COPI associated

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

COPI associated

Gene product:

COPI associated protein, putative

Species:

Leishmania major

UniProt:

Q9NF92_LEIMA

TriTrypDb:

LmjF.04.1030 , LMJLV39_040015900 , LMJSD75_040016200

Length:

194

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q9NF92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9NF92

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	153	155	PF00675	0.539
CLV_PCSK_KEX2_1	153	155	PF00082	0.539
CLV_PCSK_SKI1_1	99	103	PF00082	0.354
DOC_MAPK_gen_1	97	106	PF00069	0.494
DOC_MAPK_MEF2A_6	20	29	PF00069	0.506
DOC_PP2B_LxvP_1	9	12	PF13499	0.713
DOC_USP7_MATH_1	183	187	PF00917	0.756
DOC_WW_Pin1_4	165	170	PF00397	0.731
LIG_14-3-3_CanoR_1	14	22	PF00244	0.679
LIG_14-3-3_CanoR_1	158	164	PF00244	0.699
LIG_BIR_II_1	1	5	PF00653	0.728
LIG_EH1_1	25	33	PF00400	0.429
LIG_FHA_1	111	117	PF00498	0.532
LIG_FHA_1	49	55	PF00498	0.300
LIG_LIR_Nem_3	21	25	PF02991	0.613
LIG_Pex14_1	22	26	PF04695	0.508
LIG_Pex14_1	86	90	PF04695	0.631
LIG_Pex14_2	102	106	PF04695	0.401
LIG_SH2_CRK	60	64	PF00017	0.444
LIG_SH2_STAT5	103	106	PF00017	0.379
LIG_SH2_STAT5	60	63	PF00017	0.369
LIG_SH2_STAT5	89	92	PF00017	0.583
LIG_SUMO_SIM_anti_2	115	120	PF11976	0.372
LIG_SUMO_SIM_anti_2	30	36	PF11976	0.441
LIG_SUMO_SIM_par_1	107	113	PF11976	0.291
LIG_SUMO_SIM_par_1	129	135	PF11976	0.363
LIG_SUMO_SIM_par_1	65	70	PF11976	0.323
LIG_TRAF2_1	146	149	PF00917	0.741
LIG_UBA3_1	83	88	PF00899	0.572
MOD_CDK_SPxxK_3	165	172	PF00069	0.718
MOD_CK1_1	13	19	PF00069	0.699
MOD_CK1_1	168	174	PF00069	0.771
MOD_CK1_1	48	54	PF00069	0.357
MOD_CK2_1	185	191	PF00069	0.744
MOD_GlcNHglycan	1	4	PF01048	0.417
MOD_GlcNHglycan	160	163	PF01048	0.585
MOD_GlcNHglycan	179	182	PF01048	0.573
MOD_GlcNHglycan	47	50	PF01048	0.646
MOD_GlcNHglycan	69	72	PF01048	0.432
MOD_GSK3_1	164	171	PF00069	0.732
MOD_GSK3_1	177	184	PF00069	0.567
MOD_NEK2_1	1	6	PF00069	0.673
MOD_NEK2_1	110	115	PF00069	0.490
MOD_NEK2_1	132	137	PF00069	0.483
MOD_NEK2_1	27	32	PF00069	0.351
MOD_NEK2_1	45	50	PF00069	0.354
MOD_NEK2_1	62	67	PF00069	0.436
MOD_NEK2_1	74	79	PF00069	0.686
MOD_PKA_2	13	19	PF00069	0.667
MOD_PKA_2	157	163	PF00069	0.738
MOD_PKA_2	164	170	PF00069	0.784
MOD_Plk_4	132	138	PF00069	0.447
MOD_Plk_4	27	33	PF00069	0.398
MOD_ProDKin_1	165	171	PF00069	0.732
TRG_ENDOCYTIC_2	103	106	PF00928	0.453
TRG_ENDOCYTIC_2	60	63	PF00928	0.369
TRG_ENDOCYTIC_2	89	92	PF00928	0.587
TRG_ER_diArg_1	96	99	PF00400	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IIQ5	Bodo saltans	25%	100%
A0A1X0NKT5	Trypanosomatidae	34%	90%
A0A3R7M187	Trypanosoma rangeli	33%	87%
A0A3S5H5E3	Leishmania donovani	88%	100%
A4H417	Leishmania braziliensis	47%	69%
A4HSA0	Leishmania infantum	87%	100%
C9ZY95	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AK84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%