOD_CDK_SPK_2	862	867	PF00069	0.768
MOD_CDK_SPxK_1	349	355	PF00069	0.850
MOD_CDK_SPxK_1	638	644	PF00069	0.758
MOD_CDK_SPxxK_3	1046	1053	PF00069	0.805
MOD_CDK_SPxxK_3	193	200	PF00069	0.615
MOD_CDK_SPxxK_3	349	356	PF00069	0.851
MOD_CDK_SPxxK_3	946	953	PF00069	0.750
MOD_CK1_1	1008	1014	PF00069	0.794
MOD_CK1_1	1034	1040	PF00069	0.722
MOD_CK1_1	1060	1066	PF00069	0.799
MOD_CK1_1	115	121	PF00069	0.778
MOD_CK1_1	137	143	PF00069	0.750
MOD_CK1_1	173	179	PF00069	0.773
MOD_CK1_1	193	199	PF00069	0.744
MOD_CK1_1	212	218	PF00069	0.531
MOD_CK1_1	24	30	PF00069	0.789
MOD_CK1_1	263	269	PF00069	0.826
MOD_CK1_1	385	391	PF00069	0.828
MOD_CK1_1	45	51	PF00069	0.632
MOD_CK1_1	569	575	PF00069	0.673
MOD_CK1_1	61	67	PF00069	0.683
MOD_CK1_1	620	626	PF00069	0.739
MOD_CK1_1	630	636	PF00069	0.696
MOD_CK1_1	664	670	PF00069	0.848
MOD_CK1_1	673	679	PF00069	0.618
MOD_CK1_1	698	704	PF00069	0.762
MOD_CK1_1	717	723	PF00069	0.841
MOD_CK1_1	737	743	PF00069	0.723
MOD_CK1_1	77	83	PF00069	0.564
MOD_CK1_1	771	777	PF00069	0.795
MOD_CK1_1	799	805	PF00069	0.835
MOD_CK1_1	806	812	PF00069	0.743
MOD_CK1_1	828	834	PF00069	0.744
MOD_CK1_1	862	868	PF00069	0.691
MOD_CK1_1	940	946	PF00069	0.652
MOD_CK2_1	1099	1105	PF00069	0.627
MOD_CK2_1	61	67	PF00069	0.609
MOD_CK2_1	737	743	PF00069	0.818
MOD_Cter_Amidation	102	105	PF01082	0.863
MOD_Cter_Amidation	133	136	PF01082	0.778
MOD_GlcNHglycan	1005	1008	PF01048	0.655
MOD_GlcNHglycan	1036	1039	PF01048	0.758
MOD_GlcNHglycan	1057	1060	PF01048	0.682
MOD_GlcNHglycan	1096	1099	PF01048	0.731
MOD_GlcNHglycan	115	118	PF01048	0.847
MOD_GlcNHglycan	139	142	PF01048	0.750
MOD_GlcNHglycan	160	163	PF01048	0.776
MOD_GlcNHglycan	19	22	PF01048	0.754
MOD_GlcNHglycan	289	292	PF01048	0.795
MOD_GlcNHglycan	30	33	PF01048	0.694
MOD_GlcNHglycan	344	347	PF01048	0.773
MOD_GlcNHglycan	36	39	PF01048	0.601
MOD_GlcNHglycan	450	453	PF01048	0.743
MOD_GlcNHglycan	499	502	PF01048	0.843
MOD_GlcNHglycan	516	519	PF01048	0.513
MOD_GlcNHglycan	52	55	PF01048	0.636
MOD_GlcNHglycan	717	720	PF01048	0.784
MOD_GlcNHglycan	756	759	PF01048	0.672
MOD_GlcNHglycan	778	781	PF01048	0.724
MOD_GlcNHglycan	786	789	PF01048	0.663
MOD_GlcNHglycan	798	801	PF01048	0.708
MOD_GlcNHglycan	802	805	PF01048	0.727
MOD_GlcNHglycan	823	826	PF01048	0.795
MOD_GlcNHglycan	827	830	PF01048	0.720
MOD_GlcNHglycan	965	968	PF01048	0.797
MOD_GlcNHglycan	969	972	PF01048	0.773
MOD_GlcNHglycan	992	995	PF01048	0.780
