Transcriptional repressor TCF25 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transcriptional repressor TCF25, putative

Species:

Leishmania major

UniProt:

Q9NF87_LEIMA

TriTrypDb:

LmjF.04.1080 , LMJLV39_040016400 , LMJSD75_040016700

Length:

890

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:1990112	RQC complex	2	2

Expansion

Sequence features

Q9NF87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q9NF87

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.680
CLV_C14_Caspase3-7	543	547	PF00656	0.513
CLV_C14_Caspase3-7	668	672	PF00656	0.436
CLV_C14_Caspase3-7	718	722	PF00656	0.436
CLV_NRD_NRD_1	163	165	PF00675	0.562
CLV_NRD_NRD_1	166	168	PF00675	0.567
CLV_NRD_NRD_1	171	173	PF00675	0.574
CLV_NRD_NRD_1	175	177	PF00675	0.575
CLV_NRD_NRD_1	193	195	PF00675	0.613
CLV_NRD_NRD_1	286	288	PF00675	0.683
CLV_NRD_NRD_1	36	38	PF00675	0.803
CLV_NRD_NRD_1	425	427	PF00675	0.411
CLV_NRD_NRD_1	517	519	PF00675	0.498
CLV_NRD_NRD_1	521	523	PF00675	0.463
CLV_NRD_NRD_1	7	9	PF00675	0.657
CLV_NRD_NRD_1	704	706	PF00675	0.436
CLV_NRD_NRD_1	820	822	PF00675	0.614
CLV_PCSK_FUR_1	496	500	PF00082	0.411
CLV_PCSK_KEX2_1	161	163	PF00082	0.564
CLV_PCSK_KEX2_1	171	173	PF00082	0.573
CLV_PCSK_KEX2_1	175	177	PF00082	0.578
CLV_PCSK_KEX2_1	193	195	PF00082	0.613
CLV_PCSK_KEX2_1	286	288	PF00082	0.683
CLV_PCSK_KEX2_1	425	427	PF00082	0.411
CLV_PCSK_KEX2_1	461	463	PF00082	0.411
CLV_PCSK_KEX2_1	498	500	PF00082	0.411
CLV_PCSK_KEX2_1	517	519	PF00082	0.411
CLV_PCSK_KEX2_1	521	523	PF00082	0.463
CLV_PCSK_KEX2_1	7	9	PF00082	0.657
CLV_PCSK_KEX2_1	704	706	PF00082	0.436
CLV_PCSK_KEX2_1	820	822	PF00082	0.608
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.625
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.411
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.411
CLV_PCSK_PC7_1	167	173	PF00082	0.525
CLV_PCSK_PC7_1	282	288	PF00082	0.636
CLV_PCSK_PC7_1	517	523	PF00082	0.397
CLV_PCSK_PC7_1	700	706	PF00082	0.436
CLV_PCSK_SKI1_1	425	429	PF00082	0.367
CLV_PCSK_SKI1_1	473	477	PF00082	0.443
CLV_PCSK_SKI1_1	534	538	PF00082	0.513
CLV_PCSK_SKI1_1	594	598	PF00082	0.353
CLV_PCSK_SKI1_1	704	708	PF00082	0.436
CLV_PCSK_SKI1_1	742	746	PF00082	0.657
CLV_PCSK_SKI1_1	813	817	PF00082	0.725
CLV_PCSK_SKI1_1	99	103	PF00082	0.669
DEG_APCC_DBOX_1	812	820	PF00400	0.724
DEG_SCF_TRCP1_1	718	723	PF00400	0.513
DEG_SPOP_SBC_1	224	228	PF00917	0.726
DOC_CKS1_1	315	320	PF01111	0.460
DOC_CYCLIN_RxL_1	470	479	PF00134	0.411
DOC_CYCLIN_RxL_1	810	818	PF00134	0.650
DOC_MAPK_gen_1	291	300	PF00069	0.605
DOC_MAPK_gen_1	471	478	PF00069	0.411
DOC_MAPK_gen_1	496	506	PF00069	0.411
DOC_MAPK_RevD_3	410	426	PF00069	0.424
DOC_MAPK_RevD_3	486	499	PF00069	0.411
