Acyltransferase-like protein, copy 1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyltransferase-like protein, copy 1

Species:

Leishmania major

UniProt:

Q9NF91_LEIMA

TriTrypDb:

LmjF.04.1040 , LMJLV39_040016000 , LMJSD75_040016300

Length:

385

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 27
NetGPI	no	yes: 0, no: 27

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	23
GO:0110165	cellular anatomical entity	1	23

Expansion

Sequence features

Q9NF91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9NF91

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	5
GO:0006644	phospholipid metabolic process	4	5
GO:0006650	glycerophospholipid metabolic process	5	5
GO:0006654	phosphatidic acid biosynthetic process	6	5
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0008152	metabolic process	1	5
GO:0008610	lipid biosynthetic process	4	5
GO:0008654	phospholipid biosynthetic process	5	5
GO:0009058	biosynthetic process	2	5
GO:0009987	cellular process	1	5
GO:0019637	organophosphate metabolic process	3	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0044249	cellular biosynthetic process	3	5
GO:0044255	cellular lipid metabolic process	3	5
GO:0045017	glycerolipid biosynthetic process	4	5
GO:0046473	phosphatidic acid metabolic process	6	5
GO:0046474	glycerophospholipid biosynthetic process	5	5
GO:0046486	glycerolipid metabolic process	4	5
GO:0071704	organic substance metabolic process	2	5
GO:0090407	organophosphate biosynthetic process	4	5
GO:1901576	organic substance biosynthetic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	28
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	7	5
GO:0008374	O-acyltransferase activity	5	5
GO:0016411	acylglycerol O-acyltransferase activity	6	5
GO:0016740	transferase activity	2	28
GO:0016746	acyltransferase activity	3	28
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	5
GO:0042171	lysophosphatidic acid acyltransferase activity	6	5
GO:0071617	lysophospholipid acyltransferase activity	5	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.317
CLV_C14_Caspase3-7	253	257	PF00656	0.189
CLV_C14_Caspase3-7	362	366	PF00656	0.292
CLV_MEL_PAP_1	222	228	PF00089	0.544
CLV_NRD_NRD_1	19	21	PF00675	0.378
CLV_NRD_NRD_1	213	215	PF00675	0.534
CLV_NRD_NRD_1	344	346	PF00675	0.565
CLV_NRD_NRD_1	64	66	PF00675	0.335
CLV_PCSK_FUR_1	61	65	PF00082	0.335
CLV_PCSK_KEX2_1	19	21	PF00082	0.378
CLV_PCSK_KEX2_1	344	346	PF00082	0.573
CLV_PCSK_KEX2_1	63	65	PF00082	0.339
CLV_PCSK_PC7_1	15	21	PF00082	0.382
CLV_PCSK_SKI1_1	200	204	PF00082	0.508
DEG_APCC_DBOX_1	86	94	PF00400	0.451
DEG_Nend_UBRbox_4	1	3	PF02207	0.576
DOC_CYCLIN_RxL_1	197	207	PF00134	0.324
DOC_CYCLIN_yCln2_LP_2	28	34	PF00134	0.544
DOC_MAPK_DCC_7	133	141	PF00069	0.419
DOC_MAPK_DCC_7	87	95	PF00069	0.364
DOC_MAPK_gen_1	87	95	PF00069	0.321
DOC_MAPK_MEF2A_6	133	141	PF00069	0.398
DOC_MAPK_MEF2A_6	87	95	PF00069	0.318
DOC_MAPK_MEF2A_6	97	105	PF00069	0.261
DOC_PP1_RVXF_1	142	149	PF00149	0.346
DOC_PP1_RVXF_1	165	171	PF00149	0.432
DOC_PP2B_LxvP_1	124	127	PF13499	0.583
DOC_PP2B_LxvP_1	28	31	PF13499	0.548
DOC_PP2B_LxvP_1	32	35	PF13499	0.533
DOC_PP2B_PxIxI_1	150	156	PF00149	0.266
DOC_USP7_MATH_1	371	375	PF00917	0.489
DOC_WW_Pin1_4	194	199	PF00397	0.321
DOC_WW_Pin1_4	20	25	PF00397	0.565
DOC_WW_Pin1_4	375	380	PF00397	0.449
LIG_14-3-3_CanoR_1	167	171	PF00244	0.378
LIG_14-3-3_CanoR_1	19	24	PF00244	0.567
LIG_14-3-3_CanoR_1	278	284	PF00244	0.216
LIG_BIR_III_4	236	240	PF00653	0.199
LIG_deltaCOP1_diTrp_1	307	313	PF00928	0.294
LIG_EH1_1	99	107	PF00400	0.221
LIG_FHA_1	113	119	PF00498	0.342
LIG_FHA_1	126	132	PF00498	0.478
LIG_FHA_1	376	382	PF00498	0.352
LIG_FHA_1	39	45	PF00498	0.534
LIG_GBD_Chelix_1	77	85	PF00786	0.394
LIG_LIR_Gen_1	189	199	PF02991	0.280
LIG_LIR_Gen_1	287	296	PF02991	0.266
LIG_LIR_LC3C_4	115	119	PF02991	0.357
LIG_LIR_LC3C_4	71	75	PF02991	0.187
LIG_LIR_Nem_3	169	173	PF02991	0.349
LIG_LIR_Nem_3	186	191	PF02991	0.294
LIG_LIR_Nem_3	197	202	PF02991	0.292
LIG_LIR_Nem_3	282	288	PF02991	0.286
LIG_LIR_Nem_3	297	302	PF02991	0.310
LIG_Pex14_2	143	147	PF04695	0.396
LIG_Pex14_2	219	223	PF04695	0.319
LIG_Pex14_2	229	233	PF04695	0.299
LIG_Pex14_2	288	292	PF04695	0.282
LIG_SH2_CRK	191	195	PF00017	0.346
LIG_SH2_PTP2	83	86	PF00017	0.266
LIG_SH2_STAT3	129	132	PF00017	0.221
LIG_SH2_STAT5	129	132	PF00017	0.410
LIG_SH2_STAT5	180	183	PF00017	0.393
LIG_SH2_STAT5	232	235	PF00017	0.263
LIG_SH2_STAT5	83	86	PF00017	0.316
LIG_SH3_3	23	29	PF00018	0.554
LIG_SUMO_SIM_anti_2	71	76	PF11976	0.187
LIG_SUMO_SIM_par_1	71	76	PF11976	0.232
LIG_TYR_ITIM	81	86	PF00017	0.397
LIG_WRC_WIRS_1	280	285	PF05994	0.290
MOD_CDK_SPxK_1	194	200	PF00069	0.340
MOD_CK1_1	112	118	PF00069	0.372
MOD_CK1_1	22	28	PF00069	0.553
MOD_CMANNOS	310	313	PF00535	0.585
MOD_Cter_Amidation	61	64	PF01082	0.334
MOD_GlcNHglycan	111	114	PF01048	0.360
MOD_GlcNHglycan	162	166	PF01048	0.542
MOD_GlcNHglycan	177	180	PF01048	0.374
MOD_GlcNHglycan	260	263	PF01048	0.527
MOD_GlcNHglycan	367	370	PF01048	0.602
MOD_GSK3_1	171	178	PF00069	0.342
MOD_GSK3_1	204	211	PF00069	0.316
MOD_GSK3_1	365	372	PF00069	0.334
MOD_NEK2_1	1	6	PF00069	0.573
MOD_NEK2_1	161	166	PF00069	0.424
MOD_NEK2_1	202	207	PF00069	0.270
MOD_NEK2_1	208	213	PF00069	0.306
MOD_NEK2_1	73	78	PF00069	0.353
MOD_PIKK_1	171	177	PF00454	0.260
MOD_PIKK_1	38	44	PF00454	0.531
MOD_PKA_1	19	25	PF00069	0.567
MOD_PKA_2	166	172	PF00069	0.368
MOD_PKA_2	19	25	PF00069	0.564
MOD_Plk_1	306	312	PF00069	0.359
MOD_Plk_4	104	110	PF00069	0.326
MOD_Plk_4	183	189	PF00069	0.282
MOD_Plk_4	287	293	PF00069	0.328
MOD_Plk_4	295	301	PF00069	0.328
MOD_Plk_4	68	74	PF00069	0.479
MOD_ProDKin_1	194	200	PF00069	0.321
MOD_ProDKin_1	20	26	PF00069	0.563
MOD_ProDKin_1	375	381	PF00069	0.454
MOD_SUMO_rev_2	333	342	PF00179	0.349
MOD_SUMO_rev_2	356	366	PF00179	0.282
TRG_ENDOCYTIC_2	191	194	PF00928	0.363
TRG_ENDOCYTIC_2	285	288	PF00928	0.317
TRG_ENDOCYTIC_2	299	302	PF00928	0.292
TRG_ENDOCYTIC_2	354	357	PF00928	0.387
TRG_ENDOCYTIC_2	83	86	PF00928	0.383
TRG_ER_diArg_1	343	345	PF00400	0.398
TRG_ER_diArg_1	61	64	PF00400	0.534
TRG_ER_diArg_1	86	89	PF00400	0.410
TRG_NES_CRM1_1	322	335	PF08389	0.301