MOD_GSK3_1	1008	1015	PF00069	0.678
MOD_GSK3_1	1060	1067	PF00069	0.736
MOD_GSK3_1	135	142	PF00069	0.768
MOD_GSK3_1	15	22	PF00069	0.758
MOD_GSK3_1	169	176	PF00069	0.845
MOD_GSK3_1	24	31	PF00069	0.706
MOD_GSK3_1	259	266	PF00069	0.721
MOD_GSK3_1	310	317	PF00069	0.723
MOD_GSK3_1	378	385	PF00069	0.832
MOD_GSK3_1	45	52	PF00069	0.602
MOD_GSK3_1	514	521	PF00069	0.720
MOD_GSK3_1	553	560	PF00069	0.811
MOD_GSK3_1	563	570	PF00069	0.698
MOD_GSK3_1	630	637	PF00069	0.794
MOD_GSK3_1	638	645	PF00069	0.627
MOD_GSK3_1	661	668	PF00069	0.846
MOD_GSK3_1	670	677	PF00069	0.659
MOD_GSK3_1	68	75	PF00069	0.793
MOD_GSK3_1	685	692	PF00069	0.503
MOD_GSK3_1	698	705	PF00069	0.664
MOD_GSK3_1	715	722	PF00069	0.821
MOD_GSK3_1	750	757	PF00069	0.755
MOD_GSK3_1	759	766	PF00069	0.707
MOD_GSK3_1	774	781	PF00069	0.739
MOD_GSK3_1	795	802	PF00069	0.842
MOD_GSK3_1	821	828	PF00069	0.752
MOD_GSK3_1	891	898	PF00069	0.768
MOD_GSK3_1	932	939	PF00069	0.833
MOD_GSK3_1	963	970	PF00069	0.714
MOD_GSK3_1	995	1002	PF00069	0.657
MOD_LATS_1	663	669	PF00433	0.771
MOD_N-GLC_1	1094	1099	PF02516	0.731
MOD_N-GLC_1	173	178	PF02516	0.777
MOD_N-GLC_1	661	666	PF02516	0.844
MOD_N-GLC_1	848	853	PF02516	0.732
MOD_N-GLC_1	940	945	PF02516	0.588
MOD_NEK2_1	1057	1062	PF00069	0.798
MOD_NEK2_1	1094	1099	PF00069	0.693
MOD_NEK2_1	169	174	PF00069	0.816
MOD_NEK2_1	287	292	PF00069	0.663
MOD_NEK2_1	634	639	PF00069	0.779
MOD_NEK2_1	656	661	PF00069	0.859
MOD_NEK2_1	754	759	PF00069	0.737
MOD_NEK2_1	796	801	PF00069	0.778
MOD_NEK2_1	854	859	PF00069	0.610
MOD_NEK2_1	895	900	PF00069	0.701
MOD_NEK2_1	918	923	PF00069	0.581
MOD_NEK2_1	945	950	PF00069	0.824
MOD_PIKK_1	15	21	PF00454	0.736
MOD_PIKK_1	400	406	PF00454	0.762
MOD_PIKK_1	77	83	PF00454	0.784
MOD_PIKK_1	84	90	PF00454	0.685
MOD_PIKK_1	854	860	PF00454	0.727
MOD_PK_1	386	392	PF00069	0.831
MOD_PKA_1	135	141	PF00069	0.741
MOD_PKA_2	1003	1009	PF00069	0.773
MOD_PKA_2	1115	1121	PF00069	0.689
MOD_PKA_2	134	140	PF00069	0.846
MOD_PKA_2	212	218	PF00069	0.838
MOD_PKA_2	385	391	PF00069	0.828
MOD_PKA_2	407	413	PF00069	0.734
MOD_PKA_2	58	64	PF00069	0.781
MOD_PKA_2	664	670	PF00069	0.709
MOD_PKA_2	673	679	PF00069	0.669
MOD_PKA_2	750	756	PF00069	0.760
MOD_PKA_2	796	802	PF00069	0.852
MOD_PKA_2	849	855	PF00069	0.849
MOD_PKA_2	926	932	PF00069	0.768
MOD_PKB_1	1053	1061	PF00069	0.815
MOD_Plk_1	1094	1100	PF00069	0.731
MOD_Plk_1	263	269	PF00069	0.721
MOD_Plk_1	297	303	PF00069	0.772