DOC_PP2B_LxvP_1	554	557	PF13499	0.513
DOC_PP4_FxxP_1	315	318	PF00568	0.428
DOC_USP7_MATH_1	100	104	PF00917	0.781
DOC_USP7_MATH_1	109	113	PF00917	0.815
DOC_USP7_MATH_1	201	205	PF00917	0.761
DOC_USP7_MATH_1	224	228	PF00917	0.741
DOC_USP7_MATH_1	325	329	PF00917	0.589
DOC_USP7_MATH_1	361	365	PF00917	0.581
DOC_USP7_MATH_1	525	529	PF00917	0.513
DOC_USP7_MATH_1	606	610	PF00917	0.513
DOC_USP7_MATH_1	62	66	PF00917	0.800
DOC_USP7_MATH_1	716	720	PF00917	0.429
DOC_USP7_UBL2_3	134	138	PF12436	0.590
DOC_USP7_UBL2_3	46	50	PF12436	0.731
DOC_WW_Pin1_4	206	211	PF00397	0.806
DOC_WW_Pin1_4	280	285	PF00397	0.592
DOC_WW_Pin1_4	314	319	PF00397	0.456
DOC_WW_Pin1_4	54	59	PF00397	0.732
DOC_WW_Pin1_4	604	609	PF00397	0.513
LIG_14-3-3_CanoR_1	360	366	PF00244	0.592
LIG_14-3-3_CanoR_1	37	41	PF00244	0.624
LIG_14-3-3_CanoR_1	425	430	PF00244	0.482
LIG_14-3-3_CanoR_1	442	448	PF00244	0.287
LIG_14-3-3_CanoR_1	473	479	PF00244	0.411
LIG_14-3-3_CanoR_1	509	514	PF00244	0.280
LIG_14-3-3_CanoR_1	601	605	PF00244	0.513
LIG_14-3-3_CanoR_1	704	710	PF00244	0.436
LIG_Actin_WH2_2	445	463	PF00022	0.411
LIG_Actin_WH2_2	530	547	PF00022	0.513
LIG_BIR_II_1	1	5	PF00653	0.668
LIG_BIR_III_2	28	32	PF00653	0.767
LIG_BRCT_BRCA1_1	296	300	PF00533	0.567
LIG_BRCT_BRCA1_1	354	358	PF00533	0.479
LIG_Clathr_ClatBox_1	475	479	PF01394	0.411
LIG_Clathr_ClatBox_1	487	491	PF01394	0.411
LIG_deltaCOP1_diTrp_1	340	346	PF00928	0.660
LIG_EH1_1	700	708	PF00400	0.513
LIG_eIF4E_1	388	394	PF01652	0.411
LIG_FHA_1	244	250	PF00498	0.524
LIG_FHA_1	293	299	PF00498	0.606
LIG_FHA_1	31	37	PF00498	0.794
LIG_FHA_1	71	77	PF00498	0.747
LIG_FHA_2	112	118	PF00498	0.721
LIG_FHA_2	145	151	PF00498	0.601
LIG_FHA_2	15	21	PF00498	0.681
LIG_FHA_2	260	266	PF00498	0.454
LIG_FHA_2	332	338	PF00498	0.563
LIG_FHA_2	465	471	PF00498	0.381
LIG_FHA_2	541	547	PF00498	0.513
LIG_FHA_2	682	688	PF00498	0.440
LIG_FHA_2	803	809	PF00498	0.671
LIG_LIR_Apic_2	313	318	PF02991	0.433
LIG_LIR_Gen_1	115	126	PF02991	0.742
LIG_LIR_Gen_1	245	254	PF02991	0.620
LIG_LIR_Gen_1	446	456	PF02991	0.336
LIG_LIR_Gen_1	491	497	PF02991	0.411
LIG_LIR_Gen_1	653	662	PF02991	0.353
LIG_LIR_Nem_3	115	121	PF02991	0.746
LIG_LIR_Nem_3	245	251	PF02991	0.634
LIG_LIR_Nem_3	446	452	PF02991	0.389
LIG_LIR_Nem_3	491	495	PF02991	0.411
LIG_LIR_Nem_3	653	658	PF02991	0.411
LIG_LIR_Nem_3	739	744	PF02991	0.558
LIG_LIR_Nem_3	846	850	PF02991	0.734
LIG_LIR_Nem_3	858	864	PF02991	0.730
LIG_LYPXL_SIV_4	468	476	PF13949	0.280
LIG_OCRL_FandH_1	681	693	PF00620	0.411
LIG_PCNA_yPIPBox_3	442	452	PF02747	0.411
LIG_PTB_Apo_2	555	562	PF02174	0.411
LIG_SH2_CRK	326	330	PF00017	0.485
LIG_SH2_CRK	388	392	PF00017	0.411
LIG_SH2_CRK	492	496	PF00017	0.411
LIG_SH2_CRK	741	745	PF00017	0.641
LIG_SH2_NCK_1	862	866	PF00017	0.740