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P455	Leptomonas seymouri	55%	100%
A0A0N1HTP4	Leptomonas seymouri	64%	100%
A0A0N1I6V1	Leptomonas seymouri	35%	100%
A0A0N1IKX5	Leptomonas seymouri	35%	100%
A0A0S4IQ05	Bodo saltans	32%	100%
A0A0S4IR22	Bodo saltans	42%	100%
A0A0S4JRB2	Bodo saltans	30%	100%
A0A1X0P9F0	Trypanosomatidae	34%	100%
A0A3R7NKA0	Trypanosoma rangeli	34%	100%
A0A3S5H5E4	Leishmania donovani	89%	89%
A0A3S5H7L8	Leishmania donovani	35%	100%
A0A3S7WNW6	Leishmania donovani	51%	100%
A4H419	Leishmania braziliensis	68%	100%
A4H420	Leishmania braziliensis	55%	100%
A4HHM7	Leishmania braziliensis	33%	100%
A4HSA1	Leishmania infantum	93%	100%
A4HSA2	Leishmania infantum	51%	100%
A4I4U1	Leishmania infantum	30%	100%
A4I4U2	Leishmania infantum	36%	100%
C9ZLI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AE89	Leishmania major	30%	100%
E9AE90	Leishmania major	35%	100%
E9AK86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9ALJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
Q9NF90	Leishmania major	53%	100%
V5C201	Trypanosoma cruzi	32%	100%