MOD_Plk_1	323	329	PF00069	0.759
MOD_Plk_1	386	392	PF00069	0.714
MOD_Plk_1	617	623	PF00069	0.757
MOD_Plk_2-3	891	897	PF00069	0.768
MOD_Plk_2-3	908	914	PF00069	0.525
MOD_Plk_4	1066	1072	PF00069	0.806
MOD_Plk_4	21	27	PF00069	0.724
MOD_Plk_4	492	498	PF00069	0.646
MOD_Plk_4	505	511	PF00069	0.688
MOD_Plk_4	563	569	PF00069	0.781
MOD_Plk_4	600	606	PF00069	0.622
MOD_Plk_4	630	636	PF00069	0.822
MOD_Plk_4	674	680	PF00069	0.631
MOD_Plk_4	690	696	PF00069	0.671
MOD_Plk_4	891	897	PF00069	0.768
MOD_ProDKin_1	1046	1052	PF00069	0.805
MOD_ProDKin_1	193	199	PF00069	0.768
MOD_ProDKin_1	25	31	PF00069	0.803
MOD_ProDKin_1	310	316	PF00069	0.731
MOD_ProDKin_1	349	355	PF00069	0.850
MOD_ProDKin_1	370	376	PF00069	0.851
MOD_ProDKin_1	378	384	PF00069	0.701
MOD_ProDKin_1	42	48	PF00069	0.555
MOD_ProDKin_1	627	633	PF00069	0.773
MOD_ProDKin_1	638	644	PF00069	0.605
MOD_ProDKin_1	651	657	PF00069	0.640
MOD_ProDKin_1	68	74	PF00069	0.791
MOD_ProDKin_1	685	691	PF00069	0.779
MOD_ProDKin_1	698	704	PF00069	0.610
MOD_ProDKin_1	717	723	PF00069	0.856
MOD_ProDKin_1	724	730	PF00069	0.615
MOD_ProDKin_1	768	774	PF00069	0.835
MOD_ProDKin_1	778	784	PF00069	0.625
MOD_ProDKin_1	813	819	PF00069	0.764
MOD_ProDKin_1	828	834	PF00069	0.571
MOD_ProDKin_1	862	868	PF00069	0.844
MOD_ProDKin_1	932	938	PF00069	0.801
MOD_ProDKin_1	940	946	PF00069	0.722
MOD_ProDKin_1	951	957	PF00069	0.828
MOD_SUMO_for_1	889	892	PF00179	0.794
MOD_SUMO_rev_2	1066	1076	PF00179	0.803
MOD_SUMO_rev_2	410	419	PF00179	0.775
TRG_DiLeu_BaEn_1	328	333	PF01217	0.723
TRG_DiLeu_BaEn_4	401	407	PF01217	0.718
TRG_DiLeu_BaEn_4	579	585	PF01217	0.769
TRG_DiLeu_BaLyEn_6	471	476	PF01217	0.561
TRG_ENDOCYTIC_2	1083	1086	PF00928	0.801
TRG_ENDOCYTIC_2	845	848	PF00928	0.666
TRG_ER_diArg_1	109	111	PF00400	0.784
TRG_ER_diArg_1	233	235	PF00400	0.689
TRG_ER_diArg_1	255	258	PF00400	0.860
TRG_ER_diArg_1	355	357	PF00400	0.669
TRG_ER_diArg_1	367	370	PF00400	0.602
TRG_ER_diArg_1	425	427	PF00400	0.768
TRG_ER_diArg_1	754	756	PF00400	0.849
TRG_NLS_Bipartite_1	233	247	PF00514	0.613
TRG_NLS_MonoExtC_3	242	247	PF00514	0.623
TRG_NLS_MonoExtN_4	241	247	PF00514	0.624
TRG_NLS_MonoExtN_4	89	96	PF00514	0.622
TRG_Pf-PMV_PEXEL_1	974	979	PF00026	0.812

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5A2	Leishmania donovani	89%	100%
A4H3W1	Leishmania braziliensis	61%	100%
A4HS35	Leishmania infantum	89%	100%
E9AK22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%