LIG_SH2_STAP1	398	402	PF00017	0.411
LIG_SH2_STAP1	559	563	PF00017	0.353
LIG_SH2_STAT5	349	352	PF00017	0.552
LIG_SH2_STAT5	492	495	PF00017	0.411
LIG_SH2_STAT5	811	814	PF00017	0.645
LIG_SH3_3	102	108	PF00018	0.752
LIG_SH3_3	204	210	PF00018	0.844
LIG_SH3_3	477	483	PF00018	0.472
LIG_SH3_3	56	62	PF00018	0.734
LIG_SH3_3	73	79	PF00018	0.553
LIG_SH3_4	134	141	PF00018	0.579
LIG_SUMO_SIM_anti_2	609	615	PF11976	0.436
LIG_SUMO_SIM_anti_2	693	700	PF11976	0.416
LIG_SUMO_SIM_par_1	474	479	PF11976	0.411
LIG_SUMO_SIM_par_1	485	491	PF11976	0.411
LIG_TRAF2_1	180	183	PF00917	0.705
LIG_TRAF2_1	334	337	PF00917	0.624
LIG_TRAF2_1	367	370	PF00917	0.532
LIG_TYR_ITIM	324	329	PF00017	0.487
LIG_TYR_ITIM	490	495	PF00017	0.411
LIG_TYR_ITSM	737	744	PF00017	0.425
LIG_WRC_WIRS_1	803	808	PF05994	0.674
MOD_CDK_SPxK_1	280	286	PF00069	0.604
MOD_CDK_SPxK_1	314	320	PF00069	0.462
MOD_CDK_SPxxK_3	280	287	PF00069	0.612
MOD_CK1_1	112	118	PF00069	0.824
MOD_CK1_1	227	233	PF00069	0.822
MOD_CK1_1	443	449	PF00069	0.436
MOD_CK1_1	647	653	PF00069	0.421
MOD_CK1_1	83	89	PF00069	0.737
MOD_CK1_1	863	869	PF00069	0.698
MOD_CK2_1	119	125	PF00069	0.762
MOD_CK2_1	144	150	PF00069	0.602
MOD_CK2_1	259	265	PF00069	0.471
MOD_CK2_1	331	337	PF00069	0.603
MOD_CK2_1	464	470	PF00069	0.381
MOD_CK2_1	606	612	PF00069	0.436
MOD_CK2_1	681	687	PF00069	0.440
MOD_CK2_1	802	808	PF00069	0.628
MOD_CK2_1	82	88	PF00069	0.788
MOD_GlcNHglycan	102	105	PF01048	0.865
MOD_GlcNHglycan	111	114	PF01048	0.704
MOD_GlcNHglycan	312	315	PF01048	0.478
MOD_GlcNHglycan	405	408	PF01048	0.411
MOD_GlcNHglycan	442	445	PF01048	0.443
MOD_GlcNHglycan	580	585	PF01048	0.339
MOD_GlcNHglycan	608	611	PF01048	0.459
MOD_GlcNHglycan	614	617	PF01048	0.487
MOD_GlcNHglycan	64	67	PF01048	0.860
MOD_GlcNHglycan	667	670	PF01048	0.406
MOD_GlcNHglycan	718	721	PF01048	0.513
MOD_GlcNHglycan	833	837	PF01048	0.806
MOD_GlcNHglycan	865	868	PF01048	0.735
MOD_GSK3_1	108	115	PF00069	0.695
MOD_GSK3_1	125	132	PF00069	0.623
MOD_GSK3_1	223	230	PF00069	0.784
MOD_GSK3_1	292	299	PF00069	0.611
MOD_GSK3_1	310	317	PF00069	0.474
MOD_GSK3_1	425	432	PF00069	0.447
MOD_GSK3_1	45	52	PF00069	0.792
MOD_GSK3_1	576	583	PF00069	0.457
MOD_GSK3_1	600	607	PF00069	0.472
MOD_GSK3_1	638	645	PF00069	0.409
MOD_GSK3_1	646	653	PF00069	0.416
MOD_GSK3_1	690	697	PF00069	0.436
MOD_GSK3_1	705	712	PF00069	0.281
MOD_GSK3_1	716	723	PF00069	0.374
MOD_GSK3_1	78	85	PF00069	0.830
MOD_GSK3_1	95	102	PF00069	0.728
MOD_N-GLC_1	128	133	PF02516	0.725
MOD_N-GLC_1	742	747	PF02516	0.602
MOD_NEK2_1	310	315	PF00069	0.466
MOD_NEK2_1	351	356	PF00069	0.580
MOD_NEK2_1	429	434	PF00069	0.414
MOD_NEK2_1	490	495	PF00069	0.411
MOD_NEK2_1	646	651	PF00069	0.436
MOD_NEK2_1	681	686	PF00069	0.402
MOD_NEK2_1	750	755	PF00069	0.611
MOD_NEK2_1	82	87	PF00069	0.789
MOD_NEK2_2	296	301	PF00069	0.551
MOD_NEK2_2	540	545	PF00069	0.513
MOD_PIKK_1	647	653	PF00454	0.511
MOD_PK_1	509	515	PF00069	0.280
MOD_PKA_1	167	173	PF00069	0.637
MOD_PKA_1	425	431	PF00069	0.319
MOD_PKA_1	49	55	PF00069	0.760
MOD_PKA_2	14	20	PF00069	0.674
MOD_PKA_2	292	298	PF00069	0.623
MOD_PKA_2	36	42	PF00069	0.787
MOD_PKA_2	425	431	PF00069	0.511
MOD_PKA_2	587	593	PF00069	0.405
MOD_PKA_2	600	606	PF00069	0.427
MOD_PKA_2	745	751	PF00069	0.655
MOD_PKB_1	507	515	PF00069	0.308
MOD_PKB_1	740	748	PF00069	0.651
MOD_Plk_1	244	250	PF00069	0.658
MOD_Plk_1	490	496	PF00069	0.411
MOD_Plk_2-3	119	125	PF00069	0.748
MOD_Plk_4	244	250	PF00069	0.619
MOD_Plk_4	296	302	PF00069	0.548
MOD_Plk_4	389	395	PF00069	0.411
MOD_Plk_4	429	435	PF00069	0.473
MOD_Plk_4	443	449	PF00069	0.289
MOD_Plk_4	650	656	PF00069	0.327
MOD_Plk_4	694	700	PF00069	0.319
MOD_Plk_4	729	735	PF00069	0.587
MOD_Plk_4	745	751	PF00069	0.549
MOD_ProDKin_1	206	212	PF00069	0.803
MOD_ProDKin_1	280	286	PF00069	0.604
MOD_ProDKin_1	314	320	PF00069	0.462
MOD_ProDKin_1	54	60	PF00069	0.729
MOD_ProDKin_1	604	610	PF00069	0.513
MOD_SUMO_rev_2	527	536	PF00179	0.511
TRG_DiLeu_BaEn_1	182	187	PF01217	0.604
TRG_DiLeu_BaEn_1	694	699	PF01217	0.411
TRG_DiLeu_BaEn_4	182	188	PF01217	0.577
TRG_DiLeu_BaEn_4	687	693	PF01217	0.389
TRG_ENDOCYTIC_2	321	324	PF00928	0.499
TRG_ENDOCYTIC_2	326	329	PF00928	0.458
TRG_ENDOCYTIC_2	349	352	PF00928	0.558
TRG_ENDOCYTIC_2	492	495	PF00928	0.411
TRG_ENDOCYTIC_2	741	744	PF00928	0.543
TRG_ER_diArg_1	162	164	PF00400	0.609
TRG_ER_diArg_1	266	269	PF00400	0.515
TRG_ER_diArg_1	384	387	PF00400	0.436
TRG_ER_diArg_1	424	426	PF00400	0.411
TRG_ER_diArg_1	506	509	PF00400	0.411
TRG_ER_diArg_1	520	522	PF00400	0.411
TRG_ER_diArg_1	6	8	PF00400	0.670
TRG_ER_diArg_1	703	705	PF00400	0.436
TRG_ER_diArg_1	819	821	PF00400	0.659
TRG_NLS_Bipartite_1	37	53	PF00514	0.664
TRG_NLS_MonoCore_2	159	164	PF00514	0.617
TRG_NLS_MonoExtC_3	159	164	PF00514	0.616
TRG_NLS_MonoExtC_3	167	172	PF00514	0.627
TRG_NLS_MonoExtC_3	45	50	PF00514	0.713
TRG_NLS_MonoExtC_3	90	96	PF00514	0.772
TRG_NLS_MonoExtN_4	160	165	PF00514	0.647
TRG_NLS_MonoExtN_4	167	172	PF00514	0.586
TRG_NLS_MonoExtN_4	43	50	PF00514	0.732
TRG_NLS_MonoExtN_4	89	95	PF00514	0.772
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.651
TRG_Pf-PMV_PEXEL_1	705	709	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	813	817	PF00026	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Q4	Leptomonas seymouri	48%	100%
A0A3S5H5E5	Leishmania donovani	91%	100%
A4H423	Leishmania braziliensis	77%	100%
A4HSA5	Leishmania infantum	91%	100%
E9AK89